|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir,nirmatrelvir,and the combination显示文摘Dear Editor,Since the first outbreak in late 2019,the RNA genome of SARS-CoV-2 has been undergoing constant evolution.This is largely attributed to the viral polymerase that is intrinsically error prone and the selection pressures exerted by the host immune system.Several variants of concern harboring multiple mutations in the spike protein have emerged in the past year.The currently fast-spreading Omicron variant contains many more mutations compared with the previous variants,and most of these mutations are located around the receptor binding domain of the spike protein. | Pengfei Li Yining Wang Marla Lavrijsen Mart M.Lamers Annemarie C.de Vries Robbert J.Rottier Marco J.Bruno Maikel P.Peppelenbosch Bart L.Haagmans Qiuwei Pan | 2022 | Cell Research2022，32，3： | 11 |
| 3 | 前列腺癌印记基因表达的特殊变化一前列腺癌发展和表观遗传调控的预示显示文摘DNA高甲基化和低甲基化,EZH2过度表达以及组蛋白修饰等表观遗传失调与前列腺癌的发展相关。DNA甲基化,EZH2和组蛋白修饰同时也确保了至少62种印记基因的亲缘特异性单等位基因的表达。尽管我们可以据此得到一个非常有趣的推断:表观遗传失调可能涉及到印记基因,但在前列腺癌中仅证明了IGF2的表达改变。一篇研究前列腺癌印记基因的文章和数据库显示,尽管表观遗传机制在全局上有干扰,但绝大多数印记基因表达没有变化。相反,选择性遗传和表观遗传的改变似乎抑制了印记基因亚网络,从而有可能在前列腺细胞中通过P13K/Akt途径限制细胞的生长,调节雄激素反应和调控分化。IGF2异常调控可能导致前列腺癌的早期改变,然而该印记基因网络的失活却与癌症的发展有关。 | Teodora Ribarska Klaus-Marius Bastian Annemarie Koch Wolfgang A Schulz | 2012 | Asian Journal of Andrology2012，14，3： | 4 |
| 4 | Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?显示文摘AIM To study the relationship between overhydration(OH) in peritoneal dialysis(PD) patients and cardiac mortality.METHODS OH, as measured by body composition monitor(BCM), is associated with increased mortality in dialysis patients. BCM has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mortality, and if there was a correlation between OH and cardiac troponin-T(cT n T) levels. Finally, we wished to determine if improving OH values would lead to a decrement in cT n T. All prevalent PD patients over the study period of 57 mo who had contemporaneous BCM and cT nT measurements were followed irrespective of transplantation or PD technique failure. We also studied a cohort of patients with who had severe OH(> +2L).The Fresenius Body Composition Monitor was used to obtain hydration parameters. cT nT levels were done as part of routine clinical care. Data was analysed using SPSS version 20.0.RESULTS There were 48 deaths in the 336 patients. The patients that died from cardiac or non-cardiac causes were similar with respect to their age, incidence of diabetes mellitus, gender, ethnicity and cause of renal failure. However, the patients with cardiac causes of death had significantly shorter dialysis vintage(10.3 mo vs 37.0 mo, P < 0.0001) and were significantly more overhydrated by BCM measurement(2.95 L vs 1.35 L, P < 0.05). The mean(standard error of the means) hydration status of the 336 patients was +1.15(0.12) L and the median [interquartile range(IQR)] cT nT level was 43.5(20-90) ng/L. The cT nT results were not normally distributed and were therefore transformed logarithmically. There was a statistically significant correlation between Log(cT nT) with the OH value(Spearman r value 0.425, P < 0.0001). We identified a sub-group of patients that were severely overhydrated; median(IQR) hydration at baseline was +2.7(2.3 to 3.7) L. They were followed up for a minimum of 6 mo. Reduction in OH values in these patients over 6 mo correlated with lowering of cT nT levels(Spearman r value 0.29, P < 0.02). CONCLUSION Patients that were overhydrated had higher cT nT, and had deaths that were more likely to be cardiac related. Reduction in OH correlated with lowering of cT nT. | Elizabeth Oei Klara Paudel Annemarie Visser Hazel Finney Stanley L Fan | 2016 | World Journal of Nephrology2016，5，5： | 4 |
| 5 | Hepatic encephalopathy before and neurological complications after liver transplantation have no impact on the employment status 1 year after transplantation显示文摘AIM To investigate the impact of hepatic encephalopathybefore orthotopic liver transplantation(OLT) and neurological complications after OLT on employment after OLT.METHODS One hundred and fourteen patients with chronic liver disease aged 18-60 years underwent neurological examination to identify neurological complications, neuropsychological tests comprising the PSE-SyndromeTest yielding the psychometric hepatic encephalopathy score, the critical flicker frequency and the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS), completed a questionnaire concerning their occupation and filled in the short form 36(SF-36) to assess health-related quality of life before OLT and 12 mo after OLT, if possible. Sixty-eight(59.6%) patients were recruited before OLT, while on the waiting list for OLT at Hannover Medical School [age: 48.7 ± 10.2 years, 45(66.2%) male], and 46(40.4%) patients were included directly after OLT. RESULTS Before OLT 43.0% of the patients were employed. The patients not employed before OLT were more often non-academics(employed: Academic/non-academic 16(34.0%)/31 vs not employed 10(17.6%)/52, P = 0.04), had more frequently a history of hepatic encephalopathy(HE)(yes/no; employed 15(30.6%)/34 vs not employed 32(49.2%)/33, P = 0.05) and achieved worse results in psychometric tests(RBANS sum score mean ± SD employed 472.1 ± 44.5 vs not employed 443.1 ± 56.7, P = 0.04) than those employed. Ten patients(18.2%), who were not employed before OLT, resumed work afterwards. The patients employed after OLT were younger [age median(range, min-max) employed 47(42, 18-60) vs not employed 50(31, 29-60), P = 0.01], achieved better results in the psychometric tests(RBANS sum score mean ± SD employed 490.7 ± 48.2 vs not employed 461.0 ± 54.5, P = 0.02) and had a higher health-related quality of life(SF 36 sum score mean ± SD employed 627.0 ± 138.1 vs not employed 433.7 ± 160.8; P < 0.001) compared to patients not employed after OLT. Employment before OLT(P < 0.001), age(P < 0.01) and SF-36 sum score 12 mo after OLT(P < 0.01) but not HE before OLT or neurological complications after OLT were independent predictors of the employment status after OLT.CONCLUSION HE before and neurological complications after OLT have no impact on the employment status 12 mo after OLT. Instead younger age and employment before OLT predict employment one year after OLT. | Henning Pflugrad Anita B Tryc Annemarie Goldbecker Christian P Strassburg Hannelore Barg-Hock Jürgen Klempnauer Karin Weissenborn | 2017 | World Journal of Hepatology2017，9，10： | 3 |
| 6 | Clinical utility of the ARCHITECT HCV Ag assay for early treatment monitoring in patients with chronic hepatitis C genotype 1 infection显示文摘 | Johannes Vermehren Simone Susser Annemarie Berger Dany Perner Kai-Henrik Peiffer Regina Allwinn Stefan Zeuzem Christoph Sarrazin | 2012 | Journal of Clinical Virology2012，，1： | 3 |
| 7 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 8 | Acute hepatitis induced by an Aloe vera preparation: A case report显示文摘AIM: Aloe vera, plant extracts of Aloe barbadensis miller,is widely used in phytomedicine. The first case of acute hepatitis due to this compound was described.METHODS: Description of a clinical case.RESULTS: Hepatitis in a 57-year old female could be linked to the ingestion of Aloe barbadensis miller compounds. The patient's hepatitis resolved completely after discontinuing this medication.CONCLUSION: The case emphasizes the importance of considering phytopharmaceutical over-the-counter drugs as causative agents of hepatitis. | Christian Rabe Annemarie Musch Peter Schirmacher Wolfgang Kruis Robert Hoffmann | 2005 | World Journal of Gastroenterology2005，11，2： | 2 |
| 9 | Early Laparoscopic Cholecystectomy Improves Outcomes After Endoscopic Sphincterotomy for Choledochocystolithiasis显示文摘 | Jan Siert K. Reinders Annemarie Goud Robin Timmer Philip M. Kruyt Ben J.M. Witteman Niels Smakman Ronald Breumelhof Sandra C. Donkervoort Jeroen M. Jansen Joos Heisterkamp Marina Grubben Bert van Ramshorst Djamila Boerma | 2010 | Gastroenterology2010，，7： | 2 |
| 10 | Radiologic Imaging in Cystic Fibrosis显示文摘 | Oisin J. O’Connell Sebastian McWilliams AnneMarie McGarrigle Owen J. O’Connor Fergus Shanahan David Mullane Joseph Eustace Michael M. Maher Barry J. Plant | 2012 | Chest2012，，： | 2 |
| 11 | Cytotoxicity and non-specific cellular uptake of bare and surface-modified upconversion nanoparticles in human skin cells显示文摘cytotoxicity 和 upconversion nanoparticle ( UCNP )的最流行的作文的非特定的细胞的举起, NaYF <潜水艇class=“ a-plus-plus ”> 4 :Yb3+ :Er3+,用正常人的皮肤房间被报导,包括真皮的成纤维细胞和使不朽的人表皮的线性 keratinocytes ( HaCaT )。同样综合的 UCNP 的新 hydrophilization 反应基于 tetramethylammonium 氢氧化物(TMAH ) 启用了赤裸的 UCNP 的内在的 cytotoxicity 的评估。UCNP 表面涂层和聚苯乙烯主人的 cytotoxicity 效果在集中范围上被调查有 24-h 孵化的 62.5125 g/mL,用 MTT 测试和光显微镜学。成纤维细胞生存能力没被 UCNP 损害,而 keratinocytes 的生存能力从 52% 变化了 ? 牧灡敨敮 ???? ?? 汣獡 ?? ???????? 愠瀭畬 ? 汰獵?? ㈠ ?? ?? ￣ ???? 控慬獳??? 汰獵瀭畬 ?? ￣″ ? ?? 〨??? 吗?? | Anna E. Guller Alia N. Generalova Elena V. Petersen Andrey V. Nechaev Inna A. Trusova Nikolay N. Landyshev Annemarie Nadort Ekaterina A. Grebenik Sergey M. Deyev Anatoly B. Shekhter Andrei V. Zvyagin | 2015 | Nano Research2015，8，5： | 2 |
| 12 | Tapping the tree-ring archive for studying effects of resin extraction on the growth and climate sensitivity of Scots pine显示文摘Background: In the German Democratic Republic(GDR), resin tapping in Scots pine(Pinus sylvestris L.) forests was a major economic activity, and resin-tapped stands are frequently found up until this day. In this study, we investigate how the mechanical damage caused by resin tapping affects the growth and climate sensitivity of Scots pine using a dendroecological approach.Methods: Tree-ring samples were collected from resin-tapped and non-tapped trees in two forest areas in northeastern Germany, and tree-growth patterns were analyzed. For elucidating effects of resin tapping on the climate sensitivity of pine growth, climate-growth relationships and pointer years were studied.Results: We observed that resin tapping positively affects tree growth at breast height, likely as wood formation is concentrated on the living part of the bole(i.e. after tapping there is no growth taking place on the tapping face due to the mechanical damage done to the cambium). We observed no differences in the climate sensitivity of tapped and non-tapped trees, nor in the occurrence of extreme growth responses.Conclusion: Our results highlight that resin extraction is, apart from inflicting mechanical damage, not altering the sensitivity of Scots pine growth to climatic conditions. | Ernst van der Maaten Annemarie Mehl Martin Wilmking Marieke van der Maaten-Theunissen | 2017 | Forest Ecosystems2017，4，3： | 2 |
| 13 | A Pilot Study on the Noninvasive Evaluation of Intestinal Damage in Celiac Disease Using I-FABP and L-FABP显示文摘 | Joep P. M. Derikx Anita C. E. Vreugdenhil Anita M. Van den Neucker Joep Grootjans Annemarie A. van Bijnen Jan G. M. C. Damoiseaux L. W. Ernest van Heurn Erik Heineman Wim A. Buurman | 2009 | Journal of Clinical Gastroenterology2009，，8： | 2 |
| 14 | Sap flow for beech(Fagus sylvatica L.)in a natural and a managed forest—effect of spatial heterogeneity显示文摘Aims Beech(Fagus sylvatica L.)is an important species in natural and managed forests in Europe.This drought-sensitive species dominates even-aged stands as well more natural stands composed of a mixture of tree species,age and size classes.This study evaluates the extent that heterogeneity in spacing and tree diameter affect the seasonal availability and use of water.Methods Two stands were evaluated:(i)a heterogeneous forest remnant(NAT)with trees up to;300 years old,a mean top height of 28.4 m and a total of 733 stems ha1with stem diameters averaging 18 cm and(ii)an even-aged 80-year old stand(MAN),with a height of 25 m,and a total of 283 stems ha1 with diameters averaging 38 cm.Stem sap flow,Js(g m2 s1),was continuously measured in 12(MAN)and 13(NAT)trees using 20-mm long heat dissipation sensors.Individual tree measures of sap flow were correlated using non-linear statistical methods with air vapour pressure deficit(D,hPa)and global radiation(Rg,J m2 day1),along with constraints imposed by reductions in soil water content(SWC).SWC was measured as volumetric%using time domain reflectometry.Important Findings The daily integrated Js(Js-sum)for trees growing in the evenly spaced MAN stand and trees in canopy and closed forest positions in NAT stand decreased as the availability of soil moisture was reduced.In the heterogeneous NAT stand,SWC in a recently formed canopy gap remained high throughout the vegetation period.Based on regression models,the predicted relative decrease in Js-sum for dry relative to moist soil water conditions in the closed forest(at mean daily D=10 hPa)was 7–11%for trees near the gap and 39–42%for trees in the closed forest.In MAN,the reduction in Js-sum was 29%in dry relative to moist conditions.Js-sum in the outer 20 mm of the xylem in NAT was lower than that in MAN and the rate of decline in Js with xylem depth was less in NAT than in MAN.In MAN,Js-sum in deep and outer xylem was negatively affected at low soil moisture availability;in NAT,this was the case for only the outer xylem indicating that deep roots could be important in supplying water at times of low soil moisture in the upper soil. | Lise Dalsgaard Teis Nørgaard Mikkelsen Annemarie Bastrup-Birk | 2011 | Journal of Plant Ecology2011，4，1： | 2 |
| 15 | Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo显示文摘 | Amelia Bartholomew Cord Sturgeon Mandy Siatskas Karen Ferrer Kevin McIntosh Sheila Patil Wayne Hardy Steve Devine David Ucker Robert Deans Annemarie Moseley Ronald Hoffman | 2002 | Experimental Hematology2002，，1： | 2 |
| 16 | Hepatitis C virus infection and the brain显示文摘 | Karin Weissenborn Anita B. Tryc Meike Heeren Hans Worthmann Henning Pflugrad Georg Berding Martin Bokemeyer Hans L. Tillmann Annemarie Goldbecker | 2009 | Metabolic Brain Disease2009，，1： | 2 |
| 17 | Land Use and Land Cover Change: the LUCC Science Plan in Europe显示文摘 | Annemarie | 1997 | LUCC newsletter1997，，1： | 1 |
| 18 | 显示文摘 | Jrgen R Marcua W Annemarie G | 2000 | Infect Immun2000，68，： | 1 |
| 19 | 7-year survey after percutaneous dilatational tracheotomy on a medical intensive care unit显示文摘 | PIA L ANNEMARIE S EMEL G | 2010 | J Investigat Med2010，58，8： | 1 |
| 20 | Hydrogenation of edible oils for reduced trans fatty acid content显示文摘 | Gerard Mangnus | 2004 | INFORM2004，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员