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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Potential of microRNAs for cancer diagnostics, prognostication and therapy显示文摘 | Ramiro Garzon Guido Marcucci | 2012 | Current Opinion in Oncology2012，，6： | 1 |
| 3 | Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia显示文摘 | Parvathi Ranganathan Xueyan Yu Caroline Na Ramasamy Santhanam Sharon Shacham Michael Kauffman Alison Walker Rebecca Klisovic William Blum Michael Caligiuri Carlo M. Croce Guido Marcucci Ramiro Garzon | 2012 | Blood2012，，9： | 1 |
| 4 | Irinotecan in combination with thalidomide in patients with advanced solid tumors: a clinical study with pharmacodynamic and pharmacokinetic evaluation显示文摘 | Giacomo Allegrini Antonello Paolo Elisa Cerri Samanta Cupini Federica Amatori Gianluca Masi Romano Danesi Lorenzo Marcucci Guido Bocci Mario Tacca Alfredo Falcone | 2006 | Cancer Chemotherapy and Pharmacology2006，，5： | 1 |
| 5 | Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia显示文摘 | Krzysztof Mrózek Guido Marcucci Peter Paschka Clara D Bloomfield | 2008 | Current Opinion in Oncology2008，，6： | 1 |
| 6 | Phase I study of oblimersen sodium, an antisense to Bcl- 2, in untreated older patients with acute myeloid leukemia; pharmacokinetics, pharmacodynamics, and clinical activity显示文摘 | Guido Marcucci Wendy Stock Guowei Dai | 2005 | J Clin oncol2005，23，15： | 1 |
| 7 | Addition of Infliximab to Standard Acute Graft-versus-Host Disease Prophylaxis following Allogeneic Peripheral Blood Cell Transplantation显示文摘 | Mehdi Hamadani Craig C. Hofmeister Buffy Jansak Gary Phillips Patrick Elder William Blum Sam Penza Thomas S. Lin Rebecca Klisovic Guido Marcucci Sherif S. Farag Steven M. Devine | 2008 | Biology of Blood and Marrow Transplantation2008，，7： | 1 |
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