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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | 美国湿地保护制度变迁研究显示文摘本文提出了分析湿地保护制度变迁的理论框架,使不同国家的湿地保护制度研究能在统一语境下比较。首先基于科学计量学和系统研究方法筛选出公众、科学、政府和法律为影响湿地保护制度变迁的四个关键要素,并依赖博弈论工具建立了分析美国湿地保护制度的理论架构。基于这一架构,本文对包括关键利益相关者、政策执行路径、政策工具和管理挑战等内容的美国湿地政策史进行了讨论。对美国湿地保护制度的演化进行了四阶断之划分:'西进运动'与全民开垦(1900年之前)、'水鸟保护'与公众参与(1900-1970年)、核心法律与科学研究(1971-1980年)和完善制度与新的挑战(1980年至今)。分析得出如下结论:在湿地保护制度中,公众是源头、科学是前提、有效的政府管治和将湿地保护的规则和与政策制度化是关键。通过借鉴美国湿地保护制度变迁研究,本文构建了湿地保护制度变迁的'竹节模式'经验性模型,揭示了各动因之间的作用机理。虽然美国湿地保护制度也面临着公众教育、科学定义和政府管辖权等挑战,但中国的湿地管理者与政策制定者仍可从美国湿地政策执行的历史背景中吸取经验。同时本文的理论分析结构也可为自然资源及管理策略的研究提供参考。 | 陈溪 Magdeline Laba Robertson Morgan Barbara Cosens 王子彦 陈雪 James Anderson Marinus Otte Christopher Craft David Feldman 李杨帆 刘晶岚 Patrick Sullivan 吕宪国 | 2016 | 资源科学2016，38，4： | 13 |
| 3 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 4 | 腰椎骨盆固定和三角固定术在不稳定型骶骨骨折治疗中的应用显示文摘骶骨是构成骨盆后环的蕈要结构和脊柱重力线分佑到两侧髋臼的枢纽部位,垂直不稳定型骶骨骨折多由高能量损伤引起,常合并神经损伤和多发性创伤而引起骨盆环不稳定,特殊类型的骶骨骨折可引起脊柱一骨盆的不稳定。近年来,随着研究的深入,多种内固定方法用于垂直不稳定型骶骨骨折的治疗,包括横向固定装置,如骶髂螺钉、骶骨棒、 | 易成腊 Steven Morgan David J Hak | 2011 | 中华创伤骨科杂志2011，13，4： | 8 |
| 5 | Short and long term outcomes of 200 patients supported by continuous-flow left ventricular assist devices显示文摘AIM: To study the institutional experience over 8 years with 200 continuous-flow(CF)- left ventricular assist devices(LVAD).METHODS: We evaluated our institution's LVAD database and analyzed all patients who received a CF LVAD as a bridge to transplant(BTT) or destination therapy from March 2006 until June 2014. We identified 200 patients, of which 179 were implanted with a Heart Mate II device(Thoratec Corp., Pleasanton, CA) and 21 received a Heartware HVAD(Heart Ware Inc., Framingham, MA).RESULTS: The mean age of our LVAD recipients was 59.3 years(range 17-81), 76%(152/200) were males, and 49% were implanted for the indication of BTT. The survival rate for our LVAD patients at 30 d, 6 mo, 12 mo, 2 years, 3 years, and 4 years was 94%, 86%, 78%, 71%, 62% and 45% respectively. The mean duration of LVAD support was 581 d(range 2-2595 d). Gastrointestinal bleeding(was the most common adverse event(43/200, 21%), followed by right ventricular failure(38/200, 19%), stroke(31/200, 15%), re exploration for bleeding(31/200, 15%),ventilator dependent respiratory failure(19/200, 9%) and pneumonia(15/200, 7%). Our driveline infection rate was 7%. Pump thrombosis occurred in 6% of patients. Device exchanged was needed in 6% of patients. On multivariate analysis, preoperative liver dysfunction, ventilator dependent respiratory failure, tracheostomy and right ventricular failure requiring right ventricular assist device support were significant predictors of post LVAD survival.CONCLUSION: Short and long term survival for patients on LVAD support are excellent, although outcomes still remain inferior compared to heart transplantation. The incidence of driveline infections, pump thrombosis and pump exchange have declined significantly in recent years. | Athanasios Tsiouris Gaetano Paone Hassan W Nemeh Jamil Borgi Celeste T Williams David E Lanfear Jeffrey A Morgan | 2015 | World Journal of Cardiology2015，7，11： | 5 |
| 6 | Gene therapy and erectile dysfunction: the current status显示文摘为可勃起的机能障碍(编辑) 的当前的可得到的处理选择是有效的然而并非没有失败或副作用。尽管 phosphodiesterasetype 的发展 5 (PDE5 ) 禁止者(即 sildenafil, tadalafil 和 vardenafil ) 革命化了编辑的治疗,这些口头的药要求按需的存取并且不作为与糖尿病、前列腺切除术以后、严重的 veno 闭塞的疾病状态有关的有效 intreating 编辑。在编辑的治疗的改进依赖于理解人的肉体的光滑的肌肉音调并且在相关分子的目标的鉴定上的规定。未来编辑治疗可能考虑象基因治疗那样的分子的技术的申请。作为一个潜在的治疗学的工具,没有影响休息阴茎功能,基因治疗可能“在需求上”为 alteringintracavernous 压力提供一个有效、特定的工具。然而,基因治疗的安全仍然是一个主要障碍在作为一个主流的处理被接受让编辑基因治疗目的在编辑治好内在的条件前克服,包括纤维变性。而且,基因治疗可能帮助由改进阴茎氮的 oxidebioactivity 延长 PDE5 禁止者的功效。因为它的地点和可接近性,处于松驰的状态的低阴茎循环流动和 endotheliallined (花格平顶) 的存在空格,把基因治疗用于阴茎是可行的。这评论在编辑的管理提供基因治疗的当前的角色的简短卓见。 | David H. W. Lau Sashi S. Kommu Emad J. Siddiqui Cecil S. Thompson Robert J. Morgan Dimitri P. Mikhailidis Faiz H. Mumtaz | 2007 | Asian Journal of Andrology2007，9，1： | 2 |
| 7 | Gastrointestinal bleeding with the HeartMate II left ventricular assist device显示文摘 | Jeffrey A. Morgan Gaetano Paone Hassan W. Nemeh Scott E. Henry Rosan Patel Jessica Vavra Celeste T. Williams David E. Lanfear Cristina Tita Robert J. Brewer | 2012 | Journal of Heart and Lung Transplantation2012，，7： | 2 |
| 8 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 9 | Cavernous hemangioma arising from the gastro-splenic ligament: A case report显示文摘We present a rare case of a 45-year-old woman who presented with epigastric pain associated with early satiety and weight loss. Imaging revealed a large intraabdominal mass in the epigastrium. Despite intensive investigations, including ultrasound scanning, computed tomography, upper gastrointestinal endoscopy, and percutaneous biopsy, a diagnosis could not be obtained. A histological diagnosis of cavernous hemangioma arising from the gastro-splenic ligament was confirmed after laparoscopic excision and histological examination of the intra-abdominal epigastric mass. | Kin-Fah Chin Ghaith Khair Palani Sathish Babu David Russell Morgan | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 10 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 11 | Endoscopic Retrograde Cholangiopancreatography Gut Perforations: When to Wait! When to Operate!显示文摘 | Morgan Katherine A Fontenot Bennett B Ruddy Jean M Mickey Suzanne Adams David B | 2009 | The American Surgeon2009，，6： | 2 |
| 12 | Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy显示文摘 | Juan M. Herrerias Jonathan A. Leighton Guido Costamagna Anthony Infantolino Rami Eliakim Doron Fischer David T. Rubin Howard D. Manten Eitan Scapa Douglas R. Morgan Ari J. Bergwerk Binyamin Koslowsky Samuel N. Adler | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 13 | Will MOOCs Transform Learning and Teaching in Higher Education?Engagement and Course Retention in On- line Learning provision 显示文摘 | Sara Isabella de Freitas John Morgan David Gibson | 2015 | British Journal of Educational Technology2015，，46： | 1 |
| 14 | Behavior and effects of phosphorus in the system Na2O?K2O?Al2O3?SiO2?P2O5?H2O at 200 MPa(H2O)显示文摘 | David London George B. Morgan Harold A. Babb Jennifer L. Loomis | 1993 | Contributions to Mineralogy and Petrology1993，，4： | 1 |
| 15 | How (Un)Useful is the Pelvic Ring Stability Examination in Diagnosing Mechanically Unstable Pelvic Fractures in Blunt Trauma Patients?显示文摘 | Gil Z. Shlamovitz William R. Mower Jonathan Bergman Kenneth R. Chuang Jonathan Crisp David Hardy Martine Sargent Sunil D. Shroff Eric Snyder Marshall T. Morgan | 2009 | The Journal of Trauma: Injury, Infection, and Critical Care2009，，3： | 1 |
| 16 | Business Industry associations as facilitators of social capital:The establishment and early operations of the Melbourne Woolbrokers Association显示文摘 | David Merrett Stephen Morgan Simon Ville | | 0，，06： | 1 |
| 17 | Laserinduced incandescence study of diesel soot formation in a rapid compression machine at elevated pressures 显示文摘 | Crua Cyril Kennaird David A Heikal Morgan R | 2003 | Combustion and Flame2003，135，4： | 1 |
| 18 | Fibrosis progression in chronic hepatitis C: Morphometric image analysis in the HALT‐C trial显示文摘 | Zachary D. Goodman Anne M. Stoddard Herbert L. Bonkovsky Robert J. Fontana Marc G. Ghany Timothy R. Morgan Elizabeth C. Wright Elizabeth M. Brunt David E. Kleiner Mitchell L. Shiffman Gregory T. Everson Karen L. Lindsay Jules L. Dienstag Chihiro Morishima | 2009 | Hepatology2009，，6： | 1 |
| 19 | Transhepatic insertion of a metallic stent for the relief of malignant afferent loop obstruction显示文摘 | David G. E. Caldicott Paul Ziprin Robert Morgan | 2000 | Cardiovascular and Interventional Radiology2000，，2： | 1 |
| 20 | Laser-induced incandescence study of diesel soot formation in a rapid compression machine at elevated pressures 显示文摘 | Crua Cyril Kennaird David A Heikal Morgan R | 2003 | Combustion and Flame2003，135，4： | 1 |
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