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| 1 | 骨密度测量的准确度和精密度评价显示文摘目的采用欧洲腰椎体模(ESP)评估不同CT机的定量CT(QCT)和双能X线吸收仪(DXA)设备测量骨密度的准确度和短期精确度。方法收集2016年1月至2020年4月全国多个中心(QCT和DXA分别来自31和32个中心)的40台不同品牌的CT设备(德国Siemens 12台、荷兰Philips 12台、美国GE 9台、日本Toshiba 5台和国产联影2台)和53台不同品牌DXA设备(美国GE Lunar 34台、美国Hologic 14台和法国Medlink 5台)。QCT扫描采用Mindways QCT系统,以常规腰椎扫描条件对ESP体模重复扫描10次,每次重新摆位,测量ESP中低、中、高密度椎体的骨密度值以及3个椎体的平均骨密度值。根据实测值与体模标定值的差异计算不同设备的准确度误差,并计算标准差均方根(RMS-SD)和变异系数的均方根(RMS-%CV)来评价短期精密度误差。采用重复测量的方差分析比较不同设备间测量的骨密度值的差异。结果不同CT和DXA设备测量的不同密度椎体和平均骨密度值差异均有统计学意义(P<0.001)。Siemens的准确度误差范围为1.20%~7.60%,Philips为-1.83%~0.20%,GE为1.18%~13.20%,Toshiba为-0.12%~3.55%,联影为-1.65%~6.32%,GE Lunar为6.59%~21.34%,Hologic为-6.65%~5.45%,Medlink为-6.97%~-0.68%。QCT和DXA测量的所有椎体骨密度值的RMS-%CV为0.38%~3.85%;QCT的RMS-SD为0.54~2.45 mg/cm3。DXA的RMS-SD为0.009~0.037g/cm^(2)。不同QCT和DXA设备测量的RMS-%CV值随着骨密度的升高而呈减低趋势,RMS-SD值则呈升高趋势。结论基于ESP,不同QCT和DXA设备测量的ESP骨密度值有显著差异。不同QCT和DXA设备测量骨密度的准确度误差和短期精密度误差在合理范围,可以用于临床随访观察。QCT的短期精密度误差和准确度误差波动范围较DXA略小。 | 端木羊羊 王玲 张勇 邓克学 李凯 李娜 Blake Glen M 程晓光 | 2021 | 中华放射学杂志2021，55，4： | 14 |
| 2 | Innate immune signaling and regulation in cancer immunotherapy显示文摘先存在的 T 煽动房间的肿瘤微型环境有预示的用途并且能也为对当代的癌症免疫疗法的反应预兆。对联系肿瘤的抗原的自发的 T 房间回答的产生取决于天生的有免疫力的激活,运动打它我干扰素(IFN ) 生产。最近的工作为在这个过程察觉到的 cytosolic DNA 的 STING 小径揭示了一个主要角色。事件的这串联贡献 Batf3 系树枝状的房间(DC ) 的激活,它看起来对反肿瘤免疫中央。Non-T 煽动房间的肿瘤为 Batf3 DC 招募缺乏 chemokines,有很少 Batf3 DC,并且缺乏一种类型我 IFN 基因签名,建议那没有通过天生的有免疫力的激活可以是因缺乏自发的 T 房间激活和累积的最终的原因。与手里的这个信息,为触发天生的有免疫力的激活和 Batf3 DC 招募的新策略正在被开发,包括为 de novo 免疫者 priming 的新奇圈套收缩筋。最终,有效天生的有免疫力的使活跃之物的成功的发展应该扩展能对免疫疗法作出回应的病人的部分,例如与检查点封锁抗体。 | Leticia Corrales Vyara Matson Blake Flood Stefani Spranger Thomas F Gajewski | 2017 | Cell Research2017，27，1： | 13 |
| 3 | 纸钱的符号学研究显示文摘纸钱是整个祭礼按顺序进行的三段五步[蜡烛、(香、食物、纸钱)、鞭炮]之一,纸钱的符号功能在于全方位地建构了中国祭礼中的一种民俗事象。纸钱的符号学分析应用两种解释方案:一种是本土的模式——中国的阴阳五行论,另一种是人类学有关仪式过程的观念。 | C.Fred Blake 冉凡 | 2005 | 广西民族学院学报(哲学社会科学版)2005，27，5： | 12 |
| 4 | 近年来珠三角地区大气中痕量氟氯烃(CFCs)的浓度水平与变化特征显示文摘用预浓缩-GC/MS方法研究了珠江三角洲大气中的CCl3F、CFC-12、CFC-113和CFC-114等4种痕量氟氯烷烃气体。结果表明,2005年珠江三角洲背景点鼎湖山大气中CFC-12和CFC-11的年平均浓度高于全球本底站,说明珠三角地区还存在一定CFC-11和CFC-12的排放源;CFC-113浓度水平则与全球本底站点浓度接近,且CFC-113和CFC-114在广州城区与鼎湖山差别不显著,表明区内其排放源强度应很小。观测日内广州和鼎湖山大气中四种CFCs的日变化幅度均较小,无明显的昼夜变化规律。广州市CFCs总体呈夏秋高、冬春低的特征,与城区致冷设备高温季节使用频率较大有关;鼎湖山则呈冬春高、夏秋低的特征,主要受扩散作用和季风的影响。初步分析显示,从1997年到2005年,CFC-11、CFC-12和CFC-114浓度总体呈现先上升后缓慢降低的趋势,而CFC-113的浓度一直逐年下降。 | 张芳 王新明 李龙凤 易志刚 周凌晞 Donald R Blake 盛国英 傅家谟 | 2006 | 地球与环境2006，34，4： | 11 |
| 5 | Employability: A psycho-social construct, its dimensions, and applications显示文摘 | Mel Fugate Angelo J Kinicki Blake E Ashforth | 2003 | Journal of Vocational Behavior2003，，1： | 8 |
| 6 | 不同双能X线骨密度仪交叉校准及其骨密度参考数据库标准化显示文摘目的采用欧洲脊柱体模(European spine phantom,ESP)和志愿者用常用不同品牌的双能X线吸收测量仪(dual energy X-ray absorptiometry,DXA)测量的脊柱和髋部骨密度(bone mineral density,BMD)值进行体模校准和体内交叉校准,为建立统一的中国人群骨密度参考数据库,实现全国不同品牌DXA T值的标准化提供基础数据。方法采用FUJIFILM、GE-Lunar、Hologic、Medilink和Osteosys 5个品牌的DXA。体模校准实验使用同一个ESP(编号SN 145)在每个扫描仪上扫描10次,每次重新定位。体内交叉校准研究在同一天使用GE-Lunar iDXA系统和其他4家品牌之一的DXA对100名20~80岁健康志愿者进行腰椎(L1-4)和髋部扫描。采用SPSS 22.0完成线性回归分析,将FUJIFILM、Hologic、Medilink和Osteosys的脊柱、股骨颈和全髋BMD与GE-Lunar相对应部位的BMD进行交叉校准。并根据一个采用GE-Lunar DXA的75321名20岁及以上中国成年人全国性骨密度调查数据库计算正常参考值,采用本次体内交叉校准换算方程推导出其他4种品牌DXA的等效青年人参考数据库。结果GE-Lunar、FUJIFILM、Hologic、Medilink和Osteosys DXA的ESP L2-4 BMD(单位:g/cm^(2))均值分别为1.170±0.005、0.930±0.005、0.980±0.005、1.000±0.009和1.100±0.003,各品牌间BMD差异有统计学意义(P<0.01)。10次重复扫描的变异系数(CV%)分别为0.31%、0.53%、0.37%、0.91%和0.25%。FUJIFILM、Hologic、Medilink和Osteosys DXA脊柱和髋部的BMD测量值与GE-Lunar测量值高度相关,Pearson相关系数r为0.911~0.982,并计算出每种DXA的BMD值与GE相应部位BMD值的换算公式。列出5家DXA等效中国青年人骨密度参考范围,实现这些DXA设备扫描同一患者时计算的T值一致。结论本研究提供了国内5种品牌DXA的ESP和体内交叉校准数据以及换算公式,获得了统一的中国人DXA骨密度正常参考值,为实现全国DXA脊柱和髋部骨密度T值的标准化提供基础数据。 | 闫东 Glen M Blake 孙晓雷 崔珂 蔡舒 王文志 刘艳东 王文海 轩艳姣 程晓光 | 2022 | 中华骨质疏松和骨矿盐疾病杂志2022，15，1： | 8 |
| 7 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 8 | Prevalence of vitreous floaters in a community sample of smartphone users显示文摘AIM: To estimate the prevalence and risk factors for vitreous floaters in the general population. ·METHODS: An electronic survey was administered through a smartphone app asking various demographic and health questions, including whether users experience floaters in their field of vision. Multivariate logistic regression analysis was used to determine risk factors. ·RESULTS: A total of 603 individuals completed the survey, with 76% reporting that they see floaters, and 33% reporting that floaters caused noticeable impairment in vision. Myopes were 3.5 times more likely (P =0.0004), and hyperopes 4.4 times more likely (P =0.0069) to report moderate to severe floaters compared to those with normal vision. Floater prevalence was not significantly affected by respondent age, race, gender, and eye color. ·CONCLUSION: Vitreous floaters were found to be a very common phenomenon in this non -clinical general population sample, and more likely to be impairing in myopes and hyperopes. | Blake F. Webb Jadon R. Webb Mary C. Schroeder Carol S. North | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 7 |
| 9 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 10 | iMashup:a mashup-based framework for service composition显示文摘The Web has undergone a tremendous change from a primarily publication platform towards a participatory and'programmable'platform,where a large number of heterogeneous Web-delivered services(including SOAP and RESTful Web services,RSS and Atom feeds)are emerging.It results in the creation of Web mashup applications with rich user experiences.However,the integration of Web-delivered services is still a challenging issue.It not only requires the developers’tedious eforts in understanding and coordinating heterogeneous service types,but also results in the time-consuming development of user interfaces.In this paper,we propose the iMashup composition framework to facilitate mashup development and deployment.We provide a unified mashup component model for the common representation of heterogeneous Web-delivered service interfaces.The component model specifies necessary properties and behaviors at both business and user interface level.We associate the component model with semantically meaningful tags,so that mashup developers can fast understand the service capabilities.The mashup developers can search and put the proper mashup components into the Web browser based composition environment,and connect them by data flows based on the tag-based semantics.Such an integration manner might prevent some low-level programming eforts and improve the composition efciency.A series of experimental study are conducted to evaluate our framework. | LIU XuanZhe HUANG Gang ZHAO Qi MEI Hong BLAKE M.Brian | 2014 | Science China(Information Sciences)2014，57，1： | 6 |
| 11 | Influence of Biochars on Nitrous Oxide Emission and Nitrogen Leaching from Two Contrasting Soils显示文摘 | Singh Bhupinder Pal Hatton Blake J Singh Balwant Cowie Annette L Kathuria Amrit | 2010 | Journal of Environmental Quality2010，，4： | 4 |
| 12 | 美国文化人类学的当代理论趋势显示文摘本文试图总结美国文化人类学的当代理论和方法论。这里所讨论的这些美国人类学的当代观念是基于它们的历史脉络、继承、重现、转变和对立。从20世纪60年代起,在诸如主观性、权力和民族志表述等问题上,人类学理论和方法论发生了许多非常显著的转变和分歧。这种状况起因于人类文化学研究的文学化途径,这种途径是经由格尔茨(Geertz)以及其他学术运动,如英国的文化研究(Cultural Studies),特别是福柯(Foucault)的后现代主义而发展起来的。由此,人类学由来已久的喧嚣的科学和人文之间的对峙已经演绎出独立的认识论阵营,在某些情况下导致了一些大学中人类学系的分离。同时,这种分裂也激发或伴随着一种对当代全球化形势下文化人类学研究对象的定位的承认,比如本土性(indigenous)、下层(subalterns)研究,确认了这些研究对象在研究项目中具有合法的权利和合作的声音。这种转向使人们愈加关注应用人类学,同时也伴随着许多新的问题,例如'本土知识'的观念。另一个分裂是一些特定的专门研究领域的学科建制,如医学人类学、生态人类学和教育人类学等,而这些领域的每一个又都存在着其内部分歧和区别。这些正在发生的变化引起了对于博厄斯学派所传承下来的诸如文化、文化相对主义等观念的效用和学术规范的质疑。过去的30年是一个骚动激荡、分崩离析的时期,人类学研究在这个时期卷入了全球资本主义的新的文化逻辑的转换之中。 | C.Fred Blake 冉凡 | 2008 | 中南民族大学学报(人文社会科学版)2008，28，4： | 4 |
| 13 | Critical analysis of feeding jejunostomy following resection of upper gastrointestinal malignancies显示文摘AIM To assess nutritional recovery,particularly regarding feeding jejunostomy tube(FJT)utilization,following upper gastrointestinal resection for malignancy. METHODS A retrospective review was performed of a prospectively-maintained database of adult patients who underwent esophagectomy or gastrectomy(subtotal or total)for cancer with curative intent,from January 2001 to June 2014. Patient demographics,the approach to esophagectomy,the extent of gastrectomy,FJT placement and utilization at discharge,administration of parenteral nutrition(PN),and complications were evaluated. All patients were followed for at least ninety days or until death.RESULTS The 287 patients underwent upper GI resection,comprised of 182 esophagectomy(n=107 transhiatal,58.7%; n=56 Ivor-Lewis,30.7%)and 105 gastrectomy [n=63 subtotal(SG),60.0%; n=42 total(TG),40.0%]. 181 of 182 esophagectomy patients underwent FJT,compared with 47 of 105 gastrectomy patients(99.5% vs 44.8%,P < 0.0001),of whom most had undergone TG(n=39,92.9% vs n=8 SG,12.9%,P < 0.0001). Median length of stay was similar between esophagectomy and gastrectomy groups(14.7 d vs 17.1 d,P=0.076). Upon discharge,87 esophagectomy patients(48.1%)were taking enteral feeds,with 53(29.3%)fully and 34(18.8%)partially dependent. Meanwhile,20 of 39 TG patients(51.3%)were either fully(n=3,7.7%)or partially(n=17,43.6%)dependent on tube feeds,compared with 5 of 8 SG patients(10.6%),all of whom were partially dependent. Gastrectomy patients were significantly less likely to be fully dependent on tube feeds at discharge compared to esophagectomy patients(6.4% vs 29.3%,P=0.0006). PN was administered despite FJT placement more often following gastrectomy than esophagectomy(n=11,23.4% vs n=7,3.9%,P=0.0001). FJT-specific complications requiring reoperation within 30 d of resection occurred more commonly in the gastrectomy group(n=6),all after TG,compared to 1 esophagectomy patient(12.8% vs 0.6%,P=0.0003). Six of 7 patients(85.7%)who experienced tube-related complications required PN.CONCLUSION Nutritional recovery following esophagectomy and gastrectomy is distinct. Operations are associated with unique complication profiles. Nutritional supplementation alternative to jejunostomy should be considered in particular scenarios. | Andrew M Blakely Saad Ajmal Rachel E Sargent Thomas T Ng Thomas J Miner | 2017 | World Journal of Gastrointestinal Surgery2017，9，2： | 4 |
| 14 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 15 | 门诊烧伤的预防与治疗显示文摘大多数烧伤可由初级保健医生在门诊实施治疗。加强预防可使烧伤发生率明显下降,特别对儿童而言。与其他创伤管理相似,烧伤管理包括初级和次级评估。处理浅度烧伤可采用药液、蜂蜜、芦荟或抗生素软膏局部用药。部分皮层烧伤局部用抗菌药物或吸收性封闭敷料有助于减少疼痛、促进愈合和防止创面干燥。 | Emillia CO Lloyd Blake C Rodgers 周淑新(译) 葛军(译) | 2013 | 中国全科医学2013，16，9： | 3 |
| 16 | 'GrabCut'显示文摘 | Carsten Rother Vladimir Kolmogorov Andrew Blake | 2004 | ACM Transactions on Graphics (TOG)2004，，3： | 3 |
| 17 | Data-driven synthesis of multiple recommendation patterns to create situational Web mashups显示文摘As a typical situational application,Web mashup reflects and accommodates some key features of Internetware paradigm.Mashup provides a development fashion that integrates data,computation and UI elements from multiple resources into a single Web application,and promises the quick rollout of creating potential new functionalities opportunistically.This paper focuses on the problem of recommending useful suggestions for developing data-driven mashups by synthesis of multiple patterns.We present a rapid and intuitive system called iMashupAdvisor,for aiding mashup development based on a novel automated suggestion mechanism.The key observation guiding the development of iMashupAdvisor is that mashups developed by different users might share some common patterns,for instance,selecting similar mashup components for similar goals,and gluing them in a similar manner.Such patterns could reside in multiple sources,e.g.,the data dependency between mashup components,the interaction between users and mashup components,or the collective intelligence from existing applications created and maintained by programmers,etc.iMashupAdvisor leverages the synthesis of these patterns to recommend useful suggestions for a partial mashup,such as the missing components,connections between them,or potentially relevant options,to assist mashup completion.This paper presents the data model and ranking metrics of the synthesis process,and introduces efficient algorithms for the retrieval of recommendations.We also experimentally demonstrate the efficiency of our approach for benefiting the proposed rapid mashup development. | MA Yun LU Xuan LIU XuanZhe WANG XuDong BLAKE M.Brian | 2013 | Science China(Information Sciences)2013，56，8： | 3 |
| 18 | Emerging material platforms for integrated microcavity photonics显示文摘Many breakthroughs in technologies are closely associated with the deep understanding and development of new material platforms.As the main material used in microelectronics,Si also plays a leading role in the development of integrated photonics.The indirect bandgap,absence ofχ(2)nonlinearity and the parasitic nonlinear absorptions at the telecom band of Si imposed technological bottlenecks for further improving the performances and expanding the functionalities of Si microcavities in which the circulating light intensity is dramatically amplified.The past two decades have witnessed the burgeoning of the novel material platforms that are compatible with the complementary metal-oxide-semiconductor(COMS)process.In particular,the unprecedented optical properties of the emerging materials in the thin film form have resulted in revolutionary progress in microcavity photonics.In this review article,we summarize the recently developed material platforms for integrated photonics with the focus on chip-scale microcavity devices.The material characteristics,fabrication processes and device applications have been thoroughly discussed for the most widely used new material platforms.We also discuss open challenges and opportunities in microcavity photonics,such as heterogeneous integrated devices,and provide an outlook for the future development of integrated microcavities. | Jin Liu Fang Bo Lin Chang Chun-Hua Dong Xin Ou Blake Regan Xiaoqin Shen Qinghai Song Baicheng Yao Wenfu Zhang Chang-Ling Zou Yun-Feng Xiao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，10： | 3 |
| 19 | 有为腹的 CT 的非线性的适应过滤器的申请的放射剂量减小显示文摘 AIM:To evaluate the effect of non-linear adaptive filters (NLAF) on abdominal computed tomography (CT) images acquired at different radiation dose levels.METHODS:Nineteen patients (mean age 61.6 ± 7.9 years,M:F=8:11) gave informed consent for an Institutional Review Board approved prospective study involving acquisition of 4 additional image series (200,150,100,50 mAs and 120 kVp) on a 64 slice multidetector row CT scanner over an identical 10 cm length in the abdomen.The CT images acquired at 150,100 and 50 mAs were processed with the NLAF.Two radiologists reviewed unprocessed and processed images for image quality in a blinded randomized manner.CT dose index volume,dose length product,patient weight,transverse diameters,objective noise and CT numbers wererecorded.Data were analyzed using Analysis of Variance and Wilcoxon signed rank test.RESULTS:Of the 31 lesions detected in abdominal CT images,28 lesions were less than 1 cm in size.Subjective image noise was graded as unacceptable in unprocessed images at 50 and 100 mAs,and in NLAF processed images at 50 mAs only.In NLAF processed images,objective image noise was decreased by 21% (14.4 ± 4/18.2 ± 4.9) at 150 mAs,28.3% (15.7 ± 5.6/21.9 ± 4) at 100 mAs and by 39.4% (18.8 ± 9/30.4 ± 9.2) at 50 mAs compared to unprocessed images acquired at respective radiation dose levels.At 100 mAs the visibility of smaller structures improved from suboptimal in unprocessed images to excellent in NLAF processed images,whereas diagnostic confidence was respectively improved from probably confident to fully confident.CONCLUSION:NLAF lowers image noise,improves the visibility of small structures and maintains lesion conspicuity at down to 100 mAs for abdominal CT. | Sarabjeet Singh Mannudeep K Kalra Mi Kim Sung Anni Back Michael A Blake | 2012 | World Journal of Radiology2012，4，1： | 3 |
| 20 | Volatile organic compounds in 43 Chinese cities显示文摘 | Barbara Barletta Simone Meinardi F. Sherwood Rowland Chuen-Yu Chan Xinming Wang Shichun Zou Lo Yin Chan Donald R. Blake | 2005 | Atmospheric Environment2005，，32： | 3 |
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