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| 1 | Etiopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure.The serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk factors.Genetic predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic twins.Environmental triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical disease.Initiating mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic cells.In the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and antibody.In this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research. | Ana Lleo Pietro Invernizzi Ian R Mackay Harry Prince Ren-Qian Zhong M Eric Gershwin | 2008 | World Journal of Gastroenterology2008，14，21： | 9 |
| 2 | Xen and the art of virtualization显示文摘 | Paul Barham Boris Dragovic Keir Fraser Steven Hand Tim Harris Alex Ho Rolf Neugebauer Ian Pratt Andrew Warfield | 2003 | ACM SIGOPS Operating Systems Review2003，，5： | 6 |
| 3 | 牧草细胞壁:瘤胃内降解(英文)显示文摘牧草细胞壁在瘤胃内降解主要是瘤胃微生物起作用。本综述概略地介绍了牧草细胞壁降解所涉及的以细菌为主的微生物,细胞壁多糖分解所需的酶,细胞壁降解模型以及细胞壁降解的限制因素。 | 孙学钊 Simone O. Hoskin Keith N. Joblin Ian G. Andrew Philip J. Harris 盛亦兵 | 2007 | 草地学报2007，15，4： | 5 |
| 4 | 桡骨远端骨折——磷酸钙骨水泥注射与常规治疗的比较显示文摘最近的一些随机试验表明,新鲜桡骨远端骨折采用Norian骨骼修复系统(SRS),即磷酸钙骨水泥治疗,其临床效果优于常规方法,而且术后疼痛减轻。关于再移位骨折的小型研究发现:采用磷酸钙骨水泥握力和活动度恢复加快,但不同方法间的疼痛没有差异。对再移位骨折还需要进行更大型的研究。 | Suthorn Bavonratanavech Ian Harris David L.Helfet 陈国奋 顾立强 | 2005 | 中华创伤骨科杂志2005，7，4： | 5 |
| 5 | Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis显示文摘 | Kit Yee Chan Wei Wang Jing Jing Wu Li Liu Evropi Theodoratou Josip Car Lefkos Middleton Tom C Russ Ian J Deary Harry Campbell Wei Wang Igor Rudan | 2013 | The Lancet . 2013 (9882)2013，，9882： | 5 |
| 6 | 两步法翻修术治疗全膝关节置换术后深部感染显示文摘目的探讨治疗全膝关节置换术(TKA)术后深部感染的有效措施。方法对自2002年2月-2006年9月收治的12例TKA术后感染患者采用两步法进行翻修,术后记录不同时期的关节功能恢复情况。结果术后随访平均11.2个月(6-36个月)。参照HSS膝关节功能评分.就诊时、第1次术后及第2次术后平均HSS评分分别为(47.50±17.62)分(28-77分)、(68.42±16.95)分(41-90分)及(81.75±12.97)分(56~97分),(P〈0.05)。结论两步法纯骨水泥压模假体技术可以增加关节内的抗生素浓度,有效控制感染;能保持膝关节活动度,是有效的治疗TKA术后感染的方法。 | 张经纬 蒋垚 张先龙 Ian Harris 王琦 沈灏 邵俊杰 狄正林 曾炳芳 | 2009 | 中国骨与关节损伤杂志2009，24，7： | 3 |
| 7 | 骨盆环骨折——早期固定与延迟固定的比较显示文摘根据4项回顾性队列研究的结论,对于骨盆环骨折患者,目前仅有少量的证据支持:与延迟固定相比,早期固定能缩短住院时间和降低肺部并发症的发生率,而且可能获得更好的短期功能恢复。但这些结论可能受到混杂因素的影响。因此,应开展随机对照研究来明确这些问题,包括明确和统一“早期”和“延迟”的定义,且对患者的长期功能恢复情况进行比较分析。 | Ian Harris 王筋(译) 杨云峰(译) | 2012 | 中华创伤骨科杂志2012，14，5： | 2 |
| 8 | 儿童股骨干骨折的治疗钛弹性钉与不锈钢弹性钉的比较显示文摘对儿童股骨干骨折采用钛弹性钉与不锈钢弹性钉固定的疗效进行比较,2项回顾性队列研究的结论截然相反。1项研究显示,钛弹性钉固定发生骨折畸形愈合的几率是不锈钢弹性钉的4倍,而另1项研究则认为,不锈钢弹性钉固定组并发症的发生率更高,且股骨骨折愈合时间和负重的恢复时间均明显长于钛弹性钉固定组。因此,从目前2项研究中尚不能明确何种固定方式治疗儿童股骨干骨折更优。 | Ian Harris 王簕(译) 杨云峰(译) | 2011 | 中华创伤骨科杂志2011，13，7： | 2 |
| 9 | A fast and accurate model for the creation of explosion fragments with improved fragment shape and dimensions显示文摘Explosion models based on Finite Element Analysis(FEA)can be used to simulate how a warhead fragments.However their execution times are extensive.Active protection systems need to make very fast predictions,before a fast attacking weapon hits the target.Fast execution times are also needed in real time simulations where the impact of many different computer models is being assessed.Hence,FEA explosion models are not appropriate for these real-time systems.The research presented in this paper delivers a fast simulation model based on Mott’s equation that calculates the number and weight of fragments created by an explosion.In addition,the size and shape of fragments,unavailable in Mott’s equation,are calculated using photographic evidence and a distribution of a fragment’s length to its width.The model also identifies the origin of fragments on the warhead’s casing.The results are verified against experimental data and a fast execution time is achieved using uncomplicated simulation steps.The developed model then can be made available for real-time simulation and fast computation. | David Felix Ian Colwill Paul Harris | 2022 | Defence Technology(防务技术)2022，18，2： | 2 |
| 10 | Xen and the art of virtualization显示文摘 | Paul Barham Boris Dragovic Keir Fraser Steven Hand Tim Harris Alex Ho Rolf Neugebauer Ian Pratt Andrew Warfield | 2003 | ACM SIGOPS Operating Systems Review2003，，5： | 2 |
| 11 | 关节置换术治疗急性关节内骨折股骨头置换术与全髋关节置换术治疗股骨近端骨折的比较(对2007年研究的更新)显示文摘5项随机对照研究(RCT)或半RCT的证据提示,对于股骨近端骨折,与全髋关节置换术(THA)治疗相比,股骨头置换术(HA)治疗虽然会增加术后翻修的几率,但是术后关节脱位的发生率则明显降低。接受HA治疗的患者后期活动能力恢复可能较差,但是各研究间的统计学结果并不一致。同时基于目前报道的各种假体类型,两种治疗方法间死亡率比较差异无统计学意义。由于现有研究在方法学和假体类型选择上不一致,因此在解读本研究相关结论时仍需谨慎。 | Ian Harris 王 杨云峰 | 2012 | 中华创伤骨科杂志2012，14，8： | 2 |
| 12 | 膝关节脱位——早期与延迟处理显示文摘本报告所引用的两项小型回顾性研究中,并没有足够的证据支持膝关节脱位应该进行早期处理还是延迟处理。如果膝关节脱位的确罕见的话,则应进行多中心的随机研究、经良好设计的前瞻性群组研究及使用标准化的检测措施,以对上述问题作出判断。 | David C Ring Ian Harris 李旭(译校) | 2007 | 中华创伤骨科杂志2007，9，9： | 1 |
| 13 | Breast cancer angiogenesis — new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting显示文摘 | Adrian L. Harris Huatang Zhang Amir Moghaddam Steve Fox Prudence Scott Adam Pattison Kevin Gatter Ian Stratford Roy Bicknell | 1996 | Breast Cancer Research and Treatment1996，，1： | 1 |
| 14 | Life events and difficulties in relation to the onset of globus pharyngis显示文摘 | Marlene B. Harris Ian J. Deary Janet A. Wilson | 1996 | Journal of Psychosomatic Research1996，，6： | 1 |
| 15 | ELA-ICP-MS U–Pb zircon geochronology of regional volcanism hosting the Bajo de la Alumbrera Cu–Au deposit: implications for porphyry-related mineralization显示文摘 | Anthony C. Harris Charlotte M. Allen Scott E. Bryan Ian H. Campbell Rodney J. Holcombe J. Michael Palin | 2004 | Mineralium Deposita2004，，1： | 1 |
| 16 | Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis显示文摘 | Kit Yee Chan Wei Wang Jing Jing Wu Li Liu Evropi Theodoratou Josip Car Lefkos Middleton Tom C Russ Ian J Deary Harry Campbell Wei Wang Igor Rudan | 2013 | The Lancet2013，，9882： | 1 |
| 17 | Interim Report and Recommendations of the World Health Organization Task-Force for Osteoporosis显示文摘 | Harry K. Genant Cyrus Cooper Gyula Poor Ian Reid George Ehrlich J. Kanis B. E. Christopher Nordin Elizabeth Barrett-Connor Dennis Black J.-P. Bonjour Bess Dawson-Hughes Pierre D. Delmas J. Dequeker Sergio Ragi Eis Carlo Gennari Olaf Johnell C. Conrad John | 1999 | Osteoporosis International1999，，4： | 1 |
| 18 | Breast cancer angiogenesis — new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting显示文摘 | Adrian L. Harris Huatang Zhang Amir Moghaddam Steve Fox Prudence Scott Adam Pattison Kevin Gatter Ian Stratford Roy Bicknell | 1996 | Breast Cancer Research and Treatment1996，，1： | 1 |
| 19 | A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia显示文摘 | Simon Z. He Samantha Busfield David S. Ritchie Mark S. Hertzberg Simon Durrant Ian D. Lewis Paula Marlton Andrew J. McLachlan Ian Kerridge Kenneth F. Bradstock Glen Kennedy Andrew W. Boyd Trina M. Yeadon Angel F. Lopez Hayley S. Ramshaw Harry Iland Simone | 2015 | Leukemia & Lymphoma2015，，： | 1 |
| 20 | Xen and the art of virtualization显示文摘 | Paul Barham Boris Dragovic Keir Fraser Steven Hand Tim Harris Alex Ho Rolf Neugebauer Ian Pratt Andrew Warfield | 2003 | ACM SIGOPS Operating Systems Review2003，，5： | 1 |
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