|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 3 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 4 | p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis显示文摘成红血球细胞的 Enucleation 对哺乳动物在终端区别期间唯一。尽管 erythroid enucleation 广泛地被学习了,包括 retinoblastoma 蛋白质(Rb ) ,仅仅一些基因被识别了调整原子挤出。它由哪个仍然保持大部分未定义发信号的分子,外来的刺激例如 erythropoietin (Epo ) ,是 transduced 导致 enucleation。这里,我们显示出那 p38α,激活 mitogen 的蛋白质 kinase (MAPK ) ,为 erythroid enucleation 被要求。在包含高 Epo 层次并且模仿的一个前 vivo 区别系统强调红血球生成, p38α在 erythroid 区别期间被激活。p38α 的损失;完全堵住主要成红血球细胞的 enucleation。而且, p38α在胎儿、贫血的压力红血球生成期间在 vivo 以一种房间自治的方式调整成红血球细胞 enucleation。显著地, p38α 的损失;导致 p21 目标 Rb 的 p21,和减少的激活的 downregulation,哪个是成红血球细胞 enucleation 的重要管理者。这研究表明那 p38α在压力红血球生成期间是为成红血球细胞 enucleation 的一个关键发信号分子。 | Simon M Schultze Andreas Mairhofer Dan Li Jin Cen Hartmut Beug Erwin F Wagner Lijian Hui | 2012 | Cell Research2012，22，3： | 2 |
| 5 | Longterm multiple color imaging of live cells using quantum dot bioconjugates 显示文摘 | Jaiswal J K Mattoussi H Mauro J M Simon S F | 2003 | Nature Biotechnolgy2003，21，： | 1 |
| 6 | The biological impact of mass-spectrometry-based proteomics 显示文摘 | Cravatt B F Simon G M Yates J R 3rd | 2007 | Nature2007，450，7172： | 1 |
| 7 | Insulin resistance in epileptic girls who gain weight after therapy with valproic acid显示文摘 | Verrotti A Basciani F De Simone M | 2002 | J Child Neurol2002，17，4： | 1 |
| 8 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 9 | Estimation of the Effective Permeability in Magnetorheological Fluids 显示文摘 | Simon M Reitich F Jolly M P | 1999 | Journal of Intelligent Material Systems and Structures1999，10，11： | 1 |
| 10 | A microwavc-assisted sequential extraction of water and dilute acid soluble arsenic species from marine plant and animal tissues显示文摘 | SIMON F WILLIAM M FRANK K | 2007 | Talanta2007，71，2： | 1 |
| 11 | Hypoxia, HIFs, and cardiovascular development显示文摘 | Simon M C Ramircz-Bergeron D Mack F | 2003 | Cold Spring Harb Symp Quant Biol2003，67，： | 1 |
| 12 | Resistin regulates human cho cell invasive behaviour and en dothelial cell angiogenic processes显示文摘 | Di Simone N Di Nicuolo F Sanguinetti M | 2006 | J Endocrinol2006，189，3： | 1 |
| 13 | On the Energy Detection of Unknown Signals over Fading Channels显示文摘 | DIGHAM F F ALOUINI Mohamed-Slim SIMON M K | 2007 | IEEE Transactions on Communications2007，55，01： | 1 |
| 14 | A PhaseⅠ dose-escalation study of regorafenib (BAY 73-4506),an inhibitor of oncogenic,angiogenic,and stromal kinases,in patients with advanced solid tumors显示文摘 | Klaus M Annette F Simone S | | 0，，09： | 1 |
| 15 | Multiple right-sid-ed pulmonary nodules : metastatic cancer or resectable earlystage tumor? 显示文摘 | Cioffi U Raveglia F De Simone M | 2011 | J Cardiothorac Surg2011，6，： | 1 |
| 16 | Fludarabine and cytarabine as continuous sequential infusion for elderly patients with acute myeloid leukemia显示文摘 | Ferrara F D'Arco AM De Simone M | 2005 | Haematologica2005，90，6： | 1 |
| 17 | Neutral atmospheric delay in interferometric synthetic aperture radar applications: Statistical description and mitigation显示文摘 | Emardson T R Simons M Webb H F | 2003 | Journal of Geophysical Research2003，108，5： | 1 |
| 18 | New technique for treatment of unstable distal femur fractures by locked double-plating:Case report and biomechanical evaluation显示文摘 | Jazrawi L M Kummer F J Simon J A | 2000 | J Trauma2000，48，1： | 1 |
| 19 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 20 | Treatment with simva - statin in normocholesterolemic patients with Alzheimer' s disease : A 26 week randomized, placebo - controlled, double - blind trials 显示文摘 | Simons M Sehwarzler F Lutjohann D | 2002 | Ann Neurol2002，52，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员