|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells显示文摘AIM: Thiazolidinediones (TZD) are a new class of oral antidiabetic drugs that have been shown to inhibit growth of same epithelial cancer cells. Although TZD were found to be ligands for peroxisome proliferator-activated receptor γ (PPARγ), the mechanism by which TZD exert their anticancer effect is presently unclear. In this study,we analyzed the mechanism by which TZD inhibit growth of human pancreatic carcinoma cell lines in order to evaluate the potential therapeutic use of these drugs in pancreatic adenocarcinoma.METHODS: The effects of TZD in pancreatic cancer cells were assessed in anchorage-independent growth assay.Expression of PPARγ was measured by reverse-transcription polymerase chain reaction and confirmed by Western blot analysis. PPARγ activity was evaluated by transient reporter gene assay. Flow cytometry and DNA fragmentationassay were used to determine the effect of TZD on cell cycle progression and apoptosis respectively. The effect of TZD on ductal differentiation markers was performed by Western blot.RESULTS: Exposure to TZD inhibited colony formation in a PPARγ-dependent manner. Growth inhibition was linked to G1 phase cell cycle arrest through induction of the ductal differentiation program without any increase of the apoptotic rate.CONCLUSION: TZD treatment in pancreatic cancer cells has potent inhibitory effects on growth by a PPAR-dependent induction of pacreatic ductal differentiation. | Elisabetta Ceni Tommaso Mello Mirko Tarocchi David W Crabb Anna Caldini Pietro Invernizzi Calogero Surrenti Stefano Milani Andrea Galli | 2005 | World Journal of Gastroenterology2005，11，8： | 15 |
| 2 | Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis显示文摘瞄准:在有人半胱氨酸(HCY ) 和 haemostatic 系统的各种各样的部件的 PBC 和它的关系估计 hypercoagulability。方法:我们调查了 51 个 PBC 病人(43F/8M;意味着年龄:63+/-13.9 年) 并且 102 个健康题目(86 个 women/16 人;63+/-13 年) ,并且由 PFA-100 由 Sonoclot 分析和血小板功能在全血评估了 haemostatic 过程设备。我们然后测量了 HCY (禁食并且在蛋氨酸装载以后) ,织物因素(TF ) , thrombin-antithrombin 建筑群(梭织) , D 暗淡(D-D ) , thrombomodulin (TM ) , folic,维生素 B6 和 B12 血浆铺平。C677T 5,10-methylenetetrahydrofolate 还原酶(MTHFR ) 多型性被分析。结果:病人的 Sonoclot 率值是显著地(P<0.001 ) 比那些高控制。山峰价值的 Sonoclot 时间和 PFA-100 闭合时间在病人和控制是可比较的。梭织, TF 和 HCY 层次,两个在禁食并且蛋氨酸以后的装载,显著地(P<0.001 ) 在病人更高与比在控制。维生素缺乏在 45/51 病人(88.2%) 被检测。同型结合的 TT677 MTHFR 遗传型的流行比在控制(17.5%)(P<0.05 ) 在病人(31.4%) 是显著地更高的。Sonoclot 率价值与 HCY 层次和 TF 显著地相关。结论:在 PBC, hyper-HCY 与维生素缺少和基因预先安排因素有关。内皮激活的增加的 TF 和 HCY 层次和符号与 hypercoagulability 被联系并且可以在血凝固激活有一个重要角色。 | Maria Rosa Biagini Alessandro Tozzi Rossella Marcucci Rita Paniccia Sandra Fedi Stefano Milani Andrea Galli Elisabetta Ceni Marco Capanni Raffaele Manta Rosanna Abbate Calogero Surrenti | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 3 | Acetaldehyde Inhibits PPARγ via H 2 O 2 -Mediated c-Abl Activation in Human Hepatic Stellate Cells显示文摘 | Elisabetta Ceni David W. Crabb Marco Foschi Tommaso Mello Mirko Tarocchi Valentino Patussi Luca Moraldi Renato Moretti Stefano Milani Calogero Surrenti Andrea Galli | 2006 | Gastroenterology2006，，4： | 2 |
| 4 | Alcohol induced hepatie fibrosis:role of acetaldehyde显示文摘 | Mello T Ceni E Surrenti C | 2008 | Mol Aspects Med2008，29，12： | 1 |
| 5 | Oral S- adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis: a double-blind, placebo-controlled study 显示文摘 | Frezza M Surrenti C Manzillo G | 1990 | Gastroenterology1990，99，1： | 1 |
| 6 | Multieentre double--blind plaeebo--eortrolled study of intravenous and oral S-- adenosyl--L -- methionine in eholestatie patients with liver disease显示文摘 | IManzillo G pieeinioo F Surrenti C | 1992 | Drug In- vest1992，4，4： | 1 |
| 7 | Melanoma in a 5-year- old child with a giant congenital melanocytic naevus显示文摘 | Surrenti T Dioeiaiuti A Inserra A | 2012 | Acta Derm Venereol2012，92，6： | 1 |
| 8 | Alcohol induced hepatic fibrosis-role of acetaldehyde显示文摘 | Mello T Ceni E Surrenti C | 2008 | Mol Aspects Med2008，29，12： | 1 |
| 9 | Transforming growth factors O1 and beta2 are differentially expressed infibrotic liver disease显示文摘 | Miachael C Surrenti C Milani S | 1991 | Bone Joint- Surge1991，，73： | 1 |
| 10 | Measuring quality of life in dyspeptic patients: development and validation of a new specific health status questionnaire显示文摘 | Francesco Bamfi M.S Antonio Olivieri Fabio Arpinelli Gianfranco De Carli Giuseppe Recchia Lionello Gandolfi Lorenzo Norberto Franco Pacini Calogero Surrenti Sidney H Irvine Giovanni Apolone | 1999 | The American Journal of Gastroenterology1999，，3： | 1 |
| 11 | Pharmacokinetics of dirithromycin in patients with mild or moderate cirrhosis显示文摘 | Surrenti C Novelli A | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 12 | Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus–transgenic mice by peroxisome proliferator‐activated receptor γ–independent regulation of nucleophosmin显示文摘 | Andrea Galli Elisabetta Ceni Tommaso Mello Simone Polvani Mirko Tarocchi Francesca Buccoliero Francesca Lisi Laura Cioni Barbara Ottanelli Valeria Foresta Guido Mastrobuoni Gloriano Moneti Giuseppe Pieraccini Calogero Surrenti Stefano Milani | 2010 | Hepatology2010，，2： | 1 |
| 13 | Alcohol induced hepatic fibrosis:role of acetaldehyde显示文摘 | MELLO T CENI E SURRENTI C | 2008 | Molecular Aspects of Medicine2008，29，1： | 1 |
| 14 | Audit of constipation in ter - tiary referral gestroenterology pratice 显示文摘 | Surrenti E Rath DM Pemtberton JH | 1995 | Am J Gastroenterol1995，90，9： | 1 |
| 15 | Muhicentre double - blind placebo - controlled study of intravenous and oral S - adenosy - L - methionioe(SAMe) in cholestatic patients with liver disease 显示文摘 | Manzillo G piccinino F Surrenti C | 1992 | Drug Invest1992，4，4： | 1 |
| 16 | Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism显示文摘 | Galli A Svegliati-Baroni G Ceni E Milani S Ridolfi F Salzano R Tarocchi M Grappone C Pellegrini G Benedetti A Surrenti C Casini A | 2005 | Hepatology2005，41，5： | 1 |
| 17 | Colonic vasoactive intestinal polypeptide in ulcerative colitis显示文摘 | Surrenti C Renzi D Garcea MR | 1993 | J Physiol Paris1993，87，30： | 1 |
| 18 | Audit of constipation in a tertiary referral gastroenterology practice 显示文摘 | SURRENTI E RATH D M PEMBERTON J H | 1995 | Am J Gastroenterol1995，90，9： | 1 |
| 19 | Pharmacokinetics of dirithromyein in patients with mild or moderate cirrhosis 显示文摘 | Mazzei T Surrenti C Novelli A | 1999 | Antimierob Agents Chemother1999，43，7： | 1 |
| 20 | Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro显示文摘 | Andrea Galli David W. Crabb Elisabetta Ceni Renata Salzano Tommaso Mello Gianluca Svegliati–Baroni Francesco Ridolfi Luciano Trozzi Calogero Surrenti Alessandro Casini | 2002 | Gastroenterology2002，，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员