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| 1 | Helping the Consumers and Producers of Standards,Repositories and Policies to Enable FAIR Data显示文摘Thousands of community-developed(meta)data guidelines,models,ontologies,schemas and formats have been created and implemented by several thousand data repositories and knowledge-bases,across all disciplines.These resources are necessary to meet government,funder and publisher expectations of greater transparency and access to and preservation of data related to research publications.This obligates researchers to ensure their data is FAIR,share their data using the appropriate standards,store their data in sustainable and community-adopted repositories,and to conform to funder and publisher data policies.FAIR data sharing also plays a key role in enabling researchers to evaluate,re-analyse and reproduce each other’s work.We can map the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their use.In this paper,we show how the work of the GO-FAIR FAIR Standards,Repositories and Policies(StRePo)Implementation Network serves as a central integration and cross-fertilisation point for the reuse of FAIR standards,repositories and data policies in general.Pivotal to this effort,the FAIRsharing,an endorsed flagship resource of the Research Data Alliance that maps the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their use.Lastly,we highlight a number of activities around FAIR tools,services and educational efforts to raise awareness and encourage participation. | Peter McQuilton Dominique Batista Oya Beyan Ramon Granell Simon Coles Massimiliano Izzo Allyson L.Lister Robert Pergl Philippe Rocca-Serra Ben Schaap Hugh Shanahan Milo Thurston Susanna-Assunta Sansone | 2020 | Data Intelligence2020，2，1： | 5 |
| 2 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 3 | The gut-liver axis显示文摘 | Ruben G.J. Visschers Misha D. Luyer Frank G. Schaap Steven W.M. Olde Damink Peter B. Soeters | 2013 | Current Opinion in Clinical Nutrition and Metabolic Care2013，，5： | 2 |
| 4 | Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength显示文摘 | Laura A. Schaap Saskia M.F. Pluijm Dorly J.H. Deeg Marjolein Visser | 2006 | The American Journal of Medicine2006，，6： | 2 |
| 5 | cAMP-dependent protein kinase activity is essential for preaggregative gene expression in Dictyostelium显示文摘 | SCHAAP P | 1995 | FEBS Letters1995，368，： | 1 |
| 6 | Fatty acid-binding proteins in the heart 显示文摘 | Schaap F G van der Vusse G J Glatz J F C | 1998 | Mol Cell Biochem1998，180，12： | 1 |
| 7 | Rosetta: A com- puter program for estimating soil hydraulic parameters with hierar- chical pedotransfer functions 显示文摘 | Schaap M G Leij F J Van Genuchten M Th | 2001 | Journal of Hydrology2001，251，34： | 1 |
| 8 | Control of coccidiosis in chickens by vaccination显示文摘 | VERMEULEN A N SCHAAP D C SCHETTERS T P | | 0，，： | 1 |
| 9 | Neural network analysis for hierarchical prediction of soil hydraulic properties显示文摘 | Schaap M G Leij F J van Genuehten M T | 1998 | Soil Scienee Society of America Journal1998，62，4： | 1 |
| 10 | Improved prediction of unsaturated hydraulic conductivity with the Mualem--van Genuehten model显示文摘 | Schaap M G Leij F J | 2000 | Soil Science Society of America Journal2000，64，3： | 1 |
| 11 | Polyphosphate accumulation in the senescing mushroom Agaricus bisporus显示文摘 | Braaksma A Meer P V Schaap D J | 1996 | Post-harvest Biology and Technology1996，8，： | 1 |
| 12 | Dysregulation of anti - angiogenic agents (sFlt - 1, PIGF, and sEndoglin ) in preeclampsia - a step forward but not the definitive answer显示文摘 | Foidart JM Schaaps JP Chantraine F | 2009 | J Reprod Immunol2009，82，2： | 1 |
| 13 | Signal transduction of bone morphogenetic proteins in osteoblast differentiation 显示文摘 | Peter Ten Dijke Jingyuan FU Peter Schaap | 2003 | Bone Joint Surg Am2003，85，： | 1 |
| 14 | Cytoplasmic fatty acid-binding protein facilitates fatty acid utilization by skeletal muscle显示文摘 | GLATZ J F C SCHAAP F G BINAS B | 2003 | Acta Physiologica Scandinavica2003，178，4： | 1 |
| 15 | Considerations for improving the accuracy of permittivity measurement using time domain reflectometry 显示文摘 | Robinson D Schaap M Jones S B | 2003 | Soil Science Society of America Journal2003，67，1： | 1 |
| 16 | Standardized evaluation methodology and reference database for evaluating coronary artery centerline extraction algorithms显示文摘 | Schaap M Metz C T Walsum T | | 0，，05： | 1 |
| 17 | Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice显示文摘 | van der Vliet HN Schaap FG Levels JH | | 0，，05： | 1 |
| 18 | Induction of graft-versus-leukemia to prevent after partially lymphocyte-depleted allogeneic bone marrow transplantation by pre-emptive donor leukocyte infusion 显示文摘 | Schaap N Schattenberg A Bar B | 2001 | Leukemia2001，15，： | 1 |
| 19 | Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice显示文摘 | Van der Vliet HN Schaap FG Levels JH Ottenhoff R Looije N Wesseling JG | 2002 | Biochem Biophys Res Commun2002，295，5： | 1 |
| 20 | Prevalence of tuberculosis, HIV and respiratory symptoms in two Zambian communities: implications for tuberculosis control in the era of HIV显示文摘 | Ayles H Schaap A Nota A | 2009 | Plos One2009，4，5： | 1 |
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