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		题名	作者	年代	出处	被引量
	1	Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?显示文摘	Timothy G. Dinan Eamonn M.M. Quigley Salah M.M. Ahmed Paul Scully Sinead O’Brien Liam O’Mahony Siobhan O’Mahony Fergus Shanahan P.W. Napoleon Keeling	2006	Gastroenterology2006，，2：	3
	2	A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome显示文摘	Caroline Codling Liam O’Mahony Fergus Shanahan Eamonn M. M. Quigley Julian R. Marchesi	2010	Digestive Diseases and Sciences2010，，2：	3
	3	Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘	Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley	2005	Gastroenterology2005，，3：	2
	4	Radiologic Imaging in Cystic Fibrosis显示文摘	Oisin J. O’Connell Sebastian McWilliams AnneMarie McGarrigle Owen J. O’Connor Fergus Shanahan David Mullane Joseph Eustace Michael M. Maher Barry J. Plant	2012	Chest2012，，：	2
	5	A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘	Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher	2013	European Radiology2013，，：	2
	6	A Prospective Trial of Low-Dose Abdominal Computerised Tomography (CT) With Iterative Reconstruction vs Conventional CT in Crohn’s Disease显示文摘	Orla F. Craig Siobhan B. O’Neill Sum Leong Fiona O’Neill Owen J. O’Connor Michael M. Maher Fergus Shanahan	2011	Gastroenterology2011，，：	1
	7	Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?显示文摘	Timothy G. Dinan Eamonn M.M. Quigley Salah M.M. Ahmed Paul Scully Sinead O’Brien Liam O’Mahony Siobhan O’Mahony Fergus Shanahan P.W. Napoleon Keeling	2006	Gastroenterology2006，，2：	1
	8	Selection of Symptomatic Patients With Crohn’s Disease for Abdominopelvic Computed Tomography: Role of Serum C-Reactive Protein显示文摘	Alan N. Desmond Kevin O’Regan Neera Malik Sebastian McWilliams Siobhan O’Neill Eamonn M. Quigley Fergus Shanahan Michael M. Maher	2012	Canadian Association of Radiologists Journal2012，，4：	1
	9	Diagnostic Accuracy of Computed Tomography Using Lower Doses of Radiation for Patients With Crohn’s Disease显示文摘	Orla Craig Siobhan O’Neill Fiona O’Neill Patrick McLaughlin AnneMarie McGarrigle Sebastian McWilliams Owen O’Connor Alan Desmond Elizabeth Kenny Walsh Max Ryan Michael Maher Fergus Shanahan	2012	Clinical Gastroenterology and Hepatology2012，，：	1
	10	Software distribution for wireless devices: a re-configurable approach显示文摘	Foley G Fergus O'Reilly	2003	Integrated Network Management2003，，：	1
	11	Mucosal cytokine imbalance in irritable bowel syndrome显示文摘	John Macsharry Liam O’Mahony Aine Fanning Emer Bairead Graham Sherlock Jay Tiesman Andy Fulmer Barry Kiely Timothy G. Dinan Fergus Shanahan Eamonn M. M. Quigley	2008	Scandinavian Journal of Gastroenterology2008，，12：	1
	12	Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials显示文摘	Colum Dunne Lisa Murphy Sarah Flynn Liam O’Mahony Sile O’Halloran Maria Feeney Darrin Morrissey Gerardine Thornton Gerald Fitzgerald Charles Daly Barry Kiely Eamonn M. M. Quigley Gerald C. O’Sullivan Fergus Shanahan J. Kevin Collins	1999	Antonie van Leeuwenhoek1999，，1：	1
	13	Development and validation of a novel PCR-RFLP based method for the detection of 3 primary mitochondrial mutations in Leber's hereditary optic neuropathy patients显示文摘Background:Leber’s Hereditary Optic Neuropathy(LHON;MIM 535000)is one of the most commonly inherited optic neuropathies and it results in significant visual morbidity among young adults with a peak age of onset between the ages of 15–30.The worldwide incidence of LHON is approximately 1 in 31,000.95%of LHON patients will have one of 3 primary mitochondrial mutations,G3460A(A52T of ND1),G11778A(R340H of ND4)and T14484C(M64V of ND6).There is incomplete penetrance and a marked gender bias in the development of visual morbidity with approximately 50%of male carriers and 10%of female carriers developing optic neuropathy.Visual recovery can occur but is dependent on the mutation present with the highest level of visual recovery seen in patients who have the T14484C mutation.The 3 primary mutations are typically identified by individual end-point PCR-restriction fragment length polymorphism(RFLP)or individual targeted bi-directional Sanger sequencing reactions.The purpose of this study was to design a simple multiplex PCR-RFLP that could detect these 3 primary LHON mutations in one assay.Methods:PCR primers were designed to incorporate a MaeIII restriction site in the presence of 3460A and 14484C mutations with the 11778A mutation naturally incorporating a MaeIII site.A multiplex PCR-RFLP assay was developed to detect the 3 common mutations in a single assay.Synthetic LHON controls based on the mitochondrial genome harbouring the 3 common mutations were synthesized and cloned into plasmids to act as reliable assay controls.DNA from previously tested patients and the synthetic LHON controls were subjected to the multiplex PCR-RFLP assay.The RFLP products were detected by agarose gel electrophoresis.Results:The novel PCR-RFLP assay accurately detects the 3 primary mutations both in patient DNA and in synthesized DNA control samples with a simple visual mutation detection procedure.The synthesized DNA was demonstrated to be a robust control for the detection of LHON Mutations.Conclusion:In this paper,we describe a novel,robust and simple PCR-RFLP based method for the detection of mutations causing LHON,and report the generation of a series of LHON DNA controls suitable for all currently published assays.	Siobhan Eustace Ryan Fergus Ryan David Barton Veronica O’Dwyer Derek Neylan	2015	Eye and Vision2015，2，1：	0

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