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| 1 | Cell Wall Lignin is Polymerised by Class Ⅲ Secretable Plant Peroxidases in Norway Spruce显示文摘Class Ⅲ secretable plant peroxidases occur as a large family of genes in plants with many functions and probable redundancy. In this review we are concentrating on the evidence we have on the catalysis of lignin polymerization by class Ⅲ plant peroxidases present in the apoplastic space in the xylem of trees. Some evidence exists on the specificity of peroxidase isozymes in lignin polymerization through substrate specificity studies, from antisense mutants in tobacco and poplar and from tissue and cell culture lines of Norway spruce (Picea abies) and Zinnia elegans. In addition, real time (RT-)PCR results have pointed out that many peroxidases have tissue specific expression patterns in Norway spruce. Through combining information on catalytic properties of the enzymes, on the expression patterns of the corresponding genes, and on the presence of monolignols and hydrogen peroxide in the apoplastic space, we can show that specific peroxidases catalyze lignin polymerization in the apoplastic space of Norway spruce xylem. | Kurt V.Fagerstedt Eija M.Kukkola Ville V.T.Koistinen Junko Takahashi Kaisa Marjamaa | 2010 | Journal of Integrative Plant Biology2010，52，2： | 12 |
| 2 | 双胎输血综合征选择性激光凝固绒毛膜血管吻合支成功后,晚期胎儿并发症的发生率及其处理显示文摘Objective: This study was undertaken to report on the prevalence and management of late complications in twin-to-twin transfusion syndrome (TTTS) treated by laser therapy when both twins are alive 1 week after surgery. Study design: A total of 151 consecutive TTTS cases were treated by selective fetoscopic laser therapy. Cases in which both twins were alive 1 week after surgery were followed up with ultrasound and Doppler examination, including middle-cerebral artery peak systolic velocity measurement (MCA-PSV). Results: In the 151 cases treated with laser, both twins were still alive 7 days after the procedure in 101 cases. Intrauterine death of 1 and both twins occurred in 7 and 1 cases, respectively. Recurrence of TTTS with the polyhydramnios-oligohydramnios sequence occurred in 14 (14% ) cases. In another 13 (13% ) cases,amniotic fluid remained normal in both sacs, but MCA- PSV increased above 1.5 MoM in 1 twin and decreased concomitantly below 0.8 MoM in the co-twin. This was related to anemia and polycythemia, respectively, and resulted from unidirectional feto-fetal blood transfusion, mainly from former recipients into former donors. Late complications were managed accordingly by repeat laser, amnioreduction, cord coagulation, intrauterine blood transfusion, or elective delivery. Conclusion: MCA-PSV Doppler measurements are useful in the follow-up of double survivors to detect and manage late complications after selective laser therapy. | Robyr R. Lewi L. Salomon L.J. Y. Ville 朱国栋 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，8： | 12 |
| 3 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 4 | Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-γ production显示文摘AIM: To investigate the capacity of potentially probiotic strains from six bacterial genera to induce cytokine production alone or in combinations in order to identify potential enhancing or synergistic effects in order to select probiotic bacteria for in vivo purposes. METHODS: Cytokine production in human peripheral blood mononuclear cells (PBMC) in response to stimulation with eleven different potentially probiotic bacterial strains from Streptococcus , Lactobacillus , Bifidobacterium , Lactococcus , Leuconostoc and Propionibacterium genera was analysed. Production and mRNA expression of TNF-α, IL-12, IFN-γ and IL-10 were determined by ELISA and Northern blotting, respectively. RESULTS: All tested bacteria induced TNF-α production. The best inducers of Th1 type cytokines IL-12 and IFN-γ were Streptococcus and Leuconostoc strains. All Bifidobacterium and Propionibacterium strains induced higher IL-10 production than other studied bacteria. Stimulation of PBMC with any bacterial combinations did not result in enhanced cytokine production suggesting that different bacteria whether gram-positive or gram- negative compete with each other during host cell interactions.CONCLUSION: The probiotic S. thermophilus and Leuconostoc strains are more potent inducers of Th1 type cytokines IL-12 and IFN-γ than the probiotic Lactobacillus strains. Bacterial combinations did not result in enhanced cytokine production. | Riina A Kekkonen Elina Kajasto Minja Miettinen Ville Veckman Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，8： | 9 |
| 5 | Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells显示文摘AIM: To analyze the ability of nine different potentially probiotic bacteria to induce maturation and cytokine production in human monocyte-derived dendritic cells (moDCs). METHODS: Cytokine production and maturation of moDCs in response to bacterial stimulation was analyzed with enzyme-linked immunosorbent assay (ELISA) and flow cytometric analysis (FACS), respectively. The kinetics of mRNA expression of cytokine genes was determined by Northern blotting. The involvement of different signaling pathways in cytokine gene expression was studied using specific pharmacological signaling inhibitors. RESULTS: All studied bacteria induced the maturation of moDCs in a dose-dependent manner. More detailed analysis with S. thermophilus THS, B. breve Bb99, and L. lactis subsp. cremoris ARH74 indicated that these bacteria induced the expression of moDC maturationmarkers HLA class Ⅱ and CD86 as efficiently as pathogenic bacteria. However, these bacteria differed in their ability to induce moDC cytokine gene expression. S. thermophilus induced the expression of pro-inflammatory (TNF-α, IL-12, IL-6, and CCL20) and Th1 type (IL-12 and IFN-γ) cytokines, while B. breve and L. lactis were also potent inducers of anti- inflammatory IL-10. Mitogen-activated protein kinase (MAPK) p38, phosphatidylinositol 3 (PI3) kinase, and nuclear factor-kappa B (NF-κB) signaling pathways were shown to be involved in bacteria-induced cytokine production. CONCLUSION: Our results indicate that potentially probiotic bacteria are able to induce moDC maturation, but their ability to induce cytokine gene expression varies significantly from one bacterial strain to another. | Sinikka Latvala Taija E Pietil Ville Veckman Riina A Kekkonen Soile Tynkkynen Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，36： | 8 |
| 6 | Radiation and concomitant chemotherapy for patients with glioblastoma multiforme显示文摘Postoperative external beam radiotherapy was considered the standard adjuvant treatment for patients with glioblastoma multiforme until the advent of using the drug temozolomide(TMZ) in addition to radiotherapy. High-dose volume should be focal, minimizing whole brain irradiation. Modern imaging, using several magnetic resonance sequences, has improved the planning target volume definition. The total dose delivered should be in the range of 60 Gy in fraction sizes of 1.8-2.0 Gy. Currently, TMZ concomitant and adjuvant to radiotherapy has become the standard of care for glioblastoma multiforme patients. Radiotherapy dose-intensification and radiosensitizer approaches have not improved the outcome. In spite of the lack of high quality evidence, stereotactic radiotherapy can be considered for a selected group of patients. For elderly patients, data suggest that the same survival benefit can be achieved with similar morbidity using a shorter course of radiotherapy(hypofractionation). Elderly patients with tumors that exhibit methylation of the O-6-methylguanine-DNA methyltransferase promoter can benefit from TMZ alone. | Salvador Villà Carme Balaà Sílvia Comas | 2014 | Chinese Journal of Cancer2014，33，1： | 6 |
| 7 | Statin use and non-alcoholic steatohepatitis in at risk individuals显示文摘 | Paola Dongiovanni Salvatore Petta Ville Mannisto Rosellina Margherita Mancina Rosaria Pipitone Vesa Karja Marco Maggioni Pirjo Kakela Olov Wiklund Enrico Mozzi Stefania Grimaudo Dorota Kaminska Raffaela Rametta Antonio Craxi Silvia Fargion Valerio Nobili | 2015 | Journal of Hepatology2015，，3： | 2 |
| 8 | Effective treatment of advanced biliary tract carcinoma using 5-fluorouracil continuous infusion with cisplatin显示文摘 | M. Ducreux P. Rougier A. Fandi M.-C. Clavero-Fabri A.-L. Villing F. Fassone L. Fandi J. Zarba J.-P. Armand | 1998 | Annals of Oncology1998，，6： | 2 |
| 9 | Combination of Local and Global Line Extraction显示文摘 | Ville Kyrki | 2000 | Real-Time Imaging(6)2000，，2： | 2 |
| 10 | Treatment of extrahepatic portal hypertension in children by mesenteric-to-left portal vein bypass:a new physiological procedure显示文摘 | de Ville de Goyet J Alberti D Falchetti D | 1999 | Eur J Surg1999，165，8： | 1 |
| 11 | Nuchal translucency in the first trimester of pregnancy: ten years on and still a pain in the neck? 显示文摘 | Ville Y | 2001 | Ultrasound Obstet Gyne- col2001，18，1： | 1 |
| 12 | Noise Reduction by Fuzzy Image Filtering显示文摘 | VILLE D V D | 2003 | IEEE Transactions on Fuzzy Systems2003，4，11： | 1 |
| 13 | Slow infusion feedings enhance duodenal motor responses and gastric emptying in preterm infants显示文摘 | Knapp E Al-Tawil Y | 1998 | Am J Clin Nutr1998，68，： | 1 |
| 14 | Capillarity in microfluidic channels with hydrophilic and hydrophobic walls显示文摘 | VILLE J SAMI F | 2008 | Microfluidics Nanofluidics2008，5，4： | 1 |
| 15 | Théorie et applications de la notion de signal analytique显示文摘 | Ville J | 1948 | Cables et Transmission1948，2，： | 1 |
| 16 | Seamless management of biliary atresia显示文摘 | Davenport M Dè Ville de Goyet J Stringer MD | 2004 | Lancet2004，363，9418： | 1 |
| 17 | Thymoma with epithelial micronodules and lymphoid hyperplasia: six cases of a rare and equivocal subtype显示文摘 | Thomas De Montpréville V Zemoura L Dulmet E | 2002 | Ann Pathol2002，22，3： | 1 |
| 18 | 查看详情显示文摘 | Ville M Chiodelli G Scagliotti M | | 0，，： | 1 |
| 19 | Noise reduction by fuzzy image filtering显示文摘 | Van De Ville Nachtegael M Van dereken | 2003 | IEEE Transactions on Fuzzy Systems2003，11，8： | 1 |
| 20 | Acoustical emission technique applied to the characterization of brittle materials显示文摘 | Alchakra W Allaf K Ville J M | 1997 | Applied Acoustics1997，52，1： | 1 |
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