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| 1 | 美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准显示文摘背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 | Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.Leblanc 李焰生(译) 俞羚(译) 高枚春(译) 张静芳(译) 熊昕丽(译) 邹静(译) 林岩(译) 潘元美(译) | 2007 | 国际脑血管病杂志2007，15，1： | 63 |
| 2 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 3 | National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards显示文摘 | Vladimir Hachinski Costantino Iadecola Ron C. Petersen Monique M. Breteler David L. Nyenhuis Sandra E. Black William J. Powers Charles DeCarli Jose G. Merino Raj N. Kalaria Harry V. Vinters David M. Holtzman Gary A. Rosenberg Anders Wallin Martin Dichgans | 2006 | Stroke2006，，9： | 2 |
| 4 | Chemosensitivity of human malignant glioma: modulation by p53 gene transfer显示文摘 | Martin Trepel Peter Groscurth Ursula Malipiero Erich Gulbins Johannes Dichgans Michael Weller | 1998 | Journal of Neuro - Oncology1998，，1： | 1 |
| 5 | Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging显示文摘 | Joanna M Wardlaw Colin Smith Martin Dichgans | 2013 | Lancet Neurology2013，，： | 1 |
| 6 | Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations显示文摘 | Steve Bevan Matthew Traylor Poneh Adib-Samii Rainer Malik Nicola L. M. Paul Caroline Jackson Martin Farrall Peter M. Rothwell Cathie Sudlow Martin Dichgans Hugh S. Markus | 2012 | Stroke2012，，12： | 1 |
| 7 | Three-Dimensional MRI Analysis of Individual Volume of Lacunes in CADASIL显示文摘 | Dominique Hervé Ophélia Godin Carole Dufouil Anand Viswanathan Eric Jouvent Chahin Pacha? Jean-Pierre Guichard Marie-Germaine Bousser Martin Dichgans Hugues Chabriat | 2009 | Stroke2009，，1： | 1 |
| 8 | Pre- vention of vascular cognitive impairment 显示文摘 | Martin Dichgans Vera Zietemann | 2012 | Stroke2012，43，11： | 1 |
| 9 | Subclinical Hyperthyroidism Is a Risk Factor for Poor Functional Outcome After Ischemic Stroke显示文摘 | Frank Arne Wollenweber Vera Zietemann Andreas Gschwendtner Christian Opherk Martin Dichgans | 2013 | Stroke2013，，5： | 1 |
| 10 | CADASIL显示文摘 | Hugues Chabriat Anne Joutel Martin Dichgans Elizabeth Tournier-Lasserve Marie-Germaine Bousser | 2009 | Lancet Neurology2009，，7： | 1 |
| 11 | Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging显示文摘 | Joanna M Wardlaw Colin Smith Martin Dichgans | 2013 | Lancet Neurology2013，，5： | 1 |
| 12 | Mechanisms of spo- radic cerebral small vessel disease:insights from neuroimaging显示文摘 | Joanna M Wardlaw Colin Smith Martin Dichgans | 2013 | Lancet Neurol2013，，12： | 1 |
| 13 | National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards显示文摘 | Vladimir Hachinski Costantino Iadecola Ron C. Petersen Monique M. Breteler David L. Nyenhuis Sandra E. Black William J. Powers Charles DeCarli Jose G. Merino Raj N. Kalaria Harry V. Vinters David M. Holtzman Gary A. Rosenberg Anders Wallin Martin Dichgans | 2006 | Stroke2006，，9： | 1 |
| 14 | Meta-Analysis and Systematic Review of the Predictive Value of Carotid Plaque Hemorrhage on Cerebrovascular Events by Magnetic Resonance Imaging显示文摘 | Tobias Saam Holger Hetterich Verena Hoffmann Chun Yuan Martin Dichgans Holger Poppert Thomas Koeppel Ulrich Hofmann Maximilian F. Reiser Fabian Bamberg | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 15 | IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses显示文摘Dear Editor,A rapid immune response to signals released from pathogens and injuries is critical for maintaining tissue integrity and restoring homeostasis.This response is largely mediated by the concerted action of pattern recognition receptors(PRRs).Such cooperativity has been described for Toll-like receptors(TLRs)and NACHT,LRR,and pyrin domain-containing protein 3(NLRP3),but the underlying molecular mechanisms remain incompletely understood.Inflammasomes are multi-protein complexes defined by a cytosolic innate immune sensor,usually a PRR,which recruits the adaptor molecule apoptosis-associated speck-like protein containing a caspase-recruitment domain(ASC)to activate the effector caspase-1 leading to the release of matured IL-1βand IL-18.Active caspase-1 further cleaves gasdermin D(GSDMD)allowing the N-terminal domain of GSDMD(GSDMD-N)to form pores in the plasma membrane,thus facilitating the release of matured IL-1βand IL-18.Pore-forming GSDMD-N further induces pyroptosis,an inflammatory form of cell death. | Yaw Asare Margarita Shnipova LukaŽivković Christina Schlegl Federica Tosato Arailym Aronova Markus Brandhofer Laura Strohm Nathalie Beaufort Rainer Malik Christian Weber Jürgen Bernhagen Martin Dichgans | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
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