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| 1 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 2 | 共聚物在超声介导基因转染中的新功能显示文摘目的探讨超声和共聚物在促进基因转染中是否有协同作用.方法应用3种水溶性不同的共聚物F127,L61和P85.超声参数设定为1 MHz,1~3 W/cm2,脉冲作功周期为20%.选用C2C12,3T3-MDEI,和CHO 3种细胞系为研究对象.质粒DNA为可产生绿色荧光蛋白的GFP.应用荧光显微镜和流式细胞仪(FACS)评价转染率,台盼蓝染色评价细胞的成活率.每一实验结果至少重复3次以上.结果与以前的研究结果相同,超声可介导基因转染,但随着超声能量的增加,细胞的破坏也增加;单独应用3种共聚物未观察到基因转染.但当与超声同时应用,在较低浓度时共聚物可使超声介导的基因转染率提高2~4倍.结论在较低浓度时,共聚物可显著提高超声介导的基因转染作用. | 陈云超 张青萍 LIANG Hai-Dong David O. Cosgrove Martin JK Blomley Qi-Long Lu | 2005 | 中华超声影像学杂志2005，14，11： | 7 |
| 3 | 超声微泡造影影像学及治疗作用的研究进展显示文摘包裹型气体微泡已经发展为临床应用的超声造影剂.微泡造影剂不仅已广泛用于血池和组织灌注显像,其治疗作用也日渐突显,例如溶栓和作为药物或基因的载体.造影剂微泡的平均直径小于红细胞直径,因而能够自由运行于微循环.微泡能将生物活性物质(例如药物或基因)结合在其内或其外膜表面,并将此物质转运于体内特定组织,例如将抗肿瘤药物转运并结合于特定肿瘤组织.靶向性微泡能将肽段等特定性配体结合于其微泡表面,这种特定性配体可特异性地与血管壁表达的受体相结合,微泡因而在靶组织区域积聚[1]. | 梁海东 王兴华 Charles Sennoga Mike Halliwell David O Cosgrove Martin JK Blomley | 2004 | 中华医学超声杂志(电子版)2004，1，3： | 4 |
| 4 | Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors显示文摘 | Edward Sausville Patricia LoRusso Michael Carducci Judith Carter Mary F. Quinn Lisa Malburg Nilofer Azad David Cosgrove Richard Knight Peter Barker Sonya Zabludoff Felix Agbo Patricia Oakes Adrian Senderowicz | 2014 | Cancer Chemotherapy and Pharmacology2014，，3： | 1 |
| 5 | Nomenclature for members of the expansin superfamily of genes and proteins显示文摘 | Hans Kende Kent Bradford David Brummell Hyung-taeg Cho Daniel Cosgrove Andrew Fleming Chris Gehring Yi Lee Simon Mcqueen-mason Jocelyn Rose Laurentius Voesenek | 2004 | Plant Molecular Biology2004，，3： | 1 |
| 6 | Imaging of perfusion using ultrasound显示文摘 | David Cosgrove Nathalie Lassau | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，1： | 1 |
| 7 | Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis显示文摘 | Sallie B. Cosgrove Jody A. Wren Dawn M. Cleaver David D. Martin Kelly F. Walsh Jessica A. Harfst Stacey L. Follis Vickie L. King Joseph F. Boucher Michael R. Stegemann | 2013 | Vet Dermatol2013，，5： | 1 |
| 8 | Measurement of the Reflectivity of the Intima-Medial Layer of the Common Carotid Artery Improves the Discriminatory Value of Intima-Medial Thickness Measurement as a Predictor of Risk of Atherosclerotic Disease显示文摘 | Stephen M. Ellis Rossi P. Naoumova Clare K. Neuwirth Robert Eckersley David O. Cosgrove Gilbert R. Thompson Paul S. Sidhu | 2007 | Ultrasound in Medicine & Biology2007，，7： | 1 |
| 9 | Intra-arterial Therapy for Advanced Intrahepatic Cholangiocarcinoma: A Multi-institutional Analysis显示文摘 | Omar Hyder J. Wallis Marsh Riad Salem Elena N. Petre Sanjeeva Kalva Eleni Liapi David Cosgrove Donielle Neal Ihab Kamel Andrew X. Zhu Constantinos T. Sofocleous Jean-Francois H. Geschwind Timothy M. Pawlik | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 10 | Non-invasive diagnosis of hepatic cirrhosis by transit-time analysis of an ultrasound contrast agent显示文摘 | Thomas Albrecht Martin JK Blomley David O Cosgrove Simon D Taylor-Robinson Vijay Jayaram Robert Eckersley Albrecht Urbank Jenny Butler-Barnes Nayna Patel | 1999 | The Lancet1999，，9164： | 1 |
| 11 | A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate显示文摘 | Kim Y. C. Fung Leah Cosgrove Trevor Lockett Richard Head David L. Topping | 2012 | British Journal of Nutrition2012，，： | 1 |
| 12 | The impact of body mass index on outcomes after laparoscopic cholecystectomy显示文摘 | Daniel T. Farkas Dovid Moradi David Moaddel Kamal Nagpal John Morgan Cosgrove | 2012 | Surgical Endoscopy2012，，4： | 1 |
| 13 | Volumetric assessment of tumour response using functional MR imaging in patients with hepatocellular carcinoma treated with a combination of doxorubicin-eluting beads and sorafenib显示文摘 | Celia Pamela Corona-Villalobos Vivek Gowdra Halappa Jean-Francois H. Geschwind Susanne Bonekamp Diane Reyes David Cosgrove Timothy M Pawlik Ihab R Kamel | 2015 | European Radiology2015，，2： | 1 |
| 14 | Nomenclature for members of the expansin superfamily of genes and proteins显示文摘 | Hans Kende Kent Bradford David Brummell Hyung-taeg Cho Daniel Cosgrove Andrew Fleming Chris Gehring Yi Lee Simon Mcqueen-mason Jocelyn Rose Laurentius Voesenek | 2004 | Plant Molecular Biology2004，，3： | 1 |
| 15 | Diabetes and pancreatic cancer显示文摘 | Zoobia W. Chaudhry Erica Hall Rita R. Kalyani David P. Cosgrove Hsin-Chieh Yeh | 2013 | Current Problems in Cancer2013，，5： | 1 |
| 16 | Clinical uses of microbubbles in diagnosis and treatment显示文摘 | David Cosgrove Chris Harvey | 2009 | Med Biol Eng Comput2009，47，： | 1 |
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