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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Dual Energy CT Characterization of Urinary Calculi: Initial In Vitro and Clinical Experience显示文摘 | Anno Graser Thorsten R. C. Johnson Markus Bader Michael Staehler Nicolas Haseke Konstantin Nikolaou Maximilian F. Reiser Christian G. Stief Christoph R. Becker | 2008 | Investigative Radiology2008，，2： | 3 |
| 3 | Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis显示文摘 | Fanny Wai-Tsing Shek Robert Christopher Benyon Fiona Mairi Walker Peter Raymond McCrudden Sylvia Lin Foon Pender Elizabeth Jean Williams Penelope Ann Johnson Colin David Johnson Adrian Calvin Bateman David Roger Fine John Peter Iredale | 2002 | The American Journal of Pathology2002，，5： | 2 |
| 4 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 5 | Dual-source CT cardiac imaging: initial experience显示文摘 | Thorsten R. C. Johnson Konstantin Nikolaou Bernd J. Wintersperger Alexander W. Leber Franz Ziegler Carsten Rist Sonja Buhmann Andreas Knez Maximilian F. Reiser Christoph R. Becker | 2006 | European Radiology2006，，7： | 2 |
| 6 | Material differentiation by dual energy CT: initial experience显示文摘 | Thorsten R. C. Johnson Bernhard Krau? Martin Sedlmair Michael Grasruck Herbert Bruder Dominik Morhard Christian Fink Sabine Weckbach Miriam Lenhard Bernhard Schmidt Thomas Flohr Maximilian F. Reiser Christoph R. Becker | 2007 | European Radiology2007，，6： | 2 |
| 7 | Cancer Transmission From Organ Donors—Unavoidable But Low Risk显示文摘 | Rajeev Desai Dave Collett Christopher J. Watson Philip Johnson Tim Evans James Neuberger | 2012 | Transplantation Journal2012，，12： | 2 |
| 8 | A survey of current resaearch on online communities of practice显示文摘 | Johnson Christopher M | | 0，，： | 1 |
| 9 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet2013，，9880： | 1 |
| 10 | Outcome analysis of long-term survivors following pancreaticoduodenectomy显示文摘 | W. Scott Melvin M.D. Karl S. Buekers B.S. Peter Muscarella M.D. Jerome A. Johnson Ph.D. William J. Schirmer M.D. E. Christopher Ellison M.D | 1998 | Journal of Gastrointestinal Surgery1998，，1： | 1 |
| 11 | Carbon Lock-in through Capital Stock Inertia Associated with Weak Near-term Climate Policies显示文摘 | Christoph Bertram Nils Johnson | 2013 | Technological Forecasting and Social Change2013，1，： | 1 |
| 12 | Early-onset severe preeclampsia: induction of labor vs elective cesarean delivery and neonatal outcomes显示文摘 | Mark C. Alanis Christopher J. Robinson Thomas C. Hulsey Myla Ebeling Donna D. Johnson | 2008 | American Journal of Obstetrics and Gynecology2008，，3： | 1 |
| 13 | Mobilisation of metals in mineral tailings at the abandoned Sao Domingos copper mine (Portugal) by indigenous acidophilic bacteria显示文摘 | Bryan Christopher G Hallberg Kevin B Johnson D Barrie | 2006 | Hydrometallurgy2006，83，14： | 1 |
| 14 | Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects显示文摘 | MyPhuong T. Le Reginald F. Frye Christopher J. Rivard Jing Cheng Kim K. McFann Mark S. Segal Richard J. Johnson Julie A. Johnson | 2012 | Metabolism2012，，5： | 1 |
| 15 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 16 | Some results concerning maximum Renyi entropy distributions显示文摘 | Oliver Johnson Christophe Vignat | 2007 | Annales de I''linstitut Henri Poincare2007，43，3： | 1 |
| 17 | Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer显示文摘AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma.METHODS From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after high-dose [59.4 Gy(RBE)] proton radiotherapy with a high rate of local control,acceptable surgical morbidity,and a median survival of 24 mo. | Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J Hughes John A Stauffer Scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg | 2017 | World Journal of Gastrointestinal Surgery2017，9，4： | 1 |
| 18 | Fabrication and characterization of a multilayered optical tissue model with embedded scattering microspheres in polymeric materials 显示文摘 | Chang Robert C Johnson Peter Stafford Christopher M | 2012 | Biomedical Optics Express(S2156-7085)2012，3，6： | 1 |
| 19 | Courts and Relational Contracts显示文摘 | Johnson Simon McMillan John Christopher Woodruff | 2002 | Journal of Law Economics & Organization2002，18，1： | 1 |
| 20 | The geochemistry of iodine — a review显示文摘 | Ronald Fuge Christopher C. Johnson | 1986 | Environmental Geochemistry and Health1986，，2： | 1 |
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