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| 1 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 2 | Caffeine for Apnea of Prematurity Trial: Benefits May Vary in Subgroups显示文摘 | Peter G. Davis Barbara Schmidt Robin S. Roberts Lex W. Doyle Elizabeth Asztalos Ross Haslam Sunil Sinha Win Tin | 2010 | The Journal of Pediatrics2010，，： | 1 |
| 3 | Conversion of effector CD4^(+)T cells to a CD8^(+)MHC Ⅱ-recognizing lineage显示文摘CD4^(+)and CD8^(+)T cells are dichotomous lineages in adaptive immunity.While conventionally viewed as distinct fates that are fixed after thymic development,accumulating evidence indicates that these two populations can exhibit significant lineage plasticity,particularly upon TCR-mediated activation.We define a novel CD4^(-)CD8αβ^(+)MHC Ⅱ-recognizing population generated by lineage conversion from effector CD4^(+)T cells.CD4-CD8αβ^(+)effector T cells downregulated the expression of T helper cell-associated costimulatory molecules and inaeased the expression of cytotoxic T lymphocyte-associated cytotoxic molecules.This shift in functional potential corresponded with a CD8^(+)-lineage skewed transcriptional profile.TCRβ repertoire sequencing and in vivo genetic lineage tracing in acutely infected wild-type mice demonstrated that CD4^(-)CD8αβ^(+)effector T cells arise from fundamental lineage reprogramming of bona fide effector CD4^(+)T cells.Impairing autophagy via functional deletion of the initiating kinase Vps34 or the downstream enzyme Atg7 enhanced the generation of this cell population.These findings suggest that effector CD4^(+)T cells can exhibit a previously unreported degree of skewing towards the CD8^(+)T cell lineage,which may point towards a novel direction for HIV vaccine design. | Elizabeth Robins Ming Zheng Qingshan Ni Siqi Liu Chen Liang Baojun Zhang Jian Guo Yuan Zhuang You-Wen He Ping Zhu Ying Wan Qi-Jing Li | 2021 | Cellular & Molecular Immunology2021，18，1： | 1 |
| 4 | Concerns of patients with inflammatory bowel disease: results from a clinical population显示文摘 | Elizabeth C de Rooy Brenda B Toner Robert G Maunder Gordon R Greenberg David Baron A.Hillary Steinhart Robin McLeod Zane Cohen | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 5 | Percutaneous gastrostomy tube placement in patients with ventriculoperitoneal shunts显示文摘 | S. S. Sane Alexander Towbin Elizabeth A. Bergey Robin D. Kaye Charles R. Fitz Leland Albright Richard B. Towbin | 1998 | Pediatric Radiology1998，，7： | 1 |
| 6 | Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler’s virus infection显示文摘 | Mary W. Meagher Robin R. Johnson Erin E. Young Elisabeth G. Vichaya Shannon Lunt Elizabeth A. Hardin Marilyn A. Connor C. Jane R. Welsh | 2007 | Brain Behavior and Immunity2007，，8： | 1 |
| 7 | Governance in operating room nursing: Nurses' knowledge of individual surgeons original 显示文摘 | Robin Glenda Riley Elizabeth Manias | 2006 | Science & Medicine2006，62，6： | 1 |
| 8 | Binding of intimin from enteropathogenic Escherichia coli to Tir and host cells 显示文摘 | Elizabeth LH Miranda B Robin MD | 1999 | Molecular Microbiology1999，32，1： | 1 |
| 9 | Outcomes and DNA analysis of ex vivo expanded stem cell allograft for ocular surface reconstruction显示文摘 | Sheraz M. Daya Adam Watson Justin R. Sharpe Osama Giledi Andrea Rowe Robin Martin S. Elizabeth James | 2005 | Ophthalmology2005，，3： | 1 |
| 10 | ASPAN’s Evidence-Based Clinical Practice Guideline for the Promotion of Perioperative Normothermia: Second Edition显示文摘 | Vallire D. Hooper Robin Chard Theresa Clifford Susan Fetzer Susan Fossum Barbara Godden Elizabeth A. Martinez Kim A. Noble Denise O’Brien Jan Odom-Forren Corey Peterson Jacqueline Ross Linda Wilson | 2010 | Journal of PeriAnesthesia Nursing2010，，6： | 1 |
| 11 | Relationships among stress,coping,and mental health in high-achieving high school students显示文摘 | Shannon M Elizabeth S Robin H | 2008 | Psychology in the Schools2008，45，4： | 1 |
| 12 | Multiple-Type Human Papillomavirus (HPV) Infections: A Cross-Sectional Analysis of the Prevalence of Specific Types in 309,000 Women Referred for HPV Testing at the Time of Cervical Cytology显示文摘 | Elizabeth Louise Dickson Rachel Isaksson Vogel Robin L. Bliss Levi S. Downs | 2013 | International Journal of Gynecological Cancer2013，，7： | 1 |
| 13 | Clinical benefit of trabectedin in uterine adenosarcoma显示文摘 | Brett A. Schroeder Eve T. Rodler Elizabeth T. Loggers Seth M. Pollack Robin L. Jones | 2013 | Medical Oncology2013，，2： | 1 |
| 14 | Diffusion‐weighted imaging of the high‐risk breast: Apparent diffusion coefficient values and their relationship to breast density显示文摘 | Elizabeth A.M. O’Flynn Robin M. Wilson Steven D. Allen Imogen Locke Erica Scurr Nandita M. deSouza | 2014 | J. Magn. Reson. Imaging2014，，： | 1 |
| 15 | Management of Uncontrolled Hypertension in a Nurse-Led Clinic Compared With Conventional Care for Patients with Type 2 Diabetes 显示文摘 | Elizabeth AD Maria B Robin GW | 2003 | Diabetes Care2003，26，8： | 1 |
| 16 | Itk-mediated integration of T cell receptor and cytokine signaling regu- lates the balance between Thl7 and regulatory T cells 显示文摘 | Julio G R Elizabeth A W Robin H | 2014 | JExpMed2014，211，3： | 1 |
| 17 | A Mediational Model Relating Affect Intensity, Emotion Inhibition, and Psychological Distress显示文摘 | THOMAS R LYNCH CLIVE J ROBINS JENNIFER Q MORSE ELIZABETH D KRAUSE | 2001 | Behavior Therapy2001，32，： | 1 |
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