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| 1 | Calcium phosphate cements for bone engineering and their biological properties显示文摘Calcium phosphate cements(CPCs) are frequently used to repair bone defects. Since their discovery in the 1980 s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability,bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs,including 3 D printing, injectability, stem cell delivery, growth factor and drug delivery, and prevascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. | Hockin HK Xu Ping Wang Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao Xuedong Zhou Mark A Reynolds | 2017 | Bone Research2017，5，4： | 14 |
| 2 | 6min步行试验中不同指令对行走距离的影响显示文摘6min步行试验(6-minwalktest,6MWT)作为测定心肺功能的一种方法,一直以使患者走的尽可能远为目标,然而,特定的步行指令对患者6MWT测定的影响尚不清楚。方法:纳入肺动脉高压(pulmonaryarterialhypertension,PAH)、特发性肺间质纤维化(idiopathicpulmonaryfibrosis,IPF)和其他类型的间质性肺疾病(interstitiallungdisease,ILD)患者, | 刘莉 叶鹏 Weir NA Brown AW Shlobin OA Smith MA Reffett T Battle E Ahmad S Nathan SD | 2014 | 中华高血压杂志2014，22，2： | 13 |
| 3 | Effects of quaternary ammonium chain length on the antibacterial and remineralizing effects of a calcium phosphate nanocomposite显示文摘Composites containing nanoparticles of amorphous calcium phosphate(NACP)remineralize tooth lesions and inhibit caries.A recent study synthesized quaternary ammonium methacrylates(QAMs)with chain lengths(CLs)of 3–18 and determined their effects on a bonding agent.This study aimed to incorporate these QAMs into NACP nanocomposites for the first time to simultaneously endow the material with antibacterial and remineralizing capabilities and to investigate the effects of the CL on the mechanical and biofilm properties.Five QAMs were synthesized:DMAPM(CL3),DMAHM(CL6),DMADDM(CL12),DMAHDM(CL16),and DMAODM(CL18).Each QAM was incorporated into a composite containing 20%NACP and 50%glass fillers.A dental plaque microcosm biofilm model was used to evaluate the antibacterial activity.The flexural strength and elastic modulus of nanocomposites with QAMs matched those of a commercial control composite(n 5 6;P.0.1).Increasing the CL from 3 to 16 greatly enhanced the antibacterial activity of the NACP nanocomposite(P,0.05);further increasing the CL to 18 decreased the antibacterial potency.The NACP nanocomposite with a CL of 16 exhibited biofilm metabolic activity and acid production that were 10-fold lesser than those of the control composite.The NACP nanocomposite with a CL of 16 produced 2-log decreases in the colony-forming units(CFU)of total microorganisms,total streptococci,and mutans streptococci.In conclusion,QAMs with CLs of 3–18 were synthesized and incorporated into an NACP nanocomposite for the first time to simultaneously endow the material with antibacterial and remineralization capabilities.Increasing the CL reduced the metabolic activity and acid production of biofilms and caused a 2-log decrease in CFU without compromising the mechanical properties.Nanocomposites exhibiting strong anti-biofilm activity,remineralization effects,and mechanical properties are promising materials for tooth restorations that inhibit caries. | Ke Zhang Lei Cheng Michael D Weir Yu-Xing Bai Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，1： | 13 |
| 4 | Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells显示文摘Tissue engineering is promising to meet the increasing need for bone regeneration. Nanostructured calcium phosphate(CaP) biomaterials/scaffolds are of special interest as they share chemical/crystallographic similarities to inorganic components of bone. Three applications of nano-CaP are discussed in this review:nanostructured calcium phosphate cement(CPC); nano-CaP composites; and nano-CaP coatings. The interactions between stem cells and nano-CaP are highlighted, including cell attachment, orientation/morphology, differentiation and in vivo bone regeneration. Several trends can be seen:(i) nano-CaP biomaterials support stem cell attachment/proliferation and induce osteogenic differentiation, in some cases even without osteogenic supplements;(ii) the influence of nano-CaP surface patterns on cell alignment is not prominent due to non-uniform distribution of nano-crystals;(iii) nano-CaP can achieve better bone regeneration than conventional CaP biomaterials;(iv) combining stem cells with nano-CaP accelerates bone regeneration, the effect of which can be further enhanced by growth factors; and(v) cell microencapsulation in nano-CaP scaffolds is promising for bone tissue engineering. These understandings would help researchers to further uncover the underlying mechanisms and interactions in nano-CaP stem cell constructs in vitro and in vivo, tailor nano-CaP composite construct design and stem cell type selection to enhance cell function and bone regeneration, and translate laboratory findings to clinical treatments. | Ping Wang Liang Zhao Jason Liu Michael D Weir Xuedong Zhou Hockin H K Xu | 2014 | Bone Research2014，2，3： | 11 |
| 5 | One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms显示文摘Dental composites are commonly used restorative materials; however, secondary caries due to bio?lm acids remains a major problem. The objectives of this study were(1) to develop a composite containing quaternary ammonium dimethacrylate(QADM),nanoparticles of silver(NAg), and nanoparticles of amorphous calcium phosphate(NACP), and(2) to conduct the ?rst investigation of the mechanical properties, bio?lm response and acid production vs water-ageing time from 1 day to 12 months.A 4 × 5 design was utilized, with four composites(NACP-QADM composite, NACP-NAg composite, NACP-QADM-NAg composite,and a commercial control composite), and ?ve water-ageing time periods(1 day, and 3, 6, 9, and 12 months). After each waterageing period, the mechanical properties of the resins were measured in a three-point ?exure, and antibacterial properties were tested via a dental plaque bio?lm model using human saliva as an inoculum. After 12 months of water-ageing, NACP-QADMNAg had a ?exural strength and elastic modulus matching those of the commercial control(P40.1). Incorporation of QADM or NAg into the NACP composite greatly reduced bio?lm viability, metabolic activity and acid production. A composite containing both QADM and NAg possessed a stronger antibacterial capability than one with QADM or NAg alone(Po0.05). The anti-bio?lm activity was maintained after 12 months of water-ageing and showed no signi?cant decrease with increasing time(P40.1). In conclusion, the NACP-QADM-NAg composite decreased bio?lm viability and lactic acid production, while matching the loadbearing capability of a commercial composite. There was no decrease in its antibacterial properties after 1 year of water-ageing.The durable antibacterial and mechanical properties indicate that NACP-QADM-NAg composites may be useful in dental restorations to combat caries. | Lei Cheng Ke Zhang Chen-Chen Zhou Michael D Weir Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，3： | 8 |
| 6 | 日本血吸虫病流行区人群细胞因子水平的初步研究显示文摘为了分析和比较日本血吸虫病流行区人群细胞因子应答水平的差异,提供血吸虫病流行区人群细胞免疫应答特征的基线资料。以鄱阳湖中的南山岛上3个毗邻的自然村为研究现场,根据粪检结果对试区14~41岁人群按年龄组随机抽样,选取粪检结果阴性的65人,粪检阳性的64人为研究对象。采用全血培养法,以血吸虫可溶性虫卵抗原(SEA)及可溶性成虫粗抗原(SWAP)刺激研究对象的血细胞产生细胞因子,检测培养上清中细胞因子的水平。结果表明,存在对血吸虫抗原刺激不产生相应细胞因子的个体,从细胞因子水平的均值来看,总体上,对SEA的细胞因子应答水平较对SWAP的水平为高,每克粪卵数(EPG)为0组的细胞因子平均水平显著高于EPG大于0组的水平。研究结果提示,存在流行区人群细胞免疫应答水平被下调的可能性,其特征和机制值得进一步研究。 | 吴海玮 沈蕾 张兆松 Rosemary Weir 邵莉君 谢彰武 胡林生 陈淑贞 Martin G Taylor 张绍基 吴观陵 | 1998 | 南京医科大学学报(自然科学版)1998，18，6： | 6 |
| 7 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 8 | Serum Urate as an Independent Predictor of Poor Outcome and Future Vascular Events After Acute Stroke显示文摘 | Christopher J. Weir Scott W. Muir Matthew R. Walters Kennedy R. Lees | 2003 | Stroke: Journal of the American Heart Association2003，，8： | 5 |
| 9 | Effect of anti-biofilm glass–ionomer cement on Streptococcus mutans biofilms显示文摘Dental restorative materials with antimicrobial properties can inhibit bacterial colonization, which may result in a reduction of caries at tooth-filling interaction zones. This study aimed to develop antibacterial glass–ionomer cements(GIC) containing a quaternary ammonium monomer(dimethylaminododecyl methacrylate, DMADDM), and to investigate their effect on material performance and antibacterial properties. Different mass fractions(0, 1.1% and 2.2%) of DMADDM were incorporated into the GIC. The flexure strength, surface charge density, surface roughness and fluoride release were tested. A Streptococcus mutans biofilm model was used. Exopolysaccharides(EPS) staining was used to analyze the inhibitory effect of DMADDM on the biofilm matrix. In addition, biofilm metabolic activity, lactic acid metabolism and the expression of glucosyltransferase genes gtf B, gtf C and gtf D were measured. GIC containing 1.1% and 2.2% DMADDM had flexural strengths matching those of the commercial control(P40.1). DMADDM was able to increase the surface charge density but reduced surface roughness(Po0.05). The incorporation of 1.1% and 2.2% DMADDM elevated the release of fluoride by the GIC in the first 2 days(Po0.05). The novel DMADDM-modified GIC significantly reduced biofilm metabolic activity(Po0.05) and decreased lactic acid production(Po0.05). The quantitative polymerase chain reaction(q PCR) results showed that the expression of gtf B, gtf C and gtf D decreased when mass fractions of DMADDM increased(Po0.05). EPS staining showed that both the bacteria and EPS in biofilm decreased in the DMADDM groups. The incorporation of DMADDM could modify the properties of GIC to influence the development of S. mutans biofilms. In this study, we investigated the interface properties of antibacterial materials for the first time. GIC containing DMADDM can improve material performance and antibacterial properties and may contribute to the better management of secondary caries. | Su-Ping Wang Yang Ge Xue-Dong Zhou Hockin HK Xu Michael D Weir Ke-Ke Zhang Hao-Hao Wang Matthias Hannig Stefan Rupf Qian Li Lei Cheng | 2016 | International Journal of Oral Science2016，8，2： | 5 |
| 10 | 文献快报(3):童年期和成年期生活压力对老年期炎症基因表达的影响显示文摘生命早期的不良经历一直潜在影响着人类的健康。童年期不良经历通过对神经内分泌功能的改变影响着功体的生理功能与内环境稳定,增加了心血管疾病、糖尿病、癌症、神经退行性疾病、关节炎等的患病风险。 | LEVINE ME COLE SW WEIR DR 苏普玉 | 2015 | 中国学校卫生2015，36，3： | 4 |
| 11 | Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks显示文摘Antibacterial dimethylaminododecyl methacrylate(DMADDM) was recently synthesized. The objectives of this study were to:(1)investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and(2) compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate(QADM).Scotchbond Multi-Purpose(SBMP) bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested: SBMP control primer P, P+2.5% DMADDM, P+5% DMADDM, P+7.5% DMADDM, P+10% DMADDM, and P+10% QADM.S. mutans were impregnated into human dentin blocks, and each primer was applied to dentin to test its ability to kill bacteria in dentinal tubules. Bacteria in dentin were collected via a sonication method, and the colony-forming units(CFU) and inhibition zones were measured. The bacterial inhibition zone of P+10% DMADDM was 10 times that of control primer(Po0.05). CFU in dentin with P+10% DMADDM was reduced by three orders of magnitude, compared with control. DMADDM had a much stronger antibacterial effect than QADM, and antibacterial efficacy increased with increasing DMADDM concentration. Dentin shear bond strengths were similar among all groups(P40.1). In conclusion, antibacterial DMADDM-containing primer was validated to kill bacteria inside dentin blocks, possessing a much stronger antibacterial potency than the previous QADM. DMADDM-containing bonding agent was effective in eradicating bacteria in dentin, and its efficacy was directly proportional to DMADDM mass fraction. Therefore, DMADDM may be promising for use in bonding agents as well as in other restorative and preventive materials to inhibit bacteria. | Chen Chen Lei Cheng Michael D Weir Nancy J Lin Sheng Lin-Gibson Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，4： | 4 |
| 12 | Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement显示文摘White spot lesions(WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate(NACP) with long-term calcium(Ca) and phosphate(P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACPrechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release.The rechargeable cement consisted of pyromellitic glycerol dimethacrylate(PMGDM) and ethoxylated bisphenol A dimethacrylate(EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength(SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release(P40.1). Specimens after one recharge treatment(e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as '1 min 3 times') exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles(P40.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times43 min 2 times41 min 2 times46 min 1 time43 min 1 time41 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets. | Xian-Ju Xie Dan Xing Lin Wang Han Zhou Michael D Weir Yu-Xing Bai Hockin HK Xu | 2017 | International Journal of Oral Science2017，9，1： | 3 |
| 13 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 14 | Low-dose drug combination therapy: An alternative first-line approach to hypertension treatment显示文摘 | L.Michael Prisant Matthew R. Weir Vasilios Papademetriou Michael A. Weber Isaac A. Adegbile Demissie Alemayehu Martin P. Lefkowitz Albert A. Carr | 1995 | American Heart Journal1995，，2： | 2 |
| 15 | Rayleigh-Taylor instability experiments examining feed through growth in an incompressible convergent geometry显示文摘 | Weir S T Chandler E A Goodwin B T | 1998 | Phys Rev Lett1998，80，17： | 2 |
| 16 | Randomised controlled trial of combined spinal epidural vs. spinal anaesthesia for elective caesarean section: vasopressor requirements and cardiovascular changes显示文摘 | Alan JR Macfarlane Artur Pryn Kerry N Litchfield Fiona Bryden Steven Young Christopher Weir Elizabeth M McGrady | 2009 | European Journal of Anaesthesiology2009，，1： | 2 |
| 17 | How plants communicate using the underground information superhighway显示文摘 | Harsh Pal Bais Sang-Wook Park Tiffany L Weir Ragan M Callaway Jorge M Vivanco | 2003 | Trends in Plant Science2003，，1： | 2 |
| 18 | Survival benefit of the full selective digestive decontamination regimen显示文摘 | Luciano Silvestri Hendrick K.F. van Saene Ian Weir Antonino Gullo | 2009 | Journal of Critical Care2009，，3： | 2 |
| 19 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH1 , EGFR , and NF1显示文摘 | Roel G.W. Verhaak Katherine A. Hoadley Elizabeth Purdom Victoria Wang Yuan Qi Matthew D. Wilkerson C. Ryan Miller Li Ding Todd Golub Jill P. Mesirov Gabriele Alexe Michael Lawrence Michael O'Kelly Pablo Tamayo Barbara A. Weir Stacey Gabriel Wendy Winckler | 2010 | Cancer Cell2010，，1： | 2 |
| 20 | 揭秘人类先天无痛症的病理基础——电压门控钠通道Nav 1.7在人类痛觉中的功能作用显示文摘人类先天无痛症(congenital insensitivity to pain,CIP)可能源于电压门控钠通道(VGSC)NaV 1.7基因SCN9A的功能丧失型突变。这也提示NaV 1.7有可能作为镇痛药物研发的关键靶标。本文作者利用多模式技术方法,系统研究了NaV 1.7的突变如何导致人类对疼痛变得不敏感。皮肤活检和显微神经造影术结果显示,CIP病人的C-纤维型伤害性感受器神经元明显缺失,这也反映在对其进行的功能磁共振成像(fMRI)的结果:辣椒素对脑皮质的激活作用明显降低。内源性表达NaV 1.7的表位标记实验结果显示,NaV 1.7定位于人工诱导多能干细胞(iPSC)产生的伤害性感受器神经元的胞体细胞膜、轴突、轴突末端和郎飞结处。来源于CIP病人的iPSC伤害性感受器神经元不能对去极化刺激产生合适的反应,证明NaV 1.7是神经元兴奋性的关键调节因子。本文作者进一步应用iPSC伤害感受器神经元作为筛选平台,发现一些正进行临床试验的NaV 1.7阻断剂实际上缺乏对NaV 1.7的选择特异性。综上,CIP病人的无痛症状是由于功能性伤害感受器的严重缺失而产生,其比在啮齿动物模型上的实验结果更为明显。当然也不能排除急性药理学阻断NaV 1.7导致伤害性感受器缺失的可能性。 | McDermott LA Weir GA Themistocleous AC 单文琪(译) 张江涛(译) 刘通(校) | 2020 | 中国疼痛医学杂志2020，26，3： | 2 |
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