|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Material transportation and fluid-melt activity in the subduction channel: Numerical modeling显示文摘The subduction channel is defined as a planar to wedge-like area of variable size,internal structure and composition,which forms between the upper and lower plates during slab subduction into the mantle.The materials in the channel may experience complex pressure,temperature,stress and strain evolution,as well as strong fluid and melt activity.A certain amount of these materials may subduct to and later exhume from>100 km depth,forming high to ultra-high pressure rocks on the surface as widely discovered in nature.Rock deformation in the channel is strongly assisted by metamorphic fluids activities,which change composition and mechanical properties of rocks and thus affect their subduction and exhumation histories.In this study,we investigate the detailed structure and dynamics of both oceanic and continental subduction channels,by conducting highresolution petrological-thermomechanical numerical simulations taking into account fluid and melt activities.The numerical results demonstrate that subduction channels are composed of a tectonic rock melange formed by crustal rocks detached from the subducting slab and the hydrated mantle rocks scratched from the overriding plate.These rocks may either extrude sub-vertically upward through the mantle wedge to the crust of the upper plate,or exhume along the subduction channel to the surface near the suture zone.Based on our numerical results,we first analyze similarities and differences between oceanic and continental subduction channels.We further compare numerical models with and without fluid and melt activity and demonstrate that this activity results in strong weakening and deformation of overriding lithosphere.Finally,we show that fast convergence of orogens subjected to fluid and melt activity leads to strong deformation of the overriding lithosphere and the topography builds up mainly on the overriding plate.In contrast,slow convergence of such orogens leads to very limited deformation of the overriding lithosphere and the mountain building mainly occurs on the subducting plate. | LI ZhongHai LIU MingQi Taras GERYA | 2015 | Science China Earth Sciences2015，58，8： | 18 |
| 2 | The Immune System and the Role of Inflammation in Perinatal Depression显示文摘Major depression during pregnancy is a common psychiatric disorder that arises from a complex and multifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic–pituitary–adrenal axis hyperactivity. Dysregulation of this intricate neuroimmune communication network during pregnancy modifies the maternal milieu, enhancing the emergence of depressive symptoms and negative obstetric and neuropsychiatric outcomes. Although several studies have clearly demonstrated the role of the innate immune system in major depression, it is still unclear how the placenta, the brain, and the monoaminergic and neuroendocrine systems interact during perinatal depression. Thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during pregnancy, proposing that the same stress-related mechanisms involved in the activation of the NLRP3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. Thus, activation of Toll-like receptor 2 and 4 signaling and the NLRP3 inflammasome in placental immune cells may promote a shift of the Th1/Th2 bias towards a predominant Th1/Th17 inflammatory response, associated with increased secretion of pro-inflammatory cytokines, among other secreted autocrine and paracrine mediators, which play a crucial role in triggering and/or exacerbating depressive symptoms during pregnancy. | Philippe Leff-Gelman Ismael Mancilla-Herrera Monica Flores-Ramos Carlos Cruz-Fuentes Juan Pablo Reyes-Grajeda maría del pilar garcía-cuétara Marielle Danitza Bugnot-Perez David Ellioth Pulido-Ascencio | 2016 | Neuroscience Bulletin2016，32，4： | 17 |
| 3 | Stagnant lid tectonics:Perspectives from silicate planets,dwarf planets, large moons,and large asteroids显示文摘To better understand Earth's present tectonic style-plate tectonics—and how it may have evolved from single plate(stagnant lid) tectonics, it is instructive to consider how common it is among similar bodies in the Solar System. Plate tectonics is a style of convection for an active planetoid where lid fragment(plate) motions reflect sinking of dense lithosphere in subduction zones, causing upwelling of asthenosphere at divergent plate boundaries and accompanied by focused upwellings, or mantle plumes;any other tectonic style is usefully called 'stagnant lid' or 'fragmented lid'. In 2015 humanity completed a 50+ year effort to survey the 30 largest planets, asteroids, satellites, and inner Kuiper Belt objects,which we informally call 'planetoids' and use especially images of these bodies to infer their tectonic activity. The four largest planetoids are enveloped in gas and ice(Jupiter, Saturn, Uranus, and Neptune)and are not considered. The other 26 planetoids range in mass over 5 orders of magnitude and in diameter over 2 orders of magnitude, from massive Earth down to tiny Proteus; these bodies also range widely in density, from 1000 to 5500 kg/m^3. A gap separates 8 silicate planetoids with ρ = 3000 kg/m^3 or greater from 20 icy planetoids(including the gaseous and icy giant planets) with ρ = 2200 kg/m^3 or less. We define the 'Tectonic Activity Index'(TAI), scoring each body from 0 to 3 based on evidence for recent volcanism, deformation, and resurfacing(inferred from impact crater density). Nine planetoids with TAI = 2 or greater are interpreted to be tectonically and convectively active whereas 17 with TAI <2 are inferred to be tectonically dead. We further infer that active planetoids have lithospheres or icy shells overlying asthenosphere or water/weak ice. TAI of silicate(rocky) planetoids positively correlates with their inferred Rayleigh number. We conclude that some type of stagnant lid tectonics is the dominant mode of heat loss and that plate tectonics is unusual. To make progress understanding Earth's tectonic history and the tectonic style of active exoplanets, we need to better understand the range and controls of active stagnant lid tectonics. | Robert J.Stern Taras Gerya Paul J.Tackley | 2018 | Geoscience Frontiers2018，9，1： | 13 |
| 4 | 俯冲隧道中物质运移和流体-熔体活动的动力学数值模拟显示文摘俯冲隧道是指在会聚板块边缘、俯冲板片与上覆板片之间的剪切带及其中发生运动的物质,这些物质在俯冲隧道中经历了复杂的温度、压力、应力和应变等的演化以及流体和熔体的作用,而后部分物质可以从>100 km的深度处折返至地表,从而形成自然界中出露的高压-超高压变质岩带.动力学数值模拟是定量化的研究该俯冲隧道过程的重要手段,前人的研究大多基于热动力学模型,但是一般不包含流体的活动和影响,因此上覆岩石圈物质很少参与到俯冲隧道过程中,这些模型与地质概念模型之间尚存较大差异.本文采用了新的包含流体-熔体活动的数值模型,对俯冲隧道的精细过程进行模拟研究.结果表明,俯冲隧道中的物质既包含了从俯冲板块拆离的表壳岩,也包含了从上覆板块刮擦、蚀变的地幔岩,从而形成一个构造混杂岩体.在特定条件下,俯冲隧道中的混杂岩既可近垂直向上穿过地幔楔侵入上覆地壳中,亦可近平行于俯冲隧道斜向上折返,形成靠近缝合带的高压-超高压变质岩.基于该数值模型及前人的地质概念模型,首先对大洋俯冲隧道和大陆俯冲隧道的特征进行了细致的对比和总结.而后,又对含水模型与无水模型进行了对比,主要区别在于无水模型中由于缺少流体-熔体活动而产生的弱化作用,上覆岩石圈的变形很小,在俯冲隧道过程中的参与程度也很低.最后,对数值模型中的一个重要的边界条件,即板块会聚速率,进行数值模拟研究.结果表明快速会聚导致上覆岩石圈剧烈变形,造山带主要沿上盘单侧生长;相反,在慢速会聚条件下,上覆岩石圈变形较小,造山带主要沿下盘单侧生长;而在中等会聚速率下,造山带沿上盘、下盘同时生长. | 李忠海 刘明启 Taras GERYA | 2015 | 中国科学:地球科学2015，45，7： | 11 |
| 5 | 发达国家纵向整合临床实习模式的发展及其对我国医学教育的启示显示文摘临床实习是医学生将理论知识转化为临床能力和深入临床环境学习的重要途径。纵向整合临床实习模式目前是一种创新性的临床教学方法和理念,它将连续性作为教学原则,很好地解决了原有临床实习中缺乏医疗连续性、课程连续性和教学指导连续性的问题,越来越多的医学院应用此种模式进行临床教学改革。本文对该实习模式的核心内涵、意义和哈佛剑桥模式及其发展与衍变进行阐述,并结合中国医学教育的实际需求进行分析,认为纵向整合临床实习模式可以提高我国临床医生培养质量,促进基层医疗人才队伍建设,增强住院医师规范化培训效果,有助于我国医学教育改革发展。 | 李鸿鹤 David A Hirsh Tara A Singh Yamini Saravanan Rachel Hathaway Bianca Shagrin Elizabeth Gaufberg Arundhati Ghosh 刘君 李扬龄 闻德亮 | 2020 | 中华医学教育杂志2020，40，9： | 10 |
| 6 | Neural progenitor cells but not astrocytes respond distally to thoracic spinal cord injury in rat models显示文摘Traumatic spinal cord injury(SCI) is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells,astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI(n = 9), sham surgery(n = 8), or no surgery(n = 8). Spinal cord and brain tissues were fixed and cut at six regions of the neuroaxis. Immunohistochemistry showed increased reactivity of neural progenitor cell marker nestin in the central canal at all levels of the spinal cord. Increased reactivity of astrocyte-specific marker glial fibrillary acidic protein was found only at the lesion epicenter. The number of activated microglia was significantly increased at the lesion site,and activated microglia extended to the lumbar enlargement. Phagocytic microglia and macrophages were significantly increased only at the lesion site. There were no changes in nestin, glial fibrillary acidic protein,microglia and macrophage response in the third ventricle of rats subjected to mild-contusion thoracic SCI compared to the sham surgery or no surgery. These findings indicate that neural progenitor cells, astrocytes and microglia respond differently to a localized SCI, presumably due to differences in inflammatory signaling. These different cellular responses may have implications in the way that neural progenitor cells can be manipulated for neuroregeneration after SCI. This needs to be further investigated. | Tara Nguyen Yilin Mao Theresa Sutherland Catherine Anne Gorrie | 2017 | Neural Regeneration Research2017，12，11： | 8 |
| 7 | Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus显示文摘Diabetes mellitus(DM) is the third most common noninfectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of microand macroangiopathies. Metabolic disorders caused by insulin deficiency in diabetes significantly impede the functioning of a homeostasis system, which change the physical, biochemical, morphological, and functional properties of blood cells. As a result, the oxygen-transport function of red blood cells(RBCs), rheological properties of the blood, and functions of immunocompetent cells as well as the process of apoptosis are primarily affected. Modern pharmacotherapy focuses on the search for new preparations that aim to decrease blood glucose levels. Undesirable side effects and adverse reactions caused by synthetic medicines led to the search and investigation of new preparations of natural origin. Medicinal mushrooms play an important role among such new preparations. They are a source of a large number of high-and lowmolecular compounds with pronounced biological effects. Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaricus brasiliensis(A. brasiliensis) and Ganoderma lucidum(G. lucidum) on streptozotocin-induced DM in rats. Also, we showed that mycelium powders have membrane protective properties as evidenced by the redistribution of RBC populations towards the growth of full functional cell numbers. Normalization of parameters of leukocyte formula and suppression of apoptosis of white blood cells in diabeticrats treated with A. brasiliensis and G. lucidum mycelia indicates pronounced positive effects of these strains of mushrooms. Thus, the use of medicinal mushrooms for treatment of DM and in prevention development of its secondary complications might be a new effective approach of this disease's cure. This article is aimed at summarizing and analyzing the literature data and basic achievements concerning DM type 1 treatment using medicinal mushrooms and showing the results obtained in our research. | Taras Vitak Borys Yurkiv Solomon Wasser Eviatar Nevo Natalia Sybirna | 2017 | World Journal of Diabetes2017，8，5： | 6 |
| 8 | 应用“One Health”策略解决复杂健康问题显示文摘“One Health”意指多学科共同合作,为人类健康、动物健康、环境健康三者共同成为一个健康整体而进行的工作和努力。“One Health”是一个新的名词,但是这一概念是很早之前已经存在的。2003年4月7日,华盛顿邮报的Rick Weiss引证了兽医博士William Karesh的话“人类和家禽或者野生动物的健康再也不能分开谈论了,世界上只有‘One Health’,所有的问题解决办法需要我们各个学科的工作人员共同努力,在不同的层面为问题的解决作出贡献。”其实,我国也一直是采用类似的策略来解决复杂的公共卫生与健康问题,只是没有提出相应新的“名词”,也没有进行系统地阐述。为此,我刊特邀美国杜克大学的 Gregory C.Gray 教授撰写此文,以供国内同行借鉴。关于“One Health”,目前国内翻译的名称非常不一致,比如“唯一健康”、“共同健康”、“协同健康”,编者在此不做翻译,希望广大专家、读者广泛讨论,最终能够确定比较合适并广为接受的中文名称。 | Xiao Zheng 陆家海 Sarah K.White Tara Sabo-Attwood Gregory C.Gray | 2014 | 中华预防医学杂志2014，48，12： | 6 |
| 9 | Squamous cell cancer of the rectum显示文摘Squamous cell carcinoma of the rectum is a rare malignancy.It appears to be associated with chronic inflammatory conditions and infections.The clear association seen between Human Papilloma Virus and various squamous cancers has not been firmly established for the squamous cell cancer of the rectum. The presentation is nonspecific and patients tend to present with advanced stage disease.Diagnosis relies on endoscopic examination with biopsy of the lesion.Distinction from squamous cell cancer of the anus can be difficult,but can be facilitated by immunohistochemical staining for cytokeratins.Staging of the cancer with endoscopic ultrasound and computed tomography provides essential information on prognosis and can guide therapy.At present,surgery remains the main therapeutic option;however recent advances have made chemoradiation a valuable therapeutic addition. Squamous cell carcinoma of the rectum is a distinct entity and it is of crucial importance for the practicing Gastroenterologist to be thoroughly familiar with this disease.Compared to adenocarcinoma of the rectum and squamous cell cancer of the anal canal,squamous cell carcinoma of the rectum has different epidemiology, etiology,pathogenesis,and prognosis but,most importantly,requires a different therapeutic approach. This review will examine and summarize the available information regarding this disease from the perspective of the practicing gastroenterologist. | Tara Dyson Peter V Draganov | 2009 | World Journal of Gastroenterology2009，15，35： | 5 |
| 10 | Microstructure,mechanical response and fractography of AZ91E/Al_(2)O_(3)_(p) nano composite fabricated by semi solid stir casting method显示文摘The present study confers to the fabrication and its characterization of magnesium alloy(AZ91E)based nano composites with nano Al_(2)O_(3) particulate reinforcements.A novel Semi Solid stir casting technique was adopted for the fabrication of the composite.An average particle size of 50 nm was used as reinforcement to disperse in matrix.The effects of change in weight fraction of reinforcements on the distribution of particles,particle–matrix interfacial reactions,physical as well as mechanical properties were reported.The SEM and EDS analysis has shown the uniform distribution of particles in the composite along with the presence of elements.The mechanical properties of reinforced and unreinforced composite were evaluated and presented.Fractography of tensile specimens was also discussed. | Sameer Kumar D Suman K.N.S Tara Sasanka C Ravindra K Palash Poddar | 2017 | Journal of Magnesium and Alloys2017，5，1： | 4 |
| 11 | Helicobacter pylori infection in bleeding peptic ulcer patients after non-steroidal antiinflammatory drug consumption显示文摘AIM:To establish the prevalence of Helicobacter pylori (H. pylori ) infection in patients with a bleeding peptic ulcer after consumption of non-steroidal antiinflamma- tory drugs (NSAIDs). METHODS:A very early upper endoscopy was performed to find the source of upper gastrointestinal bleeding and to take biopsy specimens for analysis of H. pylori infection by the rapid urease (CLO) test, histological examination, and bacterial culture. IgG anti-CagA were also sought. The gold standard for identifying H. pylori infection was positive culture of biopsy specimens or contemporary positivity of the CLO test and the presence of H. pylori on tissue sections. RESULTS:Eighty patients, 61 males (76.3%), mean age 61.2 ± 15.9 years, were consecutively enrolled. Forty-seven (58.8%) patients occasionally consumed NSAIDs, while 33 (41.3%) were on chronic treatment with low-dose aspirin (LD ASA). Forty-four (55.0%) patients were considered infected by H. pylori . The infection rate was not different between patients who occasionally or chronically consumed NSAIDs. The culture of biopsy specimens had a sensitivity of 86.4% and a specificity of 100%; corresponding figures for histological analysis were 65.9% and 77.8%, for the CLO test were 68.2% and 75%, for the combined use of histology and the CLO test were 56.8% and 100%, and for IgG anti-CagA were 90% and 98%. The highest accuracy (92.5%) was obtained with the culture of biopsy specimens.CONCLUSION:Patients with a bleeding peptic ulcer after NSAID/LD ASA consumption frequently have H. pylori infection. Biopsy specimen culture after an early upper gastrointestinal tract endoscopy seems the most efficient test to detect this infection. | Francesco Manguso Elisabetta Riccio Germana de Nucci Maria Luisa Aiezza Gerardino Amato Linda Degl'Innocenti Maria Maddalena Piccirillo Gianfranco De Dominicis Tara Santoro Elena Trimarco Antonio Balzano | 2011 | World Journal of Gastroenterology2011，17，40： | 4 |
| 12 | Contrasted continental rifting via plume-craton interaction: Applications to Central East African Rift显示文摘The East African Rift system(EARS)provides a unique system with the juxtaposition of two contrasting yet simultaneously formed rift branches,the eastern,magma-rich,and the western,magma-poor,on either sides of the old thick Tanzanian craton embedded in a younger lithosphere.Data on the pre-rift,syn-rift and post-rift far-field volcanic and tectonic activity show that the EARS formed in the context of the interaction between a deep mantle plume and a horizontally and vertically heterogeneous lithosphere under far-field tectonic extension.We bring quantitative insights into this evolution by implementing high-resolution 3D thermo-mechanical numerical deformation models of a lithosphere of realistic rheology.The models focus on the central part of the EARS.We explore scenarios of plumelithosphere interaction with plumes of various size and initial position rising beneath a tectonically pre-stretched lithosphere.We test the impact of the inherited rheological discontinuities(suture zones)along the craton borders,of the rheological structure,of lithosphere plate thickness variations,and of physical and mechanical contrasts between the craton and the embedding lithosphere.Our experiments indicate that the ascending plume material is deflected by the cratonic keel and preferentially channeled along one of its sides,leading to the formation of a large rift zone along the eastern side of the craton,with significant magmatic activity and substantial melt amount derived from the mantle plume material.We show that the observed asymmetry of the central EARS,with coeval amagmatic(western)and magmatic(eastern)branches,can be explained by the splitting of warm material rising from a broad plume head whose initial position is slightly shifted to the eastern side of the craton.In that case,neither a mechanical weakness of the contact between the craton and the embedding lithosphere nor the presence of second plume are required to produce simulations that match observations.This result reconciles the passive and active rift models and demonstrates the possibility of development of both magmatic and amagmatic rifts in identical geotectonic environments. | Alexander Koptev Evgueni Burov Eric Calais Sylvie Leroy Taras Gerya Laurent Guillou-Frottier Sierd Cloetingh | 2016 | Geoscience Frontiers2016，7，2： | 4 |
| 13 | One stop shop:backbones trees for important phytopathogenic genera:Ⅰ(2014)显示文摘Many fungi are pathogenic on plants and cause significant damage in agriculture and forestry.They are also part of the natural ecosystem and may play a role in regulating plant numbers/density.Morphological identification and analysis of plant pathogenic fungi,while important,is often hampered by the scarcity of discriminatory taxonomic characters and the endophytic or inconspicuous nature of these fungi.Molecular(DNA sequence)data for plant pathogenic fungi have emerged as key information for diagnostic and classification studies,although hampered in part by non-standard laboratory practices and analytical methods.To facilitate current and future research,this study provides phylogenetic synopses for 25 groups of plant pathogenic fungi in the Ascomycota,Basidiomycota,Mucormycotina(Fungi),and Oomycota,using recent molecular data,up-to-date names,and the latest taxonomic insights.Lineagespecific laboratory protocols together with advice on their application,as well as general observations,are also provided.We hope to maintain updated backbone trees of these fungal lineages over time and to publish them jointly as new data emerge.Researchers of plant pathogenic fungi not covered by the present study are invited to join this future effort.Bipolaris,Botryosphaeriaceae,Botryosphaeria,Botrytis,Choanephora,Colletotrichum,Curvularia,Diaporthe,Diplodia,Dothiorella,Fusarium,Gilbertella,Lasiodiplodia,Mucor,Neofusicoccum,Pestalotiopsis,Phyllosticta,Phytophthora,Puccinia,Pyrenophora,Pythium,Rhizopus,Stagonosporopsis,Ustilago and Verticillium are dealt with in this paper. | Kevin D.Hyde R.Henrik Nilsson S.Aisyah Alias Hiran A.Ariyawansa Jaime E.Blair Lei Cai Arthur W.A.M.de Cock Asha J.Dissanayake Sally L.Glockling Ishani D.Goonasekara Michal Gorczak Matthias Hahn Ruvishika S.Jayawardena Jan A.L.van Kan Matthew H.Laurence C.AndréLévesque Xinghong Li Jian-Kui Liu Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda Frank N.Martin Eric H.C.McKenzie Alistair R.McTaggart Peter E.Mortimer Prakash V.R.Nair Julia Pawlowska Tara L.Rintoul Roger G.Shivas Christoffel F.J.Spies Brett A.Summerell Paul W.J.Taylor Razak B.Terhem Dhanushka Udayanga Niloofar Vaghefi Grit Walther Mateusz Wilk Marta Wrzosek Jian-Chu Xu JiYe Yan Nan Zhou | 2014 | Fungal Diversity2014，，4： | 3 |
| 14 | Cachexia and pancreatic cancer: Are there treatment options?显示文摘Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma(PDAC)and is associated with reduced survival and quality of life.Unfortunately,the therapeutic options of this multi-factorial and complex syndrome are limited.This is due to the fact that,despite extensive preclinical and clinical research,the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood.Furthermore,there is still a lack of consensus on the definition of cachexia,which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature.In order to provide an efficient therapy for cachexia,an early and reliable diagnosis and consistent monitoring is required,which can be challenging especially in obese patients.Although many substances have been tested in clinical and preclinical settings,so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia.However,recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancerassociated cachexia and ultimately improve patients’outcome.In this current review,we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients.This strategy consists of nutritional,dietary,pharmacological,physical and psychological methods. | Tara C Mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 15 | Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice显示文摘Background:Acetaminophen(APAP)overdose can cause liver injury and liver failure,which is one of the most common causes of drug-induced liver injury in the United States.Pharmacological activation of autophagy by inhibiting mechanistic target of rapamycin(mTOR)protects against APAP-induced liver injury likely via autophagic removal of APAP-adducts and damaged mitochondria.In the present study,we aimed to investigate the role of genetic ablation of mTOR pathways in mouse liver in APAP-induced liver injury and liver repair/regeneration.Methods:Albumin-Cre(Alb-Cre)mice,mTOR^(f/f) and Raptor^(f/f) mice(C57BL/6J background)were crossbred to produce liver-specific mTOR knockout(L-mTOR KO,Alb Cret/-,mTOR^(f/f))and liver-specific Raptor KO(L-Raptor,Alb Cret/-,Raptor^(f/f))mice.Alb-Cre littermates were used as wild-type(WT)mice.These mice were treated with APAP for various time points for up to 48 h.Liver injury,cell proliferation,autophagy and mTOR activation were determined.Results:We found that genetic deletion of neither Raptor,an important adaptor protein in mTOR complex 1,nor mTOR,in the mouse liver significantly protected against APAP-induced liver injury despite increased hepatic autophagic flux.Genetic deletion of Raptor or mTOR in mouse livers did not affect APAP metabolism and APAP-induced c-Jun N-terminal kinase(JNK)activation,but slightly improved mouse survival likely due to increased hepatocyte proliferation.Conclusions:Our results indicate that genetic ablation of mTOR in mouse livers does not protect against APAP-induced liver injury but may slightly improve liver regeneration and mouse survival after APAP overdose. | Hua Sun Hong-Min Ni Jennifer M.McCracken Jephte Y Akakpo Sam Fulte Tara McKeen Hartmut Jaeschke Hua Wang Wen-Xing Ding | 2021 | Liver Research2021，5，2： | 3 |
| 16 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 17 | Intraductal papillary mucinous neoplasm and the pancreatic incidentaloma显示文摘Asymptomatic pancreatic lesions(APL) are a commonly encountered problem in today's pancreatic surgical practices.Current literature regarding etiologies and incidence of APLs,particularly intraductal papillary mucinous neoplasm(IPMN),is presented.APLs constitute a wide spectrum of pathology(solid/cystic,benign/premalignant/malignant) but,overall,IPMN is now the most common diagnosis.The Sendai Guidelines and their function as a basis for risk stratification in branch duct IPMN are presented.The importance of traditionally analyzed cyst characteristics including size,presence of mucin or nodules and cyst fluid aspirate as indicators of malignancy is emphasized,noting also the potential correlation of main duct dilatation,thickened septae and elevated cyst fluid CEA with increased risk of malignancy.Current complication rates after resection of APLs are reviewed and found to be generally equivalent to those for symptomatic resections.A potential multidisciplinary treatment strategy is offered considering the costs of surgery versus repeated imaging or follow up endoscopy for these lesions.The decision for intervention is ultimately based on the Sendai Guidelines in the context of the individual patient. | Tara S Kent Charles M Vollmer Jr Mark P Callery | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 3 |
| 18 | 腐植酸对高岭土吸附四价铀的影响显示文摘在土壤中,对放射性废物处理的安全性评估,要求评价放射性核素的迁移。pH值从4到8,腐植酸浓度从15mg/kg到200mg/kg条件下,腐植酸对高岭土吸附四价铀的影响试验表明,没有腐植酸的情况下,20%~40%的四价铀存在于溶液中;pH值越高,吸附作用越强。在腐植酸的存在下,随着腐植酸浓度和pH值的升高,四价铀的溶解度随之增大,四价铀在腐植酸中的可溶性最高可达90%。腐植酸吸附和四价铀的吸附是对立的,通过测量腐植酸的吸附,可以比较腐植酸吸附四价铀的能力高低。但是,随着pH值的上升,这种吸附作用的影响减弱。敏感性分析表明,在这些系统中,腐植酸表面吸附是线性可加模型模拟这些体系的控制。 | Nick Evans Peter Warwick Tara Lewis Nick Bryan 王曰鑫 戚新革 | 2011 | 腐植酸2011，，1： | 3 |
| 19 | Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease显示文摘The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and oxygen.This supply is coordinated by the action of neurons,glial and vascular cells,known collectively as the neurovascular unit,which temporally and spatially regulate local cerebral blood flow through a process known as neurovascular coupling.In many neurodegenerative diseases,changes in functions of the neurovascular unit not only impair neurovascular coupling but also permeability of the blood-brain barrier,cerebral blood flow and clearance of waste from the brain.In order to study disease mechanisms,we need improved physiologicallyrelevant human models of the neurovascular unit.Advances towards modeling the cellular complexity of the neurovascular unit in vitro have been made using stem-cell derived organoids and more recently,vascularized organoids,enabling intricate studies of non-cell autonomous processes.Engineering and design innovations in microfluidic devices and tissue engineering are progressing our ability to interrogate the cerebrovasculature.These advanced models are being used to gain a better understanding of neurodegenerative disease processes and potential therapeutics.Continued innovation is required to build more physiologically-relevant models of the neurovascular unit encompassing both the cellular complexity and designed features to interrogate neurovascular unit functionality. | Tara M.Caffrey Emily B.Button Jerome Robert | 2021 | Neural Regeneration Research2021，16，11： | 3 |
| 20 | Citric acid:An efficient and green catalyst for rapid one pot synthesis of quinoxaline derivatives at room temperature显示文摘有 1,2-dicarbonyl 混合物的 o-phenylenediamines 的冷凝作用在乙醇在房间温度在更高的收益面对柠檬性的酸负担得起相应 quinoxaline 衍生物,并且大多数反应在不到 1 min 被完成。 | Radhakrishnan Mahesh Arghya Kusum Dhar Tara Sasank T.V.N.V. Sappanimuthu Thirunavukkarasu Thangaraj Devadoss | 2011 | Chinese Chemical Letters2011，22，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员