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| 1 | Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Mireen Friedrich–Rust Mei–Fang Ong Swantje Martens Christoph Sarrazin Joerg Bojunga Stefan Zeuzem Eva Herrmann | 2008 | Gastroenterology2008，，4： | 6 |
| 2 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 3 | Assessment of hemostatic profile in patients with mild to advanced liver cirrhosis显示文摘BACKGROUND Hemostasis of patients suffering from liver cirrhosis is challenging due to both,pro-and anticoagulatory disorders leading to hemostatic alterations with distinct abnormalities of coagulation.Pathological changes in conventional coagulation analysis and platelet count are common manifestations of decreased liver synthesis of coagulation factors and reduced platelet count in these patients.However,conventional coagulation analysis and platelet count do not reflect invivo coagulation status or platelet function.The purpose of this present observational study was therefore to assess the haemostatic profile including plasmatic coagulation using thrombelastometry and impedance aggregometry for platelet function in patients suffering from liver cirrhosis.AIM To assess the hemostatic profile of cirrhotic patients according to model for endstage liver disease(MELD)score.METHODS Our study included both in-and outpatients suffering from liver cirrhosis attending the out-and inpatient care of the department of hepatology.Demographic and biochemical data as well as medical history including cause of liver cirrhosis,end stage kidney failure and medication with anticoagulants were recorded.To assess the hemostatic profile,platelet function was analyzed by multiple electrode aggregometry(MEA)using Multiplate^■(ADP-,ASPI-and TRAP-test)and thrombelastometry using ROTEM^■(EXTEM,INTEM,FIBTEM).Data were compared using Mann-Whitney U-or χ^2-test.Spearman correlation was performed to analyze the association between MELD Score and results of thrombelastometry and MEA.RESULTS A total of 68 patients attending the out-and inpatient care suffering from liver cirrhosis were screened.Of these,50 patients were included and assigned to groups according to MELD score 6 to 11(n=25)or≥17(n=25).Baseline patient characteristics revealed significant differences for MELD score(8 vs 22,P<0.0001)and underlying laboratory parameters(international normalized ratio,bilirubine,creatinine)as well as fibrinogen level(275 mg/dL vs 209 mg/dL,P=0.006)and aPTT(30 s vs 35 s,P=0.047).MEA showed a moderately impaired platelet function(medians:AUCADP=43U,AUCASPI=71U,AUCTRAP=92U)but no significant differences between both groups.Thrombelastometry using ROTEM?(EXTEM,INTEM,FIBTEM)revealed values within normal range in both groups.No significant correlation was observed between MELD score and results of MEA/thrombelastometry.CONCLUSION Our data demonstrate a partially impaired hemostatic profile in liver cirrhosis patients unrelated to MELD score.An individual assessment of a potential coagulopathy should therefore be considered. | Elisabeth Hannah Adam Madara Mohlmann Eva Herrmann Sonia Schneider Kai Zacharowski Stefan Zeuzem Christian Friedrich Weber Nina Weiler | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 4 | Contrast‐Enhanced Ultrasound for the differentiation of benign and malignant focal liver lesions: a meta‐analysis显示文摘 | Mireen Friedrich‐Rust Tom Klopffleisch Julia Nierhoff Eva Herrmann Johannes Vermehren Maximilian D. Schneider Stefan Zeuzem Joerg Bojunga | 2013 | Liver Int2013，，5： | 3 |
| 5 | Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function显示文摘 | Olaf Eickmeier Marisa Huebner Eva Herrmann Ulrich Zissler Martin Rosewich Patrick C. Baer Roland Buhl Sabina Schmitt-Grohé Stefan Zielen Ralf Schubert | 2010 | Cytokine2010，，2： | 1 |
| 6 | Neurons Undergo Apoptosis in Animal and Cell Culture Models of Diabetes显示文摘 | James W. Russell Kelli A. Sullivan Anthony J. Windebank David N. Herrmann Eva L. Feldman | 1999 | Neurobiology of Disease1999，，5： | 1 |
| 7 | Acoustic Radiation Force Impulse-Imaging for the evaluation of the thyroid gland: A limited patient feasibility study显示文摘 | Mireen Friedrich-Rust Olga Romenski Gesine Meyer Nina Dauth Katharina Holzer Frank Grünwald Susanne Kriener Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2011 | Ultrasonics2011，，1： | 1 |
| 8 | Prediction of treatment outcome in patients with chronic hepatitis C: Significance of baseline parameters and viral dynamics during therapy显示文摘 | Thomas Berg Christoph Sarrazin Eva Herrmann Holger Hinrichsen Tilman Gerlach Reinhart Zachoval Bertram Wiedenmann Uwe Hopf Stefan Zeuzem | 2003 | Hepatology2003，，3： | 1 |
| 9 | Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit显示文摘 | Hind Medyouf Maximilian Mossner Johann-Christoph Jann Florian Nolte Simon Raffel Carl Herrmann Amelie Lier Christian Eisen Verena Nowak Bettina Zens Katja Müdder Corinna Klein Julia Obl?nder Stephanie Fey Jovita Vogler Alice Fabarius Eva Riedl Henning Roe | 2014 | Cell Stem Cell2014，，6： | 1 |
| 10 | Transient elastography with a new probe for obese patients for non-invasive staging of non-alcoholic steatohepatitis显示文摘 | Mireen Friedrich-Rust Hassan Hadji-Hosseini Susanne Kriener Eva Herrmann Ishani Sircar Annika Kau Stefan Zeuzem Joerg Bojunga | 2010 | European Radiology2010，，10： | 1 |
| 11 | An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gβ3 C825T polymorphism显示文摘 | Eva Brand Ji-Guang Wang Stefan-Martin Herrmann Jan A Staessen | 2003 | Journal of Hypertension2003，，4： | 1 |
| 12 | Acoustic radiation force impulse-imaging and transient elastography for non-invasive assessment of liver fibrosis and steatosis in NAFLD显示文摘 | Mireen Friedrich-Rust Daniela Romen Johannes Vermehren Susanne Kriener Dilek Sadet Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2011 | European Journal of Radiology2011，，3： | 1 |
| 13 | Acoustic radiation force impulse-imaging and transient elastography for non-invasive assessment of liver fibrosis and steatosis in NAFLD显示文摘 | Mireen Friedrich-Rust Daniela Romen Johannes Vermehren Susanne Kriener Dilek Sadet Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2011 | European Journal of Radiology2011，，3： | 1 |
| 14 | Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio显示文摘 | Stefan-Martin Herrmann Ji-Guang Wang Jan A. Staessen Ercan Kertmen Klaus Schmidt-Petersen Walter Zidek Martin Paul Eva Brand | 2003 | Journal of Molecular Medicine2003，，5： | 1 |
| 15 | Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Mireen Friedrich–Rust Mei–Fang Ong Swantje Martens Christoph Sarrazin Joerg Bojunga Stefan Zeuzem Eva Herrmann | 2008 | Gastroenterology2008，，4： | 1 |
| 16 | Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy显示文摘 | Christian Markus Lange J?rg Bojunga Elizabeth Ramos-Lopez Michael von Wagner Angela Hassler Johannes Vermehren Eva Herrmann Klaus Badenhoop Stefan Zeuzem Christoph Sarrazin | 2010 | Journal of Hepatology2010，，5： | 1 |
| 17 | Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon显示文摘 | Eva Herrmann Jung-Hun Lee George Marinos Marlene Modi Stefan Zeuzem | 2003 | Hepatology2003，，6： | 1 |
| 18 | Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture显示文摘AIM To investigate presence and extent of eosinophilic cholangitis(EC) as well as Ig G4-related disease in patients with indeterminate biliary stricture(IBS).METHODS All patients with diagnosis of sclerosing cholangitis(SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regardingpresence of eosinophilic infiltration and Ig G4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing cholangitis.RESULTS One hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30%(3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of Ig G4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with Ig G4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to Ig G4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n=27) and patients with primary sclerosing cholangitis(n = 14).CONCLUSION EC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS. | Dirk Walter Sylvia Hartmann Eva Herrmann Jan Peveling-Oberhag Wolf O Bechstein Stefan Zeuzem Martin-Leo Hansmann Mireen Friedrich-Rust Jorg G Albert | 2017 | World Journal of Gastroenterology2017，23，6： | 1 |
| 19 | Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Mireen Friedrich–Rust Mei–Fang Ong Swantje Martens Christoph Sarrazin Joerg Bojunga Stefan Zeuzem Eva Herrmann | 2008 | Gastroenterology2008，，4： | 1 |
| 20 | Macrophage activation is a prognostic parameter for variceal bleeding and overall survival in patients with liver cirrhosis显示文摘 | Oliver Waidmann Friederike Brunner Eva Herrmann Stefan Zeuzem Albrecht Piiper Bernd Kronenberger | 2013 | Journal of Hepatology2013，，5： | 1 |
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