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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Carcinogenic effect of nickel compounds 显示文摘 | Lu Haitian Shi Xianglin Max Costa | 2005 | Molecular and Cellular Biochemistry2005，279，： | 1 |
| 3 | Writing on dirty paper显示文摘 | Max H Costa M | 1983 | IEEE Transactions on Information Theory1983，29，3： | 1 |
| 4 | Enhanced overexpression of an HIF-1/Hypoxia-related protein in cancer cell显示文摘 | Cangul Hakan Sahikoaik Max Costa | 2002 | Metals toxicity2002，110，： | 1 |
| 5 | The involvement of hypoxia-inducible transcriiption factor-1-dependent pathway in nickel carcinogenesis显示文摘 | Konstantin Salnikow Daridson Max Costa | 2003 | Cancer Res2003，63，： | 1 |
| 6 | Writing on dirty paper显示文摘 | Max H M Costa | 1983 | IEEE Transactions on Information Theory1983，29，3： | 1 |
| 7 | Potential hazards of hexavalent chromate in our drinking water显示文摘 | Max Costa | 2003 | Toxicology and Applied Pharmacology2003，，1： | 1 |
| 8 | Potential hazards of hexavalent chromate in our drinking water显示文摘 | Max Costa | 2003 | Toxicology and Applied Pharmacology2003，，1： | 1 |
| 9 | Interlaboratory validation of a new assay for DNA-protein crosslinks显示文摘 | Max Costa Anatoly Zhitkovich Michael Gargas | 1996 | Mutation Research1996，369，： | 1 |
| 10 | Solid acid membranes for high temperature proton exchange membrane fuel cells显示文摘 | Hogarth W H J Costa J C Diniz da (Max) Lu G Q | 2005 | Journal of Power Sources2005，142，12： | 1 |
| 11 | Toxicity and Carcinoge- nicity of Chromium Compounds in Human 显示文摘 | COSTA Max KLEIN Catherine B | 2006 | Critical Re- view in Toxicology2006，2，36： | 1 |
| 12 | Carbonised template molecular sieve silica membranes in fuel processing systems permeation hydrostability and regeneration显示文摘 | Duke M C Diniz da Costa J C Lu G Q (Max) | 2004 | Journal of Membrane Science2004，241，2： | 1 |
| 13 | Serum taurine and risk of coronary heart disease: a prospective, nested case–control study显示文摘 | Oktawia P. Wójcik Karen L. Koenig Anne Zeleniuch-Jacquotte Camille Pearte Max Costa Yu Chen | 2013 | European Journal of Nutrition2013，，1： | 1 |
| 14 | The potential protective effects of taurine on coronary heart disease显示文摘 | Oktawia P. Wójcik Karen L. Koenig Anne Zeleniuch-Jacquotte Max Costa Yu Chen | 2009 | Atherosclerosis2009，，1： | 1 |
| 15 | A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo显示文摘 | Anatoly Zhitkovich Max Costa | 1992 | Carcinogenesis1992，13，8： | 1 |
| 16 | Serum taurine and risk of coronary heart disease: a prospective, nested case–control study显示文摘 | Oktawia P. Wójcik Karen L. Koenig Anne Zeleniuch-Jacquotte Camille Pearte Max Costa Yu Chen | 2013 | European Journal of Nutrition2013，，1： | 1 |
| 17 | A simple, sensitive assay to detect DNA-protein cromlinks in intact ceils and in vivo 显示文摘 | Anatoly Zhitkovich Max costa | 1992 | Carcinogenesis1992，13，8： | 1 |
| 18 | Writing on dirty paper显示文摘 | Max H M Costa | 1983 | IEEE Trans on Information Theory1983，29，3： | 1 |
| 19 | Toxicity and Carcinogenicity of Nickel Compounds显示文摘 | Timothy P. Coogan Dorothy M. Latta Elizabeth T. Snow Max Costa A. Lawrence | 1989 | CRC Critical Reviews in Toxicology1989，，4： | 1 |
| 20 | Toxicity and Carcinogenicity of Chromium Compounds in Humans显示文摘 | Max Costa Catherine B. Klein | 2006 | CRC Critical Reviews in Toxicology2006，，2： | 1 |
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