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| 1 | 基于JBI临床证据实践应用系统的新生儿PICC导管相关性血流感染预防管理实践显示文摘目的建立基于证据的新生儿经外周中心静脉导管(PICC)维护流程,提高PICC规范化维护操作的依从性,降低导管相关性血流感染的发生。方法采用JBI(Joanna Briggs Institute)临床证据系统,根据9项最佳实践建议对新生儿PICC临床维护操作进行基线审查,实施有针对性的策略并进行后期观察。比较2017年8月-2018年7月项目实施前及2018年8月-2019年7月项目实施后导管相关性血流感染的发生率。结果策略实施后依从性较实施前有了显著提升,差异有统计学意义(P<0.01)。血流感染发生率,实施后为0.085%,较实施前0.268%有了显著下降,差异有统计学意义(P<0.01)。结论最佳实践的应用提高了护理人员导管相关性血流感染的预防知识和PICC规范化操作的依从性,降低了导管相关性血流感染的发生率。 | 李丽玲 Alexa McArthur 姚莉莉 李昭颖 顾莺 胡雁 吕天婵 朱晓婷 胡晓静 | 2021 | 护士进修杂志2021，36，4： | 16 |
| 2 | 基于循证的产后妇女会阴疼痛管理计划及实践效果显示文摘目的制定基于循证证据的产后妇女的会阴疼痛管理计划,并评价其实践效果。方法该证据实施项目利用了JBI的GRiP模式,分为证据应用前的基线审查(对病房及门诊的21名护士及30名孕妇进行调查)、将证据引入实践、证据应用后的再次审查(21名护士及30名孕妇)三个阶段。结果六条审查标准的执行率均显著提高,从基线审查时的24%、3%、17%、0%、13%、30%分别提高到证据应用后的100%,100%,80%,100%,40%,100%。护士对会阴疼痛管理的知识从基线审查时的10.4分提高到证据应用后的22.3分。分娩后头3d平均疼痛评分也从基线审查时的2.78分降至证据应用后2.18分。结论目前的临床审查项目在建立妇产科医院产后妇女会阴疼痛管理循证实践方面取得了显著的进步,它有效地提高了工作人员的会阴疼痛管理能力,减少了产后妇女的会阴疼痛。 | 张玉 李莉 黄丽 Alexa McArthur 邢唯杰 | 2018 | 护士进修杂志2018，33，6： | 14 |
| 3 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 4 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 5 | 与在人的疾病的糖尿病 mellitus 和肥胖有关的肾的 hyperfiltration显示文摘 High intraglomerular pressure is associated with renal hyperf iltration, leading to the initiation and progression of kidney disease in experimental models of diabetes mellitus (DM). In humans, hyperf iltration is observed in patients with type 1 and type 2 DM, and is also seen in patients with pre-diabetic conditions, such as the metabolic syndrome. From a mechanistic perspective, both vascular and tubular factors likely contribute to the pathogenesis of hyperf iltration. Until now, human studies have primarily focused on the use of medications that inhibit the renin angiotensin system to reduce efferent vasoconstriction and thereby improve hyperfiltration. More recent advances in the development of investigational adenosine antagonists and inhibitors of sodium glucose cotransport may help to elucidate tubular factors that contribute to afferent vasodilatation. In this review, we summarize available data from experimental and human studies of type 1 and type 2 DM and obesity to provide an overview of factors that contribute to the hyperf iltration state. We have focused on the renin angiotensin system, cyclooxygenase-2 system, nitric oxide, protein kinase C and endothelin as vascular determinants of hyperfiltration. We also dis-cuss relevant tubular factors, since experimental models have suggested that inhibition of sodium-glucose cotransport may be renoprotective. | Alexa N Sasson David ZI Cherney | 2012 | World Journal of Diabetes2012，3，1： | 11 |
| 6 | Signaling events during initiation of arbuscular mycorrhizal symbiosis显示文摘Under nutrient‐limiting conditions, plants will enter into symbiosis with arbuscular mycorrhizal(AM) fungi for the enhancement of mineral nutrient acquisition from the surrounding soil. AM fungi live in close, intracellular association with plant roots where they transfer phosphate and nitrogen to the plant in exchange for carbon. They are obligate fungi,relying on their host as their only carbon source. Much has been discovered in the last decade concerning the signaling events during initiation of the AM symbiosis, including the identification of signaling molecules generated by both partners. This signaling occurs through symbiosis‐specific gene products in the host plant, which are indispensable for normal AM development. At the same time, plants have adapted complex mechanisms for avoiding infection by pathogenic fungi, including an innate immune response to general microbial molecules, such as chitin present in fungal cell walls. How it is that AM fungal colonization is maintained without eliciting a defensive response from the host is still uncertain. In this review, we present a summary of the molecular signals and their elicited responses during initiation of the AM symbiosis, including plant immune responses and their suppression. | Alexa M.Schmitz Maria J.Harrison | 2014 | Journal of Integrative Plant Biology2014，56，3： | 7 |
| 7 | 基于循证的维持性血液透析患者液体摄入依从性管理显示文摘目的将与维持性血液透析患者液体摄入依从性管理有关的最佳证据应用于临床护理实践,提高血液透析患者液体摄入控制依从性。方法将JBI临床证据实践应用系统和临床转化系统作为审查工具,基于现有的血液透析患者液体摄入依从性管理的最佳证据,制定5条审查标准。对20名护士、30例患者实施基线审查和证据应用后第2轮审查。结果基线审查时4条标准执行率较差(0~55.0%),第2轮审查时,第3条审查标准(患者自我监测液体摄入)执行率73.3%,其余4条审查标准执行率均100%。护士液体摄入管理知识和技能得分从12.70提高到14.60(P〈0.01);血液透析患者液体摄入知识和技能得分从11.13分提高到13.47分(P〈0.01),其液体摄入控制不依从率从53.33%降低至23.33%(P〈0.05)。结论基于循证的质量审查改善维持性血液透析患者液体摄入依从性管理的临床护理实践,可提高患者液体摄入控制依从性。 | 黄碧红 贾守梅 薛一帆 Alexa McArthur 曹艳佩 胡雁 陆育华 庞骄阳 | 2016 | 护理学杂志2016，31，17： | 7 |
| 8 | Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation显示文摘大多数前列腺癌症(PCas ) 作为 acinar 类型被分类(常规) 有包括雄激素受体(AR ) 和前列腺特定的抗原(PSA ) 的表示的钠区别的肿瘤房间镇静的腺癌。在腺癌的每种情况中有也散布的 neuroendocrine (NE ) 房间。NE 房间是 quiesecent,不表示 AR 或 PSA,并且他们的功能仍然保持不清楚。我们证明了那条 IL8-CXCR2-P53 小径提供一个生长禁止的信号并且把 NE 房间放在良性的前列腺和腺癌静止。有趣地,在神经质的治疗,和如此的肿瘤由是的纯 NE 房间组成以后,有腺癌的历史的一些病人与小房间 neuroendocrine 癌(SCNC ) 复发高度 proliferative 并且好攻击,由于 P53 变化和 IL8-CXCR2-P53 小径的 inactivation。SCNC 的发生将多半由于进一步禁止 AR 功能或 intratumoral 雄激素合成的新奇的药的普遍使用增加。阶段 II 试用证明了基于铂的化疗可能为如此的导致治疗的肿瘤是有用的。 | Julia Lipianskaya Alexa Cohen Clark J Chen Elaine Hsia Jill Squires Zhen Li Yaqun Zhang Wei Li Xufeng Chen Hua Xu Jiaoti Huang | 2014 | Asian Journal of Andrology2014，16，4： | 6 |
| 9 | Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease显示文摘Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many gastrointestinal(GI)cancers.However,these therapies can also induce autoimmune-like side effects in healthy tissue across the body.One of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with GI malignancies.We also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology. | Alexa R Weingarden Samuel J S Rubin John Gubatan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 10 | 使用Lloyd Relaxation的物体表面网格化显示文摘根据输入的物体表面点云生成与表面点云拓扑结构一致且几何形状接近的三角网格,在计算机图形学建模中具有很重要的作用,提出一种基于Lloyd relaxation的模型表面点云网格化方法.首先从输入点云中随机选取一些样本点,样本点的数目可以指定;然后运用扩展的Lloyd relaxation算法将这些样本点沿着物体表面移动;当得到一个近似均匀的样本点分布后,运用改进的'crust'算法根据这些样本点生成三角网格.通过在每次relaxation过程中减少网格和曲面间体积的方法,使生成的三角网格与原始表面点云的几何形状接近.实验结果证明,该方法能正确、有效地生成输入点云模型的三角网格,并可以运用在三维物体表面重建和网格简化上. | 田宽 马利庄 Marc Alexa | 2009 | 计算机辅助设计与图形学学报2009，21，8： | 3 |
| 11 | Serrated lesions:A challenging enemy显示文摘The serrated pathway accounts for 30%-35%of colorectal cancer(CRC).Unlike hyperplastic polyps,both sessile serrated lesions(SSLs)and traditional serrated adenomas are premalignant lesions,yet SSLs are considered to be the principal serrated precursor of CRCs.Serrated lesions represent a challenge in detection,classification,and removal–contributing to post-colonoscopy cancer.Therefore,it is of the utmost importance to characterize these lesions properly to ensure complete removal.A retrospective cohort study developed a diagnostic scoring system for SSLs to facilitate their detection endoscopically and subsequent removal.From the study,it can be ascertained that both indistinct border and mucus cap are essential in both recognizing and diagnosing serrated lesions.The proximal colon poses technical challenges for some endoscopists,which is why high-quality colonoscopy plays such an important role.The indistinct border of some SSLs poses another challenge due to difficult complete resection.Overall,it is imperative that gastroenterologists use the key features of mucus cap,indistinct borders,and size of at least five millimeters along with a high-quality colonoscopy and a good bowel preparation to improve the SSL detection rate. | Alexa Trovato Alla Turshudzhyan Micheal Tadros | 2021 | World Journal of Gastroenterology2021，27，34： | 3 |
| 12 | 自我护理的概念分析显示文摘目的自我护理是通过评估和教育进行护理干预的重要方面,在不同专业领域文献众多,但其定义并不统一。明确自我护理的含义并清晰表述自我护理的定义性属性、前置因素和后续影响至关重要。方法采用Walker和Avant的概念分析法对自我护理的概念进行分析。检索CINAHL、PubMed和EBSCOhost数据库中1975—2020年的文献,检索文献为经同行评议、全文出版的英文文献。共纳入31篇文章,达到内容饱和。结果通过广泛的文献回顾揭示了与自我护理概念相关的最常用术语的显著特征。依据Walker和Avant的概念分析法,3个定义性属性作为共性主题呈现:认知、自我控制和依靠自己。结论确定自我护理的定义为:通过认知、自我控制和依靠自己,以获得、维持或促进最佳健康和幸福感的照顾自己的能力。 | Nicole Martinez Cynthia D.Connelly Alexa Perez Patricia Calero | 2021 | International Journal of Nursing Sciences2021，8，4： | 2 |
| 13 | Sketch-based shape retrieval显示文摘 | Mathias Eitz Ronald Richter Tamy Boubekeur Kristian Hildebrand Marc Alexa | 2012 | ACM Transactions on Graphics (TOG)2012，，4： | 2 |
| 14 | The response of skin disease to stress:changes in the severity of acne vulgaris as affected by examination stress显示文摘 | Susna Y chon Alexa B | 2003 | J Arch Dematol2003，139，： | 1 |
| 15 | Differential coordinates for local mesh morphing and deformation显示文摘 | Alexa M | 2003 | The Visual Computer2003，19，23： | 1 |
| 16 | Passive immunoprophylaxis of edema disease in weaned piglets显示文摘 | Alexa P Hamrik J Stouracova K | 2004 | Vet Med2004，49，12： | 1 |
| 17 | Merging polyhedral shapes with scattered features 显示文摘 | Alexa M | 2000 | The Visual Computer2000，16，1： | 1 |
| 18 | Detection of virulence factors of Escherichia coli focused on prev- alence of EAST1 toxin in stool of diarrheic and non-diarrheic piglets and presence of adhesion involving virulence factors in astA positive strains显示文摘 | Zuzana Sramkova Zajacova Lucie Konstantinova Pavel Alexa | 2012 | Veterinary Microbiology2012，154，3： | 1 |
| 19 | Optimized combined harmonic filtering system显示文摘 | Dimitrie Alexa Sirbu A | 2001 | IEEE Transactions on Industrial Electronics2001，48，6： | 1 |
| 20 | Gene typing of the colonisation factors K88 (F4) in enterotoxigenic Escherichia coli strains isolated fi:om diarrhoeic piglets 显示文摘 | Alexa P Stouracova K Harnrik J Rychlik I | 2001 | Vet Med Czech2001，46，2： | 1 |
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