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| 1 | Risk factors and implications of anastomotic complications after surgery for Crohn's disease显示文摘Anastomotic complications occur more frequently in patients with Crohn's disease leading to postoperative intra-abdominal septic complications(IASC). Patients with IASC often require re-operation or drainage to controlthe sepsis and have an increased frequency of disease recurrence. The aim of this article was to examine the factors affecting postoperative IASC in Crohn's disease after anastomoses, since some risk factors remain controversial. Studies investigating IASC in Crohn's operations were included, and all risk factors associated with IASC were evaluated: nutritional status, presence of abdominal sepsis, medication use, Crohn's disease type, duration of disease, prior operations for Crohn's, anastomotic technique, extent of resection, operative timing, operative length, and perioperative bleeding. In this review, the factors associated with an increased risk of IASC are preoperative weight loss, abdominal abscess present at time of surgery, prior operation, and steroid use. To prevent IASC in Crohn's patients, preoperative optimization with nutritional supplementation or drainage of abscess should be performed, or a diverting stoma should be considered for patients with multiple risk factors. | Kristen T Crowell Evangelos Messaris | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 6 |
| 2 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 3 | Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Ting-Hui Hsieh Kristin L. Mekeel Michael D. Crowell Cuong C. Nguyen Ananya Das Bashar A. Aqel Elizabeth J. Carey Thomas J. Byrne Hugo E. Vargas David D. Douglas David C. Mulligan M. Edwyn Harrison | 2013 | Gastrointestinal Endoscopy2013，，1： | 3 |
| 4 | Measures of patient radiation exposure during endoscopic retrograde cholangiography:Beyond fluoroscopy time显示文摘AIM:to determine whether fluoroscope time is a good predictor of patient radiation exposure during endoscopic retrograde cholangiopancreatography.METHODS:this is a prospective observational study of consecutive patients undergoing endoscopic retrograde cholangiopancreatography in a tertiary care setting.Data related to radiation exposure were collected.The following measures were obtained:Fluoroscopy time(FT),dose area product(DAP)and dose at reference point(DOSERP).Coefficients of determination were calculated to analyze the correlation between FT,DAP and DOSRP.Agreement between FT and DAP/DOSRP was assessed using Bland Altman plots.RESULTS:Four hundred sixty-three data sets were obtained.Fluoroscopy time average was 7.3 min.Fluoroscopy related radiation accounted for 86%of the total DAP while acquisition films related radiation accounted for 14%of the DAP.For any given FT there are wide ranges of DAP and DOSERP and the variability in both increases as fluoroscopy time increases.The coefficient of determination(R2)on the non transformed data for DAP and DOSERP versus FT were respectively 0.416 and0.554.While fluoroscopy use was the largest contributor to patient radiation exposure during endoscopic retrograde cholangiography(ERCP),there is a wide variability in DAP and DOSERP that is not accounted for by FT.DAP and DOSERP increase in variability as FT increases.This translates into poor accuracy of FT in predicting DAP and DOSERP at higher radiation doses.CONCLUSION:DAP and DOSERP in addition to FT should be adopted as new ERCP quality measures to estimate patient radiation exposure. | Toufic Kachaamy Edwyn Harrison Rahul Pannala William Pavlicek Michael D Crowell Douglas O Faigel | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 5 | Capsule Endoscopy in Patients with Implantable Electromedical Devices is Safe显示文摘 | Lucinda A. Harris Stephanie L. Hansel Elizabeth Rajan Komandoor Srivathsan Robert Rea Michael D. Crowell David E. Fleischer Shabana F. Pasha Suryakanth R. Gurudu Russell I. Heigh Arthur D. Shiff Janice K. Post Jonathan A. Leighton Hsu Heng Yen | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 6 | Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: final results of open-label prospective trial显示文摘 | Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Juan C. Ayala Jorge Saba Alberto Perez-Castilla Manoel Galvao Neto Michael D. Crowell | 2013 | Surgical Endoscopy2013，，4： | 2 |
| 7 | A national study of cardiopulmonary unplanned events after GI endoscopy <ce:link locator='fx1'/>显示文摘 | Virender K. Sharma Cuong C. Nguyen Michael D. Crowell David A. Lieberman Patricia de Garmo David E. Fleischer | 2007 | Gastrointestinal Endoscopy2007，，1： | 2 |
| 8 | Subtypes of anal incontinence associated with bowel dysfunction:clinical, physiologic, and psychosocial characterization显示文摘 | Crowell MD Lacy BE Schettler VA | 2004 | Dis Colon Rectum2004，47，： | 1 |
| 9 | Parent-childinteractions,peripheral serotonin,and self-inflicted injury inadolescents显示文摘 | Crowell SE’Beauchaine TP McCauley Ky | 2008 | J Consult Clin Psychol2008，76，1： | 1 |
| 10 | The role of serotonin in the pathophysiology ofirritable bowel syndrome 显示文摘 | Crowell MD | 2001 | Am J Manag Care2001，7，8： | 1 |
| 11 | Coastal erosion hazards study: Phase one maplbing显示文摘 | Crowell M Honeycutt M Hatheway D | 1999 | Journal of Coastal Research1999，，28： | 1 |
| 12 | Survey of patients' attitudes after surgical correction of prognathism: study of 33 patients显示文摘 | Crowell NT Sazima HJ Elder ST | 1970 | Oral Surg1970，28，： | 1 |
| 13 | NMR based techniques in the hit identification and optimisation processes显示文摘 | Pellecchia M Becattini B Crowell K J | 2004 | Expert Opin Therapeutic Targets2004，8，： | 1 |
| 14 | Strategy and planning for chemopreventive drug development:clinical development plans Ⅱ 显示文摘 | Kelloff GJ Crowell JA Hank E J | 1996 | J Cellular Bioch1996，26，： | 1 |
| 15 | Rupture of a giant carotid aneurysm after extracranial to intracranial bypass surgery显示文摘 | Anson JA Stone JL Crowell RM | 1991 | Neurosurgery1991，28，： | 1 |
| 16 | Thresholds of focal cerebral ischemia in awake monkeys显示文摘 | Jones TH Morawetz RB Crowell RM | 1981 | J Neurosury1981，54，6： | 1 |
| 17 | Solution treatment effects in cast Al-Si-Cu alloys显示文摘 | CROWELL N SHIVKUMAR S | 1995 | AFS Transactions1995，103，： | 1 |
| 18 | A national study of cardiop-ulmonary unplanned events after GI endoscopy 显示文摘 | Sharma VK Nguyen CC Crowell MD | 2007 | Gastrointest En-dosc2007，，： | 1 |
| 19 | Formation of higher alcohols during grape juice fermentations at various temperatures显示文摘 | OUGH C S GUYMON J F CROWELL E A | 1966 | J Food Sci1966，31，： | 1 |
| 20 | Glutathione Stransferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum显示文摘 | GILLILAND F D HARMS H J CROWELL R E | 2002 | Cancer Res2002，62，8： | 1 |
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