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| 1 | Autonomy in materials research: a case study in carbon nanotube growth显示文摘Advances in materials are an important contributor to our technological progress,and yet the process of materials discovery and development itself is slow.Our current research process is human-centred,where human researchers design,conduct,analyse and interpret experiments,and then decide what to do next.We have built an Autonomous Research System(ARES)—an autonomous research robot capable of first-of-its-kind closed-loop iterative materials experimentation.ARES exploits advances in autonomous robotics,artificial intelligence,data sciences,and high-throughput and in situ techniques,and is able to design,execute and analyse its own experiments orders of magnitude faster than current research methods.We applied ARES to study the synthesis of singlewalled carbon nanotubes,and show that it successfully learned to grow them at targeted growth rates.ARES has broad implications for the future roles of humans and autonomous research robots,and for human-machine partnering.We believe autonomous research robots like ARES constitute a disruptive advance in our ability to understand and develop complex materials at an unprecedented rate. | Pavel Nikolaev Daylond Hooper Frederick Webber Rahul Rao Kevin Decker Michael Krein Jason Poleski Rick Barto Benji Maruyama | 2016 | npj Computational Materials2016，，1： | 9 |
| 2 | Survival outcomes of cemented compared to uncemented stems in primary total hip replacement显示文摘Total hip replacement(THR) is a successful and reliable operation for both relieving pain and improving function in patients who are disabled with end stage arthritis.The ageing population is predicted to significantly increase the requirement for THR in patients who have a higher functional demand than those of the past. Uncemented THR was introduced to improve the long term results and in particular the results in younger, higher functioning patients. There has been controversy about the value of uncemented compared to cemented THR although there has been a world-wide trend towards uncemented fixation. Uncemented acetabular fixation has gained wide acceptance, as seen in the increasing number of hybrid THR in joint registries, but there remains debate about the best mode of femoral fixation.In this article we review the history and current worldwide registry data, with an in-depth analysis of the New Zealand Joint Registry, to determine the results of uncemented femoral fixation in an attempt to provide an evidence-based answer as to the value of this form of fixation. | Michael Wyatt Gary Hooper Christopher Frampton Alastair Rothwell | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 3 | Acceleration of Glacier Mass Loss after 2013 at the Mt.Everest(Qomolangma)显示文摘Satellite geodesy is capable of observing glacier height changes and most recent studies focus on the decadal scale due to limitations of data acquisition and precision.Glaciers at the Mt.Everest(Qomolangma),locating at the central Himalaya,have been studied from the 1970s to 2015.Here we obtained TerraSAR-X/TanDEM-X images observed in two epochs,a group around 2013 and another in 2017.Together with SRTM observed in 2000,we derived geodetic glacier mass balance between 2000 and 2013 and 2013 and 2017.We proposed two InSAR procedures for deriving the second period,which yields with basically identical results of geodetic glacier mass balance.The differencing between DEMs derived by TerraSAR-X/TanDEM-X shows better precision than that between TerraSAR-X/TanDEM-X formed DEM and SRTM,and it can capable of providing geodetic glacier mass balance at a sub-decadal scale.Glaciers at the Mt.Everest(Qomolangma)and its surroundings present obvious speeding up in mass loss rates before and after 2013 for both the Chinese and the Nepalese sides.The previous obtained spatial heterogeneous pattern for glacier downwasting between 2000 and 2013 generally kept the same after 2013.Glaciers with lacustrine terminus present the most rapid lost rates. | Gang LI Hui LIN Qinghua YE Liming JIANG Andrew HOOPER Yinyi LIN | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 4 |
| 4 | The heterogeneity of store-operated calcium entry in melanoma显示文摘Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry(SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease. | Robert Hooper M.Raza Zaidi Jonathan Soboloff | 2016 | Science China(Life Sciences)2016，59，8： | 3 |
| 5 | Interactions Between the Microbiota and the Immune System显示文摘 | Lora V. Hooper Dan R. Littman Andrew J. Macpherson | 2012 | Science . 2012 (6086)2012，，6086： | 2 |
| 6 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 7 | Randomized Controlled Trial of Danoprevir Plus Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Patients with HCV Genotype 1 Infection显示文摘 | P. Marcellin C. Cooper L. Balart D. Larrey T. Box E. Yoshida E. Lawitz P. Buggisch P. Ferenci M. Weltman E. Labriola-Tompkins S. Le Pogam I. Nájera D. Thomas G. Hooper N.S. Shulman Y. Zhang M.T. Navarro C.Y. Lim M. Brunda N.A. Terrault E.S. Yetzer | 2013 | Gastroenterology2013，，： | 2 |
| 8 | Cytokines in Mycoplasma pneumoniae infections显示文摘 | Jun Yang W.Craig Hooper Donald J Phillips Deborah F Talkington | 2003 | Cytokine and Growth Factor Reviews2003，，2： | 2 |
| 9 | Restoration of the Joint Line in Total Knee Arthroplasty显示文摘 | Elango Selvarajah Gary Hooper | 2009 | The Journal of Arthroplasty2009，，7： | 2 |
| 10 | Immune Responses to the Microbiota at the Intestinal Mucosal Surface显示文摘 | Breck A. Duerkop Shipra Vaishnava Lora V. Hooper | 2009 | Immunity2009，，3： | 2 |
| 11 | 利用时间串联质谱方法测定高脂肪食品中低于PPT级的2,3,7,8氯代二苯二恶英和氯代二苯呋喃显示文摘离子阱串联质谱方法的检出限通过对花生油、羔羊脂肪和黄油中2,3,7,8多氯代二苯二恶英(PCDD_s)和多氯代二苯呋喃(PCDFs)的反复测定进行了评价,在黄油中可观测到10种同系物(范围0.27一2.5pg/g),羔羊脂肪中可测到9种(范围0.09- 2 6pg/g),并且所得结果精确性良好。在高脂肪食品中,对大多数的多氯代二苯二恶英/呋喃,可在 0.5 pg/g的水平达到准确和可重复的结果(七氯代二苯二恶英和七氯代二苯呋喃为1.0pg/g,八氯代二苯呋喃为2.0pg/g),而对于2,3,7,8四氯代二苯二恶英和2,3,7,8四氯代二苯呋喃可达到0.2pg/g。离子阱串联质谱方法在分析鲶鱼和鸡蛋中的2,3,7,8四氯代二苯二恶英方面性能卓越,所分析的样品来自美国大陆的大多数地区。该方法还用于羔羊脂肪、黄油和取自Kazakhstan乡村的棉子油中的四氯代二苯二恶英污染的测定。由该方法对鲶鱼和鸡蛋样品的重复分析表明其结果可与高分辨质谱方法相媲美。 | Douglas G Hayward Kim Hooper Denls Andrzejewski | 1999 | 现代科学仪器1999，0，3： | 2 |
| 12 | HOW HOST-MICROBIAL INTERACTIONS SHAPE THE NUTRIENT ENVIRONMENT OF THE MAMMALIAN INTESTINE显示文摘 | Lora V. Hooper Tore Midtvedt Jeffrey I. Gordon | 2002 | Annual Review of Nutrition2002，，： | 2 |
| 13 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 14 | Physiological functions and clinical implications of fibrinogen-like 2:A review显示文摘Fibrinogen-like 2(FGL2) encompasses a transmembrane(m FGL2) and a soluble(s FGL2) form with differential tertiary structure and biological activities. Typically, m FGL2 functions as prothrombinase that is capable of initiating coagulation in tissue without activation of the blood clotting cascade, whereas s FGL2 largely acts as an immunosuppressor that can repress proliferation of alloreactive T lymphocytes and maturation of bone marrow dendritic cells. Protein sequences of FGL2 exhibit evolutionary conservation across wide variety of species, especially at the carboxyl terminus that contains fibrinogen related domain(FRED). The FRED of FGL2 confers specificity and complexity in the action of FGL2, including receptor recognition, calcium affiliation, and substrate binding. Constitutive expression of FGL2 during embryogenesis and in mature tissues suggests FGL2 might be physiologically important. However, excessive induction of FGL2 under certain medical conditions(e.g. pathogen invasion) could trigger complement activation, inflammatory response,cellular apoptosis, and immune dysfunctions. On the other hand, complete absence of FGL2 is also detrimental as lack of FGL2 can cause autoimmune glomerulonephritis and acute cellular rejection of xenografts. All these roles involve m FGL2, s FGL2, or their combination. Although it is not clear how m FGL2 is cleaved off its host cells and secreted into the blood, circulating s FGL2 has been found correlated with disease severity and viral loading among patients with human hepatitis B virus or hepatitis C virus infection. Further studies are warranted to understand how FGL2 expression is regulated under physiological and pathological conditions. Even more interesting is to determine whether m FGL2 can fulfill an immunoregulatory role through its FRED at carboxyl end of the molecule and, and vice versa, whether s FGL2 is procoagulant upon binding to a target cell. Knowledge in this area should shed light on development of s FGL2 as an alternative immunosuppressive agent for organ transplantation or as a biomarker for predicting disease progression, monitoring therapeutic effects, and targeting FGL2 for repression in ameliorating fulminant viral hepatitis. | Genyan Yang W Craig Hooper | 2013 | World Journal of Clinical Infectious Diseases2013，3，3： | 2 |
| 15 | HOW HOST-MICROBIAL INTERACTIONS SHAPE THE NUTRIENT ENVIRONMENT OF THE MAMMALIAN INTESTINE显示文摘 | Lora V. Hooper Tore Midtvedt Jeffrey I. Gordon | 2002 | Annual Review of Nutrition2002，，： | 2 |
| 16 | A morbillivirus that caused fatal disease in horses and humans显示文摘 | Murray K Selleck P Hooper P | | 0，，： | 2 |
| 17 | Consensus Guidelines for the Management of Postoperative Nausea and Vomiting显示文摘 | Tong J. Gan Pierre Diemunsch Ashraf S. Habib Anthony Kovac Peter Kranke Tricia A. Meyer Mehernoor Watcha Frances Chung Shane Angus Christian C. Apfel Sergio D. Bergese Keith A. Candiotti Matthew TV Chan Peter J. Davis Vallire D. Hooper Sandhya Lagoo-Deena | 2014 | Anesthesia & Analgesia2014，，： | 2 |
| 18 | 面向教学设计的教学方法新分类显示文摘依据问题的呈方式现、复杂性程度和来源,本文提出了面向教学设计的教学方法分类学。这一富有启发性的理论框架将教学方法分为五个层次:接受、运用、扩展、创见和质疑,从而有希望改变教学仅仅限于传递信息的状况,为培养高层次思维能力和问题解决能力服务。 | Brad Hokanson Simon Hooper 王耐 盛群力 | 2005 | 远程教育杂志2005，23，2： | 2 |
| 19 | A human homolog of angiotensin conver-ting enzyme: cloning and functional expression as a captopril-insensitive car-hoxypeptidase显示文摘 | TIPNIS S R HOOPER N M HYDE R | 2000 | J BiolChem2000，275，33： | 1 |
| 20 | Epidermal growth factor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice显示文摘 | Overholser JP Prewett MC Hooper AT | 2000 | Cancer2000，89，1： | 1 |
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