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| 1 | Uplift, climate and biotic changes at the Eocene-Oligocene transition in south-eastern Tibet显示文摘The uplift history of south-eastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas.Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernization of the highly diverse,but threatened,Asian biota.Here,with new radiometric dating and newly collected plant-fossil archives,we quantify the surface height of part of the south-eastern margin of Tibet in the latest Eocene(~34 Ma)to be^3 km and rising,possibly attaining its present elevation(3.9 km)in the early Oligocene.We also find that the Eocene–Oligocene transition in south-eastern Tibet witnessed leaf-size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate,likely reflective of both uplift and secular climate change,and that,by the latest Eocene,floral modernization on Tibet had already taken place,implying modernization was deeply rooted in the Palaeogene. | Tao Su Robert A. Spicer Shi-Hu Li He Xu Jian Huang Sarah Sherlock Yong-Jiang Huang Shu-Feng Li Li Wang Lin-Bo Jia Wei-Yu-Dong Deng Jia Liu Cheng-Long Deng Shi-Tao Zhang Paul J. Valdes Zhe-Kun Zhou | 2019 | National Science Review2019，6，3： | 16 |
| 2 | Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared显示文摘Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity.Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs.Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor growth.This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser excitation.Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species. | Zhuang Liu Scott Tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai | 2010 | Nano Research2010，3，3： | 11 |
| 3 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 4 | Multifunctional FeCo-Graphitic Carbon Nanocrystals for Combined Imaging, Drug Delivery and Tumor-Specific Photothermal Therapy in Mice显示文摘Ultrasmall FeCo-graphitic 碳壳 nanocrystals (FeCo/GC ) 在 vivo 在 vitro 和磁性的回声成像正在答应能够高度有效的药交货的多功能的材料。在这个工作,我们通过一个 4T1 syngeneic 乳癌模型的联合的药交货,肿瘤选择的在红外线附近的 photothermal 治疗,和癌症成像为高度有效的癌症治疗表明 FeCo/GC 的使用。4 nm FeCo/GC 的 graphitic 碳壳乐意地装载 doxorubicin (纪录影片) 经由 - 叠并且吸收给加热的 photothermal 的在红外线附近的光。当为癌症治疗使用了时,当与有选择地加热肿瘤到 4345 的在红外线附近的激光照耀的 20 min 结合了时,静脉内地管理的 FeCo/GC-DOX 在 45% 老鼠导致了完全的肿瘤回归 ??????????? 椠扭污湡散 ?????????? | Sarah P. Sherlock Hongjie Dai | 2011 | Nano Research2011，4，12： | 3 |
| 5 | lnterteukin-23 rather than interleukin-12 is the critical eytokine for autoimmune inflammation of the brain显示文摘 | Cua D J Sherlock J Chen Y el al | 2003 | Nature2003，421，6924： | 1 |
| 6 | The pathology of hepatits C virus显示文摘 | Scheuer PS Ashrafzadeh P Sherlock S | 1992 | Hepatology1992，15，： | 1 |
| 7 | A model for interpreting fingerprint topo- logy 显示文摘 | Sherlock B Monro D | 1993 | Pattern Recognition1993，26，7： | 1 |
| 8 | The aetiology and management of ascites in patients with hepatic cirrhosis : a review 显示文摘 | Sherlock S Shaldon S | 1963 | Gut1963，4，： | 1 |
| 9 | Fulminant hepatic failure显示文摘 | SHERLOCK S | 1993 | Adv Intern Med1993，38，： | 1 |
| 10 | Biochar Adsorbed Ammonia Is Bioavailable显示文摘 | Arezoo Taghizadeh -Toosi Tim J Clough Robert R Sherlock | 2012 | Plant and Soil2012，350，2： | 1 |
| 11 | Excess adiposity and survival in patients with colorectal cancer: a systematic review 显示文摘 | Parkin E Olreilly DA Sherlock DJ | 2014 | Obes Rev2014，15，5： | 1 |
| 12 | Reconstmction of the genome origins andevolution of the hybrid lager yeast Saccharomyces pastorianus显示文摘 | Dunn B Sherlock G | 2008 | Genome Res2008，，18： | 1 |
| 13 | Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain显示文摘 | Cua DJ Sherlock J Chen Y | 2003 | Nature2003，421，6924： | 1 |
| 14 | Application of a diffusion bon- ding methodology to develop a Be/Cu bond suitable for the ITER banket 显示文摘 | Sherlock P Erskine A | 2003 | Fusion Eng Des2003，68，22： | 1 |
| 15 | The syndrome of inappropriate antidiuretie hormone: current and future management options 显示文摘 | Sherlock M Thompson CJ | 2010 | Eur J Endocrinol2010，1621，： | 1 |
| 16 | Participation in sport by Irish people with heamophilia显示文摘 | Sherlock E Blake C | 2008 | Heamophilia2008，14，12： | 1 |
| 17 | Analysis of large-scale geneexpression data显示文摘 | Sherlock G | 2000 | Curr Opin Immunol2000，12，2： | 1 |
| 18 | Comprehensive identification of cell cycle - regulated genes of the yeast saccharomyces cerevisiae by microarray hybridization显示文摘 | Spellman P T Sherlock G Zhang M Q | 1998 | Molecular of Biology of the Cell1998，9，12： | 1 |
| 19 | Comprehensive Identification of Cell Cycle-regulated Genes of the Yeast Saccharomyces Cerevisiae by Microarray Hybridization显示文摘 | Spellman P T Sherlock G Zhang M Q | 1998 | Mol Biol Cell1998，9，1： | 1 |
| 20 | Giant larvacean houses: Rapid carbon transport to the deep sea floor显示文摘 | Robison B H Reisenbichler K R Sherlock R E | 2005 | Science2005，308，5728： | 1 |
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