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| 1 | A New Triterpenoid Oligoglycoside Escin IVe from the Seeds ofAesculus Chinensis显示文摘A new triterpenoid saponin named escin IVr was isolated from the seeds ofAesculus chinensis its structure was established as 28-tigloylprotoaescigenin-3β-O-[β-D-glucopyranosyl (1-2 )][β-D-glucopyranosyl (1-4)] -β-D-glucopyranosiduronic acid. | Jing ZHAO Xiu Wei YANGI Yu Xin CUl Xue Hut LIU Shun He OUYANGZ(National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University.Beijing 100083Yantai Luye Pharmaceutical Co. Ltd.. 43 Yingbin Road. Yantai. Shandong 264001) | 1999 | Chinese Chemical Letters1999，10，6： | 5 |
| 2 | Four Triterpene Oligoglycosides from the seeds of Aesculus Chinensis显示文摘A pair of novel geometrically isomeric triterpenoid saponins named escins IVa and IVb .together with known escins la and fo. were isolated from the seeds of Aesculus chinensis. Their structures were determined on the basis of spectroscopic evidences and comparison. | Jing ZHAO Xiu Wei YANG Yu Xin CUI Xue Hui LIU Shu Yan LIU Hong Ying ZHI Ji Yong CHEN Fa Bing ZHU Yun Li XUE and Dian Bo LIU (National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University ,Beijing 1 00083)(Yantai Luye Pharmaceutical | 1999 | Chinese Chemical Letters1999，10，4： | 5 |
| 3 | Proteomic identification of new diagnostic biomarkers of early-stage cutaneousmycosis fungoides显示文摘Dear editor,Mycosis fungoides(MF),the most common subtype of cutaneous T cell lymphoma,is a rare disease[1,2].Patients with early-stageMF have a 5-year overall survival between 88%and 100%[3].In patients with advanced MF,the skin may present with tumors and erythroderma,and the median survival of patients with lymph node and visceral metastasis is 13 months[4].Therefore,it is important to achieve an early diagnosis to improve prognosis[5]. | Ling Leng Zhaorui Liu Jie Ma Shiyu Zhang Yukun Wang Luye Lv Yunping Zhu Dunqin Gao Yujie Wang Juncheng Wang Yuehua Liu Jie Liu | 2022 | Cancer Communications2022，42，6： | 4 |
| 4 | Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesis显示文摘Opium poppy(Papaver somniferum)is a source of morphine,codeine,and semisynthetic derivatives,including oxycodone and naltrexone.Here,we report the de novo assembly and genomic analysis of P.somniferum traditional landrace‘Chinese Herbal Medicine’.Variations between the 2.62 Gb CHM genome and that of the previously sequenced high noscapine 1(HN1)variety were also explored.Among 79,668 protein-coding genes,we functionally annotated 88.9%,compared to 68.8%reported in the HN1 genome.Gene family and 4DTv comparative analyses with three other Papaveraceae species revealed that opium poppy underwent two whole-genome duplication(WGD)events.The first of these,in ancestral Ranunculales,expanded gene families related to characteristic secondary metabolite production and disease resistance.The more recent species-specific WGD mediated by transposable elements resulted in massive genome expansion.Genes carrying structural variations and large-effect variants associated with agronomically different phenotypes between CHM and HN1 that were identified through our transcriptomic comparison of multiple organs and developmental stages can enable the development of new varieties.These genomic and transcriptomic analyses will provide a valuable resource that informs future basic and agricultural studies of the opium poppy. | Li Pei Baishi Wang Jian Ye Xiaodi Hu Lihong Fu Kui Li Zhiyu Ni Zhenlong Wang Yujie Wei Luye Shi Ying Zhang Xue Bai Mengwan Jiang Shuhui Wang Chunling Ma Shujin Li Kaihui Liu Wanshui Li Bin Cong | 2021 | Horticulture Research2021，8，1： | 4 |
| 5 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 6 | Recent advances in two-photon imaging: technology developments and biomedical applications显示文摘In the past two decades, two-photon microscopy (TPM) transforms biomedicalresearch, allowing nondestructive high-resolution fluorescent molecular imaging and label-free imaging in vivo and in real time. Here we review the recent advances of TPM technologyincluding novel laser sources, new image acquisition paradiams, and microendoscopicimaging systems. Then, we survey the capabilities of TPM imagingof biological relevant molecules such as nicotinamideadenine dinucleotide (NADH), flavin adenine dinucleotide (FAD),and reactive oxygen species (ROS). Biomedical applications of TPM in neuroscience and cancer detection are demonstrated. | Yu Chen Hengchang Guo Wei Gong Luye Qin Hossein Aleyasin Rajiv R Ratan Sunghee Cho Jianxin Chen Shusen Xie | 2013 | Chinese Optics Letters2013，11，1： | 2 |
| 7 | Synergism of hydroxyapatite nanoparticles and recombinant mutant human tumour necrosis factor‐α in chemotherapy of multidrug‐resistant hepatocellular carcinoma显示文摘 | GaopengLi ShengliDong JunyuanQu ZhengangSun ZhiyongHuang LuYe HuifangLiang XiAi WanguangZhang XiaopingChen | 2010 | Liver International2010，，4： | 2 |
| 8 | Micrometastases detected by cytokeratin 19 expression in sentinel lymph nodes of patients with early-stage cervical cancer显示文摘 | JM SUN HF LUy | 2006 | Int J Gynecol Cancer2006，16，： | 1 |
| 9 | Reproducing kernel particle methods for structural dynamics 显示文摘 | LUY W K JUN S Li S | 1995 | International Journal for Numerical Methods in Engineering1995，38，： | 1 |
| 10 | Electr-ocatalyticperformanceofself-supportingCNTs/SMF-Nihybridelctrodesfortheaerobicoxidationofp-MTtop-MBA[J]显示文摘 | FangYZ(方玉珠) JiangFT(姜芳婷) LuY(路勇) | 2010 | 物理化学学报2010，26，6： | 1 |
| 11 | Deletionanddown-regulationofnutsl-P16geneinhumangastriccancer显示文摘 | LUY GaoC GiT | 1996 | ChinJOncol1996，18，3： | 1 |
| 12 | MicroRNAsandatrialfibrillation:new fundamentals显示文摘 | WangZ LuY YangB | 2011 | Cardiovasc Res2011，89，4： | 1 |
| 13 | Foxp3regulatesratioofTregandNKTcellsinamousemodelofasthma显示文摘 | LuY GuoY XuL etal | 2015 | MolCellBiochem2015，403，12： | 1 |
| 14 | Thermoelectricpropertiesofgraphenenanosheets-modifiedpolyanilinehybridnanocompositesbyaninsituchemicalpolymeriztion显示文摘 | LuY SongY WangF | 2012 | MaterialsChemistryandPhysics2012，138，1： | 1 |
| 15 | Comparisonofstandardandlow-tubevoltage320-detectorrowvolumeCTangiographyindetectionofintracranialaneurysmswithdigitalsubtractionangiographyasgoldstandard显示文摘 | SunG DingJ LuY etal | 2012 | AcadRadiol2012，19，3： | 1 |
| 16 | The draft genome of the fast-growing non-timber forest species moso bamboo (PhyUostachys heterocycla) 显示文摘 | Peng Z H Lu Y Li L Zhao Q Feng Q Gao Z M Lu H Y Hu T YAO N Liu K Y LiY FanDL GuoYL LiW J LuY Q Weng Q J Zhou C C Zhang L Huang T Zhu C R Liu X G Yang X W Wang T Miao K Zhuang C Y Cao X L Tang W L Liu G S Liu Y L Chen J Liu Z J Yuan L C Liu Z H Huang X H LuT T Fei B H Ning Z M Han B Jiang Z H | 2013 | Nature Genetics2013，45，4： | 1 |
| 17 | Welding process opti- mization with artificial neural network applications 显示文摘 | Aktepe Adnan Ersoz Suleyman Luy Murat | 2014 | Neutral network world2014，24，6： | 1 |
| 18 | Whom you know matters: venture capital networks and investment performance 显示文摘 | HOCHBERG Y V LJUNGQVISTA LUY | 2007 | The Journal of Finance2007，62，2： | 1 |
| 19 | Networking as a barrier to entry and the competitive supply of venture capital 显示文摘 | HOCHBERG Y V LJUNGQVISTA LUY | 2010 | The Journal of Finance2010，65，3： | 1 |
| 20 | Preoperative dexmedetomidine prevents tourniquet-induced hypertension in orthopedic operation duriug general anesthesia显示文摘 | LuY ZhangY DongCS | 2013 | Kaohsiung J Med Sci2013，29，5： | 1 |
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