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| 1 | 胰腺导管腺癌放射学报告模板:腹部放射协会和美国胰腺协会的共识声明显示文摘胰腺导管腺癌(PDA)是一种具有侵袭性、死亡率高的恶性肿瘤。在肿瘤分期时,通过影像学分析,合理判定肿瘤的范围,是患者治疗措施中最重要的步骤之一。考虑到不同医生在专业知识水平和疾病严重程度的判定有所差异,以及在放射学检查时经常缺乏相关影像学表现的完整报道,有必要采用标准化的影像学报告模板以及大家一致接受和认可的胰腺实性肿瘤术语。在腹部放射协会和美国胰腺协会的共同资助下,胰腺导管腺癌(PDA)多机构专家组(包括放射学专家、胃肠病学和肝胆胰外科学专家)共同发起了一份描述标准化报告模板的共识声明。采用这种标准化的影像学报告模板将能改进PDA患者的治疗决策过程,并可通过提供一份完整、相关、精准的疾病分期报告以优化治疗方案。通过对可行手术切除的患者恰当、一致的分期,标准化报告模板有助于促进临床和科研实验设计,从而实现在不同机构之间的实验结果的比较。 | Mahmoud M.Al-Hawary Isaac R.Francis Suresh T.Chari Elliot K.Fishman David M.Hough David S.Lu Michael Macari Alec J.Megibow Frank H.Miller Dushyant V.Sahani Diane M.Simeone 黄翔 孙灿辉 | 2014 | 影像诊断与介入放射学2014，23，4： | 52 |
| 2 | Pneumatosis intestinalis显示文摘 | R. Michael Boerner MD PhD Daniel B. Fried MPH David M. Warshauer MD Dr. Kim Isaacs MD PhD | 1996 | Digestive Diseases and Sciences1996，，11： | 2 |
| 3 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 4 | Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units显示文摘Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting.Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively included.Anemia was defined as hemoglobin<130 g/L in men and<120 g/L in women.The association between anemia and mortality or readmission at six months was assessed by the Cox regression method.Results A total of 629 patients were included.Mean age was 66.6 years.A total of 197 patients(31.3%)had anemia.Coronary angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score values.Patients with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement therapies.Both ICCU and hospital stay were significantly longer in patients with anemia.Both the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia.Most patients underwent coronary angiography.Anemia was independently associated to poorer outcomes at 6 months. | Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 | 2020 | Journal of Geriatric Cardiology2020，17，1： | 2 |
| 5 | Absolute and Relative Rewards for Individuals in Team Production 显示文摘 | Dickinson David L Isaac Mark R | 1998 | Manageri- al and Decision Economics1998，19，45： | 1 |
| 6 | Intraoperative parathormone measurement from the internal jugular vein predicts post-thyroidectomy hypocalcaemia 显示文摘 | Isaac M Cranshaw David Moss | 2007 | Langenbecks Arch Surg2007，392，6： | 1 |
| 7 | Repeat liver resection for recurrent colorectal metastases: a single‐centre, 13‐year experience显示文摘 | Narendra Battula Dimitrios Tsapralis David Mayer John Isaac Paolo Muiesan Robert P. Sutcliffe Simon Bramhall Darius Mirza Ravi Marudanayagam | 2014 | HPB2014，，2： | 1 |
| 8 | A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses显示文摘 | David Cameron Michelle Casey Michael Press Deborah Lindquist Tadeusz Pienkowski C. Gilles Romieu Stephen Chan Agnieszka Jagiello-Gruszfeld Bella Kaufman John Crown Arlene Chan Mario Campone Patrice Viens Neville Davidson Vera Gorbounova Johannes Isaac Raa | 2008 | Breast Cancer Research and Treatment2008，，3： | 1 |
| 9 | Nanoparticle-based monitoring of cell therapy显示文摘 | Chenjie Xu Luye Mu Isaac Roes David Miranda-Nieves Matthias Nahrendorf James A Ankrum Weian Zhao Jeffrey M Karp | 2011 | Nanotechnology2011，，49： | 1 |
| 10 | Integrin-Associated CD151 Drives ErbB2-Evoked Mammary Tumor Onset and Metastasis显示文摘 | Xinyu Deng Qinglin Li John Hoff Marian Novak Helen Yang Hongyan Jin Sonia F. Erfani Chandan Sharma Pengcheng Zhou Isaac Rabinovitz Arnoud Sonnenberg Yajun Yi Peter Zhou Christopher S. Stipp David M. Kaetzel Martin E. Hemler Xiuwei H. Yang | 2012 | Neoplasia2012，，8： | 1 |
| 11 | PGC-1[alpha] promotes recovery after acute kidney injury during systemic inflammation in mice显示文摘 | Tran Mei Tam Denise Bardia Amit Bhasin Manoj Rowe Glenn C Kher Ajay Zsengeller Zsuzsanna K Akhavan-Sharif M Reza Khankin Eliyahu V Saintgeniez Magali David Sascha Burstein Deborah Karumanchi S Ananth Stillman Isaac E Arany Zoltan Parikh Sa | 2011 | Journal of Clinical Investigation2011，，10： | 1 |
| 12 | Angiographic evaluation and treatment of transplant renal artery stenosis显示文摘 | Spinosa RB Isaacs AH | 2001 | Current Opinion in Urology2001，11，： | 1 |
| 13 | The Use of Scintigraphy to Provide ’Proof of Concept’ for Novel Polysaccharide Preparations Designed for Colonic Drug Delivery显示文摘 | Dawn A. Adkin Carole J. Kenyon E. Itzhack Lerner Isaac Landau Eric Strauss David Caron Adel Penhasi Abraham Rubinstein Ian R. Wilding | 1997 | Pharmaceutical Research1997，，1： | 1 |
| 14 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 15 | Central corneal thickness measurement with the Pentacam Scheimpflug system, optical low-coherence reflectometry pachymeter, and ultrasound pachymetry显示文摘 | Yaniv Barkana Yariv Gerber Uri Elbaz Shulamit Schwartz Gie Ken-Dror Isaac Avni David Zadok | 2005 | Journal of Cataract & Refractive Surgery2005，，9： | 1 |
| 16 | Corneal collagen cross-linking for the treatment of progressive keratoconus: 3-year prospective outcome显示文摘 | Yakov Goldich Yaniv Barkana Orly Wussuku Lior Arie L. Marcovich Ami Hirsh Isaac Avni David Zadok | 2013 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2013，，： | 1 |
| 17 | Normal and elevated HbA1C levels correlate with severity of hypoxemia in patients with obstructive sleep apnea and decrease following CPAP treatment显示文摘 | Isaac Shpirer Micha Rapoport David Stav Arnon Elizur | 2012 | Sleep and Breathing2012，，2： | 1 |
| 18 | A comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients显示文摘 | Anthony J. Bleyer Steven K. Burke Maureen Dillon Bruce Garrett K.Shashi Kant David Lynch S.Noor Rahman Patricia Schoenfeld Isaac Teitelbaum Steven Zeig Eduardo Slatopolsky | 1999 | American Journal of Kidney Diseases1999，，4： | 1 |
| 19 | The reverse mortgage as an asset management tool显示文摘 | David W R Isaac F M Barbara A M | 1997 | Housing Policy Debate1997，8，1： | 1 |
| 20 | Synthesis and Energetic Properties of 4,4′,5,5′‐Tetranitro‐2,2′‐biimidazolate(N4BIM) Salts显示文摘 | David E. Chavez Damon Parrish Daniel N. Preston Isaac W. Mares | 2012 | Propellants Explosives Pyrotechnics2012，，6： | 1 |
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