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| 1 | 血管内皮生长因子-C、-D与肿瘤淋巴道转移研究进展显示文摘恶性肿瘤淋巴道转移的机制和抗肿瘤淋巴道转移的治疗是目前的研究热点之一,不少研究表明血管内皮生长因子-C(vascularendothelialgrowthfactor-C,VEGF-C)和血管内皮生长因子-D(VEGF-D)与恶性肿瘤的淋巴道转移密切相关。本文主要综述VEGF-C、VEGF-D的结构、功能特点、在肿瘤淋巴道转移中的可能机制及由此而引发出的抗肿瘤淋巴道转移治疗的有关进展。 | LI Qiu li, CHEN Fu jingDepartment of Head &Neck,Cancer Center,Sun Yat sen University,Guangzhou 510060,P.R.China | 2002 | 癌症2002，21，6： | 22 |
| 2 | Association between the rate of the morning surge in blood pressure and cardiovascular events and stroke显示文摘 | LUO Yu WANG Yan-li WU Ying-biao XU Yao Geoffrey A. Head Macgrathy Barry LIANG Yu-lu | 2013 | Chinese Medical Journal2013，，3： | 18 |
| 3 | Chinese Society of Clinical Oncology (CSCO) diagnosis and treatment guidelines for head and neck cancer 2018 (English version)显示文摘Contents1. Principles of diagnosis and treatment of head and neck cancer2. Diagnosis principles of head and neck cancer2.1 Image diagnosis2.2 Pathological diagnosis2.3 Staging3. Treatment principles of early and locally advanced head and neck squamous cell carcinoma3.1 Treatment of oral cancer3.1.1 Treatment of early oral cancer3.1.2 Treatment of locally advanced oral cancer. | Pingzhang Tang Ye Guo Chaosu Hu Zhengang Xu Chenping Zhang Liang Zhou | 2019 | Chinese Journal of Cancer Research2019，31，1： | 15 |
| 4 | Effects of Dangshen on isolated gastric muscle strips in rats显示文摘EfectsofDangshenonisolatedgastricmusclestripsinratsZHENGTianZhen1,LIWei1,QUSongYi1,MAYongMing1,DINGYongHui2andWEIYuLing... | ZHENG TianZhen1, LI Wei1, QU SongYi1, MA YongMing1, DING YongHui2 and WEI YuLing2Subject heading Dangshen stomach muscle, smooth muscle contraction receptors, cholinergic rats | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 5 | Anatomic structural study of cerebellopontine angle via endoscope显示文摘在颅骨底依靠寻找内视镜的技术的可能的解剖基础的背景最低限度地侵略的外科是争论的。这研究的目的是在 cerebellopontine 角度区域观察在主要的血容器和神经之间的空间关系并且为侧面、以后的颅骨底提供解剖基础经由内视镜的 retrosigmoid 锁眼 approach.Methods 的最低限度地侵略的外科这研究在三十个弄干的成年颅骨上被进行测量空间关系在之中出现以后的头部的窝的多骨的标记,并且为 retrosigmoid 锁眼 ap 定位最适当的钻区域在直径与 2.0 厘米在这个点上集中的一个洞对在 cerebellopontine 角度暴露相关结构合适。 Retrosigmoid 锁眼途径罐头减少小脑上的压力并且有效地暴露相关结构它包括面部神经, vestibulocochlear 神经,三叉的神经,舌与喉的神经,迷走神经神经,附件神经,舌下神经神经,前面的劣等的小脑的动脉,以后的劣等的小脑的动脉和迷宫的动脉,内诊镜 retrosigmoid 途径上的准确地点能避免在最低限度地侵略的外科期间拖小脑的 etc.Conclusions 。retrosigmoid 锁眼途径的申请将扩大内视镜的技术的申请。 | XIA Yin LI Xi-ping HAN De-min ZHENG Jun LONG Hai-shan SHI Jin-feng Department of Otolaryngology,Beijing Tongren Hospital,Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University),Ministry of Education,Beijing 100730,China (Xia Y,Li XP,Han DM,Zheng J,Long HS and Shi JF) | 2007 | Chinese Medical Journal2007，，20： | 7 |
| 6 | Hearing and Cochlear structures in a Swine Model显示文摘Objective To study the audition and inner ear structure in a normal swine model.Methods Auditory brainstem responses(ABRs) were determined in swine at 1 day and 1 month after birth.The form of the cochlea and hair cells were examined under a scanning electron microscope and on cochlear slices.Results ABR thresholds at 1 day and 1 month post-birth were between 40 and 50 dB SPL.The latencies of waves I,III and V in 1 day old swine were 1.97 ± 0.13,3.01± 0.16 and 4.26±0.20 ms,respectively.At 1 month,the lantancies of waves I,III and V were 2.01 ± 0.05,3.11±0.08 and 4.65 ± 0.14 ms,respectively,slightly longer than those at 1 day,although not statistically significant(p>0.05).The swine cochlea was constituted of 3 and a half turns and the cochlear hair cells lined up in four rows.Hair cell cilia in the apical turn were longer than those in other turns.Conclusions The swine cochlea is mature at the time of birth.Swine ABR thresholds are slightly higher than humans and rats.Swine appears to be a precocial animal species. | GUO Wei-wei1,Cheng Lei2,Liu Hui-zhan1,Sun Jian-he1,YANG Shi-ming1,1 Department of Otolaryngology,Head & Neck Surgery,Institute of Otolaryngology,Chinese PLA General Hospital,Beijing 100853,China 2 State Rey laboratory for Agrobio technology China Agrical universiy Beijing 100193,PR,China | 2010 | Journal of Otology2010，5，2： | 7 |
| 7 | ^(14)C CHRONOLOGY OF BEIZHUANGCUN SEDIMENTATION SEQUENCE SINCE 30,000 YEARS B. P.显示文摘The Beizhuangcun profile located at Weinan County, Shaanxi Province at an altitude of 570 m a. s. l. (34°30′N, 109°30′ E) is 16.5 m thick and is located at the eastern bank of Zhuoshui River (muddy river), a west tributary of You River upstream. The profile records the relative continuous sedimentation sequences of about 30,000 a B. P. and is des- | 周卫健 周明富 J. HEAD | 1990 | Chinese Science Bulletin1990，35，7： | 5 |
| 8 | The Early-Middle Pleistocene Transition: characterization and proposed guide for the defining boundary显示文摘 | Martin J. Head Brad Pillans Sarah A. Farquhar | 2008 | Episodes2008，31，2： | 5 |
| 9 | Backward Propagation of Otoacoustic Emissions显示文摘Normal mammalian ears not only detect but also generate sounds. The ear-generated sounds, i.e., otoacoustic emissions (OAEs), can be measured in the external ear canal using a tiny sensitive microphone. In spite of wide applications of OAEs in diagnosis of hearing disorders and in studies of cochlear functions, the question of how the cochlea emits sounds remains unclear. The current dominating theory is that the OAE reaches the cochlear base through a backward traveling wave. However, recently published works, including experimental data on the spatial pattern of basilar membrane vibrations at the emission frequency, demonstrated only forward traveling waves and no signs of backward traveling waves. These new findings indicate that the cochlea emits sounds through cochlear fluids as compression waves rather than through the basilar membrane as backward traveling waves. This article reviews different mechanisms of the backward propagation of OAEs and summarizes recent experimental results. | HE Wenxuan,1, 2 REN Tianying,1, 21. Oregon Hearing Research Center, Department of Otolaryngology and Head & Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, NRC04, Portland, Oregon 97239 USA 2. School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710061 China | 2006 | Journal of Otology2006，1，1： | 4 |
| 10 | Three-Dimensional Simulation of Nonstationary Flow Phenomena in 'Last Stage-Exhaust Hood'Compartment显示文摘Three-dimensional nonstationary model of aerodynamical interaction of turbine stage and exhaust hood is realized, based on nonstationary 3D codes for calculation of inviscid transonic flow through stage[3] and exhaust hood[4] which consist of diffuser and space under casing. The codes are built with the use of the explicit Godunov’s 2nd order difference scheme. Some results of flow simulation through the compartments 'stage-exhaust hood,' 'stage-exhaust axial-radial diffuser' for wide range of volumetric flow rates are represented. | V.G. Solodov (Heat of Department of Theoretical Mechanics and Hydraulics, Docent, Kharkov State Automobile & Highway Technical University, 310078, Kharkov, Ukraine) V.I. Gnesin (Head of Department of Aerodynamics of Power Machines, Professor, Institute fo | 1997 | Journal of Thermal Science1997，6，4： | 4 |
| 11 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 12 | Cochlear implantation in a child with auditory neuropathy spectrum disorder显示文摘Objective To report outcomes of cochlear implantation (CI) in a child with auditory neuropathy spectrum disorder (ANSD) and to provide preliminary clinical evidence of the efficacy of CI in ANSD patients.Methods A 4-year-old boy with diagnosed auditory neuropathy spectrum disorder (ANSD) received implantation of a Nucleus CI24R after an unsatisfactory trial of amplification.Post-implantation performance in both hearing sensitivity and speech recognition was assessed in different sessions.Aided hearing thresholds were tested by behavioral audiometry.Mandarin Early Speech Perception Test (MESP),Meaningful Auditory Integration Scale (MAIS),category of auditory performance (CAP) and Speech Intelligibility Rating (SIR) were used to assess the benefits in auditory skills or speech recognition the boy obtained from CI.The tests were administered before surgery and at 3 months and 7 months after opening.Results The boy demonstrated improved auditory sensitivity by using CI.Concerning speech recognition and communication,both speech audiometry and questionnaires showed an obvious benefit from CI.Conclusions CI has worked efficiently in this ANSD boy.But because of limited understanding of ANSD and rehabilitation effect by cochlear implantation in this condition,the clinical decision to implant should be cautious and only after a thorough evaluation.Meanwhile,well controlled and long term studies are needed to confirm the efficacy of cochlear implantation in patients with ANSD. | JI Fei CHEN Ai-ting HONG Meng-di SHI Wei LI Jia-nan YANG Shi-ming Department of Otolaryngology/Head and Neck Surgery,Chinese PLA Institute of Otolaryngology,Chinese PLA General Hospital,28 Fuxing Road,Beijing 100853,China | 2011 | Journal of Otology2011，6，2： | 4 |
| 13 | Prevalence of the GJB2 Mutations in Deafness Patients of Different Ethnic Origins in Xinjiang显示文摘Objective To investigate GJB2 mutation prevalences in the Uigur and Han ethnic groups in Xinjiang, China, and determine the relationship between ethnicity and GJB2 gene mutations. Methods Information regarding ethnicity of patients' families was obtained through medical records review and/or patient interview. Blood samples were collected from 61 Uigurs and 66 Hans for direct sequencing of the coding region and intron/exon boundaries of the GBJ2 gene. Results Carrier frequency of GJB2 mutations was similar between the Uigur and Han subjects. The GJB2 35delG mutation was seen only in Uigur patients with hearing loss, whereas the 235delC mutation was identified in both Uigur and Han patients. The allelic Frequency of 35delG mutation was 7.4% (9/122) in Uigur deaf students, but none in Han deaf students (0/128) and Uigur controls (0/196). The allelic frequency of GJB2 235delC mutation in Uigur and Han deaf students was 5.7% and 9.8%, and that of 299-300delAT mutation was 0.8% and 5.5%, respectively. V27I and E114G were the most frequent types of polymorphism. Conclusion We found an Asian-specific GJB2 diversity among Uigurs, and comparable GJB2 contribution to deafness in Uigur and Han patients. The high carrier frequency of 35delG in Uigurs (11.5%) is probably defined by gene drift/founder effect in a particular group. Even though GJB2 mutations have been widely reported in the literature, this discussion represents the first report of GJB2 mutations in Chinese multi-ethnic populations. | LI Qi1, DAI Pu1, HUANG De-liang1, ZHANG Jin2, WANG Guo-jian1, ZHU Qing-wen1, Liu Xin3, HAN Dong-yi1 1 Department of otolaryngology Head & Neck Surgery/Institute of Otorhinolaryngology, Genetic Testing Genter for Deafness, PLA General Hospital, Beijing 100853 2 Department of otolaryngology Head & Neck Surgery, Xinjiang Uigur Municipality People’s Hospital 3 Department of otolaryngology Head & Neck Surgery, PLA sixteenth Hospital | 2007 | Journal of Otology2007，2，1： | 3 |
| 14 | CARBON ISOTOPIC STUDY OF LAKES QARHAN AND FROME SEDIMENTS显示文摘 | J. M. Bowler H. A. Polach J. Head | 1983 | Chinese Journal of Oceanology and Limnology1983，，03： | 2 |
| 15 | Carbon isotopic study of Lakes Qarhan and frome sediments显示文摘 | Huang Qi J. M. Bowler H. A. Polach J. Head | 1983 | Chinese Journal of Oceanology and Limnology1983，，3： | 2 |
| 16 | Solid-phase sequence scanning for drug resistance detection in tuberculosis 显示文摘 | Head S R Parikh K Rogers Y H | 1999 | Mol Cellular Probes1999，13，2： | 2 |
| 17 | Manipulating perceived social presence through the web interface and its impact on attitude towards online shopping显示文摘 | Khaled Hassanein Milena Head | 2007 | International Journal of Human - Computer Studies2007，，8： | 2 |
| 18 | Recovery of the alografted smalintestine functions显示文摘RecoveryofthealograftedsmalintestinefunctionsJIANGZhiWei,LIJieShou,LINin,LIYouSheng,LIUFangLan,SHENGXueQinandCHENGYong... | JIANG Zhi Wei, LI Jie Shou, LI Nin, LI You Sheng, LIU Fang Lan, SHENG Xue Qin and CHENG Yong Min Subject headings Nutritional support small intestine/transplantation small intestine/physiopathology | 1997 | World Journal of Gastroenterology1997，3，2： | 2 |
| 19 | Regional wage and employment responses to market potential in the EU显示文摘 | Keith Head Thierry Mayer | 2006 | Regional Science and Urban Economics2006，，5： | 2 |
| 20 | Non-Europe: The magnitude and causes of market fragmentation in the EU显示文摘 | Keith Head Thierry Mayer | 2000 | Weltwirtschaftliches Archiv2000，，2： | 2 |
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