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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | Childhood constipation as an emerging public health problem显示文摘Functional constipation(FC) is a significant health problem in children and contrary to common belief, has serious ramifications on the lives of children and their families. It is defined by the Rome criteria which encourage the use of multiple clinical features for diagnosis. FC in children has a high prevalence(0.7%-29%) worldwide, both in developed and developing countries. Biopsychosocial risk factors such as psychological stress, poor dietary habits, obesity and child maltreatment are commonly identified predisposing factors for FC. FC poses a significant healthcare burden on the already overstretched health budgets of many countries in terms of out-patient care, in-patient care, expenditure for investigations and prescriptions. Complications are common and range from minor psychological disturbances, to lower health-related quality of life. FC in children also has a significant impact on families. Many paediatric clinical trials have poor methodological quality, and drugs proved to be useful in adults, are not effective in relieving symptoms in children. A significant proportion of inadequately treated children have similar symptoms as adults. These factors show that constipation is an increasing public health problem across the world with a significant medical, social and economic impact. This article highlights the potential public health impact of FC and the possibility of overcoming this problem by concentrating on modifiable risk factors rather than expending resources on high cost investigations and therapeutic modalities. | Shaman Rajindrajith Niranga Manjuri Devanarayana Bonaventure Jayasiri Crispus Perera Marc Alexander Benninga | 2016 | World Journal of Gastroenterology2016，22，30： | 10 |
| 3 | Neurovascular ageing:transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease显示文摘Ageing is one of the greatest risk factors for neurodegenerative diseases.How the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely understood.Research into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction. | Zhongqi Li Bonaventure Ip Vincent C.T.Mok Ho Ko | 2021 | Neural Regeneration Research2021，16，12： | 3 |
| 4 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 5 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 6 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 7 | An efficient algorithm to enable path diversity in link state routing networks显示文摘 | P. Mérindol P. Francois O. Bonaventure S. Cateloin J.-J. Pansiot | 2010 | Computer Networks2010，，： | 1 |
| 8 | Achieving subsecond IGP convergence in large IP networks 显示文摘 | Pierre Francois Clarence Filsfils John Evans Olivier Bonaventure | 2005 | ACM SIGCOMM Computer Communication Review2005，35，2： | 1 |
| 9 | The acyltransferase GPAT5 is required for the synthesis of suberin in seed coat and root of arabidopsis显示文摘 | Fred Beisson Yonghua Li Gustavo Bonaventure | 2007 | The Plant Cell2007，19，： | 1 |
| 10 | Avoiding transient loops during the convergence of link-state routing protocols 显示文摘 | FRANCOIS P BONAVENTURE O | 2007 | IEEE/ACM Transactions on Networking2007，15，6： | 1 |
| 11 | Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia显示文摘 | Rousseau F Bonaventure J Legeai-Mallet L | 1994 | Nature1994，371，： | 1 |
| 12 | Achieving sub- 50 milliseconds recovery upon BGP peering link failures 显示文摘 | BONAVENTURE O FILSFILS C FRANCOIS P | 2007 | IEEE/ACM Transactions on Networking2007，15，5： | 1 |
| 13 | Mutations in the gene encoding fibroblast growth factor receptor -3 in achondroplasia 显示文摘 | Rousseau F Bonaventure J Legeai - Mallet L | 1994 | Nature1994，371，6494： | 1 |
| 14 | Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia显示文摘 | Rousseau F Bonaventure J Legeai-Mallet L | 1994 | Nature1994，371，6494： | 1 |
| 15 | Linkage study in a large pedigree withStickler syndrome:exclusion of COL2A1 as the mutant gene显示文摘 | Bonaventure J Philippe C Plessis G | 1992 | Hum Genet1992，90，： | 1 |
| 16 | Experimenting with multipath TCP 显示文摘 | Barre S Ralciu C Bonaventure O | 2010 | ACM SIGCOMM Computer Communication Review2010，40，4： | 1 |
| 17 | Mutations of the fibroblast growth factor receptor- 3 gene in achondreplasia显示文摘 | Rousseau F Bonaventure J Legeai - Mallet L | 1996 | Horm Res1996，45，12： | 1 |
| 18 | The acyl- transferase GPAT5 is required for the synthesis of suberin in seed coat and root of Arabidopsis 显示文摘 | Beisson F Li Y Bonaventure G | 2007 | Plant Cell2007，19，： | 1 |
| 19 | Avoiding transient loops during the convergence of link-state routing protocols显示文摘 | FRANCOIS P BONAVENTURE O | 2007 | IEEE/ACM Trans on Networking2007，15，6： | 1 |
| 20 | Mutations in the gene encoding fi broblast growth factor receptor-3 in achondroplasia显示文摘 | Rousseau F Bonaventure J Legeai-Mallet L | 1994 | Nature1994，371，6494： | 1 |
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