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| 1 | Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease显示文摘AIM To study the genetic association and epistatic interaction of the interleukin(IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease(IBD). METHODS A total of 159 pediatric inflammatory IBD patients(Crohn's disease,n = 136; ulcerative colitis,n = 23) and 129 matched controls were studied for genetic association of selected single nucleotide polymorphisms(SNPs) of the IL-10 gene and the genes IL10 RA,IL10 RB,STAT3,and HO1,from the IL-10/STAT3 signaling pathway. As interactions between SNPs from different loci may significantly affect the associated risk for disease,additive(a) and dominant(d) modeling of SNP interactions was also performed to examine highorder epistasis between combinations of the individual SNPs. RESULTS The results showed that IL-10 rs304496 was associated with pediatric IBD(P = 0.022),but no association was found for two other IL-10 SNPs,rs1800872 and rs2034498,or for SNPs in genes IL10 RA,IL10 RB,STAT3,and HO1. However,analysis of epistatic interaction among these genes showed significant interactions:(1) between two IL-10 SNPs rs1800872 and rs3024496(additive-additive P = 0.00015,Bonferroni P value(Bp) = 0.003);(2) between IL-10 RB rs2834167 and HO1 rs2071746(dominant-additive,P = 0.0018,Bp = 0.039); and(3) among IL-10 rs1800872,IL10 RB rs2834167,and HO1 rs2071746(additivedominant-additive,P = 0.00015,Bp = 0.005),as well as weak interactions among IL-10 rs1800872,IL-10 rs3024496,and IL-10RA(additive-additive-additive,P = 0.003; Bp = 0.099),and among IL10 RA,IL10 RB,and HO1 genes(additive-dominant-additive,P = 0.008,Bp = 0.287).CONCLUSION These results indicate that both the IL-10 gene itself,and through epistatic interaction with genes within the IL-10/STAT3 signaling pathway,contribute to the risk of pediatric IBD. | Zhenwu Lin Zhong Wang John P Hegarty Tony R Lin Yunhua Wang Sue Deiling Rongling Wu Neal J Thomas Joanna Floros | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 2 | 生命周期中的家庭暴力显示文摘背景家庭暴力包括一系列虐待行为,如虐待和忽视儿童,亲密伴侣暴力和虐待老人。每种形式的虐待都会对健康和幸福造成很大的负面影响,受虐者常因多种多样的生理和心理问题咨询全科医生。全科医学在应对家庭暴力方面是独一无二的,因为其任务是照顾整个家庭,这具有挑战性,需要积极管理。目的本文旨在解决全科医生在识别和处理受到家庭暴力的病人时所遇到的临床问题。需考虑到各种类型虐待受害者的经历和如何应对施暴者。本文中的建议也适用于同性关系。讨论管理家庭暴力需要一个系统性的方法,推荐在一个安全的环境中进行,在这个环境中,家庭成员可以揭露虐待行为,全科医生也可以做出适当的反应。全科医生有识别、管理和转诊的职责。结论家庭暴力是一种常见的隐蔽问题,需要系统性的措施加以应对,包括识别其临床指征,适当提问,做出恰当的直接反应并对病人进行连续支持。全科医生之所以能够识别和帮助受虐待其及其家人,是因为他们接受了处理家庭暴力的培训,这种培训是世界卫生组织和澳大利亚皇家全科医师学会推荐的,经过培训后,所有的全科医生在病人遭到家庭暴力时,可提供一个安全、中立和移情的反应。 | Kirsty Forsdike Laura Tarzia Elizabeth Hindmarsh Kelsey Hegarty | 2014 | 中国全科医学2014，17，35： | 3 |
| 3 | Ulcerative colitis neoplasia is not associated with common IBD SNPs显示文摘 | Tara M. Connelly Arthur S. Berg Leonard R. Harris David L. Brinton John P. Hegarty Susan M. Deiling David B. Stewart Walter A. Koltun | 2014 | Surgery2014，，： | 2 |
| 4 | 热插拔电路的TVS钳位显示文摘本文探讨了在线卡输入端使用TVS二极管钳位的理由。作者利用典型系统的实验测量得出的瞬态电压波形为基础研究提供了关键参数,并介绍了选择系统保护元件的主要步骤。热插拔电路保护下一代高性能刀片服务器、数据中心、存储和通信基础设施系统使用的电源系统让人们感觉到一种需求——对速度的需求!具体来说,不断提高的处理器时钟速率和数据吞吐量的长期趋势显而易见。 | Timothy Hegarty | 2011 | 世界电子元器件2011，，10： | 2 |
| 5 | SREBP transcription factors: master regulators of lipid homeostasis显示文摘 | Delphine Eberlé Bronwyn Hegarty Pascale Bossard Pascal Ferré Fabienne Foufelle | 2004 | Biochimie2004，，11： | 2 |
| 6 | Young adults' perceptions of cigarette warning labels in the United States and Canada显示文摘 | O' Hegarty M Pederaon LL Yenokyan G | 2007 | Prey Chronic Dis2007，4，2： | 1 |
| 7 | Artificial skin in massive burns-rcsults to ten years显示文摘 | Sheridan RL Hegarty M Tompkins RG | 1994 | Eur J Plast Surg1994，17，： | 1 |
| 8 | One hundred years of schizophrenia:a meta-analysis of outcome literature显示文摘 | HEGARTY J D BALDESSARINI R J TOHEN M | 1994 | Am J Psychiatry1994，151，10： | 1 |
| 9 | Chronic active hepatitis in mice in- duced by 3 - hydroxy - 4 - pyrone 显示文摘 | Bhathal PS Ho SL Hegarty MP | 1984 | Experientia1984，40，8： | 1 |
| 10 | The Guy's stone score-grading the complexity of percutaneous nephrolithotomy procedures 显示文摘 | Thomas K Smith C Hegarty N | 2011 | Urology2011，78，2： | 1 |
| 11 | SREBP transcription factors:master regulators of lipid homeostasis显示文摘 | HEGARTY B BOSSARD P | 2004 | Biochimie2004，86，11： | 1 |
| 12 | Pressure effects on cellular systems:Is there a link with benign prostatic hyperplasia?显示文摘 | Hegnrty P Watson WG Hegarty NJ Coffey NT Fitzpatrick JM | 2004 | Urology2004，64，2： | 1 |
| 13 | Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse:a randomized crossover study for the treatment of symptomatic oral lichen planus显示文摘 | Hegarty AM Hodgson TA Lewsey JD | 2002 | J Am Acad Dermatol2002，47，2： | 1 |
| 14 | The unrec-ognized prevalence of chronic kidney disease in diabetes 显示文摘 | MIDDLETON R J FOLEY R N HEGARTY J | 2006 | JNephrol Dial Transplant2006，21，1： | 1 |
| 15 | Subsidence history of Australian southern margin: constraints on basin models 显示文摘 | Hegarty K A Weissel J K Mutter J C | 1988 | AAPG Bul/etin1988，72，： | 1 |
| 16 | Controversies in il- ioinguinal lymphadenectomy 显示文摘 | Hegarty PK Dinney CP Pettaway CA | 2010 | Urol Clin North Am2010，37，3： | 1 |
| 17 | The value of enhanced magnetic resonance imaging in the evaluation of endocochlear disease显示文摘 | Hegarty JL Patel S Fischbein N | 2002 | Laryngoscope2002，112，1： | 1 |
| 18 | The association be- tween intimate partner violence, alcohol and depression in family practice显示文摘 | Gilchrist G Hegarty K Chondros P | 2010 | BMC Faro Pratt2010，11，： | 1 |
| 19 | Effect of supercritical CO2 on arginine显示文摘 | Weder J Bokor M Hegarty M | 1992 | Food Chemistry1992，44，4： | 1 |
| 20 | Effects of dietary nitrate on fermentation, methane pro- duction and digesta kinetics in sheep 显示文摘 | NOLAN J V HEGARTY R S HEGARTY J | 2010 | Animal Pro- duction Science2010，50，8： | 1 |
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