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| 1 | 脑内出血的临床与实验显示文摘作者简介:JulianTHof,男,1936年生于美国爱达荷州。1958年毕业于斯坦福大学,获艺术学士学位;1962年在康奈尔大学医学院获医学博士学位。同年进入纽约大学医学院神经外科,在神经外科先驱者之一Ray教授的指导下完成住院医生培训。此后他就... | Hoff,JT 徐记氦 | 1999 | 中国神经精神疾病杂志1999，25，1： | 23 |
| 2 | Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors显示文摘Pancreatic carcinomas with acinar differentiation are rare,accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell carcinoma(PACC),pancreatoblastoma,and carcinomas of mixed differentiation. Patients with PACC have a prognosis better than pancreatic ductal adenocarcinomas but worse than pancreatic neuroendocrine tumors. Reports of overall survival range from 18 to 47 mo. A literature review on PACCs included comprehensive genomic profiling and whole exome sequencing on a series of more than 70 patients as well as other diagnostic studies including immunohistochemistry. Surgical resection of PACC is the preferred treatment for localized and resectable tumors. The efficacy of adjuvant treatment is unclear. Metastatic PACCs are generally not curable and treated with systemic chemotherapy. They are moderately responsive to chemotherapy with different regimens showing various degrees of response in case reports/series. Most of these regimens were developed to treat patients with pancreatic ductal adenocarcinomas or colorectal adenocarcinomas. Review of PACC's molecular profiling showed a number of gene alterations such as: SMAD4,BRAF,BRCA2,TP53,RB1,MEN1,JAK-1,BRCA-1,BRCA-2,and DNA mismatch repair abnormalities. PACCs had multiple somatic mutations with some targetable with available drugs. Therefore,molecular profiling of PACC should be an option for patients with refractory PACC. | Ahmad Al-Hader Rami N Al-Rohil Haiyong Han Daniel Von Hoff | 2017 | World Journal of Gastroenterology2017，23，45： | 8 |
| 3 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 4 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 5 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 6 | Microbiome and pancreatic cancer: A comprehensive topic review of literature显示文摘AIM To review microbiome alterations associated with pancreatic cancer, its potential utility in diagnostics, risk assessment, and influence on disease outcomes.METHODS A comprehensive literature review was conducted by allinclusive topic review from PubM ed, MEDLINE, and Web of Science. The last search was performed in October 2016.RESULTS Diverse microbiome alterations exist among several body sites including oral, gut, and pancreatic tissue, in patients with pancreatic cancer compared to healthy populations.CONCLUSION Pilot study successes in non-invasive screening strategies warrant further investigation for future translational application in early diagnostics and learn modifiable risk factors relevant to disease prevention. Pre-clinical investigations exist in other tumor types that suggest microbiome manipulation provides opportunity to favorably transform cancer response to existing treatment protocols and improve survival. | Natalie Ertz-Archambault Paul Keim Daniel Von Hoff | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 7 | Primary prevention of colorectal cancer:Myth or reality?显示文摘Colorectal cancer incidence has been rising strongly in parallel with economic development.In the past few decades,much has been learned about the lifestyle,dietary and medication risk factors for this malignancy.With respect to lifestyle,compelling evidence indicates that prevention of weight gain and maintenance of a reasonable level of physical activity can positively influence in lowering the risk.Although there is controversy about the role of specific nutritional factors,consideration of dietary pattern as a whole appears useful for formulating recommendations.Though quite often recommended,the role for many supplements,including omega-3,vitamin D,folate,and vitamin B6,remains unsettled.Only calcium and vitamin D supplementation appear to add a modest benefit,particularly in those with a low daily intake.With regard to chemoprevention,medications such as aspirin and nonsteroidal antiinflammatory drugs,and postmenopausal hormonal replacement for women might be associated with substantial reductions in colorectal cancer risk,though their utility is affected by their side effect profile.However,the role of agents such as statins,bisphosphonates and antioxidants have yet to be determined.Ultimately,primary prevention strategies focusing on modifying environmental,lifestyle risk factors,and chemopreventive drugs are options that have already been tested,and may impact on colon cancer incidence. | Marcela Crosara Teixeira Maria Ignez Braghiroli Jorge Sabbaga Paulo M Hoff | 2014 | World Journal of Gastroenterology2014，20，41： | 5 |
| 8 | On the Navier-Stokes Equations for Exothermically Reacting Compressible Fluids显示文摘Abstract We analyze mathematical models governing planar flow of chemical reaction from unburnt gasesto burnt gases in certain physical regimes in which diffusive effects such as viscosity and heat conduction aresignificant. These models can be then formulated as the Navier-Stokes equations for exothermically reactingcompressible fluids. We first establish the existence and dynamic behavior, including stability, regularity, andlarge-time behavior, of global discontinuous solutions of large oscillation to the Navier-Stokes equations withconstant adiabatic exponent γ and specific heat C_v. Our approach for the existence and regularity is to combinethe difference approximation techniques with the energy methods, total variation estimates, and weak conver-gence argumeots to deal with large jump discontinuities; and for large-time behavior is an a posteriori argumentdirectly from the weak form of the equations. The approach and ideas we develop here can be applied to solvinga more complicated model where | David Hoff Konstantina Trivisa | 2002 | Acta Mathematicae Applicatae Sinica2002，18，1： | 5 |
| 9 | Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma显示文摘 | Paolo P. Provenzano Carlos Cuevas Amy E. Chang Vikas K. Goel Daniel D. Von Hoff Sunil R. Hingorani | 2012 | Cancer Cell2012，，： | 5 |
| 10 | Mechanisms of brain injury after intracerebral haemorrhage显示文摘 | Guohua Xi Richard F Keep Julian T Hoff | 2006 | Lancet Neurology2006，，1： | 4 |
| 11 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 12 | Development of ^(18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography显示文摘Positron emission tomography(PET)is an in vivo molecular imaging tool which is widely used in nuclear medicine for early diagnosis and treatment follow-up of many brain diseases.PET uses biomolecules as probes which are labeled with radionuclides of short half-lives,synthesized prior to the imaging studies.These probes are called radiotracers.Fluorine-18 is a radionuclide routinely used in the radiolabeling of neuroreceptor ligands for PET because of its favorable half-life of 109.8 min.The delivery of such radiotracers into the brain provides images of transport,metabolic,and neurotransmission processes on the molecular level.After a short introduction into the principles of PET,this review mainly focuses on the strategy of radiotracer development bridging from basic science to biomedical application.Successful radiotracer design as described here provides molecular probes which not only are useful for imaging of human brain diseases,but also allow molecular neuroreceptor imaging studies in various small-animal models of disease,including geneticallyengineered animals.Furthermore,they provide a powerful tool for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets,to investigate pathophysiology,to discover potential drug candidates,and to evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo. | Peter Brust Jrg van den Hoff Jrg Steinbach | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 13 | Morphology and motor function of the gastrointestinal tract examined with endosonography显示文摘Endosonography 是为学习胃肠道的形态学和运动机能的一个有用工具。管腔内 ultrasonography 是用被插入到官方补给的道的体内变换器的超声考试的普通命名。因此,内脏的墙和邻近的结构能详细被想象。这评论在肠胃病学描述 endosonography 的实用性,特别地关于机械的简历和胃肠道的运动机能的研究。象 3-D EUS, elastography 和种类率成像那样的新技术被讨论。 | Svein Odegaard Lars Birger Nesje Dag Arne Lihaug Hoff Odd Helge Gilja Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，18： | 3 |
| 14 | 4种支架构建复合式口腔黏膜的组织学特点显示文摘目的利用4种不同支架材料构建复合式口腔黏膜,并比较其组织结构特点。方法体外培养人口腔黏膜的成纤维细胞和角质形成细胞,在4种支架材料中加入成纤维细胞,培养7d后,在支架表面加入角质形成细胞,培养4d后,移至气-液界面继续培养7d。苏木精-伊红染色镜下观察构建的复合式口腔黏膜的组织形态学特点。结果 4种支架均可构建形成复层上皮。其中,上皮层与脱细胞真皮基质材料(de-epidermised dermis,DED)结合紧密,形成的人工黏膜有明显的上皮钉突。不同于以往报道,上皮层与Alloderm结合并不十分紧密。以胶原凝胶为基质形成的人工口腔黏膜最厚,有明显分层。以胶原海绵-胶原凝胶为基质形成的复层上皮在部分区域长入至胶原海绵的空隙中。结论以DED和胶原凝胶为支架构建的口腔黏膜更接近于天然结构,而后者脆性较大,限制了其临床应用的可能。 | 刘加荣 JW Von den Hoff AM Kuijpers-Jagtman 陈莉莉 | 2011 | 华中科技大学学报(医学版)2011，40，5： | 3 |
| 15 | Behavioral Tests After Intracerebral Hemorrhage in the Rat显示文摘 | Ya Hua Timothy Schallert Richard F. Keep Jimin Wu Julian T. Hoff Guohua Xi | 2002 | Stroke: Journal of the American Heart Association2002，，10： | 3 |
| 16 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 17 | The Deleterious or Beneficial Effects of Different Agents in Intracerebral Hemorrhage: Think Big, Think Small, or Is Hematoma Size Important?显示文摘 | Richard F. Keep Guohua Xi Ya Hua Julian T. Hoff | 2005 | Stroke2005，，7： | 3 |
| 18 | Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model显示文摘骨头骨折愈合的起始的煽动性的阶段为愈合的过程的结果代表关键步。然而,开始这个煽动性的阶段的机制和在破裂地点在场的有免疫力的房间的功能糟糕被理解。以便在破裂 hematoma 以内学习早事件,我们建立了一在里面 vitro 破裂 hematoma 模型:我们有教养的 hematomas 在 bioenergetically 控制的条件下面在 vitro 在全部的新潮的关节造形术(THA ) 期间在腿节的截骨术(人工的骨头破裂) 期间形成。这个模型允许我们在跟随破裂的早阶段期间监视有免疫力的房间人口,房间幸存和 cytokine 表示。而且,这个模型使我们能改变 bioenergetical 条件以便模仿在里面 vivo 状况,它被假定被组织缺氧描绘并且限制了营养素的数量。用这个模型,我们发现有免疫力的房间经由 angiogenic 因素, chemoattractants 和支持 inflammatory 分子的表示适应组织缺氧。另外,联合了氧的限制,滋养的供应与 myeloid 的比较提高了淋巴细胞的选择幸存导出的房间(即, neutrophils ) 。笔记,非限制的 bioenergetical 条件没关于 cytokine 表示或有免疫力的房间子集的不同幸存率显示出任何类似的效果。在结论,我们发现 bioenergetical 条件在导致骨折愈合的起始的煽动性的阶段的关键因素之中并且因此是为在早破裂 hematoma 影响有免疫力的房间的幸存和功能的一个关键步骤。 | Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 19 | Management of borderline resectable pancreatic cancer显示文摘Pancreatic cancer is the fourth most common cause of cancer death in the United States. Surgery remains the only curative option; however only 20% of the patients have resectable disease at the time of initialpresentation. The definition of borderline resectable pancreatic cancer is not uniform but generally denotes to regional vessel involvement that makes it unlikely to have negative surgical margins. The accurate staging of pancreatic cancer requires triple phase computed tomography or magnetic resonance imaging of the pancreas. Management of patients with borderline resectable pancreatic cancer remains unclear. The data for treatment of these patients is primarily derived from retrospective single institution experience. The prospective trials have been plagued by small numbers and poor accrual. Neoadjuvant therapy is recommended and typically consists of chemotherapy and radiation therapy. The chemotherapeutic regimens continue to evolve along with type and dose of radiation therapy. Gemcitabine or 5-fluorouracil based chemotherapeutic combinations are administered. The type and dose of radiation vary among different institutions. With neoadjuvant treatment, approximately 50% of the patients are able to undergo surgical resections with negative margins obtained in greater than 80% of the patients. Newer trials are attempting to standardize the definition of borderline resectable pancreatic cancer and treatment regimens. In this review, we outline the definition, imaging requirements and management of patients with borderline resectable pancreatic cancer. | Amit Mahipal Jessica Frakes Sarah Hoffe Richard Kim | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 3 |
| 20 | The Tegafur-Based Dihydropyrimidine Dehydrogenase Inhibitory Fluoropyrimidines, UFT/Leucovorin (ORZEL and S-1: a Review of Their Clinical Development and Therapeutic Potential显示文摘 | Paulo M. Hoff | 2000 | Investigational New Drugs2000，，4： | 2 |
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