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| 1 | Colorectal cancer: From prevention to personalized medicine显示文摘Colorectal cancer(CRC)is a very heterogeneous disease that is caused by the interaction of genetic and environmental factors.CRC develops through a gradual accumulation of genetic and epigenetic changes,leading to the transformation of normal colonic mucosa into invasive cancer.CRC is one of the most prevalent and incident cancers worldwide,as well as one of the most deadly.Approximately 1235108 people are diagnosed annually with CRC,and 609051 die from CRC annually.The World Health Organization estimates an increase of77%in the number of newly diagnosed cases of CRCand an increase of 80%in deaths from CRC by 2030.The incidence of CRC can benefit from different strategies depending on its stage:health promotion through health education campaigns(when the disease is not yet present),the implementation of screening programs(for detection of the disease in its early stages),and the development of nearly personalized treatments according to both patient characteristics(age,sex)and the cancer itself(gene expression).Although there are different strategies for screening and although the number of such strategies is increasing due to the potential of emerging technologies in molecular marker application,not all strategies meet the criteria required for screening tests in population programs;the three most accepted tests are the fecal occult blood test(FOBT),colonoscopy and sigmoidoscopy.FOBT is the most used method for CRC screening worldwide and is also the primary choice in most population-based screening programs in Europe.Due to its non-invasive nature and low cost,it is one of the most accepted techniques by population.CRC is a very heterogeneous disease,and with a few exceptions(APC,p53,KRAS),most of the genes involved in CRC are observed in a small percentage of cases.The design of genetic and epigenetic marker panels that are able to provide maximum coverage in the diagnosis of colorectal neoplasia seems a reasonable strategy.In recent years,the use of DNA,RNA and protein markers in different biological samples has been explored as strategies for CRC diagnosis.Although there is not yet sufficient evidence to recommend the analysis of biomarkers such as DNA,RNA or proteins in the blood or stool,it is likely that given the quick progression of technology tools in molecular biology,increasingly sensitive and less expensive,these tools will gradually be employed in clinical practice and will likely be developed in mass. | Gemma Binefa Francisco Rodríguez-Moranta àlex Teule Manuel Medina-Hayas | 2014 | World Journal of Gastroenterology2014，20，22： | 67 |
| 2 | 欧洲的氮状况显示文摘欧洲(不包括前苏联)的氮收支表明,欧洲氮循环加速的三个主要驱动力是肥料生产(14Mt N/a)、矿物燃料燃烧及其它工业(3.3MtN/a)和各种产品中的氮输入(7.6Mt N/a)。本文估计了欧洲粮食、能源和工业产品系统中活性氮元素的各种泄漏,评估了它们对人类健康及水陆生态系统的影响。考虑到氮流转中的可能后果,未来欧洲有关封闭氮循环和减少活性氮泄漏的环境政策措施最好集中于三个主要驱动力。在确定氮排放上限和制定氮流控制的综合政策方面,如肥料使用、输入和氮水平,临界负载可能是非常有用的工具。 | Klaas van Egmond Ton Bresser Lex Bouwman 王胜 | 2002 | AMBIO-人类环境杂志2002，31，2： | 8 |
| 3 | Cognitive mechanism related to line drawings and its applications in intelligent process of visual media: a survey显示文摘 | Yongjin LIU Minjing YU Qiufang FU Wenfeng CHEN Ye LIU Lexing XIE | 2016 | Frontiers of Computer Science2016，10，2： | 5 |
| 4 | Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study显示文摘 | Roger K. Schindhelm Jacqueline M. Dekker Giel Nijpels Lex M. Bouter Coen D.A. Stehouwer Robert J. Heine Michaela Diamant | 2006 | Atherosclerosis2006，，2： | 3 |
| 5 | A pedestrian introduction to fast multipole methods显示文摘This paper provides a conceptual and non-rigorous description of the fast multipole methods for evaluating convolution kernel functions with source distributions.Both the non-oscillatory and the oscillatory kernels are considered.For non-oscillatory kernel,we outline the main ideas of the classical fast multipole method proposed by Greengard and Rokhlin.In the oscillatory case,the directional fast multipole method developed recently by Engquist and Ying is presented. | YING Lexing | 2012 | Science China Mathematics2012，55，5： | 3 |
| 6 | An overview of mortality and sequelae of preterm birth from infancy to adulthood显示文摘 | Saroj Saigal Lex W Doyle | 2008 | The Lancet2008，，9608： | 2 |
| 7 | Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis显示文摘 | D.Keith George Stefano Goldwurm Graeme A. Macdonald Lex L. Cowley Neal I. Walker Patrick J. Ward Elizabeth C. Jazwinska Lawrie W. Powell | 1998 | Gastroenterology1998，，2： | 2 |
| 8 | The consequences of uncertainties in land use, climate and vegetation responses on the terrestrial carbon显示文摘The IPCC SRES narratives were implemented in IMAGE 2.2 to evaluate thefuture condition of the climate system (including the biosphere). A series of scenario experiments was used to assess possible ranges in emissions and concentrations of greenhouse gases, climate change and impacts. These experiments focussed on the role of the terrestrial carbon cycle. The experiments show that the SRES narratives dominate human emissions and not natural processes. In contrary, atmospheric CO2 concentration strongly differs between the experiments. Atmospheric CO2 concentrations range for A1B from 714 to 1009 ppmv CO2 in 2100. The spread of this range is comparable with the full SRES range as implemented in IMAGE 2.2 (515-895 μmol/mol CO2). The most important negative and positive feedback processes in IMAGE 2.2 on the build-up of CO2 concentrations are CO2 fertilisation and soil respiration respectively. Indirect effects of these processes furtherchange land-use patterns, deforestation rates and alter the natural C fluxes. The cumulative effects of these changes have a pronounced influence on the final CO2 concentrations. Our scenario experiments highlight the importance of a proper parameterisation of feedback processes, C-cycle and land use in determining the future states of the climate system. | Rik Leemans Bas Eickhout Bart Strengers Lex Bouwman Michiel Schaeffer | 2002 | Science China(Life Sciences)2002，45，z1： | 2 |
| 9 | The diagnostic value of computed tomography histogram analysis in thyroid malignant solitary nodules showing coarse calcifications显示文摘 | Zhang Lexing Wei Peiying Han Zhijiang Xiang Jingjing Ding Jinwang Luo Dingcun Li Mingkui | 2018 | 中华内分泌外科杂志2018，12，4： | 2 |
| 10 | The ten command- ments of balanced scorecard implementation 显示文摘 | LEWY CLAUDE LEX D M | 1998 | Management Control and Accounting1998，，5： | 1 |
| 11 | Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study显示文摘 | Lex C Zaeharasiewicz A Payne DNR | 2006 | Respir Res2006，7，： | 1 |
| 12 | Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study显示文摘 | LEX C ZACHARASIEWICZ A PAYNE DN et d | 2006 | Respir Res2006，7，： | 1 |
| 13 | Protein Supplementation Increases Muscle Mass Gain During Prolonged Resistance-Type Exercise Training in Frail Elderly People: A Randomized, Double-Blind, Placebo-Controlled Trial显示文摘 | Michael Tieland Marlou L. Dirks Nikita van der Zwaluw Lex B. Verdijk Ondine van de Rest Lisette C.P.G.M. de Groot Luc J.C. van Loon | 2012 | Journal of the American Medical Directors Association2012，，8： | 1 |
| 14 | Caffeine for Apnea of Prematurity Trial: Benefits May Vary in Subgroups显示文摘 | Peter G. Davis Barbara Schmidt Robin S. Roberts Lex W. Doyle Elizabeth Asztalos Ross Haslam Sunil Sinha Win Tin | 2010 | The Journal of Pediatrics2010，，： | 1 |
| 15 | Airway eosinophilia in children with severe asthma:predictive values of noninva- sire test 显示文摘 | Lex C Ferreira F Zacharasiewicz A | 2006 | Respir Crit Care Med2006，175，12： | 1 |
| 16 | Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children 显示文摘 | Zaeharasiewiez A Wilson N Lex C | 2005 | Am J Respir Crit Care Med2005，171，10： | 1 |
| 17 | A majority of cotton genes are expressed in single-celled fiber显示文摘 | Ran Hovav Joshua A. Udall Einat Hovav Ryan Rapp Lex Flagel Jonathan F. Wendel | 2008 | Planta2008，，2： | 1 |
| 18 | The contribution of N2O to the greenhouse gas balance of first‐generation biofuels显示文摘 | EDWARD M.W.SMEETS LEX F.BOUWMAN ELKESTEHFEST DETLEF P.VAN VUUREN ADAMPOSTHUMA | 2010 | Global Change Biology2010，，8： | 1 |
| 19 | Non-invasive regime for language lateralization in right- and left-handers by means of functional MRI and dichotic listening显示文摘 | Hund-Georgiadis M Lex U Friederici AD | 2002 | Exp Brain Res2002，145，2： | 1 |
| 20 | The operative treatment of scapular fracture显示文摘 | Hardegger FH Simpson LEX A Weber BG | 1984 | J Bone and Joint Surg Br1984，66，5： | 1 |
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