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| 1 | Diagnosis of obscure gastrointestinal bleeding by intraoperative enteroscopy in 81 consecutive patients显示文摘瞄准:为了由与流血调查一系列选择病人分析 intra 起作用的肠寄生物(IOE ) 的结果和复杂并发症,怀疑了从小肠发源。方法:81 个病人(吝啬的年龄:65 年) 包括 40,男性(49.4%) 和有阴暗胃肠的流血的 41 女性(50.6%) 经历了在 1990 和 2004 之间的 IOE。病人从一个数据库被识别,数据回顾地从病人的图表被选择。所有病人在 IOE 前经历了至少一非诊断的 esophagogastroduodenoscopy,结肠镜检查,标准肠寄生物和否定腹的超声扫描。结果:在病人的中部的最小的血红素水平是 59 + 15 g/L 并且 72.8% 病人以前要求了包装红血球的输送。流血来源在 68 被检测(84%) 病人在 IOE 期间。Angiodysplasiae 在 44 个病人(54.3%) 被发现, 9 个病人(11.1%) 被溃疡在小肠影响。在小肠的一个肿瘤在另外一个被检测 6 个病人。治疗在大多数病人由 argon-plasma-coagulation,外科的缝术或有限切除术组成了。结论:Intra 起作用的肠寄生物仍然为怀疑的小肠流血的诊断被使用。最近的开发象无线的囊内视镜检查法和两倍汽球肠寄生物那样,以后可以导致 IOE 的代替。 | Ralf Jakobs Dirk Hartmann Claus Benz Dieter Schilling Uwe Weickert Axel Eickhoff Klaus Schoenleben Juergen F Riemann | 2006 | World Journal of Gastroenterology2006，12，2： | 5 |
| 2 | A prospective two-center study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding显示文摘 | Dirk Hartmann Harald Schmidt Georg Bolz Dieter Schilling Frank Kinzel Axel Eickhoff Winfried Huschner Kathleen M?ller Ralf Jakobs Peter Reitzig Uwe Weickert Klaus Gellert Harald Schultz Klaus Guenther Hartmut Hollerbuhl Klaus Schoenleben Hans-Joachim Schu | 2005 | Gastrointestinal Endoscopy2005，，7： | 2 |
| 3 | Occurrence and propagation of delamination during the machining of carbon fibre reinforced plastics (CFRPs) – An experimental study显示文摘 | Wolfgang Hintze Dirk Hartmann Christoph Schütte | 2011 | Composites Science and Technology2011，，15： | 1 |
| 4 | Optimal Lymph Node Harvest in Rectal Cancer (UICC Stages II and III) after Preoperative 5-FU–based Radiochemotherapy. Acetone Compression is a New and Highly Efficient Method显示文摘 | Anastasia Gehoff Oliver Basten Thilo Sprenger Lena-Christin Conradi Carsten Bismarck Dirk Bandorski Sabine Merkelbach-Bruse Regine Schneider-Stock Robert Stoehr Ralph M. Wirtz Julia Kitz Annegret Müller Arndt Hartmann Heinz Becker B. Michael Ghadimi Torst | 2012 | The American Journal of Surgical Pathology2012，，2： | 1 |
| 5 | PillCamColon2 after incomplete colonoscopy-A prospective multicenter study显示文摘AIM To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy(OC) and to assess the diagnostic yield.METHODS This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy(CCE) following incomplete OC performed by an experienced gastroenterologist(> 1000 colonoscopies). Patients with stenosis were excluded. According to patient preferences, CCE was performed the following day(protocol A) after staying on clear liquids and 0.75 L Moviprep in the morning or within 30 d after new split-dose Moviprep(protocol B). Boosts consisted of 0.75 L and 0.25 L Moviprep, and phospho-soda was given as a rescue if the capsule was not excreted after seven hours.RESULTS Seventy-four patients were analysed(51% of them in group A; 49% in group B). Bowel cleansing was adequate in 67% of cases, and CCE could visualize colonic segments missed by incomplete colonoscopy in 90% of patients under protocol A and 97% of patients under protocol B(P = 0.35, n.s.). Significant polyps including adenocarcinoma were detected in 24% of cases. Detection rates for all polyps and significant polyps per patient were similar in both protocols. Polyps were found predominantly in the right colon(86%) in segments that were not reached by OC. Extracolonic findings-such as reflux esophagitis, suspected Barrett esophagus, upper GI-bleeding, gastric polyps, gastric erosions and angiectasia-were detected in eight patients. Pill Cam Colon2 capsule was retained in the ileum of one patient(1.4%) without symptoms and removed during an uneventful resection for unknown Crohn's disease that was diagnosed as the cause of anemia, which was the indication for colonoscopy. CCE was well tolerated. One patient suffered from selflimiting vomiting after consuming the phospho-soda.CONCLUSION Second-generation CCE using a low-volume preparation is useful after incomplete OC, and it allows for the detection of additional relevant findings, but cleansing efficiency could be improved. | Peter Baltes Marc Bota Jorg Albert Michael Philipper Hans-Georg Horster Friedrich Hagenmüller Ingo Steinbrück Ralf Jakobs Matthias Bechtler Dirk Hartmann Horst Neuhaus Jean-Pierre Charton Rupert Mayershofer Horst Hohn Thomas Rosch Stefan Groth Tanja Nowak Peter Wohlmuth Martin Keuchel | 2018 | World Journal of Gastroenterology2018，24，31： | 1 |
| 6 | A Prospective Study of the Diagnostic Accuracy of PillCam ESO Esophageal Capsule Endoscopy Versus Conventional Upper Endoscopy in Patients With Chronic Gastroesophageal Reflux Diseases显示文摘 | Rami Eliakim Virender K Sharma Kamel Yassin Samuel N Adler Harold Jacob David R Cave Ritu Sachdev Roger D Mitty Dirk Hartmann Dieter Schilling Jurgen F Riemann Simon Bar-Meir Eytan Bardan Brian Fennerty Glenn Eisen Douglas Faigel Blair S Lewis David E Fle | 2005 | Journal of Clinical Gastroenterology2005，，7： | 1 |
| 7 | Copeptin Improves Early Diagnosis of Acute Myocardial Infarction显示文摘 | Till Keller Stergios Tzikas Tanja Zeller Ewa Czyz Lars Lillpopp Francisco M. Ojeda Alexander Roth Christoph Bickel Stephan Baldus Christoph R. Sinning Philipp S. Wild Edith Lubos Dirk Peetz Jan Kunde Oliver Hartmann Andreas Bergmann Felix Post Karl J. Lac | 2010 | Journal of the American College of Cardiology2010，，19： | 1 |
| 8 | Colon anatomy based on CT colonography and fluoroscopy: Impact on looping, straightening and ancillary manoeuvres in colonoscopy显示文摘 | Axel Eickhoff Perry J. Pickhardt Dirk Hartmann Jürgen F. Riemann | 2009 | Digestive and Liver Disease2009，，4： | 1 |
| 9 | The effects of facilitated primary PCI by guide wire on procedural and clinical outcomes in acute ST-segment elevation myocardial infarction显示文摘 | Volkhard Kurowski Evangelos Giannitsis Dirk P. Killermann Uwe K. H. Wiegand Ralph Toelg Hendrik Bonnemeier Franz Hartmann Hugo A. Katus Gert Richardt | 2007 | Clinical Research in Cardiology2007，，8： | 1 |
| 10 | CYP3A5 genotype is not associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients显示文摘 | Dennis A. Hesselink Ron H.N. van Schaik Madelon van Agteren Johannes W. de Fijter Anders Hartmann Martin Zeier Klemens Budde Dirk R.J. Kuypers Przemyslav Pisarski Yann Le Meur Richard D. Mamelok Teun van Gelder | 2008 | Pharmacogenetics and Genomics2008，，4： | 1 |
| 11 | Oc- currence and propagation of delamination during the machi- ning of carbon - fibre reinforced plastics (CFRPs) - An experimental study显示文摘 | Wolfgang Hintze Dirk Hartmann Christoph Schtitte | 2011 | Composites Science and Technolo- gy2011，71，： | 1 |
| 12 | Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture显示文摘AIM To investigate presence and extent of eosinophilic cholangitis(EC) as well as Ig G4-related disease in patients with indeterminate biliary stricture(IBS).METHODS All patients with diagnosis of sclerosing cholangitis(SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regardingpresence of eosinophilic infiltration and Ig G4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing cholangitis.RESULTS One hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30%(3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of Ig G4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with Ig G4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to Ig G4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n=27) and patients with primary sclerosing cholangitis(n = 14).CONCLUSION EC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS. | Dirk Walter Sylvia Hartmann Eva Herrmann Jan Peveling-Oberhag Wolf O Bechstein Stefan Zeuzem Martin-Leo Hansmann Mireen Friedrich-Rust Jorg G Albert | 2017 | World Journal of Gastroenterology2017，23，6： | 1 |
| 13 | Observation of a single protein by ultrafast X-ray diffraction显示文摘The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired many.It was one of the arguments for building X-ray free-electron lasers.According to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably explodes.This was first demonstrated on biological samples a decade ago on the giant mimivirus.Since then,a large collaboration has been pushing the limit of the smallest sample that can be imaged.The ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of macromolecules.Here we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single proteins.From the pattern,it is possible to determine the approximate orientation of the protein.Our experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale. | Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia | 2024 | Light(Science & Applications)2024，13，1： | 0 |
| 14 | Efficient Dynamic Floor Field Methods for Microscopic Pedestrian Crowd Simulations显示文摘Floor field methods are one of the most popular medium-scale navigation concepts in microscopic pedestrian simulators.Recently introduced dynamic floor field methods have significantly increased the realism of such simulations,i.e.agreement of spatio-temporal patterns of pedestrian densities in simulations with real world observations.These methods update floor fields continuously taking other pedestrians into account.This implies that computational times are mainly determined by the calculation of floor fields.In this work,we propose a new computational approach for the construction of dynamic floor fields.The approach is based on the one hand on adaptive grid concepts and on the other hand on a directed calculation of floor fields,i.e.the calculation is restricted to the domain of interest.Combining both techniques the computational complexity can be reduced by a factor of 10 as demonstrated by several realistic scenarios.Thus on-line simulations,a requirement of many applications,are possible for moderate realistic scenarios. | Dirk Hartmann Peter Hasel | 2014 | Communications in Computational Physics2014，16，6： | 0 |
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