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| 1 | Recent Advances in Understanding Plant Myosin Function: Life in the Fast Lane显示文摘植物肌浆球蛋白为细胞器运动被要求,并且在肌动朊组织的一个角色最近真相大白。肌浆球蛋白异种显示几粗野词法显型,最严重是侏儒症并且减少肥沃,并且在减少的细胞器运动和词法缺点之间有关联。这评论试图在肌动朊动力学,开发,和细胞器运动在关于肌浆球蛋白的角色的植物讨论最近的调查结果,更明确地 endoplasmic 蜂窝胃(嗯) 。一贯穿主题在那里是那仍然看起来比关于植物肌浆球蛋白功能和规定的答案是更多的问题。 | Imogen Sparkes | 2011 | Molecular Plant2011，4，5： | 6 |
| 2 | High mobility group box protein 1 and white matter injury following traumatic brain injury: perspectives on mechanisms and therapeutic strategies显示文摘Traumatic brain injury(TBI)is a major cause of morbidity and mortality worldwide.Despite significant medical advances over recent decades,many survivors of TBI develop long term neuro-cognitive deficits.Previously,only moderate and severe injuries were thought to account for the devastating consequences of TBI.However,there is increasing evidence that even milder injuries may result in problematic lifelong cognitive and affective disturbances.TBI is typically characterized by an an acute physical injury followed by a protracted innate neuro-inflammatory response.These reponses,mediated via neuronal,astrocyte and microglial cells,amongst others,and may result in widespread neuronal death and a micro-environment that is not conducive to brain repair(Manivannan et al.,2021).Whilst the primary physical injury often evades intervention from a medical perspective,the subsequent neuro-inflammatory response offers a potential therapeutic target.Nonetheless,effective pharmacological strategies continue to elude clinicians and scientists due to the complex underlying pathogenesis and difficulties of modelling such a heterogeneous disease.However,the majority of research to date has focused on investigating the effects of post-traumatic neuro-inflammation on grey matter injury rather than the consequences upon white matter(WM),which contributes greatly to cognitive dysfunction across many neurological diseases(Filly and Kelly,2018).Herein,we will briefly discuss:(i)high mobility group box protein 1(HMGB1)as a potential therapeutic target;(ii)the relevance of WM injury in TBI and current understanding of WM repair following injury;and(iii)perspectives on how HMGB1 may play a role. | Ronak Ved Susruta Manivannan Imogen Tasker Malik Zaben | 2022 | Neural Regeneration Research2022，17，8： | 2 |
| 3 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 4 | Vitamin D as a therapy for colitis: A systematic review显示文摘 | Imogen Nicholson A. Mark Dalzell Wael El-Matary | 2012 | Journal of Crohn’s and Colitis2012，，4： | 2 |
| 5 | Frequency tunable near-infrared metamaterials based on VO2 phase transition显示文摘 | Matthew J D Koray A Imogen M P | 2006 | Opt Expr2006，17，18： | 1 |
| 6 | Flocculation as a low-cost method for harvesting microalgae for bulk biomass production显示文摘 | Dries Vandamme Imogen Foubert Koenraad Muylaert | 2013 | Trends in Biotechnology2013，，4： | 1 |
| 7 | We are the experts: people with asthma talk about their medicine information needs显示文摘 | David K Raynor Imogen Savage Peter Knapp Jeremy Henley | 2003 | Patient Education and Counseling2003，，2： | 1 |
| 8 | Plasmonic nanoparticle enhanced pho- tocurrent in GaN/InGaN/GaN quantum well solar cells显示文摘 | Imogen M Pryce | 2010 | Appl Phys Lett2010，96，15： | 1 |
| 9 | Species distribution and susceptibilities of bacteraemic isolates from a United Kingdom Level 3 Neonatal Intensive Care Unit, a 5 year experience 显示文摘 | ABID HUSSAIN IMOGEN STOREY | 2013 | Pediatrics research international journal2013，，： | 1 |
| 10 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 11 | Influence of organic matter on flocculation of Chlorella vulgaris by calcium phosphate precipitation显示文摘 | Annelies Beuckels Orily Depraetere Dries Vandamme Imogen Foubert Erik Smolders Koenraad Muylaert | 2013 | Biomass and Bioenergy2013，，： | 1 |
| 12 | Implementation of enhanced recovery programme after pancreatoduodenectomy: A single-centre UK pilot study显示文摘 | Mohammed Abu Hilal Francesco Di Fabio AbdAllah Badran Hani Alsaati Hannah Clarke Imogen Fecher Thomas H. Armstrong Colin D. Johnson Neil W. Pearce | 2013 | Pancreatology2013，，1： | 1 |
| 13 | Predictors of Surgical Margin Status in Breast-Conserving Surgery Within a Breast Screening Program显示文摘 | Emil D. Kurniawan Matthew H. Wong Imogen Windle Allison Rose Arlene Mou Malcolm Buchanan John P. Collins Julie A. Miller Russell L. Gruen G. Bruce Mann | 2008 | Annals of Surgical Oncology2008，，9： | 1 |
| 14 | Loss of heter ozygosity at the BRCA1 and BRCA2 loci deteced in ductal lavage fluid from BRCA gene mutati on carriers and contr ols显示文摘 | Imogen L Zs Ofia KJ Elizabeth B | 2006 | Cancer Epidemiol Biomarkers Prev2006，7，15： | 1 |
| 15 | Properties of human milk and their relationship with maternal nutrition显示文摘 | PAULINE M E IMOGEN S R | 1997 | Early Hum Dev1997，49，： | 1 |
| 16 | A theory of goal attainment:Philo- sophical and ethical implications 显示文摘 | Imogene MK | 1999 | Nurs Sci Q1999，12，4： | 1 |
| 17 | Rapid, transient expression of fluorescent fusion proteins in tobacco plants and generation of stably transformed plants显示文摘 | IMOGEN S A JOHN R ANNE K | 2006 | Nature Protocols2006，1，4： | 1 |
| 18 | Properties of human milk and their relationship with maternal nutrition显示文摘 | Pauline M. Emmett Imogen S. Rogers | 1997 | Early Human Development1997，，： | 1 |
| 19 | Cell lines derived from late embryonic stages of Drosophila melanogaster显示文摘 | Imogene Schneider | 1972 | Embryol exp Morph1972，，2： | 1 |
| 20 | Flocculati on of microalgae using cationic starch显示文摘 | Dries Vandamme Imogen Foubert Boudewijn Meesschaert | 2010 | Journal of Applied Phyco logy2010，22，4： | 1 |
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