|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Developmental regulation of RI TL-DNA gene expression in roots, shoots and tubers of transformed potato (Solanum tuberosum cv. Desiree)显示文摘 | Gert Ooms David Twell Margreet E. Bossen J. Harry C. Hoge Michael M. Burrell | 1986 | Plant Molecular Biology1986，，5： | 2 |
| 3 | Inherent optical properties of the ocean: retrieval of the absorption coefficient of chromophoric dissolved organic matter from fluorescence measurements显示文摘 | Hoge F E Vodacek A Blough N V | 1993 | Limnol Oceanogr1993，38，7： | 1 |
| 4 | Atheroprotective role of intedeu- kin -6 in diet - and/or pathogen - associated atherosclerosis using an ApoE heterozygote murine model显示文摘 | Madan M Bishayi B Hoge M | 2008 | Atherosclerosis2008，197，2： | 1 |
| 5 | A new keyword spotting algorithm with pre-calculated optimal thresholds显示文摘 | JUNKAWITSCH J NEUBAUER L HOGE H | 1996 | The Fourth International Conference on Spoken Language Processing1996，，4： | 1 |
| 6 | Mental health impact of 9/11 Pentagon attack: validation of a rapid assessment tool 显示文摘 | Jordan NN Hoge CW Tobler SK | 2004 | Am J Prev Med2004，26，4： | 1 |
| 7 | The use of in situ and airborne fluorescence measurements to determine UV absorption coefficients and DOC concentrations in surface waters显示文摘 | Vodacek A Hoge F E Swift R N | 1995 | Limnol Oceanogr1995，，： | 1 |
| 8 | The Occupational Burden of Mental Disorders in the U S Military:Psychiatric Hospitalizations,Involuntary Separations,and Disability显示文摘 | Hoge CW Toboni HE Messer SC | 2005 | Am J Psychiatry2005，162，3： | 1 |
| 9 | Strategies for Developing Competency Models显示文摘 | Marrelli Anne Tondora Janis & Hoge Michael | 2005 | Administration and Policy in Mental Health and Mental2005，32，5： | 1 |
| 10 | Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan显示文摘 | Hoge C W Auchterlonie J L Milliken C S | 2006 | AMA2006，295，9： | 1 |
| 11 | Association of posttraumatic stress disorder with somatic symptoms, health care visits, and absenteeism among Iraq war veterans显示文摘 | Hoge CW Terhakopian A Castro CA | 2007 | Am I Geriatr Psychiatry2007，164，1： | 1 |
| 12 | Oxytocin levels in social anxiety disorder显示文摘 | Hoge EA Pollack MH Kaufman RE | 2008 | CNS Neurosci Ther2008，14，3： | 1 |
| 13 | Identifieation of translational displacements between N-dimensional data sets using the high-order SVD and phase correlation 显示文摘 | HOGE W S WESTIN C F | 2005 | IEEE Trans on Image Process2005，14，7： | 1 |
| 14 | Using GRAPPA to improve auto-calibrated coil sensitivity estimation for the SENSE Samily of parallel imaging reconstruction algo- rithms 显示文摘 | HOGE W S DANA H B | 2008 | Magnetic Resonance in Medicine2008，60，2： | 1 |
| 15 | Doxycycline affects diet - and bacteria- associated atherosclerosis in an ApoE heterozygote murine model: Cytokine profiling implications 显示文摘 | Madan M Bishayi B Hoge M | 2007 | Atherosclerosis2007，190，： | 1 |
| 16 | FRA3B extends over a board region and contains a spontaneous HPV16 intergration site: direct evidence for the coincidence of viralintegration sites and fragile sites 显示文摘 | Wilkc CM Hall BK Hoge A | 1996 | Hum Mol Genet1996，5，2： | 1 |
| 17 | Useful procedure in least squares, and tests of some equations for thermistors显示文摘 | HOGE H J | 1988 | Review of Scientific In- strument1988，59，8： | 1 |
| 18 | An experi- mental and numerical study of elastic strain waves on the center line of a 6061-T6 Aluminum bar显示文摘 | HABBERSTAD J L HOGE K G FOSTER J E | 1972 | Journal of ap- plied mechanics1972，39，2： | 1 |
| 19 | Inherent optical properties of the ocean: retrieval of the absorption coefficient of chromophoric dissolved organic matter from fluorescence measurements 显示文摘 | Hoge F E Vodacek A Blough N V | 1993 | Limnol Oceanogr1993，38，7： | 1 |
| 20 | The chan- ging epidemiology of invasive group A streptococcal infec- tions and the emergence of streptococcal toxin shock-like syndrome: a retrospective population-based study 显示文摘 | Hoge CW Schwartz B Talkington DF | 1993 | JAMA1993，269，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员