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| 1 | A gist of gastrointestinal stromal tumors: A review显示文摘Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). They constitute the majority of gastrointestinal mesenchymal tumors of the GIT and are known to be refractory to conventional chemotherapy or radiation. They are defined and diagnosed by the expression of a proto-oncogene protein detected by immunohistochemistry which serves as a crucial diagnostic and therapeutic target. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. The remarkable antitumor effects of the molecular inhibitor imatinib have necessitated accurate diagnosis of GIST and their distinction from other gastrointestinal mes-enchymal tumors. Both traditional and minimally invasive surgery are used to remove these tumors with minimal morbidity and excellent perioperative outcomes. The revolutionary use of specific, molecularlytargeted therapies, such as imatinib mesylate, reduces the frequency of disease recurrence when used as an adjuvant following complete resection. Neoadjuvant treatment with these agents appears to stabilize disease in the majority of patients and may reduce the extent of surgical resection required for subsequent complete tumor removal. The important interplay between the molecular genetics of GIST and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumors. This review summarizes our current knowledge and recent advances regarding the histogenesis, pathology, molecular biology, the basis for the novel targeted cancer therapy and current evidence based management of these unique tumors. | Ashwin Rammohan Jeswanth Sathyanesan Kamalakannan Rajendran Anbalagan Pitchaimuthu Senthil-Kumar Perumal UP Srinivasan Ravi Ramasamy Ravichandran Palaniappan Manoharan Govindan | 2013 | World Journal of Gastrointestinal Oncology2013，5，6： | 27 |
| 2 | Study of Bacillus subtilis on growth performance, nutrition metabolism and intestinal microflora of 1 to 42 d broiler chickens显示文摘To study the influence of different levels of Bacillus subtilis on growth performance, nutrition metabolism and intestinal microflora of 1 to 42 d Arbor Acres(AA) broilers, a total of 800 one-day-old healthy broilers were randomly divided into 5 groups with 4 replicates per group and 40 broilers per replicate. Broilers were fed a basic diet(group 1) which acted as the control group, and 4 other groups(2 to 5) were fed the basal diet with B. subtilis added at concentrations of 100, 150, 200 and 250 mg/kg, respectively for 42 days. The results showed as follow: the average daily gain(ADG) of group 4 was significantly higher than(P < 0.05) that of group 1, and the average daily feed intake(ADFI) of group 5 was the highest but the differences between groups were not significant(P > 0.05). The feed to gain ratio(F/G) of all the experimental groups was lower than that of the control and the difference was significant in group 4(P < 0.05). In addition, supplementation of B. subtilis increased the apparent metabolism of crude protein(P > 0.05), crude fat(P > 0.05), dry matter(P > 0.05) and organic matter(P < 0.05). B. subtilis decreased the Escherichia coli and Salmonella populations in the cecum. This shows that adding B. subtilis to the broiler diet can improve the growth performance, increase feed efficiency, regulate serum index and reduce harmful bacteria in the intestinal tract. Based on our study, it could be recommended that addition of B. subtilis at 200 mg/kg could improve the growth performance of broilers. | Zhenhua Gao Haohao Wu Lin Shi Xiaohui Zhang Ran Sheng Fuquan Yin Ravi Gooneratne | 2017 | Animal Nutrition2017，，2： | 23 |
| 3 | Delphi methodology in healthcare research:How to decide its appropriateness显示文摘The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptance in diverse fields of medicine.The Delphi methods assumed a pivotal role in the last few decades to develop best practice guidance using collective intelligence where research is limited,ethically/logistically difficult or evidence is conflicting.However,the attempts to assess the quality standard of Delphi studies have reported significant variance,and details of the process followed are usually unclear.We recommend systematic quality tools for evaluation of Delphi methodology;identification of problem area of research,selection of panel,anonymity of panelists,controlled feedback,iterative Delphi rounds,consensus criteria,analysis of consensus,closing criteria,and stability of the results.Based on these nine qualitative evaluation points,we assessed the quality of Delphi studies in the medical field related to coronavirus disease 2019.There was inconsistency in reporting vital elements of Delphi methods such as identification of panel members,defining consensus,closing criteria for rounds,and presenting the results.We propose our evaluation points for researchers,medical journal editorial boards,and reviewers to evaluate the quality of the Delphi methods in healthcare research. | Prashant Nasa Ravi Jain Deven Juneja | 2021 | World Journal of Methodology2021，11，4： | 21 |
| 4 | Risk assessment of heavy metal contaminated soil in the vicinity of a lead/zinc mine显示文摘Heavy metal contamination of soils through anthropogenic activities is a widespread and serious problem confronting scientists and regulators throughout the world. In this study we investigated the distribution, chemical species and availability of lead, zinc, cadmium and copper in nine surface(0 to 20 cm) soils from near an abandoned lead/zinc mine tailings located in Shaoxing, Zhejiang, China. Total heavy metal contents ranged from 5271 to 16369 mg/kg for Pb, 387 to 1221 mg/kg for Zn, 3.0 to 9.3 mg/kg for Cd and 65 to 206 mg/kg for Cu. In general, all heavy metals exceeded China National Standards for Soil Environmental Quality of Heavy Metals by a factor of 3—65 times. Comparison of the heavy metal concentrations(Pb, Zn, Cd and Cu) with clay content revealed a strongly significant relationship while significant relationship(P<0.001) was also obtained between Cd+Zn and Pb+Cu. Solid phase speciation of the soils using Tessier procedure showed that the heavy metals were distributed in the order: residual organically complexed-Fe-Mn oxides occluded>carbonate bound>exchangeable > water soluble. In the organic matter fraction, the ratio of Pb(29.1%) to its total concentration in the soils was higher than those of Zn(4.70%), Cd(3.16%) and Cu(9.50%). The percentages of the water soluble and the exchangeable fractions of Pb(1.80%) and Cd(2.74%) were markedly greater than those of Zn(0.10%) and Cu(0.15%), suggesting that Pb and Cd are relatively more mobile and hence more toxic in the contaminated soils. Strongly significant relationships between H2O-Pb, H2O-Zn and H2O-Cu, strong positive correlations between H2O-Pb, H2O-Zn, H2O-Cu and organic matter in soil were found. The content of H2O-Pb, H2O-Zn, H2O-Cu was negatively correlated with pH values. The similar negative relationships between pH values and exchangeable heavy metals were also recorded. It is suggested that increasing soil pH or liming the soil could decrease bioavailability of heavy metals in the soil. | LI Jing XIE Zheng-miao ZHU Yong-guan Ravi Naidu | 2005 | Journal of Environmental Sciences2005，17，6： | 19 |
| 5 | Nutritional support in chronic liver disease and cirrhotics显示文摘The liver is a major organ and an essential componentin maintaining an appropriate nutritional status in healthy individuals through metabolism of protein, carbohydrates, and fat. In individuals with chronic liver disease(CLD), along with a number of other essen-tial functions that the liver serves, its role in nutrition maintenance is severely impaired. Common causes of CLD include hepatitis C, alcoholic liver disease, and non-alcoholic liver disease. Amongst this population, the most common manifestation of impaired nutritional maintenance is protein-calorie malnutrition. Aside from inherent abnormalities in metabolism, such as malab-sorption and maldigestion, CLD can be associated with anorexia as well as increased metabolic requirements, all of which contribute to a state of malnutrition. Given the systemic implications and impact on prognosis of malnutrition, proper nutritional assessment is essential and can be achieved through a thorough history and physical, as well as biochemical investigations and anthropometry as needed. Following an appropriate assessment of a patient's nutritional status, an approach to management can be decided upon and is based on the extent of malnutrition which directly reflects the severity of disease. Management options can be grossly separated into enteral and parenteral nutrition. The former is usually sufficient in the form of oral supplements in less severe cases of malnutrition, but as the CLD worsens, parenteral nutrition becomes necessary. With appropriate assessment and early intervention, many of the complications of CLD can be avoided, and ultimately better outcomes can be achieved. | Ravi Shergill Wajahat Syed Syed Ali Rizvi Ikjot Singh | 2018 | World Journal of Hepatology2018，10，10： | 17 |
| 6 | CIMMYT种质及育种技术在四川小麦品种改良中的利用显示文摘1966年,第一份CIMMYT育成小麦品种Penjamo 62引入四川,1989年中国和CIMMYT签订小麦穿梭合作育种协议、四川被指定为我国3个春麦穿梭点之一。之后,四川开始较为系统地利用CIMMYT种质和育种新技术,以提高四川小麦育种水平,加速四川小麦新品种选育步伐。在这一漫长过程中,我们深刻体会到,CIMMYT真正对四川小麦育种最具影响力的是三个方面:引进有用种质;提供育种新技术和新思路;科学家交流及对青年专家的培训。如何才能在四川小麦育种中充分发挥和有效利用CIM-MYT的这些优势去提高四川小麦的育种水平?我们的基本做法是:加大CIMMYT种质在四川生态下的筛选力度;以我院原有小麦育种项目及积累的育种材料为基础,有针对性地选择冬春杂交、穿梭育种、改良混合选择和微效多基因持久抗性等CIMMYT育种新技术及新思路,结合已较为成熟的DH群体及重组自交系群体等分子技术,构建新的育种体系;由于生态条件的巨大差异,坚持以引进改良、自育创新为主,CIMMYT/四川//四川及冬/春//春已证明是利用CIMMYT种质资源较好的杂交模式;以熟悉四川育种及CIMMYT育种的专家及在CIMMYT接受过培训的青年专家为核心,组成目标明确、分工合作的育种及科研团队,并坚持不懈,是成功利用CIMMYT种质及技术的基础;加大双方科学家互访及对青年科学家的培训力度和信息资料的及时交流,增进双方科学家对对方育种理念、生态环境、育种资源、技术经验以及育种材料的田间长相等的更深刻认识和体验,从而增强双方工作的针对性与互动性,这是有效利用CIMMYT种质及技术经验的成功保证。截至2006年,选用CIMMYT种质由四川育种家育成的小麦新品种已达19个,其中有3个还通过了国家品种审定,一个是世界上首次利用CIMMYT人工合成种育成的商用小麦新品种。这批新品种在四川表现出三方面的突出优势:为四川输入了一批条锈病新抗源;使四川首次在强筋小麦育种上获得突破;打破了四川小麦育种单产水平长期徘徊的局面,创造了四川小麦高产育种新水平;预期在近几年内,将有更多用CIMMYT种质育成的小麦新品种在四川审定推广。这表明,CIMMYT小麦种质及育种新技术已成为四川小麦品种改良与创新中不可或缺的重要因素。广适应型高产育种材料及品种的创制与遗传机理研究(可用川麦42为基础)、条锈病持久抗性材料及品种研制与新抗源筛选转育(以现有持久抗性和四川核心资源为基础)、四川生态下优质稳定表达材料的筛选转育以及高产优质的节约环保型简化栽培体系开发,将是四川与CIMMYT进一步深化合作的主要技术方向,而继续强化对青年专家的培训和科学家间加强专项合作及对现场交流、指导,将是进一步取得成功与成果的重要保证。 | 邹裕春 杨武云 朱华忠 杨恩年 蒲宗君 伍铃 张颙 汤永禄 黄钢 李跃建 何中虎 Ravi Singh S.Rajaram | 2007 | 西南农业学报2007，20，2： | 15 |
| 7 | Approach to pseudomyxoma peritonei显示文摘Pseudomyxoma peritonei(PMP) is a mucinous tumour of the appendix that spreads into the peritoneal cavity in the form of gelatinous deposits. The incidence of PMP is believed to be approximately 1-3 out of a million per year. Nonetheless, due to its indolent nature, it is usually discovered at an advanced stage and severely impacts quality of life. Curative treatment for PMP is complete cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC). An extensive literature review was conducted searching EMBASE, MEDLINE, Pub Med, and Google Scholar databases for PMP in aims to delineate a clinical approach to diagnosis and treatment. Literature was limited to the years 2007-2018. We found the 5-year overall survival with CRS and HIPEC estimated to be between 23%-82% and rates of major complications as high as 24%. Therefore, it is important to appropriately stage and select patients that should undergo CRS with HIPEC. Modalities like MDCT radiological scores have been shown to have sensitivity and specificity of 94% and 81%, respectively, in being able to predict resectability and survival. Despite treatment, the disease often recurs. Tumor markers have significant potential for establishing prognosis preoperatively, and this paper will review the most recent evidence in support of them. | Syed Ali Rizvi Wajahat Syed Ravi Shergill | 2018 | World Journal of Gastrointestinal Surgery2018，10，5： | 15 |
| 8 | Environmental application and ecological significance of nano-zero valent iron显示文摘Toxicity studies considering both the bare and stabilized forms of zero valent iron nanoparticles(nZVI) could be timely, given that ecological risks identified are minimized through modification or with substitution of approaches in the synthesis, development and environmental application of the nanoparticles before succeeding to volume production.This review is focused on the fate, transport and toxicological implications of the bare nZVI and surface modified particles used for environmental applications. | Biruck D.Yirsaw Mallavarapu Megharaj Zuliang Chen Ravi Naidu | 2016 | Journal of Environmental Sciences2016，28，6： | 13 |
| 9 | Role of Helicobacter pylori in gastric cancer:Updates显示文摘Helicobacter pylori(H. pylori) infection is highly prevalent in human,affecting nearly half of the world's population; however,infection remains asymptomatic in majority of population. During its co-existence with humans,H. pylori has evolved various strategies to maintain a mild gastritis and limit the immune response of host. On the other side,presence of H.pylori is also associated with increased risk for the development of various gastric pathologies including gastric cancer(GC). A complex combination of host genetics,environmental agents,and bacterial virulence factors are considered to determine the susceptibility as well as the severity of outcome in a subset of individuals. GC is one of the most common cancers and considered as the third most common cause of cancer related death worldwide. Many studies had proved H. pylori as an important risk factor in the development of non-cardia GC. Although both H. pylori infection and GC are showing decreasing trends in the developed world,they still remain a major threat to human population in the developing countries. The current review attempts to highlight recent progress in the field of research on H. pylori induced GC and aims to provide brief insight into H. pylori pathogenesis,the role of major virulence factors of H. pylori that modulates the host environment and transform the normal gastric epithelium to neoplastic one. This review also emphasizes on the mechanistic understanding of how colonization and various virulence attributes of H. pylori as well as the host innate and adaptive immune responses modulate the diverse signaling pathways that leads to different disease outcomes including GC. | Jahanarah Khatoon Ravi Prakash Rai Kashi Nath Prasad | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 13 |
| 10 | Role of Akt signaling in resistance to DNA-targeted therapy显示文摘The Akt signal transduction pathway controls most hallmarks of cancer. Activation of the Akt cascade promotes a malignant phenotype and is also widely implicated in drug resistance. Therefore, the modulation of Akt activity is regarded as an attractive strategy to enhance the efficacy of cancer therapy and irradiation. This pathway consists of phosphatidylinositol 3 kinase(PI3K), mammalian target of rapamycin, and the transforming serine-threonine kinase Akt protein isoforms, also known as protein kinase B. DNA-targeted agents, such as platinum agents, taxanes, and antimetabolites, as well as radiation have had a significant impact on cancer treatment by affecting DNA replication, which is aberrantly activated in malignancies. However, the caveat is that they may also trigger the activation of repairing mechanisms, such as upstream and downstream cascade of Akt survival pathway. Thus, each target can theoretically be inhibited in view of improving the potency of conventional treatment. Akt inhibitors, e.g., MK-2206 and perifosine, or PI3K modulators, e.g., LY294002 and Wortmannin, have shown some promising results in favor of sensitizing the cancer cells to the therapy in vitro and in vivo, which have provided the rationale for incorporation of these novel agents into multimodality treatment of different malignancies. Nevertheless, despite the acceptable safety profile of some of these agents in the clinical studies, with regard to the efficacy, the results are still too preliminary. Hence, we need to wait for the upcoming data from the ongoing trials before utilizing them into the standard care of cancer patients. | Abolfazl Avan Ravi Narayan Elisa Giovannetti Godefridus J Peters | 2016 | World Journal of Clinical Oncology2016，7，5： | 12 |
| 11 | Embolization of liver tumors:Past,present and future显示文摘Curative therapies for hepatocellular carcinoma(HCC),such as resection and liver transplantation,can only be applied in selected patients with early tumors.More advanced stages require local or systemic therapies.Resection of HCC offers the only hope for cure.Even in patients undergoing resection,recurrences are common.Chemoembolization,a technique combining intraarterial chemotherapy with selective tumor ischemia,has been shown by randomized controlled trials to be efficacious in the palliative setting.There is now renewed interest in transarterial embolization/transarterial chemoembolization(TACE) with regards to its use as a palliative tool in a combined modality approach,as a neoadjuvant therapy,in bridging therapy before transplantation,for symptomatic indications,and even as an alternative to resection.There have also been rapid advances in the agents being embolized trans-arterially(genes,biological response modifiers,etc.).The current review provides an evidence-based overview of the past,present and future trends of TACE in patients with HCC. | Ashwin Rammohan Jeswanth Sathyanesan Sukumar Ramaswami Anand Lakshmanan Perumal Senthil-Kumar Ulagendra Perumal Srinivasan Ravi Ramasamy Palaniappan Ravichandran | 2012 | World Journal of Radiology2012，4，9： | 11 |
| 12 | Frozen shoulder-A prospective randomized clinical trial显示文摘AIM To compare the results of arthroscopic capsular release with intra-articular steroid injections in patients of frozen shoulder.METHODS Fifty-six patients with frozen shoulder were randomised to one of two treatment groups: Group 1, complete 360 degree arthroscopic capsular release and group 2, intra-articular corticosteroid injection(40 mg methyl prednisolone acetate). Both groups were put on active and passive range of motion exercises following the intervention. The outcome parameters were visual analogue scale(VAS) score for pain, range of motion and Constant score which were measured at baseline, 4, 8, 12, 16 and 20 wk after intervention.RESULTS All the parameters improved in both the groups. The mean VAS score improved significantly more in the group 1 as compared to group 2 at 8 wk. This greater improvement was maintained at 20 wk with P value of 0.007 at 8 wk, 0.006 at 12 wk, 0.006 at 16 wk and 0.019 at 20 wk. The Constant score showed a more significant improvement in group 1 compared to group 2 at 4 wk, which was again maintained at 20 wk with P value of 0.01 at 4, 8, 12 and 16 wk. The gain in abduction movement was statistically significantly more in arthroscopy group with P value of 0.001 at 4, 8, 12, 16 wk and 0.005 at 20 wk. The gain in external rotation was statistically significantly more in arthroscopy group with P value of 0.007 at 4 wk, 0.001 at 8, 12, and 16 wk and 0.003 at 20 wk. There was no statistically significant difference in extension and internal rotation between the two groups at any time. CONCLUSION Arthroscopic capsular release provides subjective and objective improvement earlier than intra-articular steroid injection. | Rudra Narayan Mukherjee R M Pandey Hira Lal Nag Ravi Mittal | 2017 | World Journal of Orthopedics2017，8，5： | 11 |
| 13 | Mercury remediation potential of a mercury resistant strain Sphingopyxis sp.SE2 isolated from contaminated soil显示文摘A mercury resistant bacterial strain SE2 was isolated from contaminated soil.The 16 s rRNA gene sequencing confirms the strain as Sphingopyxis belongs to the Sphingomonadaceae family of the α-Proteobacteria group.The isolate showed high resistance to mercury with estimated concentrations of Hg that caused 50%reduction in growth(EC_(50)) of 5.97 and 6.22 mg/L and minimum inhibitory concentrations(MICs) of 32.19 and 34.95 mg/L in minimal and rich media,respectively.The qualitative detection of volatilized mercury and the presence of mercuric reductase enzyme proved that the strain SE2 can potentially remediate mercury.ICP-QQQ-MS analysis of the remaining mercury in experimental broths indicated that a maximum of 44%mercury was volatilized within 6 hr by live SE2 culture.Furthermore a small quantity(23%) of mercury was accumulated in live cell pellets.While no volatilization was caused by dead cells,sorption of mercury was confirmed.The mercuric reductase gene merA was amplified and sequenced.Homology was observed among the amino acid sequences of mercuric reductase enzyme of different organisms from a-Proteobacteria and ascomycota groups, | Khandaker Rayhan Mahbub Kannan Krishnan Ravi Naidu Mallavarapu Megharaj | 2017 | Journal of Environmental Sciences2017，29，1： | 10 |
| 14 | Size Distributions of Aerosol Sulfates and Nitrates in Beijing during the 2008 Olympic Games: Impacts of Pollution Control Measures and Regional Transport显示文摘为 2008 个奥运会,激烈的控制措施在二氧化物(SO2 ) ,氮氧化物(没有 x ) 和处理穷人的问题的另外的污染物质通风的硫的工业、城市的排出物上被实现在北京的质量。在微粒硫酸盐和硝酸盐集中以及他们的尺寸分布上调查 SO2 和没有 x 减小的效果,分离尺寸的喷雾器样品在照原尺寸的控制前后在北京在城市、顺风的农村地点用微孔的一致存款 impactors (MOUDI ) 被收集。在采样时期期间,在城市、农村的地点的好粒子(PM1.8 ) 的集体集中分别地是 94.0 和 85.9 g m3。超过 90% 硫酸盐和 60% 硝酸盐形成了同样好的粒子。得益于有益的气象学的条件和来源控制,硫酸盐在奥林匹克期间在相当低的集中并且首先在冷凝作用模式被观察。控制措施的效果独立被分析让北风和南方的 air-mass-dominated 天说明任何偏爱。在控制措施被实现以后,当在北方的空气群众占优势时,下午,硫酸盐,和硝酸盐显著地被减少,与在更大的粒子的减小的一个更高的百分比。在控制措施被实现以后,微滴模式粒子,在控制被实现以前,统治了硫酸盐和硝酸盐,显著地在集体集中被减少。但当弄脏的南方的空气群众占优势时,本地来源控制在北京测量,有效地没从北方中国平原由于庞大的地区性的贡献减少周围的硫酸盐集中。 | WANG Xinfeng WANG Tao Ravi Kant PATHAK Mattias HALLQUIST GAO Xiaomeit NIE Wei XUE Likun GAO Jian GAO Rui ZHANG Qingzhu WANG Wenxing WANG Shulan CHAI Fahe CHEN Yizhen | 2013 | Advances in Atmospheric Sciences2013，30，2： | 8 |
| 15 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 16 | Computer aided design and analysis of a tunable muzzle brake显示文摘This research work deals with the design of a tunable muzzle brake [10] for a rifle chambered in 5.56 x 45 NATO ammunition. It proposes to solve the problem of handling differences from shooter to shooter by incorporating the feature of tunability. Beside this, it also solves the problem of requirement of optimum recoil in short recoil weapons. This innovation gives this design an edge over its already existing counterparts in the market. The product is designed using the internal ballistics calculations and the investigations been performed using solidworks flow simulation tool and ANSYS static structural to check the parameters like velocity distribution, pressure growth, and muzzle brake force along the series of ports and comparison of the so found results with those devised by the authors of the documents mentioned in references. This assures the market adaptability of the product for satisfactory performance, when brought among its already existing counterpart, though with a slight edge over them due to tunability. The results so found shall be concluded satisfactory regarding the performance of muzzle brake. | Ekansh Chaturvedi Ravi K.Dwivedi | 2019 | Defence Technology(防务技术)2019，15，1： | 8 |
| 17 | Simultaneous determination of telmisartan and amlodipine in human plasma by LC-MS/MS and its application in a human pharmacokinetic study显示文摘A rapid and sensitive liquid chromatography-tandem mass spectrometric(LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of telmisartan and amlodipine in human plasma.Carbamazepine was used as an internal standard.Analytes and the internal standard were extracted from human plasma by solid-phase extraction technique using Waters Oasis HLB 1 cm 3(30 mg) extraction cartridge.The reconstituted samples were chromatographed on a Hypurity advance C 18 column(50 mm×4.6 mm,5 μm) using a mixture of acetonitrile-5 mM ammonium acetate buffer(pH-4.0)(50:50,v/v) as the mobile phase at a flow rate of 0.8 mL/min.The calibration curve obtained was linear(r≥0.99) over the concentration range of 2.01-400.06 ng/mL for telmisartan and 0.05-10.01 ng/mL for amlodipine.Method validation was performed as per FDA guidelines and the results met the acceptance criteria.A run time of 2.5 min for each sample made it possible to analyze more than 400 human plasma samples per day.The proposed method was found to be applicable to clinical studies. | Vasu Babu Ravi Jaswanth Kumar Inamadugu Nageswara Rao Pilli Vudagandla Sreenivasulu Venkateswarlu Ponneri | 2012 | Journal of Pharmaceutical Analysis2012，2，5： | 8 |
| 18 | Genetics of acute and chronic pancreatitis: An update显示文摘Progress made in identifying the genetic susceptibility underlying acute and chronic pancreatitis has benefitted the clinicians in understanding the pathogenesis of the disease in a better way. The identification of mutations in cationic trypsinogen gene(PRSS1 gene; functional gain mutations) and serine protease inhibitor kazal type 1(SPINK1 gene; functional loss mutations) and other potential susceptibility factors in genes that play an important role in the pancreatic secretory functions or response to inflammation during pancreatic injury has changed the current concepts and understanding of a complex multifactorial disease like pancreatitis. An indi-vidual's susceptibility to the disease is governed by ge-netic factors in combination with environmental factors. Candidate gene and genetic linkage studies have iden-tified polymorphisms in cationic trypsinogen(PRSS1), SPINK1, cystic fibrosis trans-membrane conductance regulator(CFTR), Chymotrypsinogen C(CTRC), Ca-thepsin B(CTSB) and calcium sensing receptor(CASR). Individuals with polymorphisms in the mentioned genes and other as yet identified genes are at an enhanced risk for the disease. Recently, polymorphisms in genes other than those involved in 'intra-pancreatic trypsin regulatory mechanism' namely Claudin-2(CLDN2) andCarboxypeptidase A1(CPA1) gene have also been iden-tified for their association with pancreatitis. With ever growing number of studies trying to identify the genetic susceptibility in the form of single nucleotide polymor-phisms, this review is an attempt to compile the avail-able information on the topic. | VV Ravi Kanth D Nageshwar Reddy | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 7 |
| 19 | X射线荧光光谱法和X射线衍射技术在钢铁工业中的最新进展:化学分析与相分析的结合显示文摘为满足钢铁工业分析的需要,X射线分析技术取得了创新发展。钢铁冶炼过程不但要求全元素/氧化物的分析,还要求在不同阶段进行相分析。X射线荧光光谱法(XRF)已作为常规方法应用于钢铁工业中的化学分析,而X射线衍射(XRD)的应用则受到限制。通过与钢铁生产者进行紧密合作,将XRD完全与XRF相结合,为进行完全的过程控制和质量控制的相关实验室提供全面的分析能力,这种在科技上取得的突破性进展满足了行业需要。事实上,从铁矿石到烧结矿、炉渣、铸铁和各种合金,XRF-XRD综合系统能够提供完整的化学及相分析,以优化并提高高炉/炼钢炉生产过程的效率。该种方法也适合生产直接还原铁的厂商使用,可对混有金属铁的不同状态的氧化铁及其它混合物/相进行常规定量分析。波长色散X射线荧光(WDXRF)领域已经取得重大进展,钢铁工业能够完全自主地完成特定的分析任务。例如,分析炉渣、铸铁、铁合金以及电镀或电解后的镀层厚度,就只需利用低成本的WDXRF系统来解决。根据分析量以及不同元素的测定要求,设计了从低功耗到高功耗的一系列XRF系统来进行定量分析,所有的'已知'材料都可采用专用的校准程序进行分析。本文还将介绍各种不同的XRF和XRD方案,重点是其应用和分析方法;XRF和XRD二者作为钢铁工业中有价值的分析工具,本文将讨论其不同的应用实例。 | Didier Bonvin Ravi Yellepeddi | 2009 | 冶金分析2009，29，12： | 7 |
| 20 | 新加坡SUT公司用抗污染反渗透膜成功回收废水显示文摘新加坡政府运用抗污染(FoulingResistant)反渗透膜技术建立起一个全球最大(1248m3/h)的工业及市政污水回用工厂。该系统设计具有坚实的试验基础,独具匠心,运行效果良好。本文旨在分享该项目的成功经验。 | 曾宏伟 Eu Hong Gay C Ravi Kai-Uwe Hoehn | 2003 | 水处理技术2003，29，2： | 7 |
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