|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 2 | 底栖生物生产力现场测试系统(BCSPM)的建立及其初步实验结果显示文摘为对生态系统的健康评估及底栖生物资源的开发利用提供技术支撑 ,在胶州湾筏式养殖水域 ,建立了底栖生物生产力现场测试系统 (BCSPM ) ,并在光照和黑暗条件下测定了沉积物海水界面溶解氧随时间的变化、计算了氧通量、估算了底栖总初级生产力和群落呼吸。在光照较强的中午时刻测定的群落总生产力为 2 0 .76mgCm-2 h-1;养殖水域沉积物中的群落呼吸要高于邻近水域。BCSPM整体运转良好 ,初步结果为系统的改进和进一步实验提供了依据。 | 张志南 刘晓收 Guy BOUCHER 邓可 黄勇 袁伟 | 2005 | 中国海洋大学学报(自然科学版)2005，35，2： | 8 |
| 3 | Use of a new retrograde filling material(Biodentine) for endodontic surgery: two case reports显示文摘Mineral trioxide aggregate(MTA) is considered at the present time as the gold standard for root-end filling in endodontic surgery.However, this biocompatible material presents several drawbacks such as a long setting time and handling difficulties. The aim of this article is to present a new commercialized calcium silicate-based material named Biodentine with physical improved properties compared to MTA in a clinical application. Two endodontic microsurgeries were performed by using specific armamentarium(microsurgical instrumentation, ultrasonic tips) under high-power magnification with an operatory microscope. Biodentine was used as a root-end filling in order to seal the root canal system. The two cases were considered completely healed at 1 year and were followed for one more year. The 2-year follow-up consolidated the previous observation with absence of clinical symptoms and radiographic evidence of regeneration of the periapical tissues. | Grégory Caron Jean Azérad Marie-Odile Faure Pierre Machtou Yves Boucher | 2014 | International Journal of Oral Science2014，6，4： | 5 |
| 4 | Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver:A retrospective study显示文摘AIM:To investigate the efficacy and toxicity of systemic chemotherapy in a retrospective study of patients with hepatocellular carcinoma(HCC)occurring in normal or fibrotic liver without cirrhosis. METHODS:Twenty-four patients with metastatic or locally advanced HCC in a normal or a fibrotic liver were given systemic chemotherapy(epirubicin,cis- platin and 5-fluorouracil or epirubicin,cisplatin and capecitabine regimens).Tumor response,time to pro- gression,survival,and toxicity were evaluated. RESULTS:There were 7 women and 17 men,mean age 54±10 years;18 patients had a normal liver and 6 had a fibrotic liver(F1/F2 on biopsy).Mean tumor size was 14 cm,5 patients had portal vein thrombosis and 7 had metastasis.Patients received a median of 4 chemotherapy sessions.Overall tolerance was good. There were 5 partial responses(objective response rate =22%),and tumor control rate was 52%.Second line surgical resection was possible in two patients.Median survival was 11 mo,and 1-and 2-year overall survival rates were 50%±10%and 32%±11%,respectively. CONCLUSION:In patients with HCC in a non-cirrhotic liver,chemotherapy was well tolerated and associated with an objective response rate of 22%,including two patients who underwent secondary surgical resection. | Julien Edeline Jean-Luc Raoul Elodie Vauleon Anne Guillygomac'h Karim Boud jema Eveline Boucher | 2009 | World Journal of Gastroenterology2009，15，6： | 4 |
| 5 | Direct farm, production base, traceability and food safety in China显示文摘With the rapid growth of China's economy,rising demand for safety food has been accompanied by frequent food safety scandals. Given that China's farming is dominated by millions of small-scale farms,ensuring food safety is a major challenge facing the public and private sectors. The direct farm(DF) program,initiated in 2008,represents one of the government's major initiatives to modernize the distribution of fresh fruit and vegetables(FFV) and improve food safety. Under the DF program,participating national and international retailers are expected to establish more direct procurement relationships with farm communities. While it is often claimed that greater participation by retailers in the production and post-harvest processing implied the DF program will lead to improved quality,safety and traceability,systematic evidence remains elusive as existing studies are largely narrative,based on case studies,or theoretical inference. Little empirical evidence is available for a broader evaluation of the DF program. This paper aims to fill this gap by assessing the overall performance of a single retailer's DF experience with respect to the procurement and food safety of FFV. We use data from a survey of production managers of 35 DF production bases(PBs) spread across 11 provinces,3 cities and 1 autonomous region in China. The results show a mixture of opportunities and challenges. On one hand,the DF program improves production practices and distribution channels of FFV produced on its PBs,thus facilitating the move of China's food system towards improved food safety compliance. On the other hand,significant heterogeneity in the traceability of food and the ability of DF to meet higher safety standards is evident both across major product categories and across household-operated vs. firm-operated PBs. The paper concludes with policy implications. | DING Ji-ping HUANG Ji-kun JIA Xiang-ping BAI Jun-fei Steve Boucher Michael Carter | 2015 | Journal of Integrative Agriculture2015，14，11： | 4 |
| 6 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 7 | Assessment of large aperture lightweight imaging concepts 显示文摘 | BELL K D BOUCHER R H | 1999 | IEEE1999，，： | 3 |
| 8 | Volumetric Changes after 90 Y Radioembolization for Hepatocellular Carcinoma in Cirrhosis: An Option to Portal Vein Embolization in a Preoperative Setting?显示文摘 | Julien Edeline Laurence Lenoir Karim Boudjema Yan Rolland Anne Boulic Fanny Le Du Marc Pracht Jean-Luc Raoul Bruno Clément Etienne Garin Eveline Boucher | 2013 | Annals of Surgical Oncology2013，，8： | 3 |
| 9 | Helicobacter pylori arginase mutant colonizes arginase Ⅱ knockout mice显示文摘AIM: To investigate the role of host and bacterial arginases in the colonization of mice by Helicobacter pylori (H.pylori).METHODS: H.pylori produces a very powerful urease that hydrolyzes urea to carbon dioxide and ammonium,which neutralizes acid.Urease is absolutely essential to H.pylori pathogenesis;therefore,the urea substrate must be in ample supply for urease to work efficiently.The urea substrate is most likely provided by arginase activity,which hydrolyzes L-arginine to L-ornithine and urea.Previous work has demonstrated that H.pylori arginase is surprisingly not required for colonization of wild-type mice.Hence,another in vivo source of the critical urea substrate must exist.We hypothesized that the urea source was provided by host arginase Ⅱ,since this enzyme is expressed in the stomach,and H.pylori has previously been shown to induce the expression of murine gastric arginase Ⅱ.To test this hypothesis,wild-type and arginase (rocF) mutant H.pylori strain SS1 were inoculated into arginase Ⅱ knockout mice.RESULTS: Surprisingly,both the wild-type and rocF mutant bacteria still colonized arginase Ⅱ knockout mice.Moreover,feeding arginase Ⅱ knockout mice the host arginase inhibitor S-(2-boronoethyl)L-cysteine (BEC),while inhibiting > 50% of the host arginase Ⅰ?activity in several tissues,did not block the ability of the rocF mutant H.pylori to colonize.In contrast,BEC poorly inhibited H.pylori arginase activity.CONCLUSION: The in vivo source for the essential urea utilized by H.pylori urease is neither bacterial arginase nor host arginase Ⅱ;instead,either residual host arginase Ⅰ?or agmatinase is probably responsible. | Songhee H Kim Melanie L Langford Jean-Luc Boucher Traci L Testerman David J McGee | 2011 | World Journal of Gastroenterology2011，17，28： | 3 |
| 10 | Role of zoledronic acid in the prevention and treatment of osteoporosis显示文摘 | Louis-Georges Ste-Marie Louis-Georges Ste-Marie Andree Boucher Ages Rakel | 2011 | Clinical Interventions in Aging (default)2011，，： | 2 |
| 11 | Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells 显示文摘 | Charland S Boucher MJ Houde M | 2001 | Endocrinol2001，142，： | 2 |
| 12 | Characteristics of Missed or Interval Colorectal Cancer and Patient Survival: A Population-Based Study显示文摘 | N. Jewel Samadder Karen Curtin Thérèse M.F. Tuohy Lisa Pappas Ken Boucher Dawn Provenzale Kerry G. Rowe Geraldine P. Mineau Ken Smith Richard Pimentel Anne C. Kirchhoff Randall W. Burt | 2014 | Gastroenterology2014，，4： | 2 |
| 13 | Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression显示文摘 | Akihisa Fukuda Sam C. Wang John P. Morris Alexandra E. Folias Angela Liou Grace E. Kim Shizuo Akira Kenneth M. Boucher Matthew A. Firpo Sean J. Mulvihill Matthias Hebrok | 2011 | Cancer Cell2011，，： | 2 |
| 14 | Patients with type 2 diabetes demonstrate proprioceptive deficit in the knee显示文摘AIM To investigate proprioceptive discrepancies in the lower extremity in persons with type 2 diabetes mellitus(T2DM). METHODS In this cross-sectional study, a total of 46 older persons were divided into a T2DM group(n = 23) and a control group who did not have T2 DM(n = 23). Participants were given a brief warm up with stretching exercises. Diabetic neuropathy scores were collected prior to proprioceptive testing. For proprioceptive testing, participants performed leg extensions to randomized target positions of 15°, 30°, 45, 60° degrees of elevation in the sagittal plane, each target was repeated a total of four times. Subjects were guided to target positions in the absence of visual feedback via auditory cues from a custom JPS application. When the participant entered the target position, they memorized the location of their limb in space and subsequently attempted to relocate this position in space. Proprioceptive errors were measured from the target positioned, target remembered, target repositioned protocol. RESULTS Proprioceptive accuracy was lower in the diabetic groupat all levels of target angle than the control group(P < 0.05). The diabetic group had 46% greater inaccuracy than the control group at all levels of target position. Diabetics also reported greater neuropathy scores than controls in the past 12 mo P < 0.01. CONCLUSION Deficits in lower limb localization and greater diabetic neuropathy scores were identified in this study. Our findings may be associated with deafferentation as peripheral neuropathy is a common complication with the disease. These findings may help to explain the declining balance function in the older persons with T2DM which is also commonly reported. | Lucas Richard Ettinger Ami Boucher Elisabeth Simonovich | 2018 | World Journal of Diabetes2018，9，3： | 2 |
| 15 | Constitutive release of ATP and evidence for major contribution of ectonucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations显示文摘 | Lazarowski E R Boucher R C Harden T K | 2000 | J Biol Chem2000，275，31： | 1 |
| 16 | Timedependent behavior of interstitial fluid pressure in solid tumors : implications for drug delivery显示文摘 | Netti PA Baxter LT Boucher Y | 1995 | Cancer Research1995，55，： | 1 |
| 17 | Integrons:mobilizable platforms that promote genetic diversity in bacteria显示文摘 | Boucher Y Labbate M Koenig JE | 2007 | Trends Microbiol2007，15，7： | 1 |
| 18 | Health-related quality of life after short segment instrumentation of lumbar burst fractures显示文摘 | Boucher M Bhandari M Kwok D | 2001 | J Spinal Disord2001，14，5： | 1 |
| 19 | Differentiating human multipotent mesenchymal stromal cells regulate microRNAs:Prediction of microRNA regulation by PDGF during osteogenesis显示文摘 | Goff LA Boucher S Ricupero CL | 2008 | Exp Hematol2008，36，： | 1 |
| 20 | Receptor-mediated up take of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways显示文摘 | Castellino F Boucher PE Eichelberg K | 2000 | J Exp Med2000，191，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员