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| 1 | Plant species with extremely small populations(PSESP) in China:A seed and spore biology perspective显示文摘Approximately one fifth of the world's plants are at risk of extinction.Of these,a significant number exist as populations of few individuals,with limited distribution ranges and under enormous pressure due to habitat destruction.In China,these most-at-risk species are described as 'plant species with extremely small populations'(PSESP).Implementing conservation action for such listed species is urgent.Storing seeds is one of the main means of ex situ conservation for flowering plants.Spore storage could provide a simple and economical method for fern ex situ conservation.Seed and spore germination in nature is a critical step in species regeneration and thus in situ conservation.But what is known about the seed and spore biology(storage and germination) of at-risk species? We have used China's PSESP(the first group listing) as a case study to understand the gaps in knowledge on propagule biology of threatened plant species.We found that whilst germination information is available for 28 species(23%of PSESP),storage characteristics are only known for 8%of PSESP(10 species).Moreover,we estimate that 60%of the listed species may require cryopreservation for long-term storage.We conclude that comparative biology studies are urgently needed on the world's most threatened taxa so that conservation action can progress beyond species listing. | Ellie Merrett Wade Jayanthi Nadarajan Xiangyun Yang Daniel Ballesteros Weibang Sun Hugh W.Pritchard | 2016 | Plant Diversity2016，38，5： | 6 |
| 2 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 3 | Multimodality treatment of potentially curative gastric cancer: Geographical variations and future prospects显示文摘After much controversy, multimodality therapy is now accepted worldwide as the gold standard for treatment of resectable bulky localized gastric cancer. There is significant regional variation in the style of multimodality treatment with adjuvant chemoradiation the North American standard, neoadjuvant chemotherapy preferred in Europe and Australasia, whilst adjuvant chemotherapy is preferred in Asia. With further standardization of surgery and D1+/D2 resections increasingly accepted world wide, and in particular in the West, as the surgical standard of care for potentially curable disease, it is timely to reassess the multimodality regimes being used. The challenge in the use of multimodality therapy is how current outcomes can be standardized and improved further. Recent studies indicate that mere intensification of the regime in time, dosage or addition of further agents does not improve localized gastric cancer outcomes. More novel strategies including early commencement of adjuvant therapies, intra-peritoneal chemotherapy or assessing neoadjuvant response with positron emission tomography scanning may give improvements in outcomes. The introduction of targeted therapies means that the adjuvant use of biological agents needs to be explored. By proper assessment of the patient's co-morbidities, full tumour staging, and a better understanding of the tumour's molecular pathology, multimodality therapy for gastric adenocarcinoma may be individualized to optimize the likelihood of cure. | Neil D Merrett | 2014 | World Journal of Gastroenterology2014，20，36： | 2 |
| 4 | Surgical Therapy for Gastrointestinal Stromal Tumours of the Upper Gastrointestinal Tract显示文摘 | Amitabha Das Robert Wilson Andrew V. Biankin Neil D. Merrett | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 2 |
| 5 | Regulation of carbonic-anhydrase activity,inorganic-carbon uptake and photosynthetic biomass yield in Chlamydomonas reinhardtii显示文摘 | Patel B N Merrett M J 1986 | 1986 | Planta1986，169，： | 1 |
| 6 | CIinicopatho]ogic factors asated with Her - 2 - positive gastric cancer and its impact on survival outcomes a systematic review显示文摘 | Chua TC Merrett ND | 2012 | Int J Canc- er2012，130，12： | 1 |
| 7 | Kartagener's syndrome: unusual dental morphology显示文摘 | Merrett SJ Durning P | 2005 | Int J Paecliatr Dentistr2005，15，3： | 1 |
| 8 | Margin clearance and outcome in resected pancreatic cancer显示文摘 | Chang DK Johns AL Merrett ND | 2009 | J Clin Oncol2009，27，17： | 1 |
| 9 | Recombinant hu?man collagen for tissue engineered corneal substitutes显示文摘 | Liu W Merrett K Griffith M | 2008 | Biomaterials2008，29，9： | 1 |
| 10 | Business Industry associations as facilitators of social capital:The establishment and early operations of the Melbourne Woolbrokers Association显示文摘 | David Merrett Stephen Morgan Simon Ville | | 0，，06： | 1 |
| 11 | Comparison of the shaping ability of RaCe and FlexMaster rotary nickel-titanium systems in simulated canals显示文摘 | Merrett SJ Bryant ST Dummer PM | | 0，，10： | 1 |
| 12 | Integrated Water Resources Manage- ment and the Hydrosocial Balance 显示文摘 | Merrett S | 2004 | Water Inter- national2004，29，2： | 1 |
| 13 | A collaborative approach to fall prevention显示文摘 | Merrett A Thomas P Stephens A | 2011 | Can Nurs2011，107，8： | 1 |
| 14 | Interactions of Corneal Cell with Transforming Growth Factorβ 2-Modified Poly Dimethyl Siloxane Surfaces显示文摘 | Merrett K Griffith C M Deslandes Y | 2003 | Biorned Mater Res2003，67，： | 1 |
| 15 | Clinicopathologic factors associated with HER-2-positive gastric cancer and its impact on survival outcom- es : a systematic review 显示文摘 | Chua TC Merrett ND | 2012 | Int J Cancer2012，130，12： | 1 |
| 16 | Clinicopathologic factors associated with her2-positive gastric cancer and its impact on survival outcomes-- a systematic review显示文摘 | Chua TC Merrett ND | 2012 | Int J Cancer2012，130，12： | 1 |
| 17 | Superior mesenteric artery syndrome:diagnosis and treatment strategies显示文摘 | MERRETT ND WILSON RB COSMAN P | 2009 | J Gastrointest Surg2009，13，2： | 1 |
| 18 | Calcification rate in Emiliania huxleyi Lohmann in response to light, nitrate and inorganic carbon availability显示文摘 | Nimer N A Merrett M J | 1993 | New Phytologist1993，123，： | 1 |
| 19 | Superior mesenteric artery syndrome:diagnosis and treatment strategies显示文摘 | Merrett ND Wilson RB Cosman P | 2009 | J Gastro- intest Surg2009，13，2： | 1 |
| 20 | Synthetic neoglycopolymer-recombinant human collagen hybrids as biomimetic crosslinking agents in corneal tissue engineering显示文摘 | Merrett K Liu W Mitra D | 2009 | Biomaterials2009，30，： | 1 |
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