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| 1 | Plasmonic nanostructure design and characterization via Deep Learning显示文摘Nanophotonics,the field that merges photonics and nanotechnology,has in recent years revolutionized the field of optics by enabling the manipulation of light–matter interactions with subwavelength structures.However,despite the many advances in this field,the design,fabrication and characterization has remained widely an iterative process in which the designer guesses a structure and solves the Maxwell’s equations for it.In contrast,the inverse problem,i.e.,obtaining a geometry for a desired electromagnetic response,remains a challenging and time-consuming task within the boundaries of very specific assumptions.Here,we experimentally demonstrate that a novel Deep Neural Network trained with thousands of synthetic experiments is not only able to retrieve subwavelength dimensions from solely farfield measurements but is also capable of directly addressing the inverse problem.Our approach allows the rapid design and characterization of metasurface-based optical elements as well as optimal nanostructures for targeted chemicals and biomolecules,which are critical for sensing,imaging and integrated spectroscopy applications. | Itzik Malkiel Michael Mrejen Achiya Nagler Uri Arieli Lior Wolf Haim Suchowski | 2018 | Light(Science & Applications)2018，7，1： | 25 |
| 2 | Worldwide spread of the Ponseti method for clubfoot显示文摘The Ponseti method has become the gold standard for the treatment of idiopathic clubfoot. Its safety and efficacy has been demonstrated extensively in the literature, leading to increased use around the world over the last two decades. This has been demonstrated by the increase in Ponseti related Pub Med publications from many countries. We found evidence of Ponseti activity in 113 of 193 United Nations members. The contribution of many organizations which provide resources to healthcare practitioners in low and middle income countries, as well as Ponseti champions and modern communication technology, have helped to spread the Ponseti method around the world. Despite this, there are many countries where the Ponseti method is not being used, as well as many large countries in which the extent of activity is unknown. With its low rate of complication, low cost, and high effectiveness,this method has unlimited potential to treat clubfoot in both developed and undeveloped countries. Our listing of countries who have not yet shown presence of Ponseti activity will help non-governmental organizations to target those countries which still need the most help. | Lior Shabtai Stacy C Specht John E Herzenberg | 2014 | World Journal of Orthopedics2014，5，5： | 7 |
| 3 | The Arabidopsis Cysteine-Rich GASA5 Is a Redox-Active Metalloprotein that Suppresses Gibberellin Responses显示文摘Dear Editor, The plant-specific GIBBERELLIN (GA)-STIMULATED TRANSCRIPT 1 (GAST1)-like genes have been identified in numerous plant species and many of them are regulated by the phytohormone GA.All encode small proteins with a conserved cysteine-rich C-terminus,containing 12 cysteines in conserved positions.The fact that the number and positions of all 12 cysteines have not changed during the course of evolution strongly implies fundamental and important biochemical and biological functions.Although many of these genes were characterized,and different biological functions were suggested,almost nothing is known about their mode of action.We previously showed that the petunia GAST1-like GA INDUCED 2 (GIP2) and its Arabidopsis homolog GA STIMULATED 4 (GASA4) promote typical GA responses and have redox activity (Wigoda et al.,2006;Rubinovich and Weiss,2010).Mutated GASA4,in which four conserved cysteines were replaced by alanines,lost its redox activity and the ability to promote GA responses,suggesting that the two functions are linked (Rubinovich and Weiss,2010). | Lior Rubinovich Sharon Ruthstein David Weiss | 2014 | Molecular Plant2014，7，1： | 6 |
| 4 | Antiviral therapy in cytomegalovirus-positive ulcerative colitis:A systematic review and meta-analysis显示文摘AIM:To evaluate the impact of antiviral treatment on cytomegalovirus(CMV)-positive ulcerative colitis patients.METHODS:We performed a systematic review and meta-analysis(MA)of comparative cohort and casecontrol studies published between January 1966 and March 2013.Studies focusing on colectomy series and studies including only less than 3 patients in the treated or non-treated arm were excluded.The primary outcome was colectomy within 30 d of diagnosis.Secondary outcomes included colectomy during the follow-up period Subgroup analyses by method of detection of CMV,study design,risk of bias and country of origin were performed.Quality of studies was evalu-ated according to modified New-Castle Ottawa Scale.RESULTS:After full-text review,nine studies with a total of 176 patients were included in our MA.All the included studies were of low to moderate quality.Patients who have received antiviral treatment had a higher risk of 30-d colectomy(OR=2.40;95%CI:1.05-5.50;I2=37.2%).A subgroup analysis including only patients in whom CMV diagnosis was based did not demonstrate a significant difference between the groups(OR=3.41;95%CI:0.39-29.83;I2=56.9%).Analysis of long-term colectomy rates was possible for 6 studies including110 patients.No statistically significant difference was found between the treated and untreated groups(OR=1.71;95%CI:0.71-4.13;6 studies,I2=0%).Analysis of mortality rate was not possible due to a very limited number of cases.Stratification of the outcomes by disease severity was not possible.CONCLUSION:No positive association between antiviral treatment and a favorable outcome was demonstrated.These findings should be interpreted cautiously due to primary studies’quality and potential biases. | Uri Kopylov Noa Eliakim-Raz Andrew Szilagy Ernest Seidman Shomron Ben-Horin Lior Katz | 2014 | World Journal of Gastroenterology2014，20，10： | 4 |
| 5 | Adherence to acne treatment guidelines in the military environment-a descriptive,serial cross-sectional study显示文摘Background:Acne vulgaris,a common skin disease,affects up to 80% of the population.Moderate to severe acne requires treatment with a combination of topical and oral drugs such as antibiotics,hormones and retinoids.Retinoids have many contraindications and adverse effects requiring close monitoring.The study's objectives were to describe prescribing trends in acne medication over time in a military setting,and assess physician adherence to guidelines for acne treatment,including drug precautions,clinical monitoring,and treatment progression.Methods:We conducted a descriptive,serial cross-sectional study of acne drugs prescribed in the Israel Defense Forces(IDF) in the years 2002–2007,analyzing the classes of drugs prescribed and patient characteristics.In addition,the clinical quality of the medical encounter was assessed by examining physician adherence to IDF guidelines.Results:Between 2002 and 2007,64,281 patients were treated for acne.Treatment courses generally persisted for 1–2 months.Over 70% of female patients receiving oral retinoids were not concomitantly receiving oral contraceptives.Conclusions:This study provides a unique perspective of acne treatment in a military setting,overall displaying good adherence to general guidelines.The common prescription of oral retinoids to young females without concomitant contraception is alarming. | Chen Fleischmann Lior Cohen Elimelech Adams Michael Hartal | 2016 | Journal of Medical Colleges of PLA(China)2016，31，1： | 3 |
| 6 | Preventive treatment of alveolar pulmonary edema of cardiogenic origin显示文摘Objective To evaluate the efficacy of preventive treatment (PT) on alveolar pulmonary edema (APE) of cardiogenic origin using a monitor based on principles of internal thoracic impedance (ITI) measurements.Methods We conducted blinded clinical trials on patients with ST-elevation myocardial infarction (STEMI) and monitored whether the condition would progress to APE. ITI was measured noninvasively by the Edema Guard Monitor (EGM, model RS-207) every 30 min. The measurement threshold for the diagnosis of APE was fixed at > 12% decrease in ITI from baseline as described in our methodology. The patients were divided into one group that received standard treatment after the appearance of clinical signs of APE without considering the prediction of APE by EGM devise (Group 1), and another group of asymptomatic patients in whom development of APE was predicted by using only EGM measurements (Group 2). The latter participants’PT consisted of furosemide, intravenous nitroglycerine and supplemental oxygen. Results One-hundred and fifty patients with acute STEMI were enrolled into this study. Group 1 included 100 patients (53% males, age 64.1 ±12.6 years). Treatment was started after the clinical appearance of overt signs of APE. Group 2 included 50 patients (54% males, age 65.2 ±11.9 years) who received PT based on EGMmeasurements. Group 2 had significantly fewer cases of APE (n = 4, 8%) than Group 1 (n = 100, 100%) (P > 0.001). While APE was lethal in six (6%) Group 1 patients, PT resulted in prompt resolution of APE in all four (8%) Group 2 patients. Conclusion ITI is a usefulmodality for early diagnosis and PT of pulmonary edema of cardiogenic origin. | Gideon Charach Michael Shochat Alexander Rabinovich Oded Ayzenberg Jacob George Lior Charach Pavel Rabinovich | 2012 | Journal of Geriatric Cardiology2012，9，4： | 3 |
| 7 | ConfDTree: A Statistical Method for Improving Decision Trees显示文摘Decision trees have three main disadvantages: reduced performance when the training set is small; rigid decision criteria; and the fact that a single 'uncharacteristic' attribute might 'derail' the classification process. In this paper we present ConfDTree(Confidence-Based Decision Tree) — a post-processing method that enables decision trees to better classify outlier instances. This method, which can be applied to any decision tree algorithm, uses easy-to-implement statistical methods(confidence intervals and two-proportion tests) in order to identify hard-to-classify instances and to propose alternative routes. The experimental study indicates that the proposed post-processing method consistently and significantly improves the predictive performance of decision trees, particularly for small, imbalanced or multi-class datasets in which an average improvement of 5%~9% in the AUC performance is reported. | Gilad Katz Asaf Shabtai Lior Rokach Nir Ofek | 2014 | Journal of Computer Science & Technology2014，29，3： | 3 |
| 8 | 在长期的心失败的氧化反的低密度的脂蛋白抗体显示文摘 Oxidative stress may play a significant role in the pathogenesis of heart failure(HF).Antibodies to oxidized low-density lipoprotein(oxLDL Abs) reflect an immune response to LDL over a prolonged period and may represent long-term oxidative stress in HF.The oxLDL plasma level is a useful predictor of mortality in HF patients,and measurement of the oxLDL Abs level may allow better management of those patients.Antibodies to oxLDL also significantly correlate with the New York Heart Association score.Hypercholesterolemia,smoking,hypertension,and obesity are risk factors for atherosclerotic coronary heart disease(CHD) leading to HF,but these factors account for only onehalf of all cases,and understanding of the pathologic process underlying HF remains incomplete.Nutrients with antioxidant properties can reduce the susceptibility of LDL to oxidation.Antioxidant therapy may be an adjunct to lipid-lowering,angiotensin converting enzyme inhibition and metformin(in diabetes) therapy for the greatest impact on CHD and HF.Observational data suggest a protective effect of antioxidant supple-mentation on the incidence of HD.This review summarizes the data on oxLDL Abs as a predictor of morbidity and mortality in HF patients. | Gideon Charach Alexander Rabinovich Ori Argov Moshe Weintraub Lior Charach Oded Ayzenberg Jacob George | 2012 | World Journal of Cardiology2012，4，11： | 2 |
| 9 | Attention deficit hyperactivity disorder and gastrointestinal morbidity in a large cohort of young adults显示文摘BACKGROUND Although the association of attention deficit hyperactivity disorder(ADHD)with psychiatric disorders is well known,its association with somatic diseases is unclear.Only few studies have investigated the gastrointestinal(GI)morbidity in adult patients with ADHD.AIM To measure gastrointestinal comorbidity and its burden on healthcare in young adults with ADHD.METHODS The cohort included subjects aged 17-35 years recruited to the Israel Defense Forces in 2007-2013,33380 with ADHD and 355652 without(controls).The groups were compared for functional and inflammatory conditions of the gastrointestinal tract and clinic and specialist visits for gastrointestinal symptoms/disease during service(to 2016).Findings were analyzed by generalized linear models adjusted for background variables.RESULTS Compared to controls,the ADHD group had more diagnoses of functional gastrointestinal disorders(referred to as FGID),namely,dyspepsia[odds ratio(OR):1.48,95%confidence interval(CI):1.40-1.57,P<0.001],chronic constipation(OR:1.64,95%CI:1.48-1.81,P<0.001),and irritable bowel syndrome(OR:1.67,95%CI:1.56-1.80,P<0.001)but not of organic disorders(inflammatory bowel disease,celiac disease).They had more frequent primary care visits for gastrointestinal symptoms[rate ratio(RR):1.25,95%CI:1.24-1.26,P<0.001]and referrals to gastrointestinal specialists(RR:1.96,95%CI:1.88-2.03,P<0.001)and more episodes of recurrent gastrointestinal symptoms(RR:1.29,95%CI:1.21-1.38,P<0.001).Methylphenidate use increased the risk of dyspepsia(OR:1.49,95%CI:1.28-1.73,P<0.001)and constipation(OR:1.42,95%CI:1.09-1.84,P=0.009).CONCLUSION ADHD in young adults is associated with an excess of FGID and increased use of related health services.Research is needed to determine if an integrative approach treating both conditions will benefit these patients and cut costs. | Sivan Kedem Shlomit Yust-Katz Dan Carter Zohar Levi Ron Kedem Adi Dickstein Salah Daher Lior H Katz | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 10 | Absorption of protein via the intestinal wall 显示文摘 | Ziv E Lior O Kidron M | 1987 | Biochem Pharm1987，36，7： | 1 |
| 11 | Some critical transition in pool flash evapora- tion 显示文摘 | Kim J Lior N | 1997 | International Journal of Heat and Mass Trans- fer1997，40，10： | 1 |
| 12 | Proposal and analysis of a high - efficiency combined desalination and refrigeration system based on the LiBr - H20 absorption cycle---Part 1: System configuration and mathematical mode 显示文摘 | WANG Y LIOR N | 2011 | Energy Conversion and Management2011，52，1： | 1 |
| 13 | Development of a Novel Combined Ab- sorption Cycle for Power Generation and Refrigeration 显示文摘 | ZHANG N Lior N | 2007 | Transactions of the ASME Journal of Energy Resources Technology2007，129，： | 1 |
| 14 | Jet Impingement Heat Transfer:Physics, Correlations, and Numerical Modeling显示文摘 | ZUCKERMAN N LIOR N | 2006 | Advances in Heat Transfer2006，39，6： | 1 |
| 15 | Performance analysis of combined humidified gas turbine power generation and multi -effect thermal vapor compression desalination systems -- Part 1 : The desalination unit and its combination with a steam - injected gas turbine power system 显示文摘 | WANG Y LIOR N | 2006 | Desalination2006，196，13： | 1 |
| 16 | Methodology for Thermal Design of Novel Combined Refrigeration/Power Binary Fluid Sys- tems 显示文摘 | ZHANG N Lior N | 2007 | International Journal of Refrigeration2007，30，： | 1 |
| 17 | An Experi- mental Study of Flash Evaporation from Liquid Pools 显示文摘 | Gopalakrishna S Purushothaman V Lior N | 1987 | Desalination1987，65，11： | 1 |
| 18 | Clinical utility of antihuman lambda chain‐based enzyme‐linked immunosorbent assay (ELISA) versus double antigen ELISA for the detection of anti‐infliximab antibodies显示文摘 | Uri Kopylov Yoav Mazor Miri Yavzori Ella Fudim Lior Katz Daniel Coscas Orit Picard Yehuda Chowers Rami Eliakim Shomron Ben‐Horin | 2011 | Inflamm Bowel Dis2011，，9： | 1 |
| 19 | A bayesian model for efficient visual search and recognition显示文摘 | Lior E Laurent I | 2010 | Vision Research2010，50，14： | 1 |
| 20 | Energy, exergy, and second law performance criteria 显示文摘 | Lior Noam Zhang Na | 2007 | Energy2007，32，4： | 1 |
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