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| 1 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 2 | 汽车轻量化先进铸造技术显示文摘全面评述了用于汽车轻量化的铸造铝和镁合金及铸造工艺的发展。已开发的汽车用新型合金有耐磨铝合金、抗蠕变镁合金及高强度/韧性镁合金。在工艺前沿方面,开发了真空辅助压铸和高真空压铸技术,用于生产高整体性的车体和底盘零件。用低压金属型铸造工艺生产结构用薄壁空心铸件。包覆铸造技术不断得到发展,使用混合材料设计汽车的子系统,例如发动机支架、仪表板梁成为可能。开发的模拟工具用来预测不同组分之间的界面相互反应和包覆铸造系统的结构完整性,并且已被铸造实验证实。 | 罗爱华 Anil K. Sachdev Bob R. Powell 申泽骥(翻译) | 2011 | 铸造2011，60，2： | 25 |
| 3 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 4 | Current testing strategies for hepatitis C virus infection in blood donors and the way forward显示文摘Screening tests for blood donations are based upon sensitivity,cost-effectiveness and their suitability for high-throughput testing.Enzyme immunoassay(EIAs)for hepatitis C virus(HCV)antibodies were the initial screening tests introduced.The'first generation'antibody EIAs detected seroconversion after unduly long infectious window period.Improved HCV antibody assays still had an infectious window period around 66 d.HCV core antigen EIAs shortened the window period considerably,but high costs did not lead to widespread acceptance.A fourth-generation HCV antigen and antibody assay(combination EIA)is more convenient as two infectious markers of HCV are detected in the same assay.Molecular testing for HCV-RNA utilizing nucleic acid amplification technology(NAT)is the most sensitive assay and shortens the window period to only4 d.Implementation of NAT in many developed countries around the world has resulted in dramatic reductions in transfusion transmissible HCV and relative risk is now<1 per million donations.However,HCV serology still continues to be retained as some donations are serology positive but NAT negative.In resource constrained countries HCV screening is highly variable,depending upon infrastructure,trained manpower and financial resource.Rapid tests which do not require instrumentation and are simple to perform are used in many small and remotely located blood centres.The sensitivity as compared to EIAs is less and wherever feasible HCV antibody EIAs are most frequently used screening assays.Efforts have been made to implement combined antigen-antibody assays and even NAT in some of these countries. | Neelam Marwaha Suchet Sachdev | 2014 | World Journal of Gastroenterology2014，20，11： | 9 |
| 5 | Clinical development of reovirus for cancer therapy:An oncolytic virus with immune-mediated antitumor activity显示文摘 | Jun Gong Esha Sachdev Alain C Mita Monica M Mita | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 6 | 脑白质高信号与认知功能障碍:基于FLAIR高信号的定量研究显示文摘目的利用半自动化分析软件对脑白质疏松患者不同区域白质损伤进行定量,并对其与认知功能评分进行偏相关分析。方法 2011年1月-2017年1月在北京天坛医院进行健康体检的50~85岁社区'健康'人群63例,对其进行认知功能评价[简易精神状态量表(mini-mental state examination,MMSE)、蒙特利尔认知量表(Montreal cognitive assessment,Mo CA)]及影像学数据采集,基于液体衰减反转恢复序列定量计算全脑、侧脑室旁及深部皮层下脑白质受损体积,将认知功能评分与以上白质受损体积进行偏相关分析,探索白质受损在认知障碍发生发展过程中所起的作用。结果控制年龄、性别、文化程度后,全脑白质体积与MMSE评分、Mo CA评分有偏相关性(R’=-0.428,P=0.001)(R’=-0.539,P<0.001),尤其是侧脑室旁白质体积(R’=-0.427,P=0.001)(R’=-0.559,P<0.001),与深部皮层下白质也存在偏相关性(R’=-0.365,P=0.004)(R’=-0.447,P<0.001)。结论全脑、侧脑室旁、深部皮层下脑白质损伤体积增大,认知功能评分随之下降;MMSE评分、Mo CA评分与侧脑室旁白质损伤之间的相关性较深部皮层下白质损伤更大。 | 叶娜 Wei Wen 王金芳 石庆丽 李越秀 陈红燕 Perminder Sachdev 王拥军 张玉梅 | 2018 | 中国卒中杂志2018，13，8： | 5 |
| 7 | Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux显示文摘AIM: To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and af- ter 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symp- tom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbroncho- dilator forced expiratory volume in 1 second (FEV1) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS: Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9%), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antire- flux therapy compared to mean change in placebo group (P < 0.001). There was significant improvement in morn- ing PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEV1 (11.1% vs 3.78%) and FVC (9.3% vs 1.52%) in the antireflux therapy group compared to placebo on compar-ing the mean change from baseline after 16 wk (P < 0.01). | Bhavneesh Sharma Manisha Sharma Mradul Kumar Daga Gopal Krishan Sachdev Elliott Bondi | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 8 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 9 | Palliative surgical bypass for unresectable periampullary carcinoma显示文摘BACKGROUND:Around 60%to 80%of patients with periampullary carcinoma are unresectable either due to distant metastasis or local vascular invasion.With the advancement of endoscopic interventional procedures,the role of surgical bypass has diminished.However,surgical bypass is still appropriate in patients with unresectable disease discovered at the time of surgery.This study was conducted to assess the results of palliative surgical bypass for patients with unresectable periampullary carcinoma at our hospital,a tertiary referral center of Northern India. METHOD:The study group comprised 204 patients who had undergone surgical bypass for advanced periampullary carcinoma over the last 15 years. RESULTS:Between January 1990 and December 2004,204 patients(128 males,76 females)consisting of 179 patients with carcinoma of head of the pancreas,14 patients with ampullary carcinoma,8 patients with lower end cholangiocarcinoma and 3 patients with duodenal carcinoma underwent surgical bypass.Their average age was 51 years (range 20-78 years).Both biliary and gastric bypasses were done in 158(77.45%),biliary bypass alone in 37(18.13%) and gastric bypass alone in 9(4.32%).Biliary bypass was done by Roux-en-Y hepaticojejunostomy,and gastric bypass by retrocolic gastrojejunostomy.The overall postoperative mortality and morbidity were 0.98%and 26.9%,respectively The patients who died had undergone previously endoscopic intervention.Complications included wound infection in 12.25%of the patients,bile leak in 5.12%,delayed gastric emptying in 5.38%,ascitic leak from drains in 8.8%,and upper gastrointestinal bleeding in 1.96%.The incidences of wound infection and bile leak both were significantly higher in patients who had had preoperative biliary stenting None of the patients who had undergone Roux-en-Y hepati cojejunostomy+retrocolic gastrojejunostomy required any intervention later in their life.CONCLUSIONS:Surgical bypass is a safe procedure with negligible mortality and minimal morbidity.It has not lost its relevance and is an appropriate treatment in patients deemed unresectable on peroperative assessment. | Shivendra Singh Ajay Kumar Sachdev Adarsh Chaudhary Anil Kumar Agarwal | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 3 |
| 10 | Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease. | Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 11 | 钛铝中〈011]超位错的非对称形核及运动的分子动力学模拟显示文摘钛铝金属间化合物具有优异的高温性能,但室温脆性限制了其广泛应用.为探寻脆性的解决办法,需在原子尺度上理解其变形机理.作为位错与孪晶机制系统研究的一部分,本文采用分子动力学及静力学方法模拟了钛铝011]超位错的形核与运动.研究发现,与普通无序合金不同,有序的钛铝金属间化合物中沿正反[011]方向剪切时,超位错表现出非对称行为.分析表明,这种差异源自与面心立方结构相比钛铝的L10有序化使晶格对称性降低,导致沿相反方向剪切时呈现不同的屈服应力、应变、位错芯的分解及位错运动规律.沿[011]剪切变形时,晶体中4根偏位错在同一滑移面上相继形核,构成同心椭圆形超位错环.超位错芯由4根肖克莱偏位错及将其隔开的3种广义层错组成.超位错环扩张过程中其分解方式依赖于其在环上的部位(位错取向)及剪切方向.刃取向及附近的超位错呈4重分解,60°附近逐渐转变为3重分解,最后在30°附近变成2重分解.超位错开动可具有不同的临界剪切应力,与启动时的分解方式及剪切方向有关,当SISF领先时其临界应力较低. | 徐东生 王皞 杨锐 SACHDEV Anil K | 2013 | 科学通报2013，58，35： | 2 |
| 12 | Use of omental patch and endoscopic closure technique as an alternative to surgery after endoscopic full thickness resection of gastric intestinal stromal tumors: A series of cases显示文摘BACKGROUND Gastrointestinal stromal tumors(GISTs)originate from interstitial cells of Cajal.GISTs can occur anywhere along the gastrointestinal tract.Large lesions have traditionally been removed surgically.However,with recent innovations in advanced endoscopy,GISTs located within the stomach are now removed endoscopically.We describe a new innovative endoscopic technique to close large and hard to access defects after endoscopic full-thickness resection of gastric GISTs.CASE SUMMARY We present a series of three patients who were diagnosed with a gastric GIST.All patients underwent full-thickness endoscopic resection.In all cases,for closure of the surgical bed,conventional endoscopic techniques including hemoclips,endoloop and suturing were unsuccessful.We performed a new technique in which we pulled omental fat into the gastric lumen and completely closed the defect using endoscopic devices.All patients performed well post-procedure and computed tomography was carried out one day after the procedures which showed no extravasation of contrast.CONCLUSION The omental plug technique may be used as an alternative to surgery in selected cases of gastric perforation. | Amit H Sachdev Shahzad Iqbal Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura | 2020 | World Journal of Clinical Cases2020，8，1： | 2 |
| 13 | GC/MS-based differential metabolic profiling of human peptic ulcer disease to study Helicobacter pylori-induced metabolic perturbations显示文摘Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures. | GAGANJOT GUPTA DEEPAK BANSAL ANSHULA SHARMA TAWSEEF AHMAD ATUL SACHDEV AJAZ AHMAD HAMED A.EL-SEREHY BALJINDER KAUR | 2021 | BIOCELL2021，45，5： | 2 |
| 14 | 皮肤纤维瘤、细胞性纤维组织细胞瘤和隆凸性皮肤纤维肉瘤中CD163的表达与CD68、CD34及XⅢa因子表达的比较显示文摘Background: Distinction between cellular fibrous histiocytomas (FHs) with a deep component and dermatofibrosarcoma protuberans (DFSPs) can pose diagnostic problems. While cases of DFSPs. CD68, CD34, and Factor XIIIa are helpful in distinguishing between these entities, none are diagnostically absolute. Recent work with CD163, a hemoglobin scavenger receptor, has demonstrated that this marker has high specificity for monocytes, macrophages, and histiocytes. Our goal is to evaluate the utility of CD163 in the diagnosis of dermatofibromas (DFs), cellular FHs, and DFSPs. Methods: Sixty cases including 19 DFs, 23 cellular FHs with a deep component, and 18 DFSPs were tested with antibodies against CD163, CD68, CD34, and Factor XIIIa. Results: CD163 was expressed in 17/19 (89% )- DFs, 23/23 (100% ) cellular FHs, and 3/18 (17% )DFSPs. CD68 was positive in 8/19 (42% ) DFs, 19/23 (83% ) cellular FHs, and 1/16 (6% ) DFSPs. CD34 was expressed in 1/19 (5% ) DFs, 5/23 (22% ) cellular FHs, and 100% of DFSPs. Factor XIIIa labeled 4/19 (21% ) DFs, 11/23 (48% ) cellular FHs, and 0/17 cases of DFSPs. Conclusions: CD163 expression is helpful in distinguishing between cellular FHs and DFSPs and will be useful in a panel of antibodies when these entities are in the differential diagnosis. | Sachdev R. Sundram U. 吴佳纹 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，8： | 2 |
| 15 | Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system显示文摘Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceuticalpreparations such as controlled release formulations, parenteral preparations, surgicaltreatment applications, and tissue engineering. In this study, we prepared lipid-polymer hybrid nanoparticlesfor topical and site targeting delivery of Norfloxacin by emulsification solvent evaporationmethod (ESE). The design of experiment (DOE) was done by using software to optimize the result, andthen a surface plot was generated to compare with the practical results. The surface morphology, particlesize, zeta potential and composition of the lipid-polymer hybrid nanoparticles were characterized bySEM, TEM, AFM, and FTIR. The thermal behavior of the lipid-polymer hybrid nanoparticles was characterizedby DSC and TGA. The prepared lipid-polymer hybrid nanoparticles of Norfloxacin exhibited anaverage particle size from 178.6 ± 3.7 nm to 220.8 ± 2.3 nm, and showed very narrow distribution withpolydispersity index ranging from 0.206 ± 0.36 to 0.383 ± 0.66. The surface charge on the lipid-polymerhybrid nanoparticles were confirmed by zeta potential, showed the value from t23.4 ± 1.5 mVto t41.5 ± 3.4 mV. An Antimicrobial study was done against Staphylococcus aureus and Pseudomonasaeruginosa, and the lipid-polymer hybrid nanoparticles showed potential activity against these two.Lipid-polymer hybrid nanoparticles of Norfloxacin showed the %cumulative drug release of 89.72% in24 h. A stability study of the optimized formulation showed the suitable condition for the storage oflipid-polymer hybrid nanoparticles was at 4 ± 2 C/60 ± 5% RH. These results illustrated high potential oflipid-polymer hybrid nanoparticles Norfloxacin for usage as a topical antibiotic drug carriers. | Vivek Dave Renu Bala Yadav Kriti Kushwaha Sachdev Yadav Swapnil Sharma Udita Agrawal | 2017 | Bioactive Materials2017，2，4： | 2 |
| 16 | A computer-based substation switching scheme,WESCANEX 95显示文摘 | Dhakal P Sachdev M S | 1995 | Communications Power and Computing Conference Proceedings IEEE1995，1，1： | 1 |
| 17 | Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double blind controlled investigation 显示文摘 | Sachdev PS Loo CK Mitchell PB et at | 2007 | Psychol Med2007，37，11： | 1 |
| 18 | Zinc deficiency in pregnancy and fetal outcome 显示文摘 | SHAH D SACHDEV H P S | 2006 | Nutrition Reviews2006，64，1： | 1 |
| 19 | Activity-dependent plasticity in adult somatic sensory cortex显示文摘 | EBNER F F REMA V SACHDEV R SYMONS F J | 1997 | Seminars in Neuroscience1997，，9： | 1 |
| 20 | Theneuropsychological profile of vascular cognitive inlpairment in stroke and TIA patients显示文摘 | Sachdev PS Brodaty H Valenzuela M J | 2004 | Neurology2004，62，6： | 1 |
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