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| 1 | Retinopathy of prematurity: an epidemic in the making显示文摘探索阻止并且对待早熟( ROP )的严重 retinopathy 的病原学,发生和方法的目的,它很快在早熟的婴儿的增加的数字是在这评论使用的数据主要从用英语出版的 Medline 和 PubMed 的 surviving.Data 来源的世界的区域正在成为威胁到婴儿的视觉。搜索词是“早熟和早熟的出生的 retinopathy ”我们讨论的 .Study 选择历史的观点,流行和发生,在为有严重 ROP 的眼睛的外部网膜的脱离能帮助的早熟的 babies.Results 的 ROP 的分类和处理方法阻止前进到盲目和几大临床的试用在高风险眼睛显示出这个处理的有效性。作为婴儿们熬过的 VLBW 和 ELBW 的一个更大的比例,在风险的婴儿的人口增加。在世界的各种各样的区域,不同鉴定标准作为需要被用来决定哪个婴儿在盲目的风险以便提供及时诊断考试和处理。为 preventiing ROP 的方法包括处于早熟,胎儿的 corticosteroids 的使用,和更好新生的照顾惯例的率导致减小的更好胎儿、产科的照顾。最近的开发显示了氧补充的管理为严重 ROP 的预防是重要的;然而,有还没知道浸透目标什么氧应该被采用。败血增加严重 ROP 在很 preterm 婴儿。基因协会和一条 telemedicine 途径可以被探索检测 ROP。 anti-VEGF 治疗的处理在有严重 ROP 的眼睛是潜在地有用的,但是长期的效果还没被知道,如此的处理应该与大 caution.Conclusions ROP 被使用是为与在最近的年里在许多国家改进新生的服务的发展正在变得更流行的早熟的婴儿的潜在地有约束力的疾病。高优先级应该被放在开发途径由减少 preterm 出生阻止 ROP 盲目上,改进以新生的照顾单位的早熟的婴儿的照顾,并且在那些区域提供足够的眼科的服务。 | Graham E. Quinn Clare Gilbert Brian A. Darlow Andrea Zin | 2010 | Chinese Medical Journal2010，，20： | 17 |
| 2 | Switchgrass as a bioenergy crop in the Loess Plateau, China:Potential lignocellulosic feedstock production and environmental conservation显示文摘A large portion of the Loess Plateau of China is characterized as 'marginal' with serious land degradation and desertification problems. Consequently, two policies, Grain for Green and Western Development Action were established by the Chinese government in response to the demand for ecological protection and economic development in the Loess Plateau. These policies are designed to increase forest cover, expand farmlands, and enhance soil and water conservation, while creating sustainable vegetation restoration. Perennial grasses have gained attention as bioenergy feedstocks due to their high biomass yields, low inputs, and greater ecosystem services compared to annual crops. Moreover, perennial grasses limit nutrient runoff and reduce greenhouse gas emissions and soil losses while sequestering carbon. Additionally, perennial grasses can generate economic returns for local farmers through producing bioenergy feedstock or forage on marginal lands. Here, we suggest a United States model energy crop, switchgrass(Panicum virgatum L.) as a model crop to minimize land degradation and desertification and to generate biomass for energy on the Loess Plateau. | Danielle Cooney Hyemi Kim Lauren Quinn Moon-Sub Lee Jia Guo CHEN Shao-lin XU Bing-cheng D.K.Lee | 2017 | Journal of Integrative Agriculture2017，16，6： | 12 |
| 3 | 大斜度井和水平井地层评价中的经验、问题和发展方向显示文摘大斜度井和水平井(HA/HZ)测井组合的选择原则主要是指导地质导向钻井。有时(HA/HZ)井所穿过的地层或油藏某部分没有垂直评价井,只能用HA/HZ测井数据评价常规有效厚度/总厚度比、孔隙度和含水饱和度。对同一地层,HA/HZ测井响应与垂直井响应存在很大差异。研究表明,由于视倾角误差,孔隙度值偏差可达6P.u.,含水饱和度误差超过50%,大斜度井中真地层厚度偏差达到200%~300%。垂直井的常规地层评价方法不太适用于HA/HZ井地层和流体性质评价。HA/HZ井与垂直井测井响应差异的主要原因是很多测井仪器是专为探测垂直井地层而设计的,因此在HA/HZ井中,必须对解释方案进行修改,这时需考虑井眼附近地层的几何形状;测量方位;地层各向异性对电阻率、声波和核测井响应的影响;异常侵入剖面;重力引起的仪器偏心以及井眼底部聚积的岩屑。虽然井眼成像测井能有效地测量大斜度井相对地层倾角,但当井斜超过80°时地层倾角的测量仍存在很多问题。中子和密度测井响应又相当程度地受岩屑的影响。这种井的测井难度很大,将差质量测井响应与因几何形状、各向异性以及井眼影响引起的异常测井响应区分开来显得相当重要。HA/HZ井用于地质导向的定性标准测井难以满足未来地层评价的要求。许多地方不能钻垂直评价井,因此利用大位移井信息评价地层很关键。作业公司和测井服务公司必须相互协作,共同解决HA/HZ井仪器响应和数据解释问题,开发出能定量描述HA/HZ井的新仪器。 | Quinn R Passey H Yin C M Rendeiro D E Fitz 唐宇 王昌学 | 2006 | 测井技术2006，30，1： | 10 |
| 4 | Pushing the boundaries of diode-pumped solid-state lasers for high-energy applications显示文摘We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled,diode-pumped multi-slab Yb:YAG laser operating at 1 Hz.To the best of our knowledge,this is the highest energy ever recorded for a diodepumped laser system. | Saumyabrata Banerjee Paul Mason Jonathan Phillips Jodie Smith Thomas Butcher Jacob Spear Mariastefania De Vido Gary Quinn Danielle Clarke Klaus Ertel Cristina Hernez-Gomez Chris Edwards John Collier | 2020 | High Power Laser Science and Engineering2020，8，2： | 4 |
| 5 | Human immunodeficiency virus-related primary central nervous system lymphoma: factors influencing survival in 111 patients显示文摘BACKGROUND: The current study evaluated factors influencing survival in patients diagnosed with human immunodeficiency virus (HIV)-related primary central nervous system lymphoma (PCNSL), with a focus on the effects of therapeutic radiotherapy (RT) and highly active antiretroviral therapy (HAART). METHODS: A retrospective chart review of patients with a diagnosis of HIV-related PCNSL at one of five university hospitals between 1987 and 1998 was performed. Clinical details including antiretroviral agent use, brain imaging scan results, RT use, and survival outcomes were recorded. RESULTS: One hundred eleven patients with HIV-related PCNSL were identified. The annual incidence decreased significantly between 1992 and 1995 and between 1996 and 1998 (P=0.04). | Newell ME Hoy JF Cooper SG DeGraaff B Grulich AE Bryant M Millar JL Brew BJ Quinn DI | 2004 | 中国神经肿瘤杂志2004，2，2： | 4 |
| 6 | Cryptic diversity and significant cophylogenetic signal detected by DNA barcoding the rust fungi (Pucciniaceae) of Cyperaceae-Juncaceae显示文摘Plants play important roles as habitat and food for a tremendous diversity of specialist animals and fungi.The disappearance of any plant species can lead to extinction cascades of its associated biota.In consequence,documenting the diversity and specificity of plant-associated organisms is of high practical relevance in biodiversity conservation.Here,we present the first large-scale molecular investigation into the diversity,host specificity,and cophylogenetic congruence of an especially rich plant-fungal association,the rust fungi(Pucciniaceae)of Cyperaceae and Juncaceae.Using the largest rust fungi DNA barcoding dataset published to date(252 sequences,82 taxa),we reject the presence of a global ITS2-28S barcode gap,but find a local gap in Cyperaceae-Juncaceae rusts,and suggest the existence of many cryptic species in North America,with some broadly circumscribed species possibly corresponding to>10 cryptic species.We test previous hypotheses of correlations between the phylogenies of rust fungi and their Cyperaceae-Juncaceae hosts using a combination of global-fit and event-based cophylogenetic methods.A significant cophylogenetic signal is detected between rusts and their hosts,but the small number of cospeciations argues for preferential host jumps as the driving process behind these correlations.In addition,temporal congruence between the origin of major Carex clades and their rusts suggests that host diversification may have promoted parasite diversification.Finally,we discuss the relevance of rust infection patterns to the systematics of Cyperaceae,highlight some taxonomic problems uncovered by the analyses,and call attention to the promise of DNA barcoding for bridging knowledge gaps in poorly studied plant-associated microorganisms. | Étienne Léveillé-Bourret Quinn Eggertson Sarah Hambleton Julian R.Starr | 2021 | Journal of Systematics and Evolution2021，59，4： | 4 |
| 7 | Habitat suitability and herbivores determine reintroduction success of an endangered legume显示文摘Reintroductions of rare plants require detailed knowledge of habitat requirements, species interactions,and restoration techniques. Thus, incremental experimentation over many years may be required to develop adequate knowledge and techniques for successful reintroduction. To determine drivers of extinction in historical reintroductions of a federally endangered perennial(Astragalus bibullatus), we developed a reintroduction experiment to disentangle the relative importance of habitat quality, herbivores, and restoration technique on reintroduction success. In a factorial design, we manipulated access to vertebrate herbivores across different habitat types(mesic ecotone vs. xeric barren), and used founder populations comprised of more transplants and genetic sources than previous reintroduction attempts.In mesic ecotones where historical reintroductions failed, excluding herbivores, thinning woody encroachment to improve habitat quality, outplanting across a greater array of microhabitats, and increasing founder population size did not improve demographic rates over previous attempts.Compared to mesic ecotones, transplant survival rates and cumulative fruit production were more than two and ten times greater, respectively, in a xeric barren ecotone characterized by open, grassy, and dry microenvironmental conditions. Across all sites, herbivores decreased probabilities of survival and flowering of larger adult plants. Flowering rates were 80% greater inside relative to outside herbivore exclusion cages. Over a four-year period, only a single uncaged plant produced fruit. Our study demonstrates that habitat quality and vertebrate herbivory are key drivers of long-term persistence in rare plant reintroductions. Using incremental experiments that build on previous knowledge gained from long-term monitoring can improve reintroduction outcomes. | Matthew A.Albrecht Quinn G.Long | 2019 | Plant Diversity2019，41，2： | 3 |
| 8 | Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors显示文摘Human pluripotent stem cells(hPSC)hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver failure.Some of the challenges that limit the clinical/translational impact of hPSCs are high cost and difficulty in scaling-up of existing differentiation protocols.In this paper,we sought to address these challenges through the development of bioactive microcapsules.A co-axial flow focusing microfluidic device was used to encapsulate hPSCs in microcapsules comprised of an aqueous core and a hydrogel shell.Importantly,the shell contained heparin moieties for growth factor(GF)binding and release.The aqueous core enabled rapid aggregation of hPSCs into 3D spheroids while the bioactive hydrogel shell was used to load inductive cues driving pluripotency maintenance and endodermal differentiation.Specifically,we demonstrated that one-time,1 h long loading of pluripotency signals,fibroblast growth factor(FGF)-2 and transforming growth factor(TGF)-β1,into bioactive microcapsules was sufficient to induce and maintain pluripotency of hPSCs over the course of 5 days at levels similar to or better than a standard protocol with soluble GFs.Furthermore,stem cell-carrying microcapsules that previously contained pluripotency signals could be reloaded with an endodermal cue,Nodal,resulting in higher levels of endodermal markers compared to stem cells differentiated in a standard protocol.Overall,bioactive heparin-containing core-shell microcapsules decreased GF usage five-fold while improving stem cell phenotype and are well suited for 3D cultivation of hPSCs. | Kihak Gwon Hye Jin Hong Alan M.Gonzalez-Suarez Michael Q.Slama Daheui Choi Jinkee Hong Harihara Baskaran Gulnaz Stybayeva Quinn P.Peterson Alexander Revzin | 2022 | Bioactive Materials2022，7，9： | 3 |
| 9 | California Simulation of Evapotranspiration of Applied Water and Agricultural Energy Use in California显示文摘The California Simulation of Evapotranspiration of Applied Water (Cal-SIMETAW) model is a new tool developed by the California Department of Water Resources and the University of California, Davis to perform daily soil water balance and determine crop evapotranspiration (ET c ), evapotranspiration of applied water (ET aw ), and applied water (AW) for use in California water resources planning. ET aw is a seasonal estimate of the water needed to irrigate a crop assuming 100% irrigation efficiency. The model accounts for soils, crop coefficients, rooting depths, seepage, etc. that influence crop water balance. It provides spatial soil and climate information and it uses historical crop and land-use category information to provide seasonal water balance estimates by combinations of detailed analysis unit and county (DAU/County) over California. The result is a large data base of ET c and ET aw that will be used to update information in the new California Water Plan (CWP). The application uses the daily climate data, i.e., maximum (T x ) and minimum (T n ) temperature and precipitation (P cp ), which were derived from monthly USDA-NRCS PRISM data (PRISM Group 2011) and daily US National Climate Data Center (NCDC) climate station data to cover California on a 4 km×4 km change grid spacing. The application uses daily weather data to determine reference evapotranspiration (ET o ), using the Hargreaves-Samani (HS) equation (Hargreaves and Samani 1982, 1985). Because the HS equation is based on temperature only, ET o from the HS equation were compared with CIMIS ET o at the same locations using available CIMIS data to determine correction factors to estimate CIMIS ET o from the HS ET o to account for spatial climate differences. Cal-SIMETAW also employs near real-time reference evapotranspiration (ET o ) information from Spatial CIMIS, which is a model that combines weather station data and remote sensing to provide a grid of ET o information. A second database containing the available soil water holding capacity and soil depth information for all of California was also developed from the USDA-NRCS SSURGO database. The Cal-SIMETAW program also has the ability to generate daily weather data from monthly mean values for use in studying climate change scenarios and their possible impacts on water demand in the state. The key objective of this project is to improve the accuracy of water use estimates for the California Water Plan (CWP), which provides a comprehensive report on water supply, demand, and management in California. In this paper, we will discuss the model and how it determines ET aw for use in water resources planning. | Morteza N Orang Richard L Snyder Shu Geng Quinn J Hart Sara Sarreshteh Matthias Falk Dylan Beaudette Scott Hayes Simon Eching | 2013 | Journal of Integrative Agriculture2013，12，8： | 3 |
| 10 | 精神病病人和服用精神类药物病人接受和长期接受阿片类药物治疗:国家级商业保险索赔研究显示文摘越来越多的证据表明,美国的阿片类处方正遵循一种'逆向选择'模式,这种模式使得接受阿片类药物长期治疗的病人更可能处于阿片类药物不良反应的最大风险中,特别是那些物质使用障碍(SUD)和其他精神病病人。本研究调查了10311961位填写阿片类处方病人的医疗保险索赔情况,特别比较了患精神病及行为异常(比如阿片类和非阿片类SUD、自杀倾向或自残行为、机动车事故、抑郁症、焦虑症和睡眠障碍)和未患精神病及无行为异常病人、服用精神类药品(如抗抑郁药、苯二氮?类药物、安眠药、镇定剂、抗精神病药品和用于治疗SUD、烟草戒断、多动症的药物)和未服用精神类药品病人之间接受阿片类药物治疗的区别。相对于对照组,有精神病或服用精神类药品的病人随后须接受阿片类药物治疗的风险稍高,特别是,接受阿片类药物长期治疗的风险更高。利用校正型Cox回归模型可知,多动症病人接受阿片类药物长期治疗的风险是无多动症病人的1.5倍(危险比(HR)=1.53,95%可信区间:1.48-1.58),非阿片类SUD病人风险约是无此疾患病人的3倍(危险比(HR)=3.15,95%可信区间:3.06-3.24),阿片类使用障碍病人的风险是无此疾患病人的9倍(危险比(HR)=8.70,95%可信区间:8.20-9.24)。总而言之,本研究发现有精神疾病状态的商业保险病人更可能接受阿片类药物治疗。未来关于阿片类药物行为结局的研究需考虑病人的先存精神疾病状况。 | Patrick D Quinn Kwan Hur Zheng Chang 王艳娉 杨俊龙 张小梅 | 2017 | 中国疼痛医学杂志2017，23，9： | 3 |
| 11 | Conferring receptors on recipient cells with extracellular vesicles for targeted drug delivery显示文摘Triple negative breast cancer(TNBC)is a heterogeneous subset of breast cancer characterized by its lack of estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2(HER2),which altogether prevents TNBC from being treated effectively.For many years,the treatment paradigms and overall survival of patients with TNBC have remained largely stagnant.Recent attempts to convert cold tumors to hot tumors by promoting antigen presentation have shown increased T cell infiltration and significantly induced immune responses for tumor killing.Inspired by this concept,the expression of specific targetable antigens on TNBC cells may further benefit relevant targeted drug delivery.In this study,we successfully conferred sufficient HER2 on the surface of TNBC MDA-MB-231 cells via simple EV-plasma membrane fusion with HER2+extracellular vesicles(EV)derived from HER2 overexpressing BT-474 cells.Subsequently,anti-HER2 antibody conjugated paclitaxel-loaded liposomes were used for HER2-targeted drug delivery.Our findings demonstrated this HER2 grafting,in conjunction with targeted drug delivery,can improve the treatment efficacy in vitro and in vivo.This novel approach represents a facile method of altering cell membrane antigen presentation via convenient EVs uptake and may pave the way for the burgeoning wave of targeted therapy and/or immunotherapy. | Zachary Quinn Wenjun Mao Yiqiu Xia Rhea John Yuan Wan | 2021 | Bioactive Materials2021，6，3： | 3 |
| 12 | Modulation of tau phosphorylation by environmental copper显示文摘Background:The transition metal copper enhances amyloidβaggregation and neurotoxicity,and in models of concomitant amyloid and tau pathology,copper also promotes tau aggregation.Since it is not clear if the effects of environmental copper upon tau pathology are dependent on the presence of pathological amyloidβ,we tested the effects of copper overload and complexing in disease models which lack pathological amyloidβ.Methods:We used cell culture and transgenic murine models to test the effects of environmental copper on tau phosphorylation.We used oral zinc acetate as a copper lowering agent in mice and examined changes in blood and brain metals through inductively coupled plasma mass spectroscopy.Behavioral effects of copper lowering were assessed with Morris water maze and novel object recognition tasks.Changes in tau phosphorylation were examined by phosphorylation specific antibodies on Western blots.Results:In human neuroblastoma cells,excess copper promoted tau phosphorylation and a copper complexing agent,tetrathiomolybdate,attenuated tau phosphorylation.In a transgenic mouse model expressing wild type human tau,copper-lowering by oral zinc suppressed plasma and brain levels of copper,and resulted in a marked attenuation of tau phosphorylation.No significant changes in behavior were observed with copper lowering,but a trend to improved recognition of the novel object was observed in zinc acetate treated mice.Conclusions:We propose that reduction of brain copper by blocking uptake of copper from the diet may be a viable strategy for modulating tau pathology in Alzheimer’s disease.The potential benefits of this approach are tempered by the absence of a behavioral benefit and by the health risks of excessive lowering of copper. | Kellen Voss Christopher Harris Martina Ralle Megan Duffy Charles Murchison Joseph F Quinn | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 13 | Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha显示文摘 | Igor A. Schepetkin Gang Xie Liliya N. Kirpotina Robyn A. Klein Mark A. Jutila Mark T. Quinn | 2008 | International Immunopharmacology2008，，10： | 2 |
| 14 | Activated T lymphocytes support osteoclast formation in vitro显示文摘 | Horwood NJ Kartsogiannis V Quinn JM | 1999 | Biochem Biophys Res Commun1999，265，1： | 2 |
| 15 | 高密度脂蛋白可追踪脑卒中恢复情况显示文摘前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。 | Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ Fazio S Pamir N 刘青(译) 刘莉(摘/审校) | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 16 | C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study显示文摘 | Sohail Q. Khan Onkar S. Dhillon Russell J. O’Brien Joachim Struck Paulene A. Quinn Nils G. Morgenthaler Iain B. Squire Joan E. Davies Andreas Bergmann Leong L. Ng | 2007 | Circulation2007，，16： | 2 |
| 17 | Holobricks:modular coarse integral holographic displays显示文摘Here,we propose and demonstrate a modular holographic display system that allows seamless spatial tiling of multiple coarse integral holographic(CIH)displays called'holobricks'.A holobrick is a self-contained CIH module enclosing a spatial light modulator(SLM),a scanner,and periscopic coarse integral optics.Modular CIH uses a coarse pitch and small area but high-bandwidth SLM in conjunction with periscopic coarse integral optics to form the angularly tiled 3D holograms with large viewing areas and fields of view.The creation of periscopic coarse integral optics prevents the optical system from being larger than the holographic image and allows the holographic fringe pattern to fill the entire face of the holobrick.Thus,multiple holobricks can be seamlessly abutted to form a scalable spatially tiled holographic image display capable of both wide feld-of-view angle and arbitrary large-size area.We demonstrate an initial prototype that seamlessly tiles two holobricks each with 1024×768 pixels,40°FOV,full color,24 fps,displaying 2D,3D holographic stereograms,and full parallax 3D CGI Fresnel holograms. | Jin Li Quinn Smithwick Daping Chu | 2022 | Light(Science & Applications)2022，11，4： | 2 |
| 18 | Solid-state reaction between titanium carbide and titanium metal 显示文摘 | Quinn C J Kohlstedt D L | 1984 | J Am Ceram Soc1984，67，5： | 2 |
| 19 | 耐Imipenem的绿脓杆菌显示文摘Imipenem 是第一个碳青霉烯抗生素,具有包括大部分绿脓杆菌在内的异常广谱活性。不幸之处在于本品对绿脓杆菌感染的临床应用,因分离出的耐药绿脓杆菌接近20%而复杂化。此耐药性导致约半数绿脓杆菌感染的治疗失败。此耐药性最重要的微生物学特点是对其它β-内酰胺类没有交叉耐药性。这与面对用头孢菌素类或青霉素类治疗,产生耐药性时所发现的广谱耐药性适成对照。我们研究了绿脓杆菌临床分离菌的 Imipenem 选择耐药性,并特别提到耐药分离菌特有的47kD外膜蛋白(OMP)的缺失。这些资料不只为其它研究者进一步证实。接着研究了我们所做的碳青霉烯类经由一种独有而特殊的孔蛋白,透过绿脓杆菌外膜的假说。本文描述通过通透性试验。 | Quinn J P 张荣富 | 1993 | 国外医药(抗生素分册)1993，14，3： | 2 |
| 20 | Stiffened panel stability behaviour and performance gains with plate prismatic sub-stiffening显示文摘 | D. Quinn A. Murphy W. McEwan F. Lemaitre | 2009 | Thin-Walled Structures2009，，12： | 2 |
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