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| 1 | Overlap syndromes among autoimmune liver diseases显示文摘The three major immune disorders of the liver are autoimmune hepatitis(AIH),primary biliary cirrhosis(PBC) and primary sclerosing cholangitis(PSC).Variant forms of these diseases are generally called overlap syndromes,although there has been no standardised definition.Patients with overlap syndromes present with both hepatitic and cholestatic serum liver tests and have histological features of AIH and PBC or PSC.The AIH-PBC overlap syndrome is the most common form,affecting almost 10% of adults with AIH or PBC.Single cases of AIH and autoimmune cholangitis(AMA-negative PBC) overlap syndrome have also been reported.The AIH-PSC overlap syndrome is predominantly found in children,adolescents and young adults with AIH or PSC.Interestingly,transitions from one autoimmune to another have also been reported in a minority of patients,especially transitions from PBC to AIH-PBC overlap syndrome.Overlap syndromes show a progressive course towards liver cirrhosis and liver failure without treatment.Therapy for overlap syndromes is empiric,since controlled trials are not available in these rare disorders.Anticholestatic therapy with ursodeoxycholic acid is usually combined with immunosuppressive therapy with corticosteroids and/or azathioprine in both AIH-PBC and AIH-PSC overlap syndromes.In end-stage disease,liver transplantation is the treatment of choice. | Christian Rust Ulrich Beuers | 2008 | World Journal of Gastroenterology2008，14，21： | 41 |
| 2 | Predictors of premature delivery in patients with intrahepatic cholestasis of pregnancy显示文摘瞄准:在怀孕(ICP ) 的肝内胆汁郁积为早熟评估临床的症状和生物化学的参数的预兆的价值。方法:有 ICP 的六十个征兆的病人在这回顾的分析被包括。Preterm 交货在 37 wk 怀孕期前被定义为交货。preterm 交货的预言者被二进制代码多揭示变量逻辑回归分析。结果:交货的吝啬的时间是 38.1 +/- 1.7 wk。没有死胎发生了。早产在八被观察(13.3%) 病人。全部的禁食浆液胆汁酸更高(47.8 +/- 15.2 对 41.0 +/- 10.0 mumol/L, P <
0.05 ) ,并且瘙痒趋于更早开始(29.0 +/- 3.9 对 31.6 +/- 3.3 wk, P = 0.057 ) 在有早产的病人什么时候与那些相比与术语交货。二进制多逻辑回归分析揭示了的变量瘙痒的那早发作(或 1.70, 95% CI 1.23-2.95, P = 0.038 ) 并且浆液胆汁酸(或 2.13, 95% CI 1.13-3.25, P = 0.013 ) 是 preterm 的独立预言者交货。结论:瘙痒的早发作和浆液胆汁酸的高水平在 ICP 预言 preterm 交货,并且为穷人在风险定义病人的亚群新生的结果。 | Jurate Kondrackiene Ulrich Beuers Rimantas Zalinkevicius Horst-Dietmar Tauschel Vladas Gintautas Limas Kupcinskas | 2007 | World Journal of Gastroenterology2007，13，46： | 39 |
| 3 | Ursodeoxycholic acid treatment of vanishing bile duct syndromes显示文摘消失的胆汁管症候群(VBDS ) 被从肝失败导致长期的胆汁郁积,肝硬化,和早熟的死亡的许多不同疾病引起的小肝内管的进步损失描绘。有 VBDS 的成年病人的多数受不了主要胆汁性肝硬变(PBC ) 和主要致硬化的胆管炎(PSC ) 。Ursodeoxycholic 酸(UDCA ) ,吸水的 dihydroxy 胆汁酸,唯一的药当前被同意因为有 PBC 的病人的治疗,和 anticholestatic 效果为几另外的胆汁郁积的症候群被报导了。UDCA 的行动的几潜在的机制包括肝胆管分泌物的刺激被建议了, apoptosis 的抑制和对恐水病的胆汁酸的有毒的效果的 cholangiocytes 的保护。 | Thomas Pusi Ulrich Beuers | 2006 | World Journal of Gastroenterology2006，12，22： | 18 |
| 4 | Unmet clinical need in autoimmune liver diseases显示文摘 | Jessica K. Dyson Gwilym Webb Gideon M. Hirschfield Ansgar Lohse Ulrich Beuers Keith Lindor David E.J. Jones | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Overlap Syndromes显示文摘 | Ulrich Beuers Christian Rust | 2005 | Semin Liver Dis2005，，03： | 2 |
| 6 | 熊脱氧胆酸和考来烯胺治疗妊娠期肝内胆汁淤积症的功效与安全性比较显示文摘Background & Aims: Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid appears promising, but data are limited so far. The aim of this randomized study was to evaluate the efficacy and safety of ursodeoxycholic acid in comparison with cholestyramine. Methods: Eighty-four symptomatic patients with intrahepatic choles-tasis of pregnancywere randomized to receive either ursodeoxycholic acid, 8- 10 mg/kg body weight daily (n = 42), or cholestyramine, 8 g daily (n = 42), for 14 days. The primary end point was a reduction of pruritus by more than 50% after 14 days of treatment as evaluated by a pruritus score. Secondary end points were outcome of pregnancy, reduction of serum aminotransferase activities and serum bile acid levels, and drug safety. Intention-to-treat analysis was applied. Results: Pruritus was more effectively reduced by ursodeoxycholic acid than cholestyramine (66.6% vs 19.0% , respectively; P < .005). Babies were delivered significantly closer to term by patients treated with ursodeoxycholic acid than those treated with cholestyramine (38.7 ± 1.7 vs 37.4 ± 1.5 weeks, respectively, P < .05). Serum alanine and aspartate aminotransferase activities were markedly reduced by 78.5% and 73.8% , respectively, after ursodeoxycholic acid, but by only 21.4% , each, after cholestyramine therapy (P < .01 vs ursodeoxycholic acid). Endogenous serum bile acid levels decreased by 59.5% and 19.0% , respectively (P < .02). Ursodeoxycholic acid, but not cholestyramine was free of adverse effects. Conclusions: Ursodeoxycholic acid is safe and more effective than cholestyramine in intrahepatic cholestasis of pregnancy. | Kondrackiene J. Beuers U. Kupcinskas L. 陈云茹 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，2： | 2 |
| 7 | Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited显示文摘 | Gustav Paumgartner Ulrich Beuers | 2002 | Hepatology2002，，3： | 2 |
| 8 | 原发性胆汁性肝硬化的药物治疗显示文摘熊去氧胆酸(UDCA)已被广泛用于原发性胆汁性肝硬化(PBC)的治疗。80年代后期和90年代初期的随机对照试验证实,UDCA能有效改善PBC患者血清生化指标。2000年首次报道UDCA有效阻止PBC组织学进展。早期meta分析曾怀疑UDCA治疗PBC的益处,但由于其治疗时间较短和剂量不足而受质疑。最近,三组长达20年以上的队列研究表明,采用适当剂量UDCA(每日13~15mg/kg)治疗组织学为1~2期的早期患者. | U. Beuers 倪鎏达(译) | 2008 | 肝脏2008，13，1： | 2 |
| 9 | 10-year survival evaluation for glass-fiber-supported postendodontic restoration:a prospective observational clinical study显示文摘 | Naumann M Koelpin M Beuer F | 2012 | J Endod2012，38，4： | 1 |
| 10 | Targeting the ABCB4 gene to control cholesterol homeostasis显示文摘 | Oude Elferink RP Beuers U | | 0，，10： | 1 |
| 11 | New paradigms in the treatment of hepatic cholestasis:from UDCA to FXR,PXR and beyond显示文摘 | Beuers U Trauner M Jansen P | 2015 | J Hepatol2015，，： | 1 |
| 12 | What an endoscopist should know about immunoglobulin-G4-associated disease of the pancreas and biliary tree显示文摘 | L. Maillette de Buy Wenniger E. Rauws U. Beuers | 2012 | Endoscopy2012，，01： | 1 |
| 13 | New paradigms in the treatment of hepatic cholestasis:from UDCA to FXR,PXR and beyond显示文摘 | Beuers U Trauner M Jansen P et a1 | 2015 | J Hepatol2015，，： | 1 |
| 14 | Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes显示文摘 | Beuers U Probst I Soroka C et a1 | 1999 | Hepatology1999，29，： | 1 |
| 15 | 10-year survival evaluation for glass-fiber-supported postendodontic restoration:a prospective observational clinical study显示文摘 | Naumann M Koelpin M Beuer F | 2012 | J Endod2012，38，4： | 1 |
| 16 | Ursodeoxycholc acid in cholestatic liver disease mechanisms of action and therapeutic use revisit显示文摘 | Paumgartner G Beuers U | 2002 | Hepatology2002，36，： | 1 |
| 17 | Intrahepatic cholestasis of pregnancy显示文摘 | PUAL T BEUERS U | 2007 | Orphanet J Rare Dis2007，29，2： | 1 |
| 18 | The biliary HCO3' umbrella-A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies显示文摘 | Beuers U Hohenester S Maillette de Buy Wenniger LJ | 2010 | Hepatology2010，52，4： | 1 |
| 19 | Ursodeoxycholic acid in cholestatic Liver divease:mechanisms of action and thereapeutic use revisited显示文摘 | PAUMGARTNER G BEUERS U | 2002 | Hepatology2002，36，3： | 1 |
| 20 | Nucleosomal DNA fragments in autoimmune diseases显示文摘 | Holdenrieder S Eichhorn P Beuers U | 2006 | Ann N Y Acad Sci2006，1075，： | 1 |
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