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| 1 | 胰腺导管腺癌放射学报告模板:腹部放射协会和美国胰腺协会的共识声明显示文摘胰腺导管腺癌(PDA)是一种具有侵袭性、死亡率高的恶性肿瘤。在肿瘤分期时,通过影像学分析,合理判定肿瘤的范围,是患者治疗措施中最重要的步骤之一。考虑到不同医生在专业知识水平和疾病严重程度的判定有所差异,以及在放射学检查时经常缺乏相关影像学表现的完整报道,有必要采用标准化的影像学报告模板以及大家一致接受和认可的胰腺实性肿瘤术语。在腹部放射协会和美国胰腺协会的共同资助下,胰腺导管腺癌(PDA)多机构专家组(包括放射学专家、胃肠病学和肝胆胰外科学专家)共同发起了一份描述标准化报告模板的共识声明。采用这种标准化的影像学报告模板将能改进PDA患者的治疗决策过程,并可通过提供一份完整、相关、精准的疾病分期报告以优化治疗方案。通过对可行手术切除的患者恰当、一致的分期,标准化报告模板有助于促进临床和科研实验设计,从而实现在不同机构之间的实验结果的比较。 | Mahmoud M.Al-Hawary Isaac R.Francis Suresh T.Chari Elliot K.Fishman David M.Hough David S.Lu Michael Macari Alec J.Megibow Frank H.Miller Dushyant V.Sahani Diane M.Simeone 黄翔 孙灿辉 | 2014 | 影像诊断与介入放射学2014，23，4： | 52 |
| 2 | LCSH,SKOS和关联数据显示文摘论述将美国国会图书馆MARCXML格式的主题标目转换为SKOS(RDF编码格式)的技术方法。着重阐述SKOS词表的优势、可能的扩展方向以及与其他语义网词表的整合,如都柏林核心集。还介绍一个利用关联数据(LinkedData)技术在网上发布词表的Web应用。 | Ed Summers Antoine Isaac Clay Redding Dan Krech 姚小乐 刘炜(译) 张春景(校) | 2009 | 现代图书情报技术2009，，3： | 41 |
| 3 | PAM特性对砂壤土入渗及土壤侵蚀的影响显示文摘选择3种分子量(12×106、15×106和18×106Da)和3种水解度(7%、20%和35%)聚丙烯酰胺(PAM),测试PAM特性对土壤入渗和侵蚀的影响。结果表明,3种不同分子量PAM均能明显提高土壤入渗,与对照相比,稳定入渗率分别增加了58.9%、92.2%和83.3%。中分子量和高分子量PAM处理增加入渗效果明显大于低分子量处理,但前两者之间差异不显著。同样不同分子量PAM处理可显著降低土壤侵蚀量,与对照相比,土壤侵蚀量分别降低26.3%、52.6%和26.3%。3种分子量之间比较,中等分子量效果明显好于其他两种分子量。3种水解度PAM提高稳定入渗率分别为对照的1.9倍、2.4倍和2.3倍,20%中等水解度增加初始入渗效果明显高于7%与35%水解度,PAM的水解度对侵蚀量影响不明显。低分子量PAM链长较短,不能在相邻的黏粒之间形成'搭接桥',使黏结作用减弱,而高分子量PAM分子链过长,难穿透进入土壤团聚体之间的空隙,中等分子量的分子链长处于中间尺度,较易穿透土壤空隙,也可形成土壤颗粒之间搭接,产生较好黏结效果。PAM水解度小,电荷密度小,吸附作用弱,但水解度大,电荷密度大,造成分子链之间互斥作用增强,反而导致PAM黏结作用减弱,因而,中等水解度施用效果较好。 | 于健 雷廷武 Isaac Shainberg 张俊生 张季平 | 2011 | 土壤学报2011，48，1： | 48 |
| 4 | Management of pancreaticobiliary disease using a new intra-ductal endoscope:The Texas experience显示文摘AIM:To evaluate a new single-operator mini-endoscope, Spyglass,for its performance,feasibility and safety in the management of pancreaticobiliary disease. METHODS:In a multicenter retrospective analysis of patients undergoing intraductal endoscopy,we evaluated 128 patients(71 men,mean age 57.6 years).Indications were therapeutic(TX)in 72(56%) and diagnostic(DX)in 56(44%). RESULTS:Peroral endoscopy was performed in 121 and percutaneous in seven.TX indications included CBD stones in 41,PD stones in six,and biliary strictures in 25.DX indications included abnormal LFT’s in 15, abnormal imaging in 38 and cholangiocarcinoma staging in three.Visualization of the stone(s)was considered good in 31,fair in six,and poor in four. Advancement of the electrohydraulic lithotripsy probe was not possible in three patients and proper targeting of the lesion was partial in four patients.A holmium laser was used successfully in three patients.Ductal clearance was achieved in 37 patients after one procedure and in four patients after two procedures.Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.Of the modified patients,no diagnosis was available in 17.Spyglass demonstrated malignancy in 8/17 and non-malignancy in nine.Suspected pathology by imaging studies and abnormal LFT’s was modified in 43/63(66%).Staging of cholangiocarcinoma demonstrated multicentric cholangiocarcinoma in 2/3.There was no morbidity associated with the use of Spyglass. CONCLUSION:Spyglass Spyscopeis a first generation, single operator miniature endoscope that can evaluate and treat various biliary and pancreatic tract diseases. | Douglas S Fishman Paul R Tarnasky Sandeep N Patel Isaac Raijman | 2009 | World Journal of Gastroenterology2009，15，11： | 22 |
| 5 | Global blue carbon accumulation in tidal wetlands increases with climate change显示文摘Coastal tidal wetlands produce and accumulate significant amounts of organic carbon(C)that help to mitigate climate change.However,previous data limitations have prevented a robust evaluation of the global rates and mechanisms driving C accumulation.Here,we go beyond recent soil C stock estimates to reveal global tidal wetland C accumulation and predict changes under relative sea level rise,temperature and precipitation.We use data from literature study sites and our new observations spanning wide latitudinal gradients and 20 countries.Globally,tidal wetlands accumulate 53.65(95%CI:48.52-59.01)Tg C yr^(-1),which is~30%of the organic C buried on the ocean floor.Modeling based on current climatic drivers and under projected emissions scenarios revealed a net increase in the global C accumulation by2100.This rapid increase is driven by sea level rise in tidal marshes,and higher temperature and precipitation in mangroves.Countries with large areas of coastal wetlands,like Indonesia and Mexico,are more susceptible to tidal wetland C losses under climate change,while regions such as Australia,Brazil,the USA and China will experience a significant C accumulation increase under all projected scenarios. | Faming Wang Christian J.Sanders Isaac R.Santos Jianwu Tang Mark Schuerch Matthew L.Kirwan Robert E.Kopp Kai Zhu Xiuzhen Li Jiacan Yuan Wenzhi Liu Zhian Li | 2021 | National Science Review2021，8，9： | 22 |
| 6 | PKM2: A gatekeeper between growth and survival显示文摘 | Isaac Harris Susan McCracken Tak Wah Mak | 2012 | Cell Research2012，22，3： | 11 |
| 7 | Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease显示文摘Alzheimer's disease(AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disease, these efforts have not translated into any effective disease-modifying therapies. This could be because interventions are being tested too late in the disease process. While existing therapies provide symptomatic and clinical benefit, they do not fully address the molecular abnormalities that occur in AD neurons. The pathophysiology of AD is complex; mitochondrial bioenergetic deficits and brain hypometabolism coupled with increased mitochondrial oxidative stress are antecedent and potentially play a causal role in the disease pathogenesis. Dysfunctional mitochondria accumulate from the combination of impaired mitophagy, which can also induce injurious inflammatory responses, and inadequate neuronal mitochondrial biogenesis. Altering the metabolic capacity of the brain by modulating/potentiating its mitochondrial bioenergetics may be a strategy for disease prevention and treatment. We present insights into the mechanisms of mitochondrial dysfunction in AD brain as well as an overview of emerging treatments with the potential to prevent, delay or reverse the neurodegenerative process by targeting mitochondria. | Isaac G. Onyango | 2018 | Neural Regeneration Research2018，13，1： | 11 |
| 8 | HyDeploy:The UK’s First Hydrogen Blending Deployment Project显示文摘The HyDeploy project is the UK’s first practical project to demonstrate that hydrogen can be safely blended into the natural-gas distribution system without requiring changes to appliances and the associated disruption.The project is funded under Ofgem’s Network Innovation Competition and is a collaboration between Cadent Gas,Northern Gas Networks,Progressive Energy Ltd,Keele University(Keele),Health&Safety Laboratory and ITM Power.Cadent and Northern Gas Networks are the Gas Distribution Network sponsors of the project.Keele University is the host site,providing the gas-distribution network,which will receive the hydrogen blend.Keele University is the largest campus university in the UK.Health&Safety Laboratory provides the scientific laboratories and experimental expertise.ITM Power provides the electrolyser that produces the hydrogen.Progressive Energy Ltd is the project developer and project manager.HyDeploy is structured into three distinct phases.The first is an extensive technical programme to establish the necessary detailed evidence base in support of an application to the Health&Safety Executive for Exemption to Schedule 3 of the Gas Safety(Management)Regulations(GS(M)R)to permit the injection of hydrogen at 20 mol%.This is required to allow hydrogen to be blended into a natural-gas supply above the current British limit of 0.1 mol%.The second phase comprises the construction of the electrolyser and grid entry unit,along with the necessary piping and valves,to allow hydrogen to be mixed and injected into the Keele University gas-distribution network and to ensure all necessary training of operatives is conducted before injection.The third phase is the trial itself,which is due to start in the summer of 2019 and last around 10 months.The trial phase also provides an opportunity to undertake further experimental activities related to the operational network to support the pathway to full deployment of blended gas.The outcome of HyDeploy is principally developing the initial evidence base that hydrogen can be blended into a UK operational natural-gas network without disruption to customers and without prejudicing the safety of end users.If deployed at scale,hydrogen blending at 20 mol%would unlock 29 TWh pa of decarbonized heat and provide a route map for deeper savings.The equivalent carbon savings of a national roll-out of a 20-mol%hydrogen blend would be to remove 2.5 million cars from the road.HyDeploy is a seminal UK project for the decarbonization of the gas grid via hydrogen deployment and will provide the first stepping stone for setting technical,operational and regulatory precedents of the hydrogen vector. | Tommy Isaac | 2019 | Clean Energy2019，3，2： | 10 |
| 9 | Umbilical cord as a mesenchymal stem cell source for treating joint pathologies显示文摘Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life.Regrettably,the regeneration of articular cartilage is a continuing challenge for biomedical research.One of the most promising therapeutic approaches is cellbased tissue engineering,which provides a healthy population of cells to the injured site but requires differentiated chondrocytes from an uninjured site.The use of healthy chondrocytes has been found to have limitations.A promising alternative cell population is mesenchymal stem cells(MSCs),known to possess excellent proliferation potential and proven capability for differentiation into chondrocytes.The“immunosuppressive”property of human MSCs makes them an important candidate for allogeneic cell therapy.The use of allogeneic MSCs to repair large defects may prove to be an alternative to current autologous and allogeneic tissue-grafting procedures.An allogeneic cell-based approach would enable MSCs to be isolated from any donor,expanded and cryopreserved in allogeneic MSC banks,providing a readily available source of progenitors for cell replacement therapy.These possibilities have spawned the current exponential growth in stem cell research in pharmaceutical and biotechnology communities.Our objective in this review is to summarize the knowledge about MSCs from umbilical cord stroma and focus mainly on their applications for joint pathologies. | María Carmen Arufe Alexandre De la Fuente Isaac Fuentes Francisco Javier De Toro Francisco Javier Blanco | 2011 | World Journal of Orthopedics2011，2，6： | 7 |
| 10 | Household catastrophic payments for tuberculosis care in Nigeria: incidence, determinants, and policy implications for universal health coverage显示文摘Background:Studies on costs incurred by patients for tuberculosis(TB)care are limited as these costs are reported as averages,and the economic impact of the costs is estimated based on average patient/household incomes.Average expenditures do not represent the poor because they spend less on treatment compared to other economic groups.Thus,the extent to which TB expenditures risk sending households into,or further into,poverty and its determinants,is unknown.We assessed the incidence and determinants of household catastrophic payments for TB care in rural Nigeria.Methods:Data used were obtained from a survey of 452 pulmonary TB patients sampled from three rural health facilities in Ebonyi State,Nigeria.Using household direct costs and income data,we analyzed the incidence of household catastrophic payments using,as thresholds,the traditional>10%of household income and the≥40%of non-food income,as recommended by the World Health Organization.We used logistic regression analysis to identify the determinants of catastrophic payments.Results:Average direct household costs for TB were US$157 or 14%of average annual incomes.The incidence catastrophic payment was 44%;with 69%and 15%of the poorest and richest household income-quartiles experiencing catastrophic activity,respectively.Independent determinants of catastrophic payments were:age>40 years(adjusted odds ratio[aOR]3.9;95%confidence interval[CI],2.0,7.8),male gender(aOR 3.0;CI 1.8,5.2),urban residence(aOR 3.8;CI 1.9,7.7),formal education(aOR 4.7;CI 2.5,8.9),care at a private facility(aOR 2.9;1.5,5.9),poor household(aOR 6.7;CI 3.7,12),household where the patient is the primary earner(aOR 3.8;CI 2.2,6.6]),and HIV co-infection(aOR 3.1;CI 1.7,5.6).Conclusions:Current cost-lowering strategies are not enough to prevent households from incurring catastrophic out-of-pocket payments for TB care.Financial and social protection interventions are needed for identified at-risk groups,and community-level interventions may reduce inefficiencies in the care-seeking pathway.These observations should inform post-2015 TB strategies and influence policy-making on health services that are meant to be free of charge. | Kingsley Nnanna Ukwaja Isaac Alobu Seye Abimbola Philip Christy Hopewell | 2013 | Infectious Diseases of Poverty2013，2，1： | 7 |
| 11 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 12 | 食源性免疫活性肽的筛选策略及作用机制研究进展显示文摘文章综述了目前国内外对食源性免疫活性肽的筛选策略,强调计算科学在筛选中的应用前景。通过探讨食源性免疫活性肽作用的分子机理及其研究现状,提出了未来的研究新思路:结合多组学、生物信息学、细胞试验及动物试验,深入探讨食源性免疫活性肽作用的分子机理。 | 文李 NIYOKWIZERA Isaac 刘步青 许宙 陈茂龙 程云辉 | 2020 | 食品与机械2020，36，2： | 7 |
| 13 | Effects of elevation on spring phenological sensitivity to temperature in Tibetan Plateau grasslands显示文摘Vegetation phenology is an important indicator of climate change impacts on the seasonal dynamics of the biosphere. However, little is known about the influence of elevation on spring phenological sensitivity to temperature in an alpine ecosystem. Based on remotely sensed land surface phenology and temperature data from 2001 to2010, this study investigated the rate of spring phenological change of the Tibetan Plateau(TP) grasslands in response to interannual temperature variations at different elevations. Results suggest that spring phenology in the TP grasslands exhibits a stronger response to changes in temperature at higher elevations than at lower ones. In particular, spring phenology advanced by 1–2 days in response to a 1 °C increase in May average temperature at elevations from 3,000 to 3,500 m, while the rate was up to8–9 days/°C at 5,000–5,500 m. Analysis using accumulated growing degree days(AGDD) from January 1through May 31 showed the same general trend with increased elevation associated with increased sensitivity(as measured by phenological change per unit of AGDDchange). Such temperature sensitivity gradients in the TP grasslands could be partly explained by the growth efficiency hypothesis which suggests that vegetation adapted to colder climates likely requires less heat energy for the onset of growing season and vice versa in warmer climates.Furthermore, accumulated growing degree days from January 1 to the greenup date were found to decrease with increasing elevations, which provided evidence to support the applicability of the growth efficiency hypothesis in an alpine grassland ecosystem. | Lingling Liu Liangyun Liu Liang Liang Alison Donnelly Isaac Park Mark D.Schwartz | 2014 | Chinese Science Bulletin2014，59，34： | 7 |
| 14 | Infection,Pain,and Itch显示文摘Pain and itch are unpleasant sensations that often accompany infections caused by viral, bacterial,parasitic, and fungal pathogens. Recent studies show that sensory neurons are able to directly detect pathogens to mediate pain and itch. Nociceptor and pruriceptor neurons respond to pathogen-associated molecular patterns,including Toll-like receptor ligands, N-formyl peptides,and bacterial toxins. Other pathogens are able to silence neuronal activity to produce analgesia during infection.Pain and itch could lead to neuronal modulation of the immune system or behavioral avoidance of future pathogen exposure. Conversely, pathogens could modulate neuronal signaling to potentiate their pathogenesis and facilitate their spread to other hosts. Defining how pathogens modulate pain and itch has critical implications for sensory neurobiology and our understanding of hostmicrobe interactions. | Isaac M.Chiu | 2018 | Neuroscience Bulletin2018，34，1： | 7 |
| 15 | Combination of structural reliability and interval analysis显示文摘在设计应用,概率的可靠性理论看起来是一会儿然而,在许多情况中,精确概率的可靠性理论不能被认为实际事情的真实状态的模型同样足够、可信的最重要的方法。在这篇论文,当统计数据被发现不够时,我们开发了概率、非概率的可靠性理论的一个混血儿,它把结构的不明确的参数描述为间隔变量。由使用间隔分析,为计算结构的可靠性以及可靠性索引的间隔的一个新方法在这篇论文被介绍,并且传统的概率的理论与间隔分析被合并。而且,新方法保存传统的概率的可靠性理论的有用部分,但是在数据上移开它的严格的要求的限制获得。例子被举表明建议理论的可行性和有效性。 | Zhiping Qiu Di Yang Isaac Elishakoff | 2008 | Acta Mechanica Sinica2008，24，1： | 7 |
| 16 | Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding显示文摘AIM: To determine the frequency of small bowel ulcerative lesions in patients with peptic ulcer and define the significance of those lesions. METHODS: In our prospective study, 60 consecutive elderly patients with upper gastrointestinal bleeding from a peptic ulceration(cases) and 60 matched patients with a non-bleeding peptic ulcer(controls) underwent small bowel capsule endoscopy, after a negative colonoscopy(compulsory in our institution). Controls were evaluated for non-bleeding indications. Known or suspected chronic inflammatory conditions and medication that could harm the gut were excluded. During capsule endoscopy, small bowel ulcerative lesions were counted thoroughly and classified according to Graham classification. Other small bowellesions were also recorded. Peptic ulcer bleeding was controlled endoscopically, when adequate, proton pump inhibitors were started in both cases and controls, and Helicobacter pylori eradicated whenever present. Both cases and controls were followed up for a year. In case of bleeding recurrence upper gastrointestinal endoscopy was repeated and whenever it remained unexplained it was followed by repeat colonoscopy and capsule endoscopy.RESULTS: Forty(67%) cases and 18(30%) controls presented small bowel erosions(P = 0.0001), while 22(37%) cases and 4(8%) controls presented small bowel ulcers(P < 0.0001). Among non-steroidal antiinflammatory drug(NSAID) consumers, 39(95%) cases and 17(33%) controls presented small bowel erosions(P < 0.0001), while 22(55%) cases and 4(10%) controls presented small bowel ulcers(P < 0.0001). Small bowel ulcerative lesions were infrequent among patients not consuming NSAIDs. Mean entry hemoglobin was 9.3(SD = 1.4) g/d L in cases with small bowel ulcerative lesions and 10.5(SD = 1.3) g/dL in those without(P = 0.002). Cases with small bowel ulcers necessitate more units of packed red blood cells. During their hospitalization, 6(27%) cases with small bowel ulcers presented bleeding recurrence most possibly attributed to small bowel ulcers, nevertheless 30-d mortality was zero. Presence of chronic obstructive lung disease and diabetes was related with unexplained recurrence of hemorrhage in logistic regression analysis, while absence of small bowel ulcers was protective(relative risk 0.13, P = 0.05).CONCLUSION: Among NSAID consumers, more bleeders than non-bleeders with peptic ulcers present small bowel ulcers; lesions related to more severe bleeding and unexplained episodes of bleeding recurrence. | Panagiotis Tsibouris Chissostomos Kalantzis Periklis Apostolopoulos Antonios Zalonis Peter Edward Thomas Isaacs Mark Hendrickse Georgios Alexandrakis | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 6 |
| 17 | 储罐底板钢点蚀过程中声发射信号的聚类分析显示文摘联合采用声发射和电化学技术研究储罐底板钢试样在w(NaCl)=3.0%,pH=2.0的酸性溶液中的点蚀特征,基于K-均值聚类算法对点蚀声发射信号特征参数进行聚类分析,从而提取各类信号的自身特征。将分类后的信号作为样本训练BP人工神经网络,成功对平行试验采集的声发射信号进行识别。研究结果表明,底板钢在酸性条件下的点蚀过程主要产生氢气泡、膜破裂和蚀坑生长这3类典型的声发射信号,通过聚类方法可以区分这3类信号,并能用神经网络对声发射源进行有效识别。这对现场常压金属储罐底板腐蚀声发射检测结果的解释和评价具有指导意义,有助于提高检测结果可靠性,降低储罐运行风险,保证其运行安全。 | 毕海胜 李自力 胡德栋 罗琴 ISAAC Toku-Gyamerah 吴向阳 | 2015 | 中国石油大学学报(自然科学版)2015，39，6： | 6 |
| 18 | Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases显示文摘Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. | Isaac G.Onyango James P.Bennett Gorazd B.Stokin | 2021 | Neural Regeneration Research2021，16，8： | 6 |
| 19 | Chinese social media reaction to the MERS-CoV and avian influenza A(H7N9) outbreaks显示文摘Background:As internet and social media use have skyrocketed,epidemiologists have begun to use online data such as Google query data and Twitter trends to track the activity levels of influenza and other infectious diseases.In China,Weibo is an extremely popular microblogging site that is equivalent to Twitter.Capitalizing on the wealth of public opinion data contained in posts on Weibo,this study used Weibo as a measure of the Chinese people’s reactions to two different outbreaks:the 2012 Middle East Respiratory Syndrome Coronavirus(MERS-CoV)outbreak,and the 2013 outbreak of human infection of avian influenza A(H7N9)in China.Methods:Keyword searches were performed in Weibo data collected by The University of Hong Kong’s Weiboscope project.Baseline values were determined for each keyword and reaction values per million posts in the days after outbreak information was released to the public.Results:The results show that the Chinese people reacted significantly to both outbreaks online,where their social media reaction was two orders of magnitude stronger to the H7N9 influenza outbreak that happened in China than the MERS-CoV outbreak that was far away from China.Conclusions:These results demonstrate that social media could be a useful measure of public awareness and reaction to disease outbreak information released by health authorities. | Isaac Chun-Hai Fung King-Wa Fu Yuchen Ying Braydon Schaible Yi Hao Chung-Hong Chan Zion Tsz-Ho Tse | 2013 | Infectious Diseases of Poverty2013，2，1： | 6 |
| 20 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
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