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| 1 | Anticoagulation with direct thrombin inhibitors during extracorporeal membrane oxygenation显示文摘Use of extracorporeal membrane oxygenation to support patients with critical cardiorespiratory illness is increasing.Systemic anticoagulation is an essential element in the care of extracorporeal membrane oxygenation patients.While unfractionated heparin is the most commonly used agent,unfractionated heparin is associated with several unique complications that can be catastrophic in critically ill patients,including heparin-induced thrombocytopenia and acquired antithrombin deficiency.These complications can result in thrombotic events and subtherapeutic anticoagulation.Direct thrombin inhibitors(DTIs)are emerging as alternative anticoagulants in patients supported by extracorporeal membrane oxygenation.Increasing evidence supports DTIs use as safe and effective in extracorporeal membrane oxygenation patients with and without heparininduced thrombocytopenia.This review outlines the pharmacology,dosing strategies and available protocols,monitoring parameters,and special use considerations for all available DTIs in extracorporeal membrane oxygenation patients.The advantages and disadvantages of DTIs in extracorporeal membrane oxygenation relative to unfractionated heparin will be described. | Barry Burstein Patrick M Wieruszewski Yan-Jun Zhao Nathan Smischney | 2019 | World Journal of Critical Care Medicine2019，8，6： | 12 |
| 2 | Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation显示文摘瞄准:在 thromboembolism 的开发在胰腺的癌症和它的角色学习织物因素(TF ) 的表示。方法:TF 表示被北污点和间接免疫荧光在八根人的胰腺的癌房间线学习。或者拼接的 TF (asTF ) 的表示被 RT-PCR 估计。另外, TF 表示被免疫荧光与胰腺的腺癌(PCa ) 在 19 个病人的胰腺的纸巾决定,有慢性胰炎(CP ) 的 9 个病人和 20 正常控制。血浆样品(30 PCa 病人, 13 CP 病人和 20 控制) 为可溶的 TF 层次和凝结激活标记被调查[thrombin-antithrombin III 建筑群(梭织) ,凝血素碎片 1 + 2 (F1 + 2 )] 。结果:所有胰腺的癌房间线表示了 TF (8/8 ) ,他们中的大多数表示了 asTF (6/8 ) 。在蛋白质水平的 TF 表示没与癌房间线的区别相关。几乎,二件胰腺的癌症组织样品染色了为 TF (17/19 ) 积极。在 CP 的所有样品,弱染色被限制为胰腺的管房间,而一些仅仅内皮下房间在正常控制的 9/20 是积极的。TF 并且在 PCa 病人梭织层次而 2 铺平的提高的 F1 + 没与控制相比到达统计意义,显著地与控制相比被提高。在病人们梭织的 CP 和 F1 + , 2 个层次证明了显著地与控制相比被提高,尽管梭织举起少些比在 PCa 病人被读。结论:我们结束那除了起来房间膜上的 TF 的调整表示,可溶的 TF 可能在胰腺的癌症贡献凝结系统的激活。 | Stephan L Haas Ralf Jesnowski Michael Steiner Frank Hummel Jrg Ringel Christine Burstein Horst Nizze Stefan Liebe J Matthias Lhr | 2006 | World Journal of Gastroenterology2006，12，30： | 9 |
| 3 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 4 | 胃肠外应用COX1/COX2抑制剂终止伴触诱发痛的偏头痛和发展中的中枢致敏作用 | Jakubowski M. Levy D. Goor-Aryeh I. R. Burstein 邓剑平 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，11： | 2 |
| 5 | Moderate to severe thrombocytopenia during pregnancy显示文摘 | Michal Parnas Eyal Sheiner Ilana Shoham-Vardi Eliezer Burstein Tikva Yermiahu Itai Levi Gershon Holcberg Ronit Yerushalmi | 2006 | European Journal of Obstetrics and Gynecology2006，，1： | 2 |
| 6 | Percutaneous Left Atrial Appendage Occlusion for Patients in Atrial Fibrillation Suboptimal for Warfarin Therapy显示文摘 | Peter C. Block Steven Burstein Paul N. Casale Paul H. Kramer Paul Teirstein David O. Williams Mark Reisman | 2009 | JACC: Cardiovascular Interventions2009，，7： | 2 |
| 7 | Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure 显示文摘 | Shiroshita-Takeshita A Brundel B J Burstein B | 2007 | Cardiovasc Res2007，74，1： | 1 |
| 8 | Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2 positive, trastuzumab refractory metastatic breast cancer 显示文摘 | Blackwell KL Burstein H J Storniolo AM | 2010 | J Clin Oncol2010，28，7： | 1 |
| 9 | Atrial remodeling and atrial fibrillation mechanisms and implications显示文摘 | Nattel S Burstein B Dobrev D | 2008 | Circ Arrhythm Electrophysiol2008，1，： | 1 |
| 10 | The development of cutaneous allodynia during a migraine attack:clinical evidence for sequential recruitment of spinal and supraspinal nociceptive neurons in migraine 显示文摘 | Burstein R Cutrer MF Yarnitsky D | 2000 | Brain2000，123，： | 1 |
| 11 | Randoumized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-postivie, trastu- zumab-refractory metastatic breast cancer 显示文摘 | Blackwell KL Burstein HJ Storniolo AM | 2010 | J Clin Oncol2010，28，7： | 1 |
| 12 | Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy:5-year results of the PLAATO (Percutanous Left Atrial Appendage Transcatheter Occlusion) Study显示文摘 | Block PC Burstein S Casale PN | 2009 | JACC Cardiovasc Interv2009，2，： | 1 |
| 13 | Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy : 5 - year results of the PLAATO ( Percutaneous Left Atrial Appendage Transcatheter Occlusion) Study 显示文摘 | Block PC Burstein S Casale PN | 2009 | JACC Cardiovasc Interv2009，2，： | 1 |
| 14 | Viral aetiology of hemangiosarcoma outbreaks among layer hens显示文摘 | BURSTEIN H GILEAD M BENDHEIM U at al | 1984 | Avian Pathology1984，13，4： | 1 |
| 15 | A Model for Mechanical Seals with Regular Microsurface Structure显示文摘 | Etsion I Burstein L | 1996 | Tribology Transaction1996，39，3： | 1 |
| 16 | maxillary-midface distraction in children with cleft lip and palate: a preliminary report 显示文摘 | Cohen SR Burstein FD Stewart MB | 1997 | Plast Reconstr Surg1997，99，5： | 1 |
| 17 | Anomalous optical absorption limit in InSb 显示文摘 | Burstein E | 1954 | Physics Review1954，93，3： | 1 |
| 18 | Percutaneous pinning using threaded pins as a treatment option for unstable two-and three-part fractures of the proximal humerus:a retrospective study显示文摘 | Fenichel L Oran A Burstein G | 2006 | Int Orthop2006，30，3： | 1 |
| 19 | The far-ultraviolet spectra of early-type galaxies显示文摘 | BURSTEIN D BERTOLA F BUSON L M et ai | 1988 | Astrophysics Journal1988，328，： | 1 |
| 20 | Membranous glomerunephritis and malignancy显示文摘 | Burstein P Korbet SM Schwartz MM | 1993 | Am J Kidney Dis1993，22，1： | 1 |
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