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| 1 | Anterior knee pain following primary total knee arthroplasty显示文摘Despite improvements in technique and technology for total knee arthroplasty(TKA),anterior knee pain impacts patient outcomes and satisfaction.Addressing the prosthetic and surgical technique related causes of pain after TKA,specifically as it relates to anterior knee pain,can aid surgeons in addressing these issues with their patients.Design features of the femoral and patellar components which have been reported as pain generators include: Improper femoral as well as patellar component sizing or designs that result in patellofemoral stuffing; a shortened trochlear groove distance from the flange to the intercondylar box; and then surgical technique related issues resulting in: Lateral patellar facet syndrome; overstuffed patella/flange combination; asymmetric patellar resurfacing,improper transverse plane component rotation resulting in patellar subluxation/tilt.Any design consideration that allows impingement of extensor mechanism anatomical elements has the possibility of impacting outcome by becoming a pain generator.As the number of TKA procedures continues to increase,it is increasingly critical to develop improved,evidence based prostheses that maximize function and patient satisfaction while minimizing pain and other complications. | David Shervin Katelyn Pratt Travis Healey Samantha Nguyen William M Mihalko Mouhanad M El-Othmani Khaled J Saleh | 2015 | World Journal of Orthopedics2015，6，10： | 15 |
| 2 | World Review of Laparoscopic Liver Resection—2,804 Patients显示文摘 | Kevin Tri Nguyen T Clark Gamblin David A. Geller | 2009 | Annals of Surgery2009，，5： | 8 |
| 3 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 4 | Advances in adjuvant systemic therapy for non-small-cell lung cancer显示文摘Non-small-cell lung cancer remains a leading cause of death around the world. For most cases, the only chance of cure comes from resection for localised disease, however relapse rates remain high following surgery. Data has emerged over recent years regarding the utility of adjuvant chemotherapy for improving disease-free and overall survival of patients following curative resection. This paper reviews the clinical trials that have been conducted in this area along with the studies integrating radiation therapy in the adjuvant setting. The role of prognostic gene signatures are reviewed as well as ongoing clinical trials including those incorporating biological or targeted therapies. | David Leong Rajat Rai Brandon Nguyen Andrew Lee Desmond Yip | 2014 | World Journal of Clinical Oncology2014，5，4： | 7 |
| 5 | Studies on sustainable features of vernacular architecture in different regions across the world:A comprehensive synthesis and evaluation显示文摘Due to the increasing pressure brought by recent global environmental problems,building designers are embracing regionalism and the knowledge of traditional structures,arguing that these structures are energy efficient and highly sustainable.We observe clear evidence of the increasing interest in vernacular architecture among the research community.This study therefore aims to clarify the contents and issues raised in the studies on vernacular architecture and the knowledge and recommendations that can be derived from them.A database of the research is established by collecting many studies from primary sources.Obtained data is carefully refined and categorized into a table where synthesized information is introduced.The results of this study show an uneven geographic and climatic distribution of the studies;the trend in selecting research objectives and research objects;the choice of research methods with a clear shift towards quantitative research methods,and the generic findings from the database of the research.These results can support diverse inquiries about vernacular architecture across the world and be used as a resource or an orientation to support numerous subsequent studies. | Anh Tuan Nguyen Nguyen Song Ha Truong David Rockwood Anh Dung Tran Le | 2019 | Frontiers of Architectural Research2019，8，4： | 6 |
| 6 | 水飞蓟素的肝脏保护作用研究(英文)显示文摘目的:研究水飞蓟素对人正常肝细胞(Chang细胞株)的保护作用,尤其是其抗氧化活性和对细胞抗凋亡的保护作用。方法:采用400μmol/L H2O2处理Chang细胞20 min后,通过二氯荧光黄(dichlorofluorescein,DCF)荧光强度检测细胞内自由基水平,并检测了细胞活性及细胞内Bax表达水平和ATP水平。结果:水飞蓟素明显降低了DCF荧光信号,显示细胞内自由基生成减少。MTT实验结果显示水飞蓟素可增强细胞活性,增加细胞内ATP水平,而减少促凋亡蛋白Bax的转录和表达水平。结论:水飞蓟素可抑制Bas表达,具有保护细胞抗氧化应激所致自由基损伤的作用。水飞蓟素可作为治疗特异性肝脏疾病的有效辅助药物。 | Frank J.Burczynski 汪谷奇 David Nguyen 陈宇非 Howard J.Smith 巩跃文 | 2012 | 中南大学学报(医学版)2012，37，1： | 4 |
| 7 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 8 | One-Year Outcomes of the DA VINCI Study of VEGF Trap-Eye in Eyes with Diabetic Macular Edema显示文摘 | Diana V. Do Quan Dong Nguyen David Boyer Ursula Schmidt-Erfurth David M. Brown Robert Vitti Alyson J. Berliner Bo Gao Oliver Zeitz Rene Ruckert Thomas Schmelter Rupert Sandbrink Jeff S. Heier | 2012 | Ophthalmology2012，，8： | 4 |
| 9 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 10 | Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Ting-Hui Hsieh Kristin L. Mekeel Michael D. Crowell Cuong C. Nguyen Ananya Das Bashar A. Aqel Elizabeth J. Carey Thomas J. Byrne Hugo E. Vargas David D. Douglas David C. Mulligan M. Edwyn Harrison | 2013 | Gastrointestinal Endoscopy2013，，1： | 3 |
| 11 | α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma显示文摘 | Jorge A. Marrero Ziding Feng Yinghui Wang Mindie H. Nguyen Alex S. Befeler Lewis R. Roberts K. Rajender Reddy Denise Harnois Josep M. Llovet Daniel Normolle Jackie Dalhgren David Chia Anna S. Lok Paul D. Wagner Sudhir Srivastava Myron Schwartz | 2009 | Gastroenterology2009，，1： | 3 |
| 12 | 天然裂缝性储层的特征显示文摘天然裂缝性储层给开采带来了一个矛盾难题。这类储层包括低油气采收率储层,这些储层最初可能表现出高产,但产能下降得非常快。此外,这类储层还经常出现早期见气或见水等问题。而另一方面,一些天然裂缝性储层也是全球最大、产量最高的储层。这类储层的这种矛盾特性激发业界尽力去深入了解其特征,以便更有把握地对其进行模拟分析。 | Tom Bratton DaoViet Canh Nguyen Van Que Nguyen V.Duc VietSovPetro Paul Gillespie David Hunt Hydro BingjianLi Richard Marcinew Satyaki Ray Bernard Montaron Ron Nelson David Schoderbek Lars Sonneland | 2008 | 国外测井技术2008，23，1： | 2 |
| 13 | Two-Year Outcomes of the Ranibizumab for Edema of the mAcula in Diabetes (READ-2) Study显示文摘 | Quan Dong Nguyen Syed Mahmood Shah Afsheen A. Khwaja Roomasa Channa Elham Hatef Diana V. Do David Boyer Jeffery S. Heier Prema Abraham Allen B. Thach Eugene S. Lit Bradley S. Foster Erik Kruger Pravin Dugel Thomas Chang Arup Das Thomas A. Ciulla John S. P | 2010 | Ophthalmology2010，，11： | 2 |
| 14 | Primary End Point (Six Months) Results of the R anibizumab for E dema of the m A cula in D iabetes (READ-2) Study显示文摘 | Quan Dong Nguyen Syed Mahmood Shah Jeffery S. Heier Diana V. Do Jennifer Lim David Boyer Prema Abraham Peter A. Campochiaro | 2009 | Ophthalmology2009，，11： | 2 |
| 15 | Endoscopic treatment of anastomotic biliary strictures after deceased donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Shabana F. Pasha M. Edwyn Harrison Ananya Das Cuong C. Nguyen Hugo E. Vargas Vijayan Balan Thomas J. Byrne David D. Douglas David C. Mulligan | 2007 | Gastrointestinal Endoscopy2007，，1： | 2 |
| 16 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 17 | Aryl Hydrocarbon Receptor Regulates Pancreatic IL-22 Production and Protects Mice From Acute Pancreatitis显示文摘 | Jing Xue David T.C. Nguyen Aida Habtezion | 2012 | Gastroenterology2012，，6： | 2 |
| 18 | EBUS-TBNA在肺部疾病(包括肺癌分期)中的作用综述显示文摘本综述重点阐述EBUS-TBNA在日常肺部疾病诊疗中的作用。所列举的病例为EBUS-TBNA的常见适应征,包括:①肺癌分期;②确诊胸部恶性淋巴结;③诊断中央型肺部肿块;④诊断肺结节病;⑤诊断炎性/良性胸部淋巴结。这项技术应用广泛,有经验的支气管镜医师经过适当的训练后,该技术将成为支气管镜检查的一部分。 | David FIELDING Farzad BASHIRZADEH Phan NGUYEN Alan HODGSON Daniel JAMES 吴齐 吴楠 | 2010 | 中国肺癌杂志2010，，5： | 2 |
| 19 | Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically显示文摘 | Tracy L. Putoczki Stefan Thiem Andrea Loving Rita A. Busuttil Nicholas J. Wilson Paul K. Ziegler Paul Nguyen Adele Preaudet Ryan Farid Kirsten Edwards Yeliz Boglev Rodney B. Luwor Andrew Jarnicki David Horst Alex Boussioutas Joan K. Heath Oliver M. Sieber | 2013 | Cancer Cell2013，，： | 2 |
| 20 | HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma显示文摘 | Anne Nguyen Kovochich Michael Arensman Anna R. Lay Nagesh P. Rao Timothy Donahue Xinmin Li Samuel W. French David W. Dawson | 2012 | Cancer2012，，3： | 2 |
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