|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Melanoma of the rectum: A rare entity显示文摘A 41-year-old man presented with a 6-mo history of changed defecation and rectal bleeding. A 3-cm polypoid tumor of the lower rectum was found at rectosigmoidos- copy, which proved to be a leiomyosarcoma upon biopsy. Dissemination studies did not show any metastases. He was underwent to an abdomino-perineal resection (APR). Histopathology of the specimen showed a melanoma (S-100 stain positive). Two years after the resection, me- tastases in the abdomen and right lung were found. He died one and half years later. Primary anorectal melano- ma is a rare and very aggressive disorder. According to current data, one should always perform a S-100 stain when anorectal sarcoma is suspected. A positive S-100 stain suggests the tumour to be most likely a melanoma. Subsequently, thorough dissemination studies need to be performed. Depending on the outcome of the dissemina- tion studies, a surgical resection has to be performed. Nowadays, a sphincter-saving local excision combined with adjuvant loco-regional radiotherapy should be pre- ferred in case of small tumors. The same loco-regional control is achieved with less 'loss of function' compared to non-sphincter saving surgery. Only in the case of large and obstructing tumors an abdomino-perineal resection is the treatment of choice. | PM van Schaik MF Ernst HA Meijer K Bosscha | 2008 | World Journal of Gastroenterology2008，14，10： | 3 |
| 2 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | The 5-HT2c receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation显示文摘有终生的早泄(LPE ) 的人的坚持的短 intravaginal 射精潜伏时间(IELT ) 与 5-hydroxytryptamine (HT ) 有关是 2C 受体工作,这被要求了。这研究的目的是与 LPE 在人调查 Cys23Ser 5-HT 2C 受体基因多型性和 IELT 的持续时间的关系。因此,未来的研究与 LPE 在 64 个荷兰的白种人人被进行。基线 IELT 被秒表在一个 1 月的时期上在性交期间估计。所有人是为 Cys23Ser 5-HT 2C 受体基因多型性的 genotyped。Cys 的等位基因频率和 5-HT 2C 受体基因多型性的重量的单位变体是坚定的。在 Cys/Cys 和重量的单位 / 重量的单位遗传型和在有 LPE 的人的 IELT 的自然对数之间的协会被调查。作为结果,几何吝啬、中部、自然的吝啬的 IELT 是 25.2, 27.0, 33.9 s 分别地。所有人, 20.0% , 10.8% , 23.1% 和 41.5% 在 10 以内射精,在阴道穿入以后的 10-20, 20-30 和 30-60 s。64 个人,为 5-HT 2C 受体基因的 Cys23Ser 多型性的 Cys/Cys 和重量的单位 / 重量的单位遗传型频率分别地是 81% 和 19% 。wildtypes (Cys/Cys ) 的几何吝啬的 IELT 显著地更低(22.6 s;95% CI 18.3-27.8 s ) 比在男同型结合的异种(重量的单位 / 重量的单位)(40.4 s;95% CI 20.3-80.4 s )(P = 0.03 ) 。Cys23Ser 5-HT 2C 受体基因多型性与 LPE 在人与 IELT 被联系,这被结束。有 Cys/Cys 遗传型的人与重量的单位 / 重量的单位遗传型比人有更短的 IELT。 | Paddy KC Janssen Ron van Schaik Berend Olivier Marcel D Waldinger | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 4 | Social capital and growth in European regions: an empirical test显示文摘 | Sjoerd Beugelsdijk Ton van Schaik | 2004 | European Journal of Political Economy2004，，2： | 2 |
| 5 | The use of perfusion CT for the evaluation of therapy combining AZD2171 with gefitinib in cancer patients显示文摘 | Martijn R. Meijerink Hester Cruijsen Klaas Hoekman Matthijs Kater Cors Schaik Jan Hein T. M. Waesberghe Giuseppe Giaccone Radu A. Manoliu | 2007 | European Radiology2007，，7： | 2 |
| 6 | The Pseudomonas aeruginosa type Ⅳ pilin receptor binding domain functions as an adhesin for both biotic and abiotic surfaces显示文摘 | Gilmer CL van Schaik EJ Audette GF | 2006 | Mol Microbiol2006，59，4： | 1 |
| 7 | Risk fhctors for introduction of BHV1 into BHVl-free l)utch dairy farms: a case-control study显示文摘 | Schaik G V Schukken Y H Dijkhuizen A A l | 2001 | Vet Quart2001，23，： | 1 |
| 8 | Modeling User Experience with Web Sites: Usability, Hedonic Value, Beauty and Goodness显示文摘 | Paul van Schaik | 2008 | Interacting with Computers2008，，20： | 1 |
| 9 | Genetic polymorphisms of the CYP3A4,CYP3A5,and MDR21 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus显示文摘 | Hesselink DA van Schaik RH van der Heiden IP | 2003 | Clin Pharmacol Ther2003，74，3： | 1 |
| 10 | Out-of-hospital airway management by paramedics and emergency physicians using laryngeal tubes显示文摘 | Schaik R Byhahn C Fausel F | 2010 | Re suscitation2010，81，3： | 1 |
| 11 | CYP3A5 variant allele frequencies in Dutch Caucasians显示文摘 | Schaik R N Heiden I R Lindemans J | 2002 | Clin Chem2002，48，： | 1 |
| 12 | Diffusion of Salts in Clay-Water Systems 显示文摘 | KEMPER W J VAN SCHAIK | 1966 | Soil Science Society of America Journal1966，30，5： | 1 |
| 13 | The influence of font type and line length on visual search and information retrieval in Web pages 显示文摘 | LING J SCHAIK P V | 2006 | International Journal of Human-Computer Studies2006，64，5： | 1 |
| 14 | Parents as educators of sex and relationship education: the role for effective communication in british families 显示文摘 | TUMBULL TRIECE VAN WERSCH ANNA VAN SCHAIK PAUL | 2011 | Health Education Journal2011，70，3： | 1 |
| 15 | Familial cortical myoclonic tremor with epilepsy : a singlesyndromic classification for a group of pedigrees bearing commonfeatures显示文摘 | Van Rootselaar AF Van Schaik IN Van den Maagdenberg AM | 2005 | Mov Disord2005，20，6： | 1 |
| 16 | Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus显示文摘 | Hesselink DA van Schaik RH van der Heiden | 2003 | Clin Pharmacol Ther2003，74，3： | 1 |
| 17 | Conditions of discharge-free operation of XLPE insulated power cable systems显示文摘 | SCHAIK N V CZASZEJKO T | 2008 | IEEE Transactions on Dielectrics and Electrical Insulation2008，15，4： | 1 |
| 18 | The human transcriptome map:clustering of highly expressed genes in chromosomal domains显示文摘 | Schaik B Merlijn M | 2001 | Science2001，291，： | 1 |
| 19 | Inhibition of the muhidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats 显示文摘 | van Vliet EA van Schaik R Edelbroek PM | 2006 | Epilepsia2006，47，4： | 1 |
| 20 | Sequence of cDNA encoding human insulin-like growth factor I precursor显示文摘 | Jansen M van Schaik FMA Ricker AT | 1983 | Nature1983，306，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员