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| 1 | Treatment of colorectal cancer in the elderly显示文摘Colorectal cancer has a high incidence, and approxi-mately 60% of colorectal cancer patients are older than 70, with this incidence likely increasing in the near future. Elderly patients(> 70-75 years of age) are a very heterogeneous group, ranging from the very fit to the very frail. Traditionally, these patients have often been under-treated and recruited less frequently to clinical trials than younger patients, and thus are underrepresented in publications about cancer treatment. Recent studies suggest that fit elderly patients can be treated in the same way as their younger counterparts, but the treatment of frail patients with comorbidities is still a matter of controversy. Many factors should be taken into account, including fitness for treatment, the wishes of the patient and family, and quality of life. This review will focus on the existing evidence for surgical, oncologic, and palliative treatment in patients over 70 years old with colorectal cancer. Careful patient assessment is necessary in order to individualize treatment approach, and this should rely on a multidisciplinary process. More well-designed controlled trials are needed in this patient population. | Monica Millan Sandra Merino Aleidis Caro Francesc Feliu Jordi Escuder Tani Francesch | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 9 |
| 2 | Portal hypertensive colopathy is associated with portal hypertension severity in cirrhotic patients显示文摘AIM:To assess the prevalence of portal hypertension (PH) related colorectal lesions in liver transplant candidates, and to evaluate its association with the severity of PH.METHODS: Between October 2004 and December 2005, colonoscopy was performed in 92 cirrhotic liver transplant candidates. We described the lesions resulting from colorectal PH and their association with the grade of PH in 77 patients who underwent measurement of hepatic venous pressure gradient (HVPG).RESULTS: Mean age was 55 years and 80.7% of patients were men. The main etiology of cirrhosis was alcoholism (45.5%). Portal hypertensive colopathy (PHC) was found in 23.9%, colonic varices in 7.6% and polyps in 38% of patients (adenomatous type 65.2%). One asymptomatic patient had a well-differentiated adenocarcinoma. The manifestations of colorectal PH were not associated with the etiology of liver disease or with the Child-Pugh grade. Ninety percent of patients with colopathy presented with gastroesopha-geal varices (GEV), and 27.5% of patients with GEV presented with colopathy (P=0.12). A relationship between higher values of HVPG and presence of col-opathy was observed (19.9±6.2 mmHg vs 16.8±5.4 mmHg, P=0.045), but not with the grade of col-opathy (P=0.13). Preneoplastic polyps and neoplasm (P=0.02) and spontaneous bacterial peritonitis (P=0.006) were more prevalent in patients with colopathy. We did not observe any association between previous β-blocker therapy and the presence of colorectal portal hypertensive vasculopathy.CONCLUSION: PHC is common in cirrhotic liver trans-plant candidates and is associated with higher portal pressure. | Antonio Diaz-Sanchez Oscar Nuez-Martinez Cecilia Gonzalez-Asanza Ana Matilla Beatriz Merino Diego Rincon Inmaculada Beceiro Maria Vega Catalina Magdalena Salcedo Rafael Baares Gerardo Clemente | 2009 | World Journal of Gastroenterology2009，15，38： | 6 |
| 3 | Selective suspension of single layer graphene mechanochemically exfoliated from carbon nanofibres显示文摘 | Antonio Esau Del Rio-CastilloI Cesar Merino Enrique Diez-Barra Ester Vazquez | 2014 | Nano Research2014，7，7： | 4 |
| 4 | Metabolic effects of testosterone during prolonged physical exercise and fasting显示文摘 | C. Y. Guezennec P. Ferre B. Serrurier D. Merino M. Aymonod P. C. Pesquies | 1984 | European Journal of Applied Physiology and Occupational Physiology1984，，： | 3 |
| 5 | Intravoxel incoherent motion MR imaging for prostate cancer: An evaluation of perfusion fraction and diffusion coefficient derived from different b ‐value combinations显示文摘 | Yuxi Pang Baris Turkbey Marcelino Bernardo Jochen Kruecker Samuel Kadoury Maria J. Merino Bradford J. Wood Peter A. Pinto Peter L. Choyke | 2012 | Magn Reson Med2012，，： | 2 |
| 6 | Pitting corrosion behaviour of austenitic stainless steels – combining effects of Mn and Mo additions显示文摘 | A. Pardo M.C. Merino A.E. Coy F. Viejo R. Arrabal E. Matykina | 2008 | Corrosion Science2008，，6： | 2 |
| 7 | National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards显示文摘 | Vladimir Hachinski Costantino Iadecola Ron C. Petersen Monique M. Breteler David L. Nyenhuis Sandra E. Black William J. Powers Charles DeCarli Jose G. Merino Raj N. Kalaria Harry V. Vinters David M. Holtzman Gary A. Rosenberg Anders Wallin Martin Dichgans | 2006 | Stroke2006，，9： | 2 |
| 8 | Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF kappaB显示文摘 | Pozo Guisado E Merino J M Mulero-Navarro S el al | 2005 | Int J Cancer2005，115，1： | 1 |
| 9 | Resveratrol- induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-KappaB 显示文摘 | Pozo-Guisado E Merino JM Mulero-Navano S | 2005 | Int J Cancer2005，115，： | 1 |
| 10 | Evaluation and optimization of an on- line admieelle- based extraction- liquid chromatography approach for the analysis of ionic organic compounds 显示文摘 | Merino F Rubio S Perez- Bendito D | 2004 | Anal Chem2004，76，： | 1 |
| 11 | Collecting duct carcinoma of the kidney显示文摘 | Kennedy SM Merino MJ Linehan WM | 1990 | Hum Pathol1990，21，4： | 1 |
| 12 | Identifying predictive factors for therapy nonadherence among hypertensive, older adults from a community in southern Chile显示文摘 | Mendoza-Parra S Merino JM Barriga OA | 2009 | Rev Panam Salud Publica2009，25，2： | 1 |
| 13 | ABB Varspeed generator boosts efficiency and operating flexibility of hydropower plant 显示文摘 | Merino J M Lopez A | 1996 | ABB Review1996，3，： | 1 |
| 14 | Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas显示文摘 | Rojo J V Merino A M Gonzalez L O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，104，1： | 1 |
| 15 | Tick vaccines and the control of tick-borne pathogens显示文摘 | Merino O | 2013 | Frontiers in Cellular & Infection Microbiology2013，3，7： | 1 |
| 16 | Relationship between wear rate,surface pullout and microstructure during abrasive wear of alumina and alumina/SiC nanocomposites显示文摘 | MERINO J O L TODD R I | 2005 | Acta Materialia2005，53，12： | 1 |
| 17 | Primary cutaneous cryptoeoecosis in an immunocompetent host: case report and review of the literature 显示文摘 | Revenga F Parieio JF Merino FJ | 2002 | Dermatology2002，204，2： | 1 |
| 18 | Collecting duct carcinoma of the kidney显示文摘 | KENNEDY S M MERINO M J LINEHAN W M | 1990 | Hum Pathol1990，21，4： | 1 |
| 19 | Immunohistochemical detection of P-glycoprotein in endometrial adenocarcinoma显示文摘 | Axiotis CA Monteagudo C Merino M J | 1991 | Am J Pathol1991，138，： | 1 |
| 20 | Pitting Corrosion Be haviour of Austenitic Stainless Steels Combining Effects of Mn and Mo Additions 显示文摘 | Pardo A Merino M C Coy A E | 2008 | Corrosion Science2008，50，6： | 1 |
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