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| 1 | 迟发性性腺功能减退症与骨化二醇的关系显示文摘男性迟发性性腺功能减退症是指具有血清睾酮(T)水平降低和典型临床症状的综合征。而血清睾酮浓度是否总能真实反应Leydig细胞的功能目前仍不确定。轻度睾丸改变只有通过检测额外的生化标记物如黄体生成素(LH)和25.羟维生素D才能确诊。这些标记物可以帮助诊断称之为“亚临床”型的性腺功能减退(血清睾酮正常,LH升高)。性腺功能减退患者通常由于睾丸中CYP2Rt羟化酶受损而具有较低水平的25.羟维生素D。然而,目前仍无证据阐释维生素D3亦或骨化二醇是治疗此类病人的最佳选择。因此我们分析了26位具有典型性腺功能减退患者(总T[TT]〈12nmol 1^-1,LH≥8IU 1^-1)及46位亚临床型性腺功能减退患者(TT≥12nmol 1^-1,LH≥8IU 1^-1)以及低25-羟维生素D患者(〈50nmol 1^-1)。其中20名患者接受每周5000IU的维生素D3治疗,46名患者接受每周4000IU的骨化二醇治疗。治疗3个月后,患者25-羟维生素D及甲状旁腺激素升高。在两组患者中(原发型16人,亚临床型30人)补充骨化二醇可以显著提高25-羟维生素D水平并显著降低甲状旁腺激素水平,而补充维生素D3的患者,其25-羟维生素D和甲状旁腺激素水平并无明显变化。本研究首次阐述服用骨化二醇而非维生素D3,可以提高男性迟发性性腺功能减退患者25-羟维生素D水平。 | Carlo Foresta Aldo E Calogero Francesco Lombardo Andrea Lenzi Alberto Ferlin | 2015 | Asian Journal of Andrology2015，17，2： | 2 |
| 2 | Efficacy of penile low-intensity shockwave treatment for erectile dysfunction:correlation with the severity of cavernous artery disease显示文摘We analyzed the efficacy of penile low-intensity extracorporeal shockwave treatment for erectile dysfunction(ED)combined with cavernous artery disease(CAD).ED was evaluated by the International Index of Erectile Function,subdividing patients into mild and moderate/severe forms.CAD was assessed using penile color Doppler ultrasonography.Patients(n=111)with a positive outcome after treatment,based upon the minimal clinically important difference of the International Index of ED,were followed up for 3 months and 6 months.We found a significant mean increase in the index of erectile function,with an overall improvement in hemodynamic parameters of the cavernous artery.In particular,93.9%of the patients with mild ED without CAD responded to treatment and 72.7%resumed normal erectile function.Only 31.2%of the patients with moderate/severe ED and CAD responded to treatment,and none resumed normal erectile function.All patients with mild ED and no CAD maintained the effects of therapy after 3 months,while no patients with moderate/severe ED and CAD maintained the benefits of treatment after 3 months.Thus,patients with mild ED and no CAD have better and longer lasting responses to such treatment,with a higher probability of resuming normal erectile function than patients with moderate/severe ED and CAD. | Nicola Caretta Maurizio De Rocco Ponce Nadia Minicuci Ilaria De Santis Pierfrancesco Palego Andrea Garolla Carlo Foresta | 2021 | Asian Journal of Andrology2021，23，5： | 2 |
| 3 | Prognostic Value of Y deletion analysis The role of current methods显示文摘 | Foresta C Moro E Ferlin A | 2001 | Hum Reprod2001，16，8： | 1 |
| 4 | Blood levels, apoptosis, and homing of the endothelial progenitor ceils after skin burns and eschareetomy 显示文摘 | Foresta C Schipilliti M De Toni L | 2011 | J Trauma2011，70，2： | 1 |
| 5 | Reduced number of circulating endothelial progenitor cells in hypogonadal men显示文摘 | Foresta C Caretta N Lana A | | 0，，11： | 1 |
| 6 | High frequency of well - defined Y - chromosome deletions in idiopathic sertoli cell - only syudrom显示文摘 | Foresta C Ferlin A Garolla A | 1998 | Hum Reprod1998，13，2： | 1 |
| 7 | Y chromosome microdeletions and alterations of spermatogenesis显示文摘 | Foresta C Moro E Ferlin A | 2001 | Endocr Rev2001，22，2： | 1 |
| 8 | Follicle-stimulating hormone treatment of male infertility显示文摘 | Foresta C Selice R Garolla A | 2008 | Curr Opin Urol2008，18，： | 1 |
| 9 | Detergents as probes of hydrophobic binding cavities in serum albumin and other water - soluble proteins 显示文摘 | KRAGH- HANSEN U HELLEC F DE FORESTA B | 2001 | Biophys J2001，80，6： | 1 |
| 10 | 查看详情显示文摘 | Ferlin A Schipilliti M Foresta C | | 0，，06： | 1 |
| 11 | Microdeletion of chromosome Y in male infertility:role of the DAZ gene显示文摘 | Foresta C Ferlin A Moro E | 2001 | Ann Ital Med Int2001，16，2： | 1 |
| 12 | Hing frequency of well- defined Y- chromosome in idiopathic sertoli cell- only syndrome显示文摘 | Foresta C Ferlin A Giaroll A Garolla A | 1998 | Hum Reprod1998，13，： | 1 |
| 13 | Semen washing procedures do not eliminate human papilloma virus sperm infection in infertile patients显示文摘 | Foresta C Pizzol D Bertoldo A | 2011 | Fertil Steril2011，96，5： | 1 |
| 14 | Mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa显示文摘 | Foresta C Patassini C Bertoldo A | 2011 | PLoS One2011，6，15： | 1 |
| 15 | Multivariate multi-scale permutation entropy for complexity analysis of Alzheimer's disease EEG显示文摘 | Morabito F C Labate D La Foresta F | 2012 | Entropy2012，14，7： | 1 |
| 16 | Y-chromosome deletions in idiopathic severe testiculopathies 显示文摘 | Ferlin A Garolla A | 1997 | J Clin Endocrinol and Metab1997，82，： | 1 |
| 17 | Deletion and expression analysis of AZFa genes on the humanY chromosome revealed amajor role for DBY inmale infertility 显示文摘 | Foresta C Ferlin A Moro E | 2000 | Hum Mol Genet2000，9，8： | 1 |
| 18 | Role of androgens inerectile function显示文摘 | Foresta C Caretta N Rossato M | 2004 | J Uroloy2004，171，61： | 1 |
| 19 | Y chromosome microdeletions and alterations of spermatogenesis 显示文摘 | Foresta C Moro E Ferlin A | 2001 | Endocr Rev2001，22，2： | 1 |
| 20 | Deformation and fracture of aluminium foams under proportional and non proportional multi-axialloading: statistical analysis and size effect 显示文摘 | Blazy J S Marie-Louisea A Foresta S | 2004 | International Journal of Mechanical Science2004，46，： | 1 |
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