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| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | Measurement of grain growth in the recrystallization of rapidly frozen solutions of antifreeze glycoproteins显示文摘 | YEH Y FEENEY R E MCKOWN R L | 1994 | Biopolymers1994，84，： | 1 |
| 3 | Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia显示文摘 | Gates GA Anderson ML Feeney MP | 2008 | Arch Otolaryngol Head Neck Surg2008，134，7： | 1 |
| 4 | Working models of attachment shape perceptions of social support:evidence from experimental and observational studies显示文摘 | Collins NL Feeney BC | 2004 | J Pers Soc Psychol2004，87，3： | 1 |
| 5 | The development of regret显示文摘 | Connor E.O Tereas M Feeney A | | 0，，： | 1 |
| 6 | Zidovudine/ lamivudine but not nevirapine in combination with lopina- vir/ritonavir decreases subcutaneous adipose tissue mito- chondrial DNA显示文摘 | Feeney ER Van Vonderen MG Wit F | 2012 | AIDS2012，26，17： | 1 |
| 7 | Methodology and local effects of contusions in the rat 显示文摘 | Feeney DM Boyeson MG Linn RT Responses to cor- tical injury: I | 1981 | Brain Res1981，211，1： | 1 |
| 8 | Reversible reductive alkylation of amino groups in proteins 显示文摘 | Geoghegan K F Ybarra D M Feeney R E | 1979 | Biochemistry1979，18，： | 1 |
| 9 | Sudactant - free emulsion polymerization: Predictions of the coagulative nucleation theory 显示文摘 | Feeney P J | 1987 | Macromolecules1987，20，： | 1 |
| 10 | Retival VEGF mRNA measured by SYBR green Ⅰ fluorescence: A versatile approach to quantitative PCR显示文摘 | Simpson DA Feeney S Boyle C Stitt AW | 2000 | Mol Vis2000，6，10： | 1 |
| 11 | The Theory of Land Tenure and Property Rights 显示文摘 | Feder G D Feeney | 1993 | World Bank Economic Review1993，5，7： | 1 |
| 12 | Responses to eortieal injury:Methodology and local effeets of contusions in the ratl 显示文摘 | Feeney DM Boyeson MG Linn RT | 1981 | Brain Res1981，，211： | 1 |
| 13 | Comparisons,mental models,and the action effect in judgments of regret显示文摘 | Feeney A Handley S.J | | 0，，07： | 1 |
| 14 | Three-dimensional primate molar enamel thickness显示文摘 | Olejniczak A J Tafforeau P Feeney RN | 2008 | Journal of Human Evolution2008，54，2： | 1 |
| 15 | The resistances of conalbumin and its iron complex to physical and ehemical treatments 显示文摘 | Azari PR Feeney RE | 1961 | Arch Biochem Biophys1961，92，： | 1 |
| 16 | Stakeholder Red Tape:Com- paring Perceptions of Public Managers and Their Pri- vate Consultants 显示文摘 | Feeney MK Bozeman B | 2009 | Public Administration Review2009，69，4： | 1 |
| 17 | Classification of wood species byneural network analysis of ultrasonic signals显示文摘 | R Jordan F Feeney N Nesbitt | 1998 | Ultrasonics1998，36，1： | 1 |
| 18 | Responses to cortical injury 1, Methodology and local effects of contusions in the rat显示文摘 | Feeney DM Boyeson MG Linn RT | 1981 | Brain Res1981，211，1： | 1 |
| 19 | Amphetamine,haloperidol and ex-perience interact to affect rate of recovery after motor cortex injury显示文摘 | Feeney DM GonzalezA Law WA | 1982 | Science1982，217，4562： | 1 |
| 20 | Wideband energy reflectance measurements in adults with middle-ear disorders显示文摘 | Feeney MP Grant IL Marryott LP | 2003 | J Speech Lang Hear Res2003，46，4： | 1 |
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