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| 1 | Estimation of intra-operator variability in perfusion parameter measurements using DCE-US显示文摘AIM:To investigate intra-operator variability of semiquantitative perfusion parameters using dynamic contrast-enhanced ultrasonography(DCE-US),following bolus injections of SonoVue.METHODS:The in vitro experiments were conducted using three in-house sets up based on pumping a fluid through a phantom placed in a water tank.In the in vivo experiments,B16F10 melanoma cells were xenografted to five nude mice.Both in vitro and in vivo,images were acquired following bolus injections of the ultrasound contrast agent SonoVue(Bracco,Milan,Italy) and using a Toshiba Aplio ultrasound scanner connected to a 2.9-5.8 MHz linear transducer(PZT,PLT 604AT probe)(Toshiba,Japan) allowing harmonic imaging('Vascular Recognition Imaging') involving linear raw data.A mathematical model based on the dye-dilution theory was developed by the Gustave Roussy Institute,Villejuif,France and used to evaluate seven perfusion parameters from time-intensity curves.Intra-operator variability analyses were based on determining perfusion parameter coefficients of variation(CV).RESULTS:In vitro,different volumes of SonoVue were tested with the three phantoms:intra-operator variability was found to range from 2.33% to 23.72%.In vivo,experiments were performed on tumor tissues and perfusion parameters exhibited values ranging from 1.48% to 29.97%.In addition,the area under the curve(AUC) and the area under the wash-out(AUWO) were two of the parameters of great interest since throughout in vitro and in vivo experiments their variability was lower than 15.79%.CONCLUSION:AUC and AUWO appear to be the most reliable parameters for assessing tumor perfusion using DCE-US as they exhibited the lowest CV values. | Marianne Gauthier Ingrid Leguerney Jessie Thalmensi Mohamed Chebil Sarah Parisot Pierre Peronneau Alain Roche Nathalie Lassau | 2011 | World Journal of Radiology2011，3，3： | 6 |
| 2 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 3 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 4 | The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): Update 2011 on non-hepatic applications显示文摘 | F. Piscaglia C. Nols?e C. Dietrich D. Cosgrove O. Gilja M. Bachmann Nielsen T. Albrecht L. Barozzi M. Bertolotto O. Catalano M. Claudon D. Clevert J. Correas M. D'Onofrio F. Drudi J. Eyding M. Giovannini M. Hocke A. Ignee E. Jung A. Klauser N. Lassau E. L | 2012 | Ultraschall in Med2012，，01： | 2 |
| 5 | Benefits of contrast-en- hanced sonography for the detection of liver lesions: compari- son with histologic findings显示文摘 | Chami L Lassau N Malk D | 2008 | A JR Am J Roentgenol2008，190，3： | 1 |
| 6 | Doppler US with perfusion softwareand contrast medium injection in the early evaluation of radiofrequency in breast cancerrecurrences: a prospective phase II study显示文摘 | Lamuraglia M Lassau N Garbay JR | 2005 | Eur J Radiol2005，56，3： | 1 |
| 7 | Retroperitoneal drainage after complete paraaortic lymphadenectomy for gynecologic cancer 显示文摘 | Morice P Lassau N Pautier P | 2001 | Obstet Gynecol2001，97，2： | 1 |
| 8 | Benefits of contrast-enhancedsonography for the detection of liver lesions:comparison with histo-logic findings显示文摘 | Chami L Lassau N Malka D | 2008 | AJR2008，190，3： | 1 |
| 9 | Advanced hepatocellular carcinoma: early evaluation of response to targeted therapy and prognostic value of perfusion CT and dynamic contrast enhanced-ul- trasound 显示文摘 | Frampas E Lassau N Zappa M | 2013 | Eur J Radiol2013，82，5： | 1 |
| 10 | Impact of Surgery on Advanced Gastrointestinal Stromal Tumors (GIST) in the Imatinib Era显示文摘 | S. Bonvalot H. Eldweny C. Le Péchoux D. Vanel P. Terrier A. Cavalcanti C. Robert N. Lassau A. Le Cesne | 2006 | Annals of Surgical Oncology2006，，12： | 1 |
| 11 | 2009 European guideline on the management of male non-gonococcal urethritis 显示文摘 | Shahrnanesh M Moi H Lassau F | 2009 | Int J STD AIDS2009，20，7： | 1 |
| 12 | Imaging of perfusion using ultrasound 显示文摘 | Cosgrove D Lassau N | 2010 | Eur J Nucl Med Mol Imaging2010，37，1： | 1 |
| 13 | Benefits of contrast-enhanced ultrasonography for the detection of liver lesions: comparison with histologic findings显示文摘 | Chami L Lassau N Malka D | 2008 | AJR Am J Roentgenol2008，190，3： | 1 |
| 14 | Dynamic contrast-enhanced ultrasonography (DCE-US) and anti-angiogenictreatments 显示文摘 | Lassau N Chami L Chebil M | 2011 | Discov Med2011，11，56： | 1 |
| 15 | Imaging of perfusion using ultrasound显示文摘 | Cosgrove d Lassau N | 2010 | Eur J Nucl Med Mol Imaging2010，37，1： | 1 |
| 16 | Metastatic renal cell carcinoma treated with sunitinib: early evaluation of treatment response using dynamic contrast-enhanced ultrasonography显示文摘 | Lassau N Koscielny S Albiges L | 2010 | Clin Cancer Res2010，16，4： | 1 |
| 17 | Dynamic contrast-enhanced ultrasonography(DCE-US)and anti-angiogenic treatment显示文摘 | Lassau N Chami L Chebil M | 2011 | Discov Med2011，11，56： | 1 |
| 18 | High-frequency sonogra-phy and color Doppler in the management of pigmented skin Ie-sions显示文摘 | Bessoud B Lassau N Koscielny S | 2003 | Ultrasound Med Biol2003，29，6： | 1 |
| 19 | High pregnancy rate after early human freezing显示文摘 | Testart J LassaUe B Belaisch-Allart J | 1986 | Fertil Steril1986，46，2： | 1 |
| 20 | Imaging of perfusion using ultrasound显示文摘 | David Cosgrove Nathalie Lassau | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，1： | 1 |
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