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| 1 | Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases显示文摘Dear Editor, Sequence-specific nucleases,including zinc-finger nucleases,meganucleases,TAL effector nucleases (TALENs),and CRISPR/ Cas systems,have been used to introduce targeted mutations in a wide range of plant species (Voytas,2013;Baltes and Voytas,2015).However,delivery of these nucleases using traditional transformation methods (e.g.,particle bombardment,Agrobacterium or protoplast transformation) may result in undesired genetic alterations due to random insertion of nucleaseencoding DNA intothe host genome. | Song Luo Jin Li Thomas J. Stoddard Nicholas J. Baltes Zachary L. Demorest Benjamin M. Clasen Andrew Coffman Adam Retterath Luc Mathis Daniel F. Voytas Feng Zhang | 2015 | Molecular Plant2015，8，9： | 7 |
| 2 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Mimicry and masquerade from the avian visual perspec-tive显示文摘 | Mary Caswell STODDARD | 2012 | Current Zoology2012，58，4： | 2 |
| 5 | Regional scale evidence for improvements in surface water chemistry 1990-- 2001显示文摘 | Skjelkvale B L Stoddard J L Jeffries D S | 2005 | Environmental Pollu- tion2005，137，： | 1 |
| 6 | Interaction of heat- moisture conditions and physical properties in oat processing: II Flake quality显示文摘 | Gates F K Sontag Strohm T Stoddard F L | 2008 | Journal of Cereal Science2008，，48： | 1 |
| 7 | Cu+- and Cu2x-sensitive PEBBLE fluorescent nanosensors u- sing DsRed as the recognition element 显示文摘 | Sumner J P Westerberg N M Stoddard A K | 2006 | Sens Actuators B2006，113，： | 1 |
| 8 | Inter-organizational Business Process Redesign:Merging Technological and Process Innovation显示文摘 | Clark Theodore H Stoddard Donna B | 1996 | Journal of Management Information Systems1996，13，2： | 1 |
| 9 | Controversies in family planning:timingof ovulation after abortion and the conundrum of postabortionintrauterine device insertion显示文摘 | Stoddard A Eisenberg DL | 2011 | Contraception2011，84，2： | 1 |
| 10 | Recommendations for quantification of Doppler echocardiogTaphy a report from the Doppler quantification task force of the nomenclature and standards committee of the American Society of Echocardiography 显示文摘 | QUinones MA Otto CM Stoddard M | 2010 | J Am SocEchocar- diogr2010，15，2： | 1 |
| 11 | EMAP-surface water:a multi-assemblage probability survey of ecological integrity in the USA显示文摘 | Hughes R M Paulsen S G Stoddard J L | 2000 | Hydrobiologia2000，422，4： | 1 |
| 12 | Follow up exercise studies in paediatric obesity: implications for long term effectiveness 显示文摘 | Maziekas MT LeMura LM Stoddard NM | 2003 | Br J Sports Med2003，37，5： | 1 |
| 13 | Preconditioning of human myocardium with adenosine during coronary angioplasty显示文摘 | Leesar MA Stoddard M Ahmed M | 1997 | Circulation1997，95，： | 1 |
| 14 | An experiment in verbal learning显示文摘 | Stoddard G.D | | 0，，20： | 1 |
| 15 | The osteoporosis self-assessment screening tool:A useful tool for the orthopaedic surgeon显示文摘 | Skedros JG Sybrowsky CL Stoddard GJ | 2007 | JBJS2007，4，89： | 1 |
| 16 | A permanent-mag- net tubular linear generator for ocean wave energy conversion显示文摘 | PRUDELL J STODDARD M AMON E | 2010 | IEEE Transactions on Industry Applications2010，46，11： | 1 |
| 17 | Ansa-RLN reinnervation for uni- lateral vocal fold paralysis in adolescents and young adults显示文摘 | Smith ME Roy N Stoddard K | 2008 | Int J Pediatr Otorhinolaryngol2008，72，9： | 1 |
| 18 | Risk factors for adverse drug events: a 10-year anaIysis显示文摘 | Evans RS Lloyd JF Stoddard GJ | 2005 | Ann Pharmacother2005，89，78： | 1 |
| 19 | Inter-evaluator reliability of the ALS functional rating scale 显示文摘 | Miano B Stoddard GJ Davis S | 2004 | Amyotroph Lateral Scler Other Motor Neuron Disord2004，5，： | 1 |
| 20 | Effect of varying protein content and glutenin-to-gliadin ration the functional properties of wheat dough显示文摘 | Uthayakumaran S Gras P W Stoddard F L | 1999 | Cereal Chemistpy1999，76，3： | 1 |
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