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| 1 | Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma显示文摘AIM: To assess the safety and efficacy of trans-arterial chemo-embolization (TACE) in very elderly patients. METHODS: A prospective cohort study, from 2001 to 2010, compared clinical outcomes following TACE between patients ≥ 75 years old and younger patients (aged between 65 and 75 years and younger than 65 years) with hepatocellular carcinoma (HCC), diagnosed according to the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases criteria. The decision that patients were not candidates for curative therapy was made by a multidisciplinary HCC team. Data collected included demographics, co-morbidities, liver disease etiology, liver disease severity and the number of procedures. The primary outcome was mortality; secondary outcomes included post-embolization syndrome (nausea, fever, abdominal right upper quadrant pain, increase in liver enzymes with no evidence of sepsis and with a clinical course limited to 3-4 d post procedure) and 30-d complications. Additionally, changes in liver enzyme measurements were assessed [alanine and aspartate aminotransferase (ALT and AST), gamma-glutamyl transpeptidase and alkaline phosphatase] in the week following TACE. Analysis employed both univariate and multivariate methods (Cox regression models). RESULTS: Of 102 patients who underwent TACE as sole treatment, 10 patients (9.8%) were > 80 years old at diagnosis; 13 (12.7%) were between 75 and 80 years, 45 (44.1%) were between 65 and 75 years and 34 (33.3%) were younger than 65 years. Survival analysis demonstrated similar survival patterns between the elderly patients and younger patients. Age was also not associated with the adverse event rate. Survival rates at 1, 2 and 3 years from diagnosis were 74%, 37% and 31% among patients < 65 years; 83%, 66% and 48% among patients aged 65 to 75 years; and 86%, 41% and 23% among patients ≥ 75 years. There were no differences between the age groups in the pre-procedural care, including preventive treatment for contrast nephropathy and prophylactic antibiotics. Multivariate survival analysis, controlling for disease stage at diagnosis with the Barcelona Clinic Liver Cancer score, number of TACE procedures, sex and alphafetoprotein level at the time of diagnosis, found no significant difference in the mortality hazard for elderly vs younger patients, and there were no differences in post-procedural complications. Serum creatinine levels did not change after 55% of the procedures, in all age groups. In 42% of all procedures, serum creatinine levels increased by no more than 25% above the baseline levels prior to TACE. Overall, there were 69 post-embolization events (23%). Hepatocellular enzymes often increased following TACE, with no association with prognosis. In 40% of the procedures, ALT and AST levels rose by at least 100%. The increases in hepatocellular enzymes occurred similarly in all age groups. CONCLUSION: TACE is safe and effective in very elderly patients with HCC, and is not associated with decreased survival or increased complication rates. | Matan J Cohen Allan I Bloom Orly Barak Alexander Klimov Tova Nesher Daniel Shouval Izhar Levi Oren Shibolet | 2013 | World Journal of Gastroenterology2013，19，16： | 13 |
| 2 | Long noncoding RNAs and human disease显示文摘 | Orly Wapinski Howard Y. Chang | 2011 | Trends in Cell Biology2011，，6： | 7 |
| 3 | Effect of a specialized injury prevention program on static balance, dynamic balance and kicking accuracy of young soccer players显示文摘AIM To study the effect of balance intervention program using the 'FIFA 11+' program on static and dynamic balance and kicking accuracy of young soccer players.METHODS Twenty young soccer players were allocated to experimental(n = 10) or control(n = 10) groups. The experimental group performed the 'FIFA 11+' program three times a week for six weeks. The control group performed their normal warm-up routine. The primary outcomes were measured pre and post intervention, and assessed kicking accuracy, static balance and dynamic balance.RESULTS No differences were found in kicking accuracy following intervention, for both groups, however, static balance improved significantly among the experimental group with significant interaction with the control group, and with high effect size. In addition, the dynamic balance of the left leg of the experimental group, with medium effect size for interaction between groups.CONCLUSION The large effect size of balance improvement that was observed following six weeks of intervention sessions, implies that soccer trainers and coaches should consider the inclusion of 'FIFA 11+' as components of programs aimed at improving balance ability/control in young soccer players, as improvement in balance abilities may prevent injuries. | Ayelet Dunsky Ido Barzilay Orly Fox | 2017 | World Journal of Orthopedics2017，8，4： | 6 |
| 4 | Non-imaging-guided fine-needle aspiration of liver lesions:aretrospective study of 279 patients显示文摘RESULTSBasedonhistologic,cytologicandclinicalfindings,finalliverdiagnoseswerereachedin265patients,ofwhom171hadmalignantand94... | Yeouda Edoute 1,4 , Ehud Malberger 2,4 , Orly Tibon Fisher 2 and Nimer Assy 3,4 | 1999 | World Journal of Gastroenterology1999，5，2： | 2 |
| 5 | The influence of calcium phosphate biomaterials on human bone cell activities 显示文摘 | Gregoire M Orly I Menanteau J | 1990 | J Biomed Mater Res1990，24，2： | 1 |
| 6 | Mobilized bone rmnow cells repairtheinfracted heart, irnptovingfunotion and strvlval显示文摘 | Orlie D Kajstura J Chimenti S | 2001 | Pros NailAcacl Sci2001，98，10： | 1 |
| 7 | 'How the Alphabet was Born from Hieroglyphs'显示文摘 | Orly Goldwasser | | 0，，02： | 1 |
| 8 | Neurological mechanisms of green tea polyphenols inAlzheimer's and Parkinson's diseases显示文摘 | Orly W Silvia M Tamar A | 2004 | J Nutri Biochem2004，15，： | 1 |
| 9 | CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth显示文摘 | Katia Beider Michal Begin Michal Abraham Hanna Wald Ido D. Weiss Ori Wald Eli Pikarsky Evelyne Zeira Orly Eizenberg Eithan Galun Izhar Hardan Dan Engelhard Arnon Nagler Amnon Peled | 2011 | Experimental Hematology2011，，3： | 1 |
| 10 | The murine 3beta-hydroxysteroid dehydrogenase ( 3beta-HSD) gene family ; apostulated role for 3beta-HSD VI during early pregnancy显示文摘 | Peng L Arensburg J Orly J | 2002 | Mol Cell Endocrinol2002，187，12： | 1 |
| 11 | Do English and Mandarin speakers think about time differently?显示文摘 | Lera Boroditsky Orly Fuhrman Kelly McCormick | 2010 | Cognition2010，，1： | 1 |
| 12 | Wide intrascene dynamic range CMOS APS using dual sampling显示文摘 | Yadid-Pecht Orly Fossum Eric R | 1997 | IEEE Trans Electron Devices1997，44，10： | 1 |
| 13 | “How the Alphabetwas Born from Hieroglyphs”显示文摘 | Orly Goldwasser | | 0，，： | 1 |
| 14 | A cellular mineral deposition in collagen-based biomaterials incubated in cell culture media 显示文摘 | Chevallay B Orly I | 2000 | Caicif Tissue Int2000，66，3： | 1 |
| 15 | Developmental competence of nuclear transfer after direct injection of fibroblast nuclei 显示文摘 | LACHAM -KAPLAN Orly DIAMENTE Maria PUSHETT David | 2000 | Cloning2000，2，2： | 1 |
| 16 | Testicular cell conditioned medium supports differentiation of embryonic stem(ES) cells into ovarian structures containing oocytes显示文摘 | Orly LK Hun Chy Trounson A | 2005 | Stem Cell2005，，： | 1 |
| 17 | Neurogenesis and Alzheimer’s disease: At the crossroads显示文摘 | Orly Lazarov Robert A. Marr | 2009 | Experimental Neurology2009，，2： | 1 |
| 18 | Neuroprotective molecular mechanisms of (?)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties显示文摘 | Orly Weinreb Tamar Amit Silvia Mandel Moussa B. H. Youdim | 2009 | Genes & Nutrition2009，，4： | 1 |
| 19 | Utilization of lignocellulosic waste by the edible mushroom, Pleurotus显示文摘 | Yitzhak Hadar Zohar Kerem Barbara Gorodecki Orly Ardon | 1992 | Biodegradation1992，，2： | 1 |
| 20 | Dichotomous or categorical response? Analyzing self-rated health and lifetime social class显示文摘 | Orly M Sharon M Chris P | | 0，，01： | 1 |
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