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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Impact of diabetes mellitus on risk of cardiovascular disease and all-cause mortality: Evidence on health outcomes and antidiabetic treatment in United States adults显示文摘AIMTo examine the epidemic of diabetes mellitus (DM) and its impact on mortality from all-cause and cardiovascular disease (CVD), and to test the effect of antidiabetic therapy on the mortality in United States adults. METHODS The analysis included a randomized population sample of 272149 subjects ages ≥ 18 years who participated in the National Health Interview Surveys (NHIS) in2000-2009. Chronic conditions (hypertension, DM and CVD) were classified by participants’ self-reports of physician diagnosis. NHIS-Mortality Linked Files, and NHIS-Medical Expenditure Panel Survey Linkage Fileson prescribed medicines for patients with DM were used to test the research questions. χ 2, Poisson and Cox’s regression models were applied in data analysis.RESULTS Of all participants, 22305 (8.2%) had DM. The prevalence of DM significantly increased from 2000 to 2009 in all age groups (P < 0.001). Within an average 7.39 (SD= 3) years of follow-up, male DM patients had 1.56 times higher risk of death from all-cause (HR = 1.56, 95%CI:1.49-1.64), 1.72 times higher from heart disease [1.72 (1.53-1.93)], 1.48 times higher from cerebrovascular disease [1.48 (1.18-1.85)], and 1.67 times higher from CVD [1.67 (1.51-1.86)] than subjects without DM,respectively. Similar results were observed in females. In males, 10% of DM patients did not use any antidiabetic medications, 38.1% used antidiabetic monotherapy, and 51.9% used ≥ 2 antidiabetic medications. These corresponding values were 10.3%, 40.4% and 49.4% in females. A significant protective effect of metformin monotherapy or combination therapy (except for insulin) on all-cause mortality and a protective but non-significant effect on CVD mortality were observed. CONCLUSION This is the first study using data from multiple linkage files to confirm a significant increased prevalence of DM in the last decade in the United States. Patients with DM have significantly higher risk of death from all-cause and CVD than those without DM. Antidiabetic mediations,specifically for metformin use, show a protective effect against all-cause and CVD mortalities. | Longjian Liu Barbara Simon Jinggaofu Shi Arshpreet Kaur Mallhi Howard J Eisen | 2016 | World Journal of Diabetes2016，7，18： | 12 |
| 3 | Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K+ Channel TPK1 by Calcium-Dependent Protein Kinases (CDPKs)显示文摘 | Andreas Latz Norbert Mehlmer Simone Zapf Thomas D. Mueller Bernhard Wurzinger Barbara Pfister Edina Csaszar Rainer Hedrich Markus Teige Dirk Becker | 2013 | Molecular Plant2013，6，4： | 5 |
| 4 | Volatile organic compounds in 43 Chinese cities显示文摘 | Barbara Barletta Simone Meinardi F. Sherwood Rowland Chuen-Yu Chan Xinming Wang Shichun Zou Lo Yin Chan Donald R. Blake | 2005 | Atmospheric Environment2005，，32： | 3 |
| 5 | Volatile organic compounds in 43 Chinese cities显示文摘 | Barbara Barletta Simone Meinardi F. Sherwood Rowland Chuen-Yu Chan Xinming Wang Shichun Zou Lo Yin Chan Donald R. Blake | 2005 | Atmospheric Environment2005，，32： | 1 |
| 6 | Volatile organic compounds in 43 Chinese cities显示文摘 | Barbara B Simone M F Sherwood R | 2005 | Atmospheric Environment2005，39，32： | 1 |
| 7 | Effect of ancient Khorasan wheat on gut microbiota,inflammation,and short-chain fatty acid production in patients with fibromyalgia显示文摘BACKGROUND Fibromyalgia(FM)syndrome is mainly characterized by widespread pain,sleeping disorders,fatigue,and cognitive dysfunction.In many cases,gastrointestinal distress is also reported,suggesting the potential pathogenic role of the gut microbiota(GM).The GM is deeply influenced by several environmental factors,especially the diet,and recent findings highlighted significant symptom improvement in FM patients following various nutritional interventions such as vegetarian diet,low-fermentable oligosaccharides,disaccharides,monosaccharides,and polyols based diets,gluten-free diet,and especially an ancient grain supplementation.In particular,a recent study reported that a replacement diet with ancient Khorasan wheat led to an overall improvement in symptom severity of FM patients.AIM To examine the effects of ancient Khorasan wheat on the GM,inflammation,and short-chain fatty acid production in FM patients.METHODS After a 2-wk run-in period,20 FM patients were enrolled in this randomized,double-blind crossover trial.In detail,they were assigned to consume either Khorasan or control wheat products for 8 wk and then,following an 8-wk washout period,crossed.Before and after treatments,GM characterization was performed by 16S rRNA sequencing while the fecal molecular inflammatory response and the short-chain fatty acids(SCFAs)were respectively determined with the Luminex MAGPIX detection system and a mass chromatography-mass spectrometry method.RESULTS The Khorasan wheat replacement diet,in comparison with the control wheat diet,had more positive effects on intestinal microbiota composition and on both the fecal immune and SCFAs profiles such as the significant increase of butyric acid levels(P=0.054),candidatus Saccharibacteria(P=9.95e-06)and Actinobacteria,and the reduction of Enterococcaceae(P=4.97e-04).Moreover,the improvement of various FM symptoms along with the variation of some gut bacteria after the Khorasan wheat diet have been documented;in fact we reported positive correlations between Actinobacteria and both Tiredness Symptoms Scale(P<0.001)and Functional Outcome of Sleep Questionnaire(P<0.05)scores,between Verrucomicrobiae and both Widespread Pain Index(WPI)+Symptom Severity scale(SS)(P<0.05)and WPI(P<0.05)scores,between candidatus Saccharibacteria and SS score(P<0.05),and between Bacteroidales and Sleep-Related and Safety Behaviour Questionnaire score(P<0.05).CONCLUSION The replacement diet based on ancient Khorasan wheat results in beneficial GM compositional and functional modifications that positively correlate with an improvement of FM symptomatology. | Simone Baldi Giuditta Pagliai Monica Dinu Leandro Di Gloria Giulia Nannini Lavinia Curini Marco Pallecchi Edda Russo Elena Niccolai Giovanna Danza Stefano Benedettelli Giovanna Ballerini Barbara Colombini Gianluca Bartolucci Matteo Ramazzotti Francesco Sofi Amedeo Amedei | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 8 | Effect of water deficit on Merlot grape tannins and anthocyanins across four seasons显示文摘 | Barbara Bucchetti Mark A. Matthews Luigi Falginella Enrico Peterlunger Simone D. Castellarin | 2011 | Scientia Horticulturae2011，，3： | 1 |
| 9 | Volatile organic compounds in 43 Chinese cities显示文摘 | BARBARA B SIMONE M F SHERWOOD R | 2005 | Atmospheric Environment2005，39，32： | 1 |
| 10 | A comparative study of fine depth perception on two-view 3D displays显示文摘 | Froner Barbara Holliman Nicolas S Simon P | 2008 | Displays(S0141-9382)2008，29，5： | 1 |
| 11 | Volatile organic compounds in 43 Chinese cities显示文摘 | Barbara Barletta Simone Meinardi F. Sherwood Rowland Chuen-Yu Chan Xinming Wang Shichun Zou Lo Yin Chan Donald R. Blake | 2005 | Atmospheric Environment2005，，32： | 1 |
| 12 | Ebstein anomaly associated with left ventricular noncompaction: An autosomal dominant condition that can be caused by mutations in MYH7显示文摘 | Alexa M.C. Vermeer Klaartje van Engelen Alex V. Postma Marieke J.H. Baars Imke Christiaans Simone De Haij Sabine Klaassen Barbara J.M. Mulder Bernard Keavney | 2013 | Am. J. Med. Genet2013，，： | 1 |
| 13 | Primary Sjogren's Syndrome:health experiences and predictors of health quality among patients in the United States显示文摘 | Barbara S Simon JB Phili PCF | 2009 | Health Qual Life Outcomes2009，7，： | 1 |
| 14 | Translating Physical Activity Recommendations into a Pedometer-Based Step Goal显示文摘 | Simon J. Marshall Susan S. Levy Catrine E. Tudor-Locke Fred W. Kolkhorst Karen M. Wooten Ming Ji Caroline A. Macera Barbara E. Ainsworth | 2009 | American Journal of Preventive Medicine2009，，： | 1 |
| 15 | Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus–transgenic mice by peroxisome proliferator‐activated receptor γ–independent regulation of nucleophosmin显示文摘 | Andrea Galli Elisabetta Ceni Tommaso Mello Simone Polvani Mirko Tarocchi Francesca Buccoliero Francesca Lisi Laura Cioni Barbara Ottanelli Valeria Foresta Guido Mastrobuoni Gloriano Moneti Giuseppe Pieraccini Calogero Surrenti Stefano Milani | 2010 | Hepatology2010，，2： | 1 |
| 16 | Osteoprotegerin (OPG) Production by Cells in the Osteoblast Lineage is Regulated by Pulsed Electromagnetic Fields in Cultures Grown on Calcium Phosphate Substrates显示文摘 | Zvi Schwartz Maya Fisher Christoph H. Lohmann Bruce J. Simon Barbara D. Boyan | 2009 | Annals of Biomedical Engineering2009，，3： | 1 |
| 17 | Morphological and molecular characteristics of a new species of Pasteuria parasitic on Meloidogyne ardenensis显示文摘 | Alistair H. Bishop Simon R. Gowen Barbara Pembroke James R. Trotter | 2007 | Journal of Invertebrate Pathology2007，，1： | 1 |
| 18 | Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health显示文摘 | Karin Dilger Simon Hohenester Ursula Winkler-Budenhofer Barbara A.J. Bastiaansen Frank G. Schaap Christian Rust Ulrich Beuers | 2012 | Journal of Hepatology2012，，1： | 1 |
| 19 | Volatile organic compounds in 43 Chinese cities显示文摘 | Barletta Barbara Meinardi Simone Rowland F Sherwood | 2005 | Atmospheric Environment2005，39，： | 1 |
| 20 | Relation between place of residence and postpartum depression显示文摘 | Simone N. Vigod Lesley A. Tarasoff Barbara Bryja Cindy-Lee Dennis Mark H. Yudin Lori E. Ross | 2013 | Canadian Medical Association Journal2013，，13： | 1 |
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